What is the chemical in Grapefruit keeps AED's from working?

[Nakamova]

Unlike other fruits, grapefruit contains a large amount of naringin, a chemical that helps many drugs be absorbed more easily. But not all anti-epileptic drugs are affected by it.

[Nakamova]

The anti-epileptic drugs that ARE affected are Trileptal, Tegretol, and Zonegran. I think that's it, but you can always check with your neurologist or pharmacist to make sure.

[McGill]

I have never had any problems with grapefruit & anti-epileptic drugs, in spite of what I read. Like Brain, I'm an avid grapefruit lover and I eat them the same way I eat an orange. The only factor for me is cost & availability R/T the citris crop in Florida.

I just saw your post, Nakamova. Thanks for the information!

[morgan86]

i stay away from it because of the anti epileptic drugs and also because i have no gallbladder. a word of warning for those of you who also dont have one. dont eat grapefruit!!! i tried once just to see wut would happen, immediately. it felt like my esophagus was on fire LOL. i had phantom gallbladder pains for 2 days. i think i was too busy in pain from that to notice any sort of abnormal seizure activity tho.