Epilepsy and Seizure News
Seizure Outcomes and Complications After MRgLITT, RFTC, and SRS -
The following is a summary of “Outcome of Surgery for Hypothalamic Hamartoma-Related Epilepsy: A Systematic Review and Individual Participant Data Meta-Analysis,” published in the December 2024 issue ...
Many Women With Epilepsy Unaware of Seizure Meds' Risks to Pregnancy -
FRIDAY, Dec. 6, 2024 (HealthDay News) -- Many women with epilepsy who are of childbearing age might not realize their anti-seizure drugs can raise the risk of birth defects or dampen the effectiveness ...
Novel Drug Fails for Two Rare Seizure Disorders -
The novel agent soticlestat flopped in a pair of phase III trials for rare seizure disorders, researchers reported here. Among Dravet syndrome patients in the SKYLI ...
Epilepsy and seizures: Know the similarities and differences -
Epilepsy and seizures are distinct. A seizure, a temporary electrical brain disturbance, can stem from various factors, including brain diseases or other organ dysfunctions. Epilepsy, however, is a ...
Epilepsy, family, talking the tough stuff: New Hollywood musical -
Emmy winner Ben Decter’s new musical shows the impact of his daughter’s epilepsy on their family, and the importance of communication.
Epilepsy 101: What Patients and Caregivers Need to Know -
Epilepsy is a disorder of the brain characterized by recurring, unprovoked seizures. A seizure occurs when there is an abnormal surge of electrical activity in the brain, which can temporarily affect ...
Algorithm better identifies the origin of a seizure to guide more precise surgical interventions -
Epilepsy is one of the most common neurological diseases in the world, afflicting more than 50 million people. While most forms can be treated with therapeutics, patients with drug-resistant epilepsy ...
Newer epilepsy medications used during pregnancy do not affect neurological development in children -
Children of mothers who took certain anti-seizure medications while pregnant do not have worse neurodevelopmental outcomes at age 6, according to a long-running study.
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Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury-EpiBioS4Rx Project 1 study -
OBJECTIVE: To test a hypothesis that acutely regulated plasma microRNAs (miRNAs) can serve as prognostic biomarkers for the development of post-traumatic epilepsy (PTE).
The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy -
Epilepsy is a group of chronic neurological brain disorders characterized by recurrent spontaneous unprovoked seizures, which are accompanied by significant neurobiological, cognitive, and psychosocial impairments. With a global prevalence of approximately 0.5-1 % of the population, epilepsy remains a serious public health concern. Despite the development and widespread use of over 20 anticonvu...
Glutamic Acid Decarboxylase 65 Antibody-associated Epilepsy and Diplopia: Two Case Reports with Literature Review -
Glutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy and diplopia are relatively rare. This article retrospectively analyzed the disease development, diagnosis and treatment process of two cases of GAD65-associated epilepsy with diplopia. Both patients initially exhibited seizures, followed by the onset of diplopia and nystagmus. Due to differences in their diagnostic processes, ...
Effects of CYP2C19 and CYP2C9 polymorphisms on the efficacy and plasma concentration of lacosamide in pediatric patients with epilepsy in China -
CONCLUSION: LCM plasma concentrations were strongly associated with its clinical efficacy and toxicity. CYP2C19 polymorphisms affect the plasma concentration and treatment efficacy in pediatric patients with epilepsy. CYP2C19 PMs with two no-function alleles are likely to have higher LCM plasma concentrations.
MRI in older patients-A focused review -
MRI has considerably increased our pathophysiological knowledge of age-related brain abnormalities. Brain abnormalities regularly seen on MRI of older adults are atrophy, and changes related to small vessel disease (SVD). SVD-related changes include white matter hyperintensities (WMH), lacunes, microbleeds, microinfarcts and perivascular spaces. While atrophy, WMH and lacunes are recognized as ...
Circuit reorganization of subicular cell-type-specific interneurons in temporal lobe epilepsy -
The subiculum represents a crucial brain pivot in regulating seizure generalization in temporal lobe epilepsy (TLE), primarily through synergy of local GABAergic and long-projecting glutamatergic signaling. However, little is known about how subicular GABAergic interneurons are involved in a cell-type-specific way. Here, employing Ca^(2+) fiber photometry, retrograde monosynaptic viral tracing ...
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