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Exploratory analysis of cell-free miRNA expression changes in patients with isolated first seizure and new-onset epilepsy -
One in ten individuals will experience a seizure in their lives, but only 43%-61% will be diagnosed with new-onset epilepsy (NOE). Existing methods to distinguish between a first unprovoked seizure and a diagnosis of epilepsy are inadequate and often lead to unnecessary treatment with antiseizure medications. To uncover potential targets associated with NOE, we analyzed cell-free circulating mi...
Epilepsy at the Airport -
CONCLUSION: These findings suggest that patients with IGE may be at higher risk of seizures in these circumstances. The predominance of events in departure terminals, particularly before morning flights, highlights a potentially modifiable risk factor. Targeted counselling on modifiable risk factors may reduce risk and anxiety and should be incorporated into routine clinical care to support saf...
Calcitonin gene-related peptide (CGRP) in epilepsy: Mechanistic insights from preclinical models -
Calcitonin gene-related peptide (CGRP) is a pleiotropic neuropeptide widely expressed in the central and peripheral nervous systems, with established roles in neurovascular regulation, synaptic transmission, and neuroinflammation. While CGRP has been extensively characterized in migraine pathophysiology, its role in epilepsy remains incompletely defined and is primarily supported by experimenta...
Predictors of Early Postoperative Seizures Following STA-MCA Bypass in Adult Moyamoya Angiopathy -
Background: Postoperative epileptic seizures are a recognized complication after superficial temporal artery-middle cerebral artery (STA-MCA) bypass for Moyamoya angiopathy (MMA), but their determinants remain incompletely understood. We aimed to identify clinical, radiological, and perioperative factors associated with early postoperative seizures following adult STA-MCA bypass. Methods: We re...
An ESP32-S3 Multimodal Wearable Sensor Platform with Embedded XGBoost for Focal-to-Bilateral Tonic-Clonic Seizure Detection and IoT Alerting -
Wearable seizure-detection systems can provide objective event monitoring and rapid caregiver alerting without continuous bedside observation. This study presents a resource-constrained multimodal wearable sensor platform for focal-to-bilateral tonic-clonic seizure (FBTCS) detection using edge artificial intelligence and Internet of Things (IoT) communication. The prototype integrates an ESP32-...
Temporal Patterns of Serum Neuroprotectin D1 and Resolvin D1 After Motor and Nonmotor Epileptic Seizures: A Prospective Repeated-Measures Study -
Objective: Neuroinflammatory activation is well recognized in epilepsy, whereas the temporal behavior of specialized pro-resolving mediator (SPM) responses after seizures remains poorly defined. We evaluated changes in serum neuroprotectin D1 (NP-1) and resolvin D1 (RvD1) between the early postictal period and a seizure-free period of at least 1 month and compared both time points with healthy ...
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