I gained 15lb in six weeks while on the Lyrica/Keppra combination. My neurologist decided to wean me off the Lyrica because I will continue to gain and I was experiencing, in my husband's words, crabiness. This is week three. I am down to 75mg Lyrica a day. 500mg Keppra mornings, 1000mg Keppra evenings. 38.5mg Phenobarb morning and 4 times that in the evening. I am constantly tired. I fall asleep within an hour,at most, of my evening meds. I started back to work on a perm. pt basis (2.5 days a week) I barely make it thru the day and am depressed. I could sit and cry. Is it the meds??? After 38 years of having epilepsy this has been the worst year I have ever had. So many changes in meds and adjustments. I feel like a zombie. Please tell me this will work out. I am at the end of my rope and feel like I can't hold on anymore. I am so thankful for the family, here, that truely understands the "pain" of this condition.