Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Emergency Department Visits for Falls and First-Time Seizure -
BACKGROUND AND OBJECTIVES: Unrecognized seizures occur in up to 77% of individuals with epilepsy, leading to delays in diagnosis with significant consequences including injury, mortality, impaired psychosocial functioning, and negative socioeconomic impacts. Falls are a common reason to present to the emergency department (ED) and may be a sentinel sign of an unrecognized seizure. Whether falls...
Cross-Subject Localization of Epileptogenic Zone for Drug-Resistant Epilepsy Based on the Causal Brain Network - CONCLUSION: Causal brain network features extracted by FCCM are robust biomarkers for localizing the EZ.
Brain volumetric signatures of neighborhood disadvantage in focal epilepsy - OBJECTIVE: Social disadvantage is an important determinant of health in focal epilepsy, but its neurobiological basis remains unclear. We examined whether brain morphometric alterations represent a structural signature of deprivation.
Prognosis of acute symptomatic seizures and impact of prolonged treatment with anti-seizure medication - OBJECTIVES: Acute symptomatic epileptic seizures (ASySs) occur in temporal proximity to acute brain insults. Given their low risk of subsequent unprovoked seizures, current guidelines recommend either no treatment with anti-seizure medication (ASM) or early discontinuation, yet ASM treatment is often continued beyond hospital discharge. We aimed at investigating the cumulative 3-year risk and p...
Neurometabolite abnormalities and associations with epilepsy duration and cognition in patients with idiopathic generalized epilepsies - OBJECTIVE: This study investigated whether idiopathic generalized epilepsies (IGEs) are associated with neuroinflammation by measuring neurometabolite levels and brain temperature using whole-brain magnetic resonance spectroscopy imaging (MRSI). We compared patients with IGEs to healthy controls (HCs), and in IGEs examined relationships with seizure control, MRSI markers, epilepsy duration, and...
Deep whole genome sequencing of epileptogenic brain lesions - OBJECTIVE: Malformations of cortical development and low-grade epilepsy-associated tumors often cause drug-resistant lesional focal epilepsy (LFE) amenable to surgical treatment. Genetic testing of resected brain tissue can provide diagnostic and mechanistic information and may eventually support personalized treatment approaches. However, systematic >300× whole genome sequencing (GS) of bulk e...
Cross-Subject Localization of Epileptogenic Zone for Drug-Resistant Epilepsy Based on the Causal Brain Network - CONCLUSION: Causal brain network features extracted by FCCM are robust biomarkers for localizing the EZ.
Brain volumetric signatures of neighborhood disadvantage in focal epilepsy - OBJECTIVE: Social disadvantage is an important determinant of health in focal epilepsy, but its neurobiological basis remains unclear. We examined whether brain morphometric alterations represent a structural signature of deprivation.
Prognosis of acute symptomatic seizures and impact of prolonged treatment with anti-seizure medication - OBJECTIVES: Acute symptomatic epileptic seizures (ASySs) occur in temporal proximity to acute brain insults. Given their low risk of subsequent unprovoked seizures, current guidelines recommend either no treatment with anti-seizure medication (ASM) or early discontinuation, yet ASM treatment is often continued beyond hospital discharge. We aimed at investigating the cumulative 3-year risk and p...
Neurometabolite abnormalities and associations with epilepsy duration and cognition in patients with idiopathic generalized epilepsies - OBJECTIVE: This study investigated whether idiopathic generalized epilepsies (IGEs) are associated with neuroinflammation by measuring neurometabolite levels and brain temperature using whole-brain magnetic resonance spectroscopy imaging (MRSI). We compared patients with IGEs to healthy controls (HCs), and in IGEs examined relationships with seizure control, MRSI markers, epilepsy duration, and...
Deep whole genome sequencing of epileptogenic brain lesions - OBJECTIVE: Malformations of cortical development and low-grade epilepsy-associated tumors often cause drug-resistant lesional focal epilepsy (LFE) amenable to surgical treatment. Genetic testing of resected brain tissue can provide diagnostic and mechanistic information and may eventually support personalized treatment approaches. However, systematic >300× whole genome sequencing (GS) of bulk e...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.