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Impact of Antiseizure Medication on Thyroid Function in Children With Epilepsy: A Case-Control Study -
Background Epilepsy, chronic monotherapy of antiseizure medications (ASMs), as well as the secondary disturbance of the thyroid axis, which includes both subclinical and clinical hypo- and hyperthyroidism, are crucial endocrine challenges during children's development. In this study, the levels of thyroid hormones in children with epilepsy who underwent chronic monotherapy were compared with th...
Epileptic seizures temporally associated with recombinant human growth hormone therapy in children: A case series of three patients -
We report three pediatric patients who developed epileptic seizures while receiving recombinant human growth hormone therapy. Case 1 was a 12-year-old girl with a history of febrile seizures and epilepsy whose seizures recurred after discontinuation of antiepileptic medication during ongoing recombinant human growth hormone therapy. Case 2 was an 11-year-old boy born extremely preterm who devel...
Efficacy and sleep impact of perampanel versus levetiracetam monotherapy for SeLECTS: A pilot prospective cohort study -
CONCLUSION: Both LEV and PER monotherapy were tolerated and associated with short-term seizure control in children with SeLECTS. There are some indications that PER may offer small additional benefits for the sleep architecture, resulting in a decrease in the proportion of N1 and NAW. However, prospective studies with longer follow-up are needed to confirm the observations.
Exploring the caregiver journey through randomized controlled trials in dravet syndrome: insights from a cross-sectional survey -
CONCLUSIONS: To our knowledge, this is the first survey exploring the caregivers' perceptions of participation in epilepsy clinical trials. Patient and stakeholder engagement is essential for optimizing trial recruitment, acceptance and understanding of the failures.
Treatment engagement and 12-month outcomes after diagnostic communication and individualized treatment planning in patients with functional neurological disorder -
OBJECTIVES: To evaluate treatment engagement and 12-month outcomes following structured diagnostic communication and individualized treatment planning in inpatients with the most common functional neurological disorder (FND) presentations encountered in epilepsy services and to explore the relationship between treatment engagement and adherence.
Alpha power and brain functional connectivity as signatures of altered network dynamics in functional/dissociative seizures: A proof of concept study -
CONCLUSION: Our findings suggest that FDS are characterized by a paradoxical hypersynchronization in the EEG alpha band, similar to EC, despite concurrent motor activity. Increased functional alpha connectivity, simultaneous with elevated heart rate during FDS, suggests that FDSs involve altered brain network dynamics rather than simple alpha power suppression by voluntary motor activity. These...
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