Agreed, I also need to review, including the light induced (checkerboard) local brain pH change. To the contrary, recall that carbon dioxide halts seizure because it raises acidity suggesting the brain is too alkaline. But maybe that's more about lowering serotonin where high serotonin is known to cause seizure.
Here's another study showing inverse relationship where the body is in a state of low oxygen acidosis causing brain alkalosis leading to seizure in newborns:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501974/
"The mechanisms underlying birth asphyxia seizures are unknown."
Since modern science still believes the fetal gastrointestinal tract is sterile without any evidence whatsoever, it's no wonder the acidosis is not associated with microbial imbalance.
Why the inverse relationship?
"It is not known how post-asphyxia brain alkalosis is caused."
"Thus, the rise in both extracellular and intracellular pH recorded in the brain implies a net loss of acid equivalents and is attributable to net extrusion of acid across the blood–brain barrier."
I think the real question is what is the blood-brain barrier such that it extrudes acid? What (or who!) is soaking-up the carbon dioxide leading to alkalosis and seizure? I don't believe the brain is a sterile environment, nor was it ever meant to be sterile, but is reliant on balanced flora just like the gut. There's only one study proving brain flora exists where most microbes were found to be alphaproteobacteria located in the blood-brain barrier (glial cells/white matter). High level scientists fearing the entire concept of brain flora refuse to give the study credibility. Perhaps microbes are the most important part of the blood-brain barrier, but out of balance, they absorb too much carbon dioxide:
http://www.bostonglobe.com/ideas/20...y-your-head/gjohGUkh4tEc62b33gVCYJ/story.html
It even seems possible fetal brain development relies on microbial omega-3 fatty acid biosynthesis normally considered of maternal origin. First the fetal gut develops. Then in the third trimester, the brain triples in weight.
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020146
Alphaproteobacteria are phototropic, meaning they respond to light. This is why their genes are used in the new science of optogenetics which uses light to control the brain. In fact, the entire science is based on this type of bacteria while pioneers of the science likely believe the brain is sterile.
Here's another study showing inverse relationship where the body is in a state of low oxygen acidosis causing brain alkalosis leading to seizure in newborns:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501974/
"The mechanisms underlying birth asphyxia seizures are unknown."
Since modern science still believes the fetal gastrointestinal tract is sterile without any evidence whatsoever, it's no wonder the acidosis is not associated with microbial imbalance.
Why the inverse relationship?
"It is not known how post-asphyxia brain alkalosis is caused."
"Thus, the rise in both extracellular and intracellular pH recorded in the brain implies a net loss of acid equivalents and is attributable to net extrusion of acid across the blood–brain barrier."
I think the real question is what is the blood-brain barrier such that it extrudes acid? What (or who!) is soaking-up the carbon dioxide leading to alkalosis and seizure? I don't believe the brain is a sterile environment, nor was it ever meant to be sterile, but is reliant on balanced flora just like the gut. There's only one study proving brain flora exists where most microbes were found to be alphaproteobacteria located in the blood-brain barrier (glial cells/white matter). High level scientists fearing the entire concept of brain flora refuse to give the study credibility. Perhaps microbes are the most important part of the blood-brain barrier, but out of balance, they absorb too much carbon dioxide:
http://www.bostonglobe.com/ideas/20...y-your-head/gjohGUkh4tEc62b33gVCYJ/story.html
It even seems possible fetal brain development relies on microbial omega-3 fatty acid biosynthesis normally considered of maternal origin. First the fetal gut develops. Then in the third trimester, the brain triples in weight.
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020146
Alphaproteobacteria are phototropic, meaning they respond to light. This is why their genes are used in the new science of optogenetics which uses light to control the brain. In fact, the entire science is based on this type of bacteria while pioneers of the science likely believe the brain is sterile.
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