Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Epilepsy and Seizure News
Enrolment concludes in Biohaven’s RISE3 trial for epilepsy -
Biohaven has concluded enrolment in the pivotal RISE3 Phase II/III trial assessing the selective Kv7.2/7.3 channel activator, opakalim (BHV-7000), for refractory focal epilepsy. T ...
Modifiable Factors Responsible for Most Epilepsy Relapses - In patients with newly diagnosed epilepsy, nearly 70% of seizure relapses are linked to potentially modifiable factors, including poor adherence and inadequate ASM dosing, rather than drug resistance.
Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
People with focal epilepsy often have seizures while driving before a diagnosis - Prior to being diagnosed with epilepsy, 5% of people with a type of epilepsy called focal epilepsy had a seizure while driving, according to a new study published in the June 7, 2023, online issue of ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
New tools map seizures in the brain, improve epilepsy treatment - Two new models could solve a problem that's long frustrated millions of people with epilepsy and the doctors who treat them: how to find precisely where seizures originate to treat exactly that part ...
Modifiable Factors Responsible for Most Epilepsy Relapses - In patients with newly diagnosed epilepsy, nearly 70% of seizure relapses are linked to potentially modifiable factors, including poor adherence and inadequate ASM dosing, rather than drug resistance.
Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
People with focal epilepsy often have seizures while driving before a diagnosis - Prior to being diagnosed with epilepsy, 5% of people with a type of epilepsy called focal epilepsy had a seizure while driving, according to a new study published in the June 7, 2023, online issue of ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
New tools map seizures in the brain, improve epilepsy treatment - Two new models could solve a problem that's long frustrated millions of people with epilepsy and the doctors who treat them: how to find precisely where seizures originate to treat exactly that part ...
Neurofeedback News
Rewiring Your Brain: Neurofeedback Goes Mainstream -
See more of our trusted coverage when you search. Prefer Newsweek on Google to see more of our trusted coverage when you search. Will Strahl walked up to my door with a massive black briefcase in his ...
What Is Neurofeedback Therapy And How Does It Work? - Ashwini Nadkarni, M.D., is a board-certified psychiatrist, Assistant Professor at Harvard Medical School and Interim Vice Chair for Faculty Affairs in the Department of Psychiatry at Brigham and Women ...
Elite athletes enhance their performance with 'neurofeedback'—and you can get a device for $99 - When you think of the training tools that professional athletes have at their disposal, high-tech sports equipment and state-of-the-art athletic facilities come to mind. But training for peak ...
Mountain Vista Psychology offers neurofeedback services in Englewood to help individuals with anxiety and depression. - Mountain Vista Psychology provides neurofeedback services in Englewood to support anxiety and depression recovery ...
What Is Neurofeedback? - Whenever I mention that neurofeedback helped me regain my life after my multiple brain injuries — or that I’m now a neurofeedback provider — the first reaction is to ask me, what is neurofeedback? I’m ...
What Is Neurofeedback Therapy And How Does It Work? - Ashwini Nadkarni, M.D., is a board-certified psychiatrist, Assistant Professor at Harvard Medical School and Interim Vice Chair for Faculty Affairs in the Department of Psychiatry at Brigham and Women ...
Elite athletes enhance their performance with 'neurofeedback'—and you can get a device for $99 - When you think of the training tools that professional athletes have at their disposal, high-tech sports equipment and state-of-the-art athletic facilities come to mind. But training for peak ...
Mountain Vista Psychology offers neurofeedback services in Englewood to help individuals with anxiety and depression. - Mountain Vista Psychology provides neurofeedback services in Englewood to support anxiety and depression recovery ...
What Is Neurofeedback? - Whenever I mention that neurofeedback helped me regain my life after my multiple brain injuries — or that I’m now a neurofeedback provider — the first reaction is to ask me, what is neurofeedback? I’m ...
Medical News Today
PubMed
Silymarin Reverses Seizure-Precipitating Effects of Alcohol and Associated Psychiatric Comorbidities, and Neurotoxicity in Pentylenetetrazol Pre-Kindled Mice -
Heavy alcohol consumption has multiple negative cognitive, psychological, and neurobiological consequences for people with epilepsy. However, the psychopharmacological interactions remain unclear with limited therapeutic interventions. In this study, we investigated the diverse impact of alcohol on experimental simulated pentylenetetrazol-induced seizures and alcohol-use disorder, and the effec...
