Normally a female won't reveal something like this, but being
a female with Epilepsy, since starting menses just before 10
years of age (I was 9), and had been irregular since, and the
previous Epi had this "order" for me to take it 15 days before
the "cycle" started.
NOW before Birdy falls on the floor dying of laugher,
how the (bleep) am I supposed to know when my 15 days
before the cycle starts? My menses span can range from 22
days to as long as 40+ days before it starts?
And then HE has the gall to say that's for me to figure it out?
Out of those choices I am taking "Lyrica". Overall it isn't too bad.
The only major problem I'm having with it is swelling & weight gain. I don't eat that much to be gaining that much weight. So it must be the medicine. At this time my Neurologist wants me to stay on my current meds. while I'm testing for possible surgery.
Hopefully a medicine will be finally developed that has no or minimal side effects.
We can all wish can't we?
Well I'm gonna have to go with Lyrica, my nuero told only side effects were weight gain and a unsteady feeling that should go a way. I was 187lbs. for about 10 years , started taking Lyrica last Sept. and now I weigh 209.Thats 22lbs, but Lyrica works great for me. I wouldn't think about a med change.
I guess, I would put Keppra at the top of my list,wanted to jump off a bridge on that one. Trileptal gained a good 15+ lbs, without even eating, if I'm going to gain weight I want to at least enjoy food. Well, Trileptal was hair falling out AED as to.
Let's see, Zonegran caused stomach issues and blew up my stomach like a balloon.
I won't bore you with my long list of AEDs I've gone through them all.
Topamax and Lamictal make my hair fall out, but control my seizures very well. I'm having maybe 1 or 2 seizures a month.
I won't bore you with my long list of AED and side effects but I've been through them all.
Does anybody know what the choices for meds were in the 50's and 60's? What might be easier is when each med came into use. I have/had absence seizures when I was a child, and was treated with phenobarbitol and Zarontin. All it did was make me high, and make the symptoms worse. I had no say in the treatment.
In the following list, the dates in parentheses are the earliest approved use of the drug.
Main article: Aldehydes
* Paraldehyde (1882). One of the earliest anticonvulsants. Still used to treat status epilepticus, particularly where there are no resuscitation facilities.
Aromatic allylic alcohols
* Stiripentol (2001 - limited availability). Indicated for the treatment of severe myoclonic epilepsy in infancy (SMEI).
Main article: Barbiturates
Barbiturates are drugs that act as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. The following are classified as anticonvulsants:
* Phenobarbital (1912). See also the related drug primidone.
* Methylphenobarbital (1935). Known as mephobarbital in the US. No longer marketed in the UK
* Metharbital (1952). No longer marketed in the UK or US.
* Barbexaclone (1982). Only available in some European countries.
Phenobarbital was the main anticonvulsant from 1912 till the development of phenytoin in 1938. Today, phenobarbital is rarely used to treat epilepsy in new patients since there are other effective drugs that are less sedating. Phenobarbital sodium injection can be used to stop acute convulsions or status epilepticus, but a benzodiazepine such as lorazepam, diazepam or midazolam is usually tried first. Other barbiturates only have an anticonvulsant effect at anaesthetic doses.
Main article: Benzodiazepines
The benzodiazepines are a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and muscle relaxant properties. The relative strength of each of these properties in any given benzodiazepine varies greatly and influences the indications for which it is prescribed. Long-term use can be problematic due to the development of tolerance and dependency. Of the many drugs in this class, only a few are used to treat epilepsy:
* Clobazam (1979). Notably used on a short-term basis around menstruation in women with catamenial epilepsy.
* Clonazepam (1974).
* Clorazepate (1972).
The following benzodiazepines are used to treat status epilepticus:
* Diazepam (1963). Can be given rectally by trained care-givers.
* Midazolam (N/A). Increasingly being used as an alternative to diazepam. This water-soluble drug is squirted into the side of the mouth but not swallowed. It is rapidly absorbed by the buccal mucosa.
* Lorazepam (1972). Given by injection in hospital.
Main article: Bromides
* Potassium bromide (1857). The earliest effective treatment for epilepsy. There would not be a better drug for epilepsy until phenobarbital in 1912. It is still used as an anticonvulsant for dogs and cats.
Main article: Carbamates
* Felbamate (1993). This effective anticonvulsant has had its usage severely restricted due to rare but life-threatening side effects.
Main article: Carboxamides
The following are carboxamides:
* Carbamazepine (1963). A popular anticonvulsant that is available in generic formulations.
* Oxcarbazepine (1990). A derivative of carbamazepine that has similar efficacy but is better tolerated.
Main article: Fatty acids
The following are fatty-acids:
* The valproates — valproic acid, sodium valproate, and divalproex sodium (1967).
* Vigabatrin (1989).
* Tiagabine (1996).
Vigabatrin and progabide are also analogs of GABA.
The ketogenic diet is a strict medically supervised diet that has an anticonvulsant effect. It is typically used in children with refractory epilepsy.
The vagus nerve stimulator (VNS) is a device that sends electric impulses to the left vagus nerve in the neck via a lead implanted under the skin. It was FDA approved in 1997 as an adjunctive therapy for partial-onset epilepsy.
Marketing approval history
The following table lists anticonvulsant drugs together with the date their marketing was approved in the US, UK and France. Data for the UK and France is incomplete. In recent years, the European Medicines Agency has approved drugs throughout the European Union. Some of the drugs are no longer marketed.
ugh...every med that Ive tried has given me a great amount of side effects...on this list I have only tried Klonopin (which I am on right now) and Valium. They both stop the seizures...but Valium makes me Talk in a British accent, call people names like "Grapenut, Goldfish, or Gorilla" read things backwards, pretend to kick things, laugh at people in the ER when they are seriously ill (I dont normally do that), you get the point. And Klonopin makes me sing in classrooms, very tired, I cant pay attention in class, I dont have good grades anymore (which I cant blame 100% on Klonopin), laugh in an incredibly high voice, and pretend to be a fairy...Im on Klonopin mostly for Panic Disorder (I've been running out of classrooms ever since I was put on Topamax) but it helps very well with my starring spells...
Hi Brain. thanks for the meds info.
Phenobarbitol and Zarontin left me with more damage than what I originally thought I had. Even after my dilibertate discontinuation of these nasty drugs, I still have nasty side effects that will not get better.
I wish doctors would think more.
I think I can work on the 'drunken sailor gait' side effect of the phenobarbitol, and maybe lessen some of the other side effects with deliberate co-ordination excersizes, but my co-ordination skills will take more time. And as far as my liver and Zarontin...
the worst side effect I ever had was with zonegran. the story goes like this. I just met this lady while I was doing some testing at a hospital. She lived about 2.5 hours out of the metro area. We hit it off right away, so I went north to spend a week with her. I had just started taking zonegran and about half way through the trip I started itching real bad around my man zone. So I said to her what did you give me but not in that fashion. We went back and forth about the topic so I left and saw my primary doctor and asked for a test. Well the results negative and asked what meds my neuro put me on and he started laughing told that it was a side effect of the drug, boy was I relieved. To this day I still laugh at the memory of that medication which I don't take anymore