I'm nearly non-functional at times now. I have to force myself not to be. I hate it. I feel more functional late at night than in the early mornings. Used to be the opposite.Aye, the depression is a real drag to deal with, no doubt about it. When they upped me to 4000 MG of Keppra/day, I could feel the depression trying to set in again. At least I was able to recognize those kinds thoughts, and know to ignore them. Been better at 3000MG/day now, but still....... I move slow, walk slow, get stiff a few hours after taking it, then the stiffness becomes pain. And I'm exhausted by mid-afternoon.
I was nearly non-functional when they added Lamictal. Then dropped it when I got an alergic rash reaction to it.
I feel that I tend to over research things sometimes, but yes, I do need to look more into it.
February 23, 2009 the U.S. Food and Drug Administration (FDA) issued a warning that zonisamide can cause metabolic acidosis in some patients. It is now recommended that serum bicarbonate levels are assessed before starting treatment and periodically during treatment with zonisamide, even in the absence of symptoms.
...metabolic acidosis is a condition that occurs when the body produces too much acid or when the kidneys are not removing enough acid from the body. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low (less than 7.35) due to increased production of hydrogen by the body or the inability of the body to form bicarbonate (HCO3-) in the kidney.
I took note of that too, especially since using it as a monotherapy is what they are talking about as a possiblity for me."Zonisamide is not approved for monotherapy treatment of epilepsy in adults."