Epilepsy News

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

First seizure clinic provides visit, pediatric epilepsy diagnosis in less than a week - Please provide your email address to receive an email when new articles are posted on . The model expedites access to specialists after a first seizure. The mean time between the referral and the ...

Why treating epilepsy isn't just about stopping seizures - Epilepsy was viewed for a long time as a disorder of sudden electrical disruption, but we now know the story is more complex ...

Focal treatment-resistant epilepsy symptoms improved with antiseizure medication - Please provide your email address to receive an email when new articles are posted on . Monthly seizure frequency percentage reduction was 68.73% for the entire study cohort. For those followed up in ...

Understanding epilepsy: Seven ways to respond to an epileptic seizure - At the forefront of epilepsy research and treatment is the University of Alabama at Birmingham Epilepsy Center, a collaborative initiative between the UAB Department of Neurology and UAB Hospital, ...

Depolarization block paradoxically drives surges of neurotransmitter release during seizure activity - OBJECTIVE: This study was undertaken to investigate the mechanisms underlying the paradoxical phenomena of excessive neurotransmitter release and suppressed sodium-spike generation due to depolarization block (DB) during seizure activity.

Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats - OBJECTIVE: Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic-clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic kainic acid (KA) rats, a temporal lobe epilepsy model w...

Informed acceptance and perceptions of the 2025 ILAE seizure classification following structured teaching - OBJECTIVE: To assess informed acceptance and perceptions of the 2025 update of the International League Against Epilepsy (ILAE) seizure classification-after participants had received a focused educational introduction to the updated classification.

Changes in serum cardiac troponin I after seizures: A marker for persistent subtle left ventricular myocardial dysfunctions in children with epilepsy - CONCLUSIONS: Postseizure serum cTnI is a valuable marker of persistent, subtle LV myocardial changes in epileptic children, especially TDI and 2D-STE-derived parameters. The normalization of cTnI is an indicator of the myocardial stunning process in children that would lead to persistent LV myocardial injury following recurrence of seizure, which warrants strict seizure control and cardiac surv...

Studies on the anticonvulsant potential of 6-gingerol, an active ingredient of ginger rhizome - Ginger (Zingiber officinale), due to its diverse therapeutic properties, continues to attract researchers' attention. One of these properties is its anticonvulsant activity, which, as our previous studies have shown, may result from the presence of 6-gingerol, a compound that reduced pentylenetetrazole (PTZ)-induced hyperlocomotion in zebrafish larvae. In the present study, we further investiga...

Development and validation of a clinical nomogram for predicting suboptimal concentration of valproate in pediatric with epilepsy: a retrospective study - CONCLUSION: We developed and internally validated a predictive nomogram that integrates dose, AKI, ALI, and meropenem use to assess the risk of suboptimal concentrations of valproate in pediatric epilepsy. This tool can aid in the early identification of high-risk patients, enabling targeted therapeutic drug monitoring.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.