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Prenatal exposure to Antiseizure Medications for all indications and the risk of neurodevelopmental disorders in offspring: a nationwide population-based cohort study in South Korea -
CONCLUSION: In this nationwide Korean cohort, prenatal ASM exposure was associated with dose-dependent risks of ASD and ID. These findings underscore the importance of preconception counseling and early pregnancy management for all women receiving ASMs, beyond those with epilepsy.
From recurrence risk to seizure temporal phenotyping: the next step for wake-onset EEG in epilepsy with generalized tonic-clonic seizures alone -
No abstract
A stereotactic laser interstitial thermal therapy strategy to flank dense calcifications within epileptogenic lesions: illustrative case -
BACKGROUND: Laser interstitial thermal therapy is a minimally invasive surgical technique commonly used for treating epileptogenic foci in patients with drug-resistant epilepsy. Densely calcified lesions pose a challenge because they prevent the placement of a laser cannula within them and act as a heat shield. A 22-year-old male presented with intractable epilepsy with imaging demonstrating a ...
The role of SCN1A mutations in temporal lobe epilepsy: Genetic insights and clinical implications -
CONCLUSION: Current evidence suggests that SCN1A may act as a genetic modifier contributing to TLE susceptibility, pharmacoresistance, and clinical heterogeneity in certain contexts. Integration of genetic and molecular data may support improved phenotypic characterization and individualized management in selected patients. However, larger and well-designed studies incorporating multi-omics and...
Integrating weighted gene co-expression network analysis and machine learning reveal that NDUFA4L2 alleviates KA-induced HT22 cell neurotoxicity, apoptosis, oxidative stress, and mitochondrial dysf... -
Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy, with frequent seizures often leading to cognitive, emotional, and psychiatric issues. A prominent pathological change associated with TLE is hippocampal sclerosis (HS), characterized by neuronal loss, gliosis, and increased neuron fibre density. However, the pathogenesis of Temporal lobe epilepsy with hippocampal sclerosi...
Occurrence and clinical correlates of depressive symptoms in adults with epilepsy: A study in Georgia -
OBJECTIVE: To evaluate the occurrence, clinical correlates, and screening accuracy of depressive symptoms (DS) among adults with epilepsy in Georgia, a country with limited mental health resources.
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