The mysterious rise in
rickets seems instructive with regard to seizure, including photosensitive seizure, related to both malabsorption and potassium ion channels. Disturbing news in England the past few years and this recent article:
http://www.telegraph.co.uk/health/h...ee-epidemic-of-vitamin-deficiency-expert.html
As with vitamin D deficiency, rickets is normally attributed to poor diet and lack of sunshine in complete disregard of microbial imbalance as cause. Just as children are now born predisposed to obesity and diabetes, rickets is again rearing its ugly head. It's not about diet and sunshine per experts such as Dr. Michael Holick and all the professors quoted in the article. They are missing the microbial target.
Rickets is a known cause of seizure, yet no one yet understands the real cause of rickets:
http://www.sciencedirect.com/science/article/pii/S1875957212001052
Both gastrointestinal symptoms and opthamalic lesions including
night blindness are known in rickets:
http://www.ijo.in/article.asp?issn=...e=27;issue=4;spage=229;epage=229;aulast=Reddy
Intracellular calcium is known to be crucial for bone mineralization.
http://www.ncbi.nlm.nih.gov/pubmed/21440636
http://www.pnas.org/content/early/2012/08/08/1208916109.abstract
Vitamin D (calcitrol) is known to increase intracellular calcium which is responsible not just for bone mineralization, but increasing our innate immunity by stimulating macrophage activity, reducing microbial loads.
But intracellular calcium is not just about vitamin D which is why
vitamin D resistant rickets is not a rare disorder.
Intracellular calcium is also generated by
calcium activated potassium ion channels by calcium itself called Calcium Induced Calcium Release (CICR):
http://physrev.physiology.org/content/89/4/1153.full
jp.physoc.org/content/555/3/627.full.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC160467/
So, if
potassium ion channels are blocked via previous posts here, it seems a possible explanation for the rise in rickets associated with seizure.
Compounding the problem or even causing it is imbalanced gut flora at root of vitamin D deficiency where microbes toy with vitamin D receptors:
http://www.urmc.rochester.edu/news/story/index.cfm?id=2923
This is also one reason zinc deficiency is so important as a zinc molecule is required at the base of the vitamin D receptor. This may actually be the most important function of zinc, also required for some antioxidant enzymes. Boron is another overlooked deficiency with regard to vitamin D deficiency as it somehow modulates D.