Epilepsy News

Involvement of the Claustrum in Human Epileptic Seizures - CONCLUSIONS: Our study suggests that the claustrum is often involved during seizures arising from the temporal lobe and cingulate cortexes and could play a role in modulation of the epileptogenic network.

Brain Research Bulletin NF-kappaB as a context-dependent inflammatory regulator of glial programs in epilepsy - Neuroinflammation is increasingly recognized as an important contributor to epileptogenesis and seizure recurrence, with microglia and astrocytes serving as major regulators of the inflammatory microenvironment. Among the pathways implicated in glia-mediated inflammation, nuclear factor kappa B (NF-κB) occupies a central position by integrating danger signals, metabolic stress, and activity-dep...

Utilizing wearable activity trackers to promote physical activity in people with epilepsy: a randomized controlled trial - OBJECTIVE: To evaluate exercise education alone versus exercise education in combination with a wearable physical activity tracker in people with epilepsy (PWE) to determine the effect on physical activity and measure potential impact on depression, anxiety, sleep, and quality of life (QoL).

Therapeutic Potential of Formononetin in Drug-Resistant Epilepsy: Evidence from a Rotenone-PTZ-Lamotrigine Mouse Model - Drug-resistant epilepsy (DRE) affects nearly one-third of individuals with epilepsy and remains a major therapeutic challenge despite the availability of multiple antiseizure medications. Mitochondrial dysfunction and chronic neuroinflammation, particularly NLRP3 inflammasome activation, are increasingly recognized as key contributors to pharmacoresistance. Formononetin, a plant-derived isoflav...

Revealing Pharmacological Target for Comorbid Epilepsy in Alzheimer's Disease: Neurochemical Insights from STZ Mice - Despite growing evidences of shared neurochemical alterations linked to comorbid epilepsy in AD, effective unified therapeutic strategies remain lacking. Thus, the present investigation was designed to identify shared neurochemical changes associated with lowered convulsive threshold in STZ (streptozotocin) model of AD-type dementia to pharmacologically address this comorbidity. Swiss albino mi...

Prescriptions for seizure cluster rescue therapy are not associated with decreased pediatric ED utilization - OBJECTIVE: Seizure clusters, or acute repetitive seizures, are a phenomenon often experienced by patients with epilepsy and pose a significant treatment challenge for clinicians. Several rescue medications have been approved by the Food and Drug Administration for the treatment of seizure clusters - including diazepam rectal gel, intranasal midazolam, and intranasal diazepam - which are commonl...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.