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Medication adherence in epilepsy: Validation of the short medication adherence scale (SMAS-7) and mediation analysis of quality-of-life pathways -
CONCLUSION: The SMAS-7 is a valid, reliable, and clinically useful tool for assessing medication adherence in adults with epilepsy. When each predictor was considered individually, medication adherence showed partial indirect associations linking financial wellbeing, mental health burden, and AED adverse effects with QOL; however, these associations were attenuated to near zero in a mutually ad...
A potential therapeutic role of unilateral anterior thalamic deep brain stimulation in epileptic spasms: A case report -
OBJECTIVE: Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is an established palliative therapy for drug-resistant focal epilepsy; however, its efficacy for epileptic spasms (ES) and the clinical utility of unilateral stimulation remain unclear. To address these issues, we report a case of drug-resistant focal epilepsy with ES treated with unilateral ANT-DBS.
Seizure prophylaxis versus epilepsy prevention after acquired brain injury: a cross-sectional clinicaltrials.gov registry analysis, 2000-2026 -
CONCLUSIONS: The seizure management pipeline after acquired brain injury registered on ClinicalTrials.gov is concentrated in brain tumor/neurosurgery and TBI, with sparse representation of hemorrhagic stroke and few completed pharmacologic trials targeting late epilepsy prevention. The registry findings support a clearer separation of the objectives of acute seizure prophylaxis, treatment of ac...
Targeting glycine transporter type 1 (GlyT1) in epilepsy: Pathophysiological rationale and therapeutic perspectives -
Glycine transporter type 1 (GlyT1) plays a crucial role in regulating extracellular glycine concentrations, thereby maintaining the balance between excitatory and inhibitory neurotransmission in the central nervous system. GlyT1 is expressed predominantly in astrocytes, as well as in neurons, throughout most regions of the mammalian brain, and dysregulation of glycinergic transmission has been ...
Comparison of oral prednisolone and ACTH therapies in infantile epileptic spasms syndrome: using BASED and E-Chess scores -
CONCLUSION: High-dose oral prednisolone and ACTH therapies demonstrated comparable efficacy in reducing electrographic and clinical seizure burden in children with IESS. Improvement in epileptiform activity, as reflected by reductions in the BASED score, is strongly associated with better clinical outcomes. Additionally, a high pretreatment medication burden may serve as an early indicator of a...
The Mechanism of Long Non-coding RNA GABPB1-AS1/SLC12A5 Regulating Neuronal Ferroptosis in Epileptic Seizures -
Epilepsy, a common neurological disorder, is distinguished by abnormal neuronal activity. This study explored the mechanism of the long non-coding RNA (lncRNA) GABPB1-AS1/SLC12A5 pathway modulating neuronal ferroptosis during epileptic seizures. Loss- and gain-of-function approaches were conducted in a mouse model of kainic acid-induced seizures and glutamic acid (Glu)-treated HT22 neurons to e...
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