Epilepsy and Seizure News
I’m a Mom With Epilepsy—These Are Some of the Biggest Misconceptions I Face Every Day
"We had exhausted all of the options available to me at the point when I had found out about this medication, but after learning about XCOPRI®, I felt optimistic that I might eventually be able to ...
Epilepsy Foundation and the American Stroke Association Collaborate to Raise Awareness about Seizure Risk Among Stroke Survivors
Nearly one in 10 stroke survivors will experience a seizure,1 which is why the Epilepsy Foundation and the American Stroke Association, ...
Fracture Risk is Raised With a Common Anti-seizure Medication in Kids
Elevated fracture risk is seen in kids with epilepsy who are on two most common anti-seizure medications as per a study "Effect of levetiracetam and oxcarbazepine on 4-year fragility fracture risk ...
Local student is helping others understand what it's like to live with Epilepsy
According to the Epilepsy Foundation, Epilepsy is a "seizure-causing brain disorder" that affects 1 in 26 people in the United States.
For one mom, it paid to be persistent
But she encourages other parents to be persistent and find doctors willing to work with their family. “Don’t give up,” she said. “Listen to your gut. If you’re in the wrong office, go find another.” ...
Epilepsy Foundation of Arizona, Waymo partner to raise awareness about epilepsy and mobility needs
Epilepsy is a neurological disorder that may cause seizures and loss of consciousness, and it can affect people of all ages in a number of ways. For adults, it can also affect their ability to drive.
Swedish girl with rare condition undergoes specialized treatment in Utah
Carl Molstad said his daughter Edith, who turns 11 on Wednesday, has lived two different lives: one before her seizures, and one after.
Common anti-seizure medication associated with elevated fracture risk in kids with epilepsy
A study of the two most commonly prescribed anti-seizure medications found one was associated with a higher risk of fracture for children and teens with epilepsy. This is significant for this ...
Neurelis Initiates Study Of VALTOCO® (diazepam nasal spray) In Children With Seizure Clusters Aged Two To Five
Neurelis, Inc. announced today that it has initiated a clinical program to investigate the use of VALTOCO® (diazepam nasal spray) in ...
Seizure a First Sign of COVID in Kids?
Seizures, including status epilepticus, may be the main presenting manifestation of acute SARS-CoV-2 infection in children and require a high index of suspicion for early diagnosis and infection ...
Medical News Today
Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures
Autoantibodies targeting the GABAA receptor (GABAAR) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with further autoantibodies and the lack of patient-derived mAbs. Five GABAAR mAbs from cerebrospinal fluid cells bound to various epitopes involving the α1 and γ2 recep...
Intraoperative MR Imaging in epilepsy surgery: systematic review of the literature and meta-analysis
CONCLUSIONS: This work presents the first meta-analysis of the value of iopMRI in epilepsy surgery. Its use resulted in an improvement of the desired extent of resection and led to a better seizure outcome compared to conventional surgery. Understanding its benefits might help improve surgical strategies in traditional, open epilepsy surgery.
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model
Epilepsy, which is caused by abnormal neuronal firing in the brain, is a common neurological disease and affects motor and cognitive functions. Excessive levels of glutamate and insufficient levels of inhibitory GABA are involved in its pathophysiology. Valproic acid (Val), a GABAergic agonist, is one of the first-line antiepileptic drugs, but it shows many adverse side effects at the clinical ...
Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR antibody) encephalitis, a distinct neuro-immunological disorder in which specific human autoantibodies bind and crosslink the surface of NMDAR proteins thereby causing internalization and a state of NMDAR hypofunction. To further understand ictogenesis in this disorder, and to test a potential treatment compound, ...
Slo2/K(Na) Channels in Drosophila Protect Against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na(+) Current
Na^(+)-sensitivity is a unique feature of Na^(+)-activated K^(+) (K(Na)) channels, making them naturally suited to counter a sudden influx in Na^(+) ions. As such, it has long been suggested that K(Na) channels may serve a protective function against excessive excitation associated with neuronal injury and disease. This hypothesis, however, has remained largely untested. Here, we examine K(Na) ...
Somatostatin-positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy
SCN8A epileptic encephalopathy is a devastating epilepsy syndrome caused by mutant SCN8A which encodes the voltage-gated sodium channel Na(V)1.6. To date, it is unclear if and how inhibitory interneurons, which express Na(V)1.6, influence disease pathology. Using both sexes of a transgenic mouse model of SCN8A encephalopathy, we found that selective expression of the R1872W SCN8A mutation in so...