Epilepsy News

What to know about epilepsy and seizure first aid - November is Epilepsy Awareness Month. Many people may already be aware of the condition from its prevalence in medical dramas, but that portrayal is often exaggerated and does not fully encapsulate ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

First seizure clinic provides visit, pediatric epilepsy diagnosis in less than a week - Please provide your email address to receive an email when new articles are posted on . The model expedites access to specialists after a first seizure. The mean time between the referral and the ...

Focal treatment-resistant epilepsy symptoms improved with antiseizure medication - Please provide your email address to receive an email when new articles are posted on . Monthly seizure frequency percentage reduction was 68.73% for the entire study cohort. For those followed up in ...

Understanding epilepsy: Seven ways to respond to an epileptic seizure - At the forefront of epilepsy research and treatment is the University of Alabama at Birmingham Epilepsy Center, a collaborative initiative between the UAB Department of Neurology and UAB Hospital, ...

Exploring human GABA transporter 3 binders for epilepsy through quantum reactivity analysis, molecular dynamics, machine learning prediction, and network pharmacology - CONTEXT: Drug-resistant epilepsy (DRE) remains a major therapeutic challenge, affecting millions of patients globally who do not respond to conventional antiepileptic medications. Recent evidence highlights GABA transporter 3 (GAT3), a glial subtype responsible for regulating extracellular GABA levels, as a promising molecular target for seizure control. Despite its therapeutic potential, selec...

A Brain-Permeable Selenocyanate Near-Infrared (NIR) Probe Platform for H2S Dynamics Imaging: Insights into Redox Homeostasis and Antiepileptic Therapy - The spatiotemporal dynamics of hydrogen sulfide (H(2)S) in the living brain remain elusive, primarily due to the lack of molecular probes that can concurrently resist biothiol interference, cross the blood-brain barrier (BBB), and yield reliable in vivo signals.This work presents a selenocyanate-based sensing trigger relying on a specific H(2)S-initiated cascade cyclization that exhibits superi...

Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic-clonic seizures - OBJECTIVE: Most therapies for drug-resistant epilepsy (DRE) focus on focal-onset seizures, the most common seizure types. Studying primary generalized tonic-clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment difficulties. While vagus nerve stimulation (VNS) therapy is globally established in DRE with focal-onset seizures, approved indications vary by region. This stud...

Integrating Therapeutic Drug Monitoring and Metabolomics to Explore Interindividual Variability in Lamotrigine Response in Epilepsy - CONCLUSION: Higher LTG plasma concentrations were associated with better seizure control, and VPA co‑administration enhances LTG exposure and efficacy. The distinct amino acid profile in high-concentration responders suggests amino acid metabolism and redox balance may modulate LTG efficacy.

Assessing the efficacy and safety of transcranial magnetic stimulation and vagus nerve stimulation for drug-resistant epilepsy: A systematic review - CONCLUSION: Evidence reported that both TMS and VNS greatly improve seizure control in patients with drug-resistant epilepsy, potentially enhancing quality of life and reducing seizure frequency. A large amount of our findings support the integration of neuromodulation techniques into future treatment regimens for drug-resistant epilepsy, which might be accompanied by calls for future clinical ...

Wearable Technologies for Clinical Assessment and Monitoring in Pediatric Neurodevelopmental Disorders : A Narrative Review - Pediatric neurodevelopmental disorders (NDDs) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision : intellectual disabilities, communication disorders, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), specific learning disorder, and motor disorders together with closely associated pediatric neurological conditions...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.