Neurologists' Views on the Management of Uncontrolled Epilepsy in Spain: A Preliminary Survey - CONCLUSION: There is a discrepancy between neurologists' treatment goals and their acceptance of persistent seizures in Spanish neurological practice. Several factors may be limiting the achievement of early seizure freedom, including short patient consultations and a lack of familiarity with new treatments, especially among epilepsy non-specialists. Addressing these barriers could improve outc...
GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cycling - GATOR1 is an evolutionarily-conserved negative regulator of mTORC1-dependent signal transduction with pathogenic mutations linked to epilepsy, infantile spasms, and autism spectrum disorders. While a biochemical role of GATOR1 in amino acid-signaling is established, its cell-type specific contributions within the brain remain poorly defined. Here, we show that loss of GATOR1 function in astrocy...
Glial High-Mobility Group Box 1 Translocation Promotes Post-Stroke Epileptic Seizures - Post-stroke epilepsy (PSE) is a common type of epilepsy, often refractory to conventional pharmacological interventions. In the present study, we investigate the role of high mobility group box 1 (HMGB1) in PSE and evaluate therapeutic efficacy of the anti-HMGB1 monoclonal antibody therapy. We found that photothrombotic model of ischemic stroke enhanced seizure susceptibility, particularly in c...
Preictal reduction in heart rate variability entropy is associated with functional/dissociative seizures and provides modest discrimination from epileptic seizures - CONCLUSIONS: FDS was associated with preictal reduction in HRV entropy, indicating more regular, less complex cardiac dynamics. Within-subject changes appeared to provide more discriminative than static ECG features. Although current performance does not support standalone diagnostic use, entropy-based HRV measures offer interpretable peri-ictal autonomic markers, suggesting visceral changes co...
Anti-seizure medication in Germany over 25 years: trends in prices and prescription patterns from national data from 2000 to 2024 - CONCLUSION: The observed prescription shifts align well with the recommendations of German clinical practice guidelines, which advocate preferential use of lamotrigine and levetiracetam and lacosamide as first-line agents in focal epilepsies, whilst discouraging the use of enzyme-inducing ASMs due to their unfavourable pharmacokinetic interaction profiles and long-term tolerability concerns. Th...
Neurologists' Views on the Management of Uncontrolled Epilepsy in Spain: A Preliminary Survey - CONCLUSION: There is a discrepancy between neurologists' treatment goals and their acceptance of persistent seizures in Spanish neurological practice. Several factors may be limiting the achievement of early seizure freedom, including short patient consultations and a lack of familiarity with new treatments, especially among epilepsy non-specialists. Addressing these barriers could improve outc...
GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cycling - GATOR1 is an evolutionarily-conserved negative regulator of mTORC1-dependent signal transduction with pathogenic mutations linked to epilepsy, infantile spasms, and autism spectrum disorders. While a biochemical role of GATOR1 in amino acid-signaling is established, its cell-type specific contributions within the brain remain poorly defined. Here, we show that loss of GATOR1 function in astrocy...
Glial High-Mobility Group Box 1 Translocation Promotes Post-Stroke Epileptic Seizures - Post-stroke epilepsy (PSE) is a common type of epilepsy, often refractory to conventional pharmacological interventions. In the present study, we investigate the role of high mobility group box 1 (HMGB1) in PSE and evaluate therapeutic efficacy of the anti-HMGB1 monoclonal antibody therapy. We found that photothrombotic model of ischemic stroke enhanced seizure susceptibility, particularly in c...
Preictal reduction in heart rate variability entropy is associated with functional/dissociative seizures and provides modest discrimination from epileptic seizures - CONCLUSIONS: FDS was associated with preictal reduction in HRV entropy, indicating more regular, less complex cardiac dynamics. Within-subject changes appeared to provide more discriminative than static ECG features. Although current performance does not support standalone diagnostic use, entropy-based HRV measures offer interpretable peri-ictal autonomic markers, suggesting visceral changes co...
Anti-seizure medication in Germany over 25 years: trends in prices and prescription patterns from national data from 2000 to 2024 - CONCLUSION: The observed prescription shifts align well with the recommendations of German clinical practice guidelines, which advocate preferential use of lamotrigine and levetiracetam and lacosamide as first-line agents in focal epilepsies, whilst discouraging the use of enzyme-inducing ASMs due to their unfavourable pharmacokinetic interaction profiles and long-term tolerability concerns. Th...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.