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Diffusion MRI Assessment of White Matter Microstructure and Free-Water Fraction in Drug-Naïve Children with SeLECTS -
Self-limited epilepsy with centrotemporal spikes (SeLECTS) is a common childhood-onset focal epilepsy syndrome. Although seizures are typically self-limited, some children may show neurodevelopmental or cognitive vulnerability. Diffusion MRI may provide insight into white matter alterations in SeLECTS. Objective To evaluate white matter diffusion differences in newly diagnosed, drug-naïve child...
D2 dopamine and CB2 cannabinoid receptor cooperation restores striatal LTP in an epilepsy model -
Increasing evidence suggests that subcortical structures contribute to seizure susceptibility and cognitive impairment in several epileptic syndromes. However, research into mechanisms linking neuronal excitability and synaptic dysfunction in epilepsy has mainly focused on the cortex and hippocampus, leaving basal ganglia contributions largely unexplored. Using a genetic murine model of Lafora ...
Responsive Neurostimulation of the Centromedian Nucleus of the Thalamus for the Treatment of Drug-Resistant Idiopathic Generalized Epilepsy: A Retrospective Analysis of Efficacy and Exploratory Rol... -
CONCLUSIONS: The results of this cases series suggest CMN-RNS therapy in people with drug-resistant IGE may significantly reduce the frequency of GTC. Preliminary evidence may support alternative paradigms of mid and low-frequency stimulation when high-frequency stimulation is poorly tolerated or not efficacious.
Epilepsy-associated potassium channel KCNT1 is required for multiciliated cell specification in Xenopus -
Pathogenic, presumed gain-of-function variants in the gene KCNT1, which encodes a sodium-activated potassium channel, cause a severe neurodevelopmental disorder with intractable epilepsy. In addition to seizures, affected individuals commonly present with severe respiratory issues and structural heart defects not commonly observed in other genetic pediatric epilepsies, suggesting additional dev...
Awake resection of temporal encephalocele associated with drug-resistant epilepsy: illustrative case -
BACKGROUND: The association between temporal encephaloceles (TEs) and drug-resistant epilepsy (DRE) is well recognized, yet the literature regarding therapeutic management remains scarce and largely retrospective. Reported strategies vary from conservative approaches to extensive resection of encephaloceles including the adjacent epileptogenic zone (EZ). Surprisingly, although the EZ may be loc...
Prevalence and Treatment Gap of Epilepsy in Rural Ludhiana: A Community-Based Study -
CONCLUSIONS: The study underscores the significant prevalence and treatment gap of epilepsy in rural Ludhiana, highlighting the need for improved awareness, targeted healthcare strategies, and rehabilitation efforts. Strengthening counseling services at the primary healthcare level may substantially improve treatment adherence. A multifaceted approach is required considering socioeconomic, educ...
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