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Endoscopic endonasal depth EEG-guided resection of a temporal encephalocele resulting in seizure freedom: illustrative case -
BACKGROUND: Temporal encephaloceles (TEs) are increasingly recognized as epileptogenic lesions in drug-resistant temporal lobe epilepsy. However, endoscopic endonasal surgery performed primarily to resect epileptogenic lesions remains extremely rare, largely because defining the optimal extent of resection is challenging without direct electrophysiological confirmation.
Child Neurology: Expanding the LGI1 Spectrum: Homozygous Loss-of-Function Variant in an Infant With Epileptic Encephalopathy -
Epilepsy syndromes are clinically defined by their specific set of features, including seizure types, age at onset, electroencephalographic patterns, and prognosis. For example, autosomal-dominant lateral temporal lobe epilepsy (ADLTE) is a well-recognized epilepsy syndrome associated with heterozygous leucine-rich glioma inactivated-1 (LGI1) gene variants. Relatedly, developmental and epilepti...
The functional impact of LGI1 autoantibodies on human CA3 pyramidal neurons -
Autoantibodies against leucine-rich glioma inactivated 1 protein (LGI1) lead to limbic encephalitis, a rare neurological autoimmune disorder characterized by faciobrachial dystonic seizures and memory deficits. While animal models provide precious insights into the mechanisms of LGI1 autoantibody action, species-specific confirmation is lacking. In this study, we investigated the effects of pat...
Neuropsychiatric adverse effects associated with the use of levetiracetam in adults: A Systematic Review and Meta-analysis -
CONCLUSION: Patients treated with levetiracetam have a greater risk of developing neuropsychiatric effects, such as somnolence and fatigue, compared to placebo.
Neuroimaging spectrum of GATOR1-related epilepsy (GATORopathies) -
CONCLUSION: GATOR1-related epilepsy demonstrates substantial variability in neuroimaging and electroclinical features, extending beyond focal cortical malformations to include diffuse cortical malformations, generalized neuroparenchymal atrophy, and MRI-negative presentations. These findings highlight the value of integrated genetic, imaging, and electroclinical assessment in routine clinical p...
Comparative Predictive Performance of Serum and Dose-Normalized Valproate Levels for Seizure Control in Adults With Epilepsy -
Background Valproate is a widely used antiepileptic drug, but its clinical response shows considerable interindividual variability. Conventional therapeutic ranges may not reliably predict seizure control, and the role of dose-normalized valproate levels in forecasting seizure as an outcome remains unclear. Objective To evaluate the predictive performance of serum valproate levels for seizure c...
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