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Contrasting effects of PHD finger protein 24 (PHF24) on brain morphology of the spontaneous generalized tonic-clonic seizure model; Noda epileptic rat (NER) and Phf24-null rat -
Noda epileptic rat (NER) is a mutant model for epilepsy that exhibits spontaneous generalized tonic-clonic seizure. Epileptogenesis of NER remains to be elucidated; but it is detected an insertion of an endogenous retrovirus sequence in intron 2 of the PHