Epilepsy News
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Epilepsy and Seizure News
Enrolment concludes in Biohaven’s RISE3 trial for epilepsy -
Biohaven has concluded enrolment in the pivotal RISE3 Phase II/III trial assessing the selective Kv7.2/7.3 channel activator, opakalim (BHV-7000), for refractory focal epilepsy. T ...
Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
Medical News Today
PubMed
Tumor Recurrence or Radionecrosis: A Clinical Dilemma in Long-Term Survivors of Low-Grade Diffuse Glioma With Drug-Resistant Epilepsy -
Low-grade diffuse gliomas with isocitrate dehydrogenase (IDH) mutations predominantly affect young adults and are frequently associated with prolonged survival, requiring extended neuro-oncological follow-up. In these patients, differentiating tumor recurrence from radionecrosis after radiotherapy remains a major diagnostic challenge because both entities may present with overlapping clinical m...
Education Research: Educational Informatics: Characterizing Child Neurology Resident Clinical Experiences Using Electronic Health Record Data - BACKGROUND AND OBJECTIVES: Gaps in preparedness for independent practice are common among recent graduates. Clinical experiences serve as the foundation for learning during residency, yet the breadth and variability of clinical exposure of child neurology residents remain poorly characterized. To inform programmatic curricular development and precision medical education (PME), we must better ch...
Prevalence and factors associated with intellectual impairment in children with epilepsy in two national referral hospitals in Uganda - CONCLUSIONS: Intellectual impairment is common among Ugandan children and adolescents with epilepsy and is associated with older age, school non-attendance, special-needs school placement, delayed speech, and anti-seizure medication polypharmacy. These findings underscore the need for routine assessment of intellectual functioning and targeted interventions, including academic support, speech t...
Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy - Epilepsy, a common neurological disorder is frequently linked to genetic variants in synaptic proteins. Here, we describe a de novo pathogenic missense variant in the gephyrin G-domain (G134R) identified in an individual with developmental delay, epileptic seizures, microcephaly, dysmorphic features and short stature. Functional analyses reveal that G134R disrupts higher-order oligomerization, ...
Low-cost UWB CPW microwave tattoo sensor for respiratory monitoring using near-field phase variation - This paper presents a flexible, ultra-thin, and transparent tattoo-based CPW slot microwave sensor designed for respiratory monitoring with potential applications in epilepsy-related assessment. The sensor is fabricated using gold leaf on transparent PVC, enabling excellent skin conformity and long-term comfort. The proposed microwave sensor achieves an ultra-wide operating bandwidth of 2.4-17 ...
Impact of Intravenous Immunoglobulin on Neuroinflammation Markers in Patients With Electrical Status Epilepticus During Slow Sleep - CONCLUSION: IVIg treatment dampens the neuroinflammatory response and thus immune-modulatory treatment in combination with ASD may contribute to the improvement of ESES symptoms. CXCL13, HMGB1 and IL-1β may serve as markers of immune-modulatory treatment response in ESES.
Education Research: Educational Informatics: Characterizing Child Neurology Resident Clinical Experiences Using Electronic Health Record Data - BACKGROUND AND OBJECTIVES: Gaps in preparedness for independent practice are common among recent graduates. Clinical experiences serve as the foundation for learning during residency, yet the breadth and variability of clinical exposure of child neurology residents remain poorly characterized. To inform programmatic curricular development and precision medical education (PME), we must better ch...
Prevalence and factors associated with intellectual impairment in children with epilepsy in two national referral hospitals in Uganda - CONCLUSIONS: Intellectual impairment is common among Ugandan children and adolescents with epilepsy and is associated with older age, school non-attendance, special-needs school placement, delayed speech, and anti-seizure medication polypharmacy. These findings underscore the need for routine assessment of intellectual functioning and targeted interventions, including academic support, speech t...
Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy - Epilepsy, a common neurological disorder is frequently linked to genetic variants in synaptic proteins. Here, we describe a de novo pathogenic missense variant in the gephyrin G-domain (G134R) identified in an individual with developmental delay, epileptic seizures, microcephaly, dysmorphic features and short stature. Functional analyses reveal that G134R disrupts higher-order oligomerization, ...
Low-cost UWB CPW microwave tattoo sensor for respiratory monitoring using near-field phase variation - This paper presents a flexible, ultra-thin, and transparent tattoo-based CPW slot microwave sensor designed for respiratory monitoring with potential applications in epilepsy-related assessment. The sensor is fabricated using gold leaf on transparent PVC, enabling excellent skin conformity and long-term comfort. The proposed microwave sensor achieves an ultra-wide operating bandwidth of 2.4-17 ...
Impact of Intravenous Immunoglobulin on Neuroinflammation Markers in Patients With Electrical Status Epilepticus During Slow Sleep - CONCLUSION: IVIg treatment dampens the neuroinflammatory response and thus immune-modulatory treatment in combination with ASD may contribute to the improvement of ESES symptoms. CXCL13, HMGB1 and IL-1β may serve as markers of immune-modulatory treatment response in ESES.
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.