John Sturgis
Pillar
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I have learned that glutamate receptors have been discovered to have a role in the onset of epilepsy.I know that anti-epileptic drug Perampanel is SET UP as an orally administered, highly selective non-competitive AMPA-type glutamate receptor antagonist. My nocturnal seizures are under control with an anti-epileptic drug-GERD diet combo. I agree that when my personal glutamate level is high it creates excitotoxicity which is the pathological process in which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. I know that Perampanel has not been approved yet by the FDA but I was wondering what anyones thoughts are on this new approach type drug. By the way, for the first time, I had an active positive discussion, in April 2011, with my neurologist at Beth Israel Hospital - Boston on the affects that msg, sweeteners, etc. have on my seizure occurrences.Thanks again, John Sturgis