Epilepsy News

Nursing care of a pediatric patient with anti-NMDAR encephalitis complicated by secondary epilepsy: A case report - RATIONALE: Autoimmune encephalitis in children often presents with neuropsychiatric symptoms and seizures and may progress to secondary epilepsy with prolonged functional impairment. Immunotherapy is the principal disease-modifying treatment, whereas comprehensive nursing care supports safety, complication prevention, rehabilitation, and continuity of care.

Analysis of pediatric absence epilepsy electroencephalograms using a mining-based association rule approach: A cross-sectional study based on realistic data - Association rule mining (ARM) is an interpretable data mining method that can identify co-occurrence patterns among predefined clinical features. This study applied ARM to clinically labeled EEG data from children with absence epilepsy to identify association rules linking abnormal EEG discharge morphology, scalp distribution, and absence seizure duration. Key association rules included polyspi...

Precision diagnosis guides ketogenic diet therapy in inherited metabolic epilepsies: Concurrent non-ketotic hyperglycinemia and biotinidase deficiency - Non-ketotic hyperglycinemia (NKH) and biotinidase deficiency are rare inborn errors of metabolism that individually predispose to severe, drug-resistant epilepsy. Their concurrent occurrence in a single patient represents an exceptionally uncommon diagnostic and therapeutic challenge. The ketogenic diet (KD) has emerged as an adjuvant effective intervention in metabolic epilepsies, yet its role...

Vagus Nerve Stimulation Exerts Disease-Modifying Effects in Epileptic Rats by Enhancing Hippocampal Adenosine Signalling - CONCLUSIONS: VNS exerts disease-modifying effects in epileptic rats by enhancing hippocampal adenosine signalling. These effects are associated with VNS-evoked adenosine release, inhibition of ADK overexpression, and restoration of A1R-mediated anticonvulsant signalling.

Neuroradiologic Findings in Patients With SCN2A Disease: A Systematic Review and Retrospective Multicenter Cohort Study - BACKGROUND AND OBJECTIVES: SCN2A disease spans a broad clinical spectrum from self-limited (familial) neonatal-infantile epilepsy to severe developmental and epileptic encephalopathies. Systematic characterization of the spectrum of neuroradiologic abnormalities in SCN2A disease has not been performed. This study aimed to delineate MRI findings across SCN2A phenotypes, their frequency and evolu...

Prediction of Post-Cardiac Arrest Seizures Using Heart Rate Variability - CONCLUSIONS: Heart rate variability changed before post-cardiac arrest seizures, with 18 minutes before onset appearing optimal for prediction.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.