Epilepsy News

Efficacy and Safety of Adjunctive Perampanel in Young Children (7-46 Months) With Drug-Resistant Epilepsy: A Real-World Study - CONCLUSION: Adjunctive PER demonstrated clinically meaningful efficacy and a favorable safety profile in young children with DRE, supporting its potential role as a broad-spectrum ASM in this age group.

Cerebral hemangioma in a 5-month-old Chow Chow dog displaying seizures of acute onset - CONCLUSIONS: This case report underlines the importance of considering cerebral hemangiomas accompanied by acute hemorrhage as a possible differential diagnosis in cases with an acute onset of epileptic cluster seizures with accompanying interictal neurological signs, here found in a juvenile dog.

Post-stroke epilepsy in Saudi Arabia - frequency, management and outcomes at a comprehensive stroke center in Riyadh, Kingdom of Saudi Arabia - CONCLUSIONS: Post-stroke epilepsy was common in our cohort. The patients with hemorrhagic stroke were more likely to have post-stroke epilepsy compared to ischemic stroke. Generalized seizures were the commonest type of seizure. Most patients had good control at last follow up requiring only monotherapy.

BDNF-modulated plastic changes to dendritic spines in the hippocampus and prefrontal cortex underlie the NMDA-induced pre-convulsive stereotyped behavior in rats - Systemic administration of NMDA induces stereotyped behavior followed frequently, but not always, by generalized epileptiform seizures. Increased NMDA activity provokes overstimulation of NMDA glutamate receptors in neurons with dendritic spines. Systemic administration of 100 mg/kg of NMDA i.p. induced stereotyped behavior in adult male rats 5-10 min post-injection. Then, the density and propo...

Climate change and neurological disorders in childhood: A scoping review - CONCLUSIONS: Current evidence suggests that climate change-related exposures, particularly extreme temperatures, temperature variability, and natural disasters, negatively affect paediatric neurological health directly (increased seizure risk, impaired myelination) and indirectly (disrupted treatment access, emotional stress). Neuroinfectious diseases were also strongly associated with climatic...

Association between persisting peritumoral brain edema and seizures as well as worse functional outcome after meningioma surgery: a retrospective study of 218 patients - CONCLUSIONS: Persisting PTBE is associated with worse functional outcome and with persisting and new-onset seizures. Based on EEG findings, persisting PTBE (i.e., gliosis) may be the epileptogenic focus in some patients. Future studies are needed to assess whether these gliotic sites could even be therapeutic targets for seizure control.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.