Epilepsy News

Anticonvulsant role of nitric oxide synthase inhibitors in epilepsy (Review) - Epilepsy is a pathophysiological process triggered by an imbalance between excitatory and inhibitory mechanisms in the brain, resulting in the sudden and synchronized excessive electrical discharges of neurons. Nitric oxide (NO) is a cellular signaling molecule that functions as both a neurotransmitter and neuromodulator in the central nervous system. Despite its critical role in neuronal funct...

Plasma untargeted metabolomics reveals metabolic signatures associated with epilepsy and anti-seizure medication responsiveness - CONCLUSION: This study revealed plasma metabolic signatures associated with epilepsy and anti-seizure medication responsiveness. The identified candidate metabolites and pathways provide preliminary metabolic evidence that requires further validation in independent cohorts and mechanistic studies.

High-frequency oscillations arise through distinct mechanisms in models of alpha- synucleinopathy and channelopathy-induced epilepsy - Background Pathological high-frequency oscillations (HFOs), widely researched in epilepsy, are increasingly being investigated as potential biomarkers of network hyperexcitability in neurodegenerative disorders. This interest is driven by growing evidence of comorbidity between epilepsy and neurodegenerative diseases, particularly Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), su...

Development of Rest-Activity Rhythms in Infancy and Their Disruption in Infantile Epileptic Spasms Syndrome - CONCLUSIONS: During infancy, rest-activity rhythms display a stereotyped maturation in height, complexity and day to day consistency, revealing a developmental "growth curve" of RAR maturation. Severe RAR disruptions in infants with IESS may relate to the encephalopathy imposed by the underlying genetic/metabolic condition, structural lesion, and/or the psychomotor retardation imparted by antis...

GIRK Channel Loss of Function Increases Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy - GNB1 encephalopathy (GNB1-E) is a rare neurodevelopmental disorder associated with motor dysfunction, epilepsy and learning disability caused by mutations in the gene encoding the G protein subunit Gβ (1) . Previous work has shown that altered Gβ (1) can disrupt activation of G-protein-coupled inwardly rectifying potassium (GIRK) channels, dysregulate neuronal excitability and cause seizures. H...

Alternating hemiplegia of childhood - a systematic review - CONCLUSIONS: Alternating hemiplegia of childhood is a complex multisystem disorder requiring early diagnosis, continuous monitoring, and multidisciplinary care. Disease-modifying treatments remain urgently needed.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.