Epilepsy and Seizure News
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Cerebral hemangioma in a 5-month-old Chow Chow dog displaying seizures of acute onset -
CONCLUSIONS: This case report underlines the importance of considering cerebral hemangiomas accompanied by acute hemorrhage as a possible differential diagnosis in cases with an acute onset of epileptic cluster seizures with accompanying interictal neurological signs, here found in a juvenile dog.
Post-stroke epilepsy in Saudi Arabia - frequency, management and outcomes at a comprehensive stroke center in Riyadh, Kingdom of Saudi Arabia -
CONCLUSIONS: Post-stroke epilepsy was common in our cohort. The patients with hemorrhagic stroke were more likely to have post-stroke epilepsy compared to ischemic stroke. Generalized seizures were the commonest type of seizure. Most patients had good control at last follow up requiring only monotherapy.
BDNF-modulated plastic changes to dendritic spines in the hippocampus and prefrontal cortex underlie the NMDA-induced pre-convulsive stereotyped behavior in rats -
Systemic administration of NMDA induces stereotyped behavior followed frequently, but not always, by generalized epileptiform seizures. Increased NMDA activity provokes overstimulation of NMDA glutamate receptors in neurons with dendritic spines. Systemic administration of 100 mg/kg of NMDA i.p. induced stereotyped behavior in adult male rats 5-10 min post-injection. Then, the density and propo...
Climate change and neurological disorders in childhood: A scoping review -
CONCLUSIONS: Current evidence suggests that climate change-related exposures, particularly extreme temperatures, temperature variability, and natural disasters, negatively affect paediatric neurological health directly (increased seizure risk, impaired myelination) and indirectly (disrupted treatment access, emotional stress). Neuroinfectious diseases were also strongly associated with climatic...
Association between persisting peritumoral brain edema and seizures as well as worse functional outcome after meningioma surgery: a retrospective study of 218 patients -
CONCLUSIONS: Persisting PTBE is associated with worse functional outcome and with persisting and new-onset seizures. Based on EEG findings, persisting PTBE (i.e., gliosis) may be the epileptogenic focus in some patients. Future studies are needed to assess whether these gliotic sites could even be therapeutic targets for seizure control.
Vagus nerve stimulation for refractory epilepsy: a 24-year single-center experience -
CONCLUSIONS: This study showed that patients with refractory epilepsy who experience low baseline seizure frequency (< 1-2/month and < 1-2/year) received the most benefit from VNS. All patients with refractory seizures should be considered for VNS therapy but should undergo careful case selection to manage expectations and maximize seizure outcomes and medication burden.
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