Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring -
NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...
Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? -
Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...
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PubMed
Safety and Local Tolerability of Diazepam Nasal Spray for Children With Epilepsy Aged 2-5 Years: Final Results of a Phase 1/2a Trial -
Diazepam nasal spray is approved to treat seizure clusters in patients aged ≥2 years. A long-term safety study in patients aged 6-65 years found a safety profile similar to diazepam rectal gel. We conducted an open-label, phase 1/2a trial of diazepam nasal spray in children with epilepsy aged 2-5 years with motor seizures or seizures with clear alteration of awareness. After a pharmacokinetic p...
Metabolic Outputs of the Gut Microbiome: Implications for Epilepsy -
CONCLUSIONS: Some microbial-derived metabolites may serve as promising biomarkers and mechanistic mediators of epilepsy; however, further investigation is needed to define the molecular and cellular pathways through which these metabolites influence seizure susceptibility and epileptogenesis.
Gambling Disorder as a Behaviorally Driven Systemic Medical Condition: From Reward Circuitry to Multi-System Morbidity -
Historically framed as a behavioral addiction, gambling disorder (GD) has had its somatic dimension neglected by standard clinical evaluation. This is a narrative, hypothesis-generating review focusing on the somatic aspects of GD. Cross-sectional and prospective evidence increasingly shows a somatic phenotype distributed across four axes: cardiovascular (hypertension, angina, stroke, acute str...
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes -
New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
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