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Robust Epilepsy Diagnosis in Neonates Via Spatio-Temporal Graph Learning and Balanced Test-Time Training -
Timely diagnosis of neonatal epilepsy is critical for mitigating long-term neurodevelopmental deficits. However, while neonates exhibiting extensive seizure burden are readily identified, accurately diagnosing epileptic infants with sparse or no overt seizure onset during monitoring remains a formidable challenge using electroencephalogram (EEG) signals alone. Current automated systems predomin...
Early seizure risk after stereotactic radiosurgery for brain metastases: a multicenter analysis of LINAC- and gamma knife-treated cohorts -
CONCLUSIONS: Early post-SRS seizures are an uncommon complication in patients without a history of epilepsy. Seizure risk appears mainly driven by intracranial disease burden, reflected by total irradiated volume and number of lesions at diagnosis, whereas technical SRS parameters do not seem to affect seizure incidence.
Serotonergic Modulation in Absence Epilepsy: The Role of Thalamo-cortical Networks and 5-hydroxytryptamine Receptors -
Absence epilepsy is characterized by brief nonconvulsive seizures and generalized spike-and-wave discharges (SWDs) generated within distributed cortico-thalamo-cortical networks. Although the roles of T-type calcium channels, GABAergic inhibition, and network synchronization are well established, serotonergic modulation of these circuits remains incompletely defined. This review integrates evid...
Robustness of MEG source imaging in pediatric patients with surgical cavities: A case series -
CONCLUSIONS: In this pediatric epilepsy case series with surgical cavities, MSI showed broad agreement across simple spherical and advanced realistic head models. These findings did not establish a consistent localization advantage of one head model over another. However, larger prospective cohorts with independent ground truths are needed to validate and generalize these findings across cavity...
A representation-level wavelet-EMD fusion framework for spectral analysis and detection of epileptiform patterns in pediatric EEG: computational validation with a roadmap for external benchmarking -
CONCLUSION: Representation-level wavelet-EMD fusion provides an interpretable and transparent computational framework for analyzing non-stationary pediatric epileptiform EEG whose advantage over classical time-frequency baselines persists, at feasibility scale, on real CHB-MIT recordings and remains competitive with deep-learning baselines. Because the primary evaluation is synthetic and the ex...
Beyond seizures: the hidden burden of developmental epileptic encephalopathies -
Developmental and epileptic encephalopathies (DEEs) are a group of severe childhood-onset disorders characterized by drug-resistant epilepsy and a broad spectrum of neurodevelopmental, behavioral, psychiatric, and systemic manifestations. Although seizure control has traditionally been the primary therapeutic goal, growing evidence indicates that non-seizure manifestations often represent the m...
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