Vitamin B12

[RobinN]

I am not sure if there is another thread with this thought running through it:

Vitamin B12 deficiency causing neuropsychiatric manifestations such as peripheral neuropathy, subacute combined degeneration of cord, dementia, ataxia, optic atrophy, psychosis and mood disturbances is well known.[1],[2],[3] We report a case with recurrent seizures resulting from vitamin B12 deficiency.

http://www.neurologyindia.com/articl...3;aulast=Kumar
http://www.seizure-journal.com/artic...02032/abstract

I know other B Vitamins have been proven to help in seizure control.

[brain]

Robin ... Zoe?

Just for you ... why not do a research
on Vitamin B-9 deficiency? Which is
caused by birth, genetic, DNA - and
you'll be surprised and all the problematic
issues that comes from it and not just
that but also Nervous system pathology,
primarily CNS, mitochondrial DNA or
mitochondria.

It'll be a real eye-opener for you!



I already know what's behind
those doors and it's a lot and
a mouthful, err - a postful!

[Zoe]

Robin ... Zoe?

Just for you ... why not do a research on Vitamin B-9 deficiency? Which is
caused by birth, genetic, DNA - and you'll be surprised and all the problematic
issues that comes from it and not just that but also Nervous system pathology,
primarily CNS, mitochondrial DNA or mitochondria.

It'll be a real eye-opener for you!



I already know what's behind
those doors and it's a lot and
a mouthful, err - a postful!

Have you done a search on each of the drugs you take and folic acid {B9}?

[Zoe]

I am not sure if there is another thread with this thought running through it:

http://www.neurologyindia.com/articl...3;aulast=Kumar
http://www.seizure-journal.com/artic...02032/abstract

I know other B Vitamins have been proven to help in seizure control.

Hi Robin,
The low B12 levels will contribute to the build up of homocysteine which will lower the seizure threshold. Awesome stuff.
The internet connection is acting up here so can't get the links to post for you. Will do so later.

[brain]

Have you done a search on each of the drugs you take and folic acid {B9}?

Have I? Oh yes.

[Andrew]

Hi Brain,

How long have you been using Folic Acid (vitamin B9) and do you take any anti-epileptic drugs with your Folic Acid?

I have been using Pyridoxine HCL (vitamin B6) for nearly 37 years. For the first 19 years of my life Pyridoxine HCL was the only medication I used to contol my seizures. At 19 years of age I introduced a multi B complex tablet* to my medication. This stopped an aura that I was experiencing almost every morning. Apart from absent seizures I have been approx. 17 years seizure free.

Andrew

* I have had my multi B complex tablet checked out at the hospital and it is safe for me to take.

[brain]

Hi Andrew - I take B-9 due to birth defect;
which is a type of Folic Acid and if you clicked
on my USER ID, the menu will drop down and
click on my profile and it will show you what
anti-epileptic drug's I'm on. I've been on a lot of different
anti-epileptic drug's for many years - Dilantin being the
longest of them all with Klonopin right behind
it; but Dilantin was wrecking a havoc on me
teeth. So in came the "rookie" - Zonegran, and
I actually like Zonegran, but I would rather be
on Zonegran and Dilantin, than Zonegran and
Klonopin. I don't have any side effects with any
of them.

[Zoe]

I am not sure if there is another thread with this thought running through it:

http://www.neurologyindia.com/articl...3;aulast=Kumar
http://www.seizure-journal.com/artic...02032/abstract

I know other B Vitamins have been proven to help in seizure control.

The article from NeurologyIndia was vey interesting. Here's one more abstract with a focus on B12. Think homocysteine levels.



1: Fortschr Neurol Psychiatr. 2007 Sep;75(9):515-27.

[Review of the role of hyperhomocysteinemia and B-vitamin deficiency in
neurological and psychiatric disorders--current evidence and preliminary
recommendations]

[Article in German]

Herrmann W, Lorenzl S, Obeid R.

Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum des
Saarlandes, Kirrberger Strasse, Gebaude 57, 66421 Homburg.
prof.wolfgang.herrmann@uni-klinikum-saarland.de

Elevated concentration of total homocysteine (Hcy) in plasma (> 12 micromol/l) is
a risk factor for several diseases of the central nervous system. Epidemiological
studies have shown a dose-dependent relationship between concentrations of Hcy
and the risk for neurodegenerative diseases. Hcy is a marker for B-vitamin
deficiency (folate, B12, B6). Hyperhomocysteinemia (HHcy) causes hypomethylation
which is an important mechanism that links Hcy to dementia. Supplementation with
vitamins B aims at reducing the risk of neurodegenerative diseases. Current
evidence suggests that Hcy-lowering treatment has a positive effect for the
secondary and primary prevention of stroke. HHcy is very common in patients with
Parkinson disease particularly those who receive L-dopa treatment. Furthermore, a
positive association has been reported between HHcy and multiple sclerosis.
Moreover, HHcy and vitamin B deficiency are reported to have a causal role in
depression, and epilepsy. In addition several anti-epileptic drugs cause
secondary HHcy. Therefore, sufficient intakes of the vitamins are recommended for
patients who have already developed neuropsychiatric diseases. Vitamin B
deficiency should be suspected in children with development disorders, failure to
thrive and unexplained neurological manifestations. Elderly people are also an
important at-risk group where vitamin B deficiency and HHcy have been linked to
neurodegenerative diseases. Treatment with folate, B12, and B6 can improve
cerebral function. Preventive vitamin B supplementation and sufficient intake
seem very important for secondary and primary prevention of neuropsychiatric
disorders, especially in subjects with a low intake or status of the vitamins.

PMID: 17729191 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/sites/entrez