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Pediatric stroke: From emergent evaluation to rehabilitation -
Pediatric stroke, though less common than adult stroke, is a significant cause of morbidity and mortality in children, affecting neonates, infants, and adolescents. Strokes in children could be due to ischemic, hemorrhagic, or venous-thrombotic events. Timely recognition and intervention to optimize neurologic outcomes and minimize long-term disability is most critical. Clinical symptoms are de...
Educational attainment of children with self-limited epilepsy with CentroTemporal spikes (SELECTS), other epilepsies, and without epilepsy: A retrospective cohort study -
CONCLUSIONS: There was a trend for poorer educational achievement for children with SELECTS at KS4; this was only borderline statistically significant in the adjusted model. Children with other epilepsies had an increased risk of poorer attainment across all ages when compared to children without epilepsy.
Cenobamate in adult patients with epilepsy and intellectual disability -
OBJECTIVE: In people with intellectual disability (ID), prevalence of epilepsy is up to 50-times higher than in the general population and often difficult to treat. Multiple randomized controlled, observational and retrospective studies have demonstrated favorable efficacy of adjunctive cenobamate (CNB). So far, people with epilepsy and ID (PWE+ID) have remained significantly underrepresented. ...
Seizure control, delivery, and neonatal outcomes in pregnant women with focal epilepsies: a prospective cohort study -
CONCLUSION: Seizure occurrence during pregnancy, rather than the specific form of FE alone, can be considered the primary factor contributing to adverse maternal and neonatal outcomes. These findings emphasize the importance of continuous seizure management, ASM adherence, and individualized perinatal care in WWE.
Shared and divergent neuromagnetic network signatures in childhood absence epilepsy and self-limited epilepsy with centrotemporal spikes -
OBJECTIVES: Childhood Absence Epilepsy (CAE) and Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS) are common, clinically associated syndromes, yet their shared and distinct pathophysiological mechanisms remain unclear. This study aimed to systematically compare interictal resting-state neuromagnetic networks among drug-naive children with CAE, SeLECTS, and healthy controls (HC) to ide...
Isolated hippocampal sclerosis and focal dysplasia type IIIa: Comparative study of anatomo-electro-clinical profile and seizure outcome -
OBJECTIVE: Distinguishing drug-resistant temporal lobe epilepsy (TLE) caused by isolated hippocampal sclerosis (iHS) from focal cortical dysplasia type IIIa (FCD IIIa) remains a presurgical challenge. This study aimed to compare the clinical characteristics, electrophysiological data, and postsurgical seizure outcomes between these pathologies.
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