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Effect of the ketogenic diet on absence seizures in rats with genetic absence epilepsy -
CONCLUSION: This study is an original investigation into the efficacy of the ketogenic diet on absence epilepsy in 30-day-old rats, with consideration of the sex factor. The findings of our study contribute to a deeper understanding of the therapeutic potential of the ketogenic diet in the treatment of absence epilepsy.
Long-term efficacy of subthalamic nucleus deep brain stimulation in focal motor seizures and implications for candidate selection -
Focal motor seizures (FMS) are often unresectable because of motor risk. We aimed to evaluate the long-term effectiveness and safety of subthalamic nucleus deep brain stimulation (STN-DBS) in patients with FMS and to identify suitable candidate patients. We analyzed long-term outcomes in 22 patients with FMS treated with STN-DBS, classifying patients as responders (≥50% seizure reduction) or no...
RLIM variant associated with X-linked epilepsy with neurodevelopmental disorders and the molecular sub-regional effects -
CONCLUSIONS: RLIM variants are associated with X-linked epilepsy with NDDs. Molecular subregional effects, genotype-phenotype association, and expression-phenotype correlations provide critical insights into the clinical diagnosis, management and mechanistic investigation of RLIM-related disorders.
Association between disconnected networks and surgical outcome in drug-resistant temporal lobe epilepsy -
CONCLUSION: The SFC of disconnected networks showed widespread reductions in TLE. Exploratory analyses suggested that second-tier SFC may be related to postoperative seizure outcome, highlighting the potential relevance of resection-anchored network organization in TLE surgery.
Heterozygous gain-of-function and mixed-type Kcna2 variants recapitulate SUDEP and increased cortical Npy-Npy1r signaling -
CONCLUSION: GoF and mixed-type KCNA2 pathogenic variants converged on a seizure-induced premature death phenotype that recapitulated SUDEP and a shared cortical Npy-Npy1r signaling pathway. Enhanced Npy-Npy1r signaling may represent a potential therapeutic target for KCNA2-related epilepsies.
Vision-Based Artificial Intelligence Technologies for Epilepsy Monitoring: Scoping Review and Taxonomy Development Study -
CONCLUSIONS: Vision-based AI technologies for epilepsy monitoring are still dominated by proof-of-concept and pilot evaluations, indicating a gap between technical feasibility and deployment-ready systems. This scoping review presents an implementation-oriented taxonomy integrating application context, system architecture, visual analysis, AI models, performance reporting, and feedback design i...
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