Epilepsy News

Non-invasive neurostimulation for drug-resistant epilepsy: systematic review and meta-analysis of effectiveness, safety, and optimal stimulation parameters - Drug-resistant epilepsy is a common and disabling condition, with few non-surgical treatment options. Non-invasive neurostimulation is an emerging therapy for drug-resistant epilepsy, though evidence is mixed and comparisons between modalities remain challenging. This review systematically appraises and compares the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS)...

Temporal Dynamics of c-Fos Expression in a Zebrafish Larva Model of Pentylenetetrazole-Induced Seizures - The use of zebrafish (Danio rerio) larva as an experimental model has gained a lot of interest in epilepsy research due to its multiple advantages over mammalian models. The present study investigated the time-dependent expression of c-fos, an immediate early gene, and a marker of neuronal activation, following pentylenetetrazole (PTZ)-induced seizures in zebrafish larvae at 7-day post-fertiliz...

Early neurological symptoms and epilepsy outcomes in individuals with the recurrent GABRG2 p.(Ala106Thr) gain-of-function variant: Structural and phenotypic insights - OBJECTIVE: Variants in GABRG2, encoding the γ2 subunit of the γ-aminobutyric acid type A receptor, are linked to epilepsy phenotypes of varying severity, with gain-of-function (GoF) variants associated with the more severe phenotypes than loss-of-function variants. Here, we provide a comprehensive analysis of the early clinical features, motor, language, and eating abilities, and structural con...

Detection of interictal epileptiform discharges using multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode: A clinical feasibility... - OBJECTIVE: To assess the feasibility, technical performance, and safety of a novel endovascular electroencephalogram (eEEG) electrode, EP-01, designed for minimally invasive seizure localization in patients with drug-resistant epilepsy.

Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment - Adult glioma is associated with a wide range of symptoms and variable survival that are not fully explained by tumour location or subtype. Recent work suggests that the disease may be better understood using a network-based framework, as opposed to more traditional localizationist thinking. In this Review, we describe three major types of network scaffolds relevant in people with glioma: sympto...

Lightweight Seizure Prediction Model based on Kernel-Enhanced Global Temporal Attention - Clinically, epilepsy manifests as a chronic condition marked by unprovoked, recurrent seizures, plaguing over 70 million individuals with debilitating seizures and life-threatening complications. Approximately 30% of patients with epilepsy do not respond to conventional antiepileptic drugs, indicating the limited efficacy of these medications in controlling seizures universally. Therefore, seiz...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.