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Understanding MEG Source Profiles in Tuberous Sclerosis -
CONCLUSIONS: This study demonstrates a localization concordance between MEG and sEEG that is related to postsurgical seizure outcomes in patients with TSC. However, no correlation between MEG source number, laterality (unilateral vs. bilateral), and surgical outcomes was found, supporting the continued use of MEG as a presurgical epilepsy tool in this patient population, no matter the number of...
Sustained Seizure Freedom After Stereo-Electroencephalography Without Definitive Intervention: Evidence for Network Modulation by Invasive EEG -
Stereo-electroencephalography (sEEG) is a diagnostic technique used to localize seizure-onset networks in drug-resistant epilepsy, typically guiding resection, ablation, or neuromodulation. Sustained seizure freedom after diagnostic implantation alone is rarely described. We describe two patients who achieved long-term remission after sEEG monitoring without definitive surgical intervention. A ...
The Impact of Plasmapheresis on Serum Concentrations of Antiseizure Medications: A Systematic Review -
Seizures are an important neurological manifestation of several autoimmune and antibody-mediated disorders and often require treatment with antiseizure medications (ASMs). Therapeutic plasma exchange (TPE) is frequently used to treat these antibody-mediated conditions by removing circulating pathogenic factors. However, TPE is non-selective and may also remove protein-bound ASMs, particularly t...
Rotavirus-associated mild encephalitis with a reversible splenial lesion of the corpus callosum -
No abstract
Selective γ8 transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor regulatory protein negative allosteric modulators: Efficacy in preclinical antiseizure models -
OBJECTIVE: RAP-219, a potent selective negative allosteric modulator (NAM) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) associated with γ8 transmembrane AMPAR regulatory protein (TARPγ8), is in phase 3 development for refractory focal epilepsy. This study was undertaken to assess efficacy and motor function following administration of AMPAR/TARPγ8 NAMs.
Self- and other-directed harmful behavior following deep brain stimulation of the anterior nucleus of the thalamus for drug-resistant epilepsy -
OBJECTIVE: The current study examined the occurrence, clinical predictors, and neuroanatomical correlates of self- or other-directed harmful ideation or behavior (HIB) following deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) for drug-resistant epilepsy.
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