Epilepsy News

Impact of epilepsy-related stigma on employability: A review of the evidence for primary care practice - CONCLUSIONS: Stigma remains a determinant of occupational exclusion in epilepsy. Primary care and occupational medicine play complementary roles in the detection and assessment of stigma and in its management through clinical and psychosocial interventions, individualized workplace accommodations and inclusive employment policies.

Neuron-derived neurotrophic factor-positive interneurons: a cellular target for anti-seizure therapies - BACKGROUND: Failure of epilepsy pharmacotherapy is common, justifying efforts to identify optimal cell targets for advanced therapies. Genetic manipulations of the inhibitory system in principle offer a finely tuned intervention that cannot be achieved with a broad reduction of pyramidal neuron excitability. In this context, neuron-derived neurotrophic factor-expressing (NDNF+) interneurons evo...

Vigabatrin therapy for infantile epileptic spasms syndrome with periventricular leukomalacia - CONCLUSION: Vigabatrin was effective for treating 42.8% of our patients with both IESS and PVL. Vigabatrin was well tolerated, with only a mild effect observed in patients with IESS and PVL. Some treatment-related ERG abnormalities were normalized after vigabatrin was reduced or stopped.

Clinical and Neuroimaging Features of Basal Ganglia Encephalitis in Children - CONCLUSIONS: Basal ganglia encephalitis is a distinct immune-mediated pediatric syndrome frequently associated with M. pneumoniae, radiologically characterized by symmetric basal ganglia lesions. The majority of patients achieve favorable outcomes with anti-infective and immunotherapy.

Sleep Duration and Epilepsy Risk: Mendelian Randomization and Functional Validation of CACNA1A rs2228130-Related Inhibitory Synaptic Dysfunction - Objectives To evaluate the causal association between sleep traits and epilepsy risk using Mendelian randomization, and to investigate the mechanism of a prioritized epilepsy-risk variant through gene-level enrichment analysis and functional validation. Methods Large-scale European GWAS datasets were analysed using multiple Mendelian randomization methods, including inverse variance weighted, M...

Seizure forecasting: The long and winding road to clinical translation - Seizure forecasting has progressed from theoretical aspiration to a rapidly advancing research domain, yet clinical translation remains limited. Over the past decades, advances in algorithm development, chronic electroencephalography (EEG), wearable sensors, and the characterization of seizure cycles have demonstrated that seizure risk is not random but fluctuates according to identifiable biol...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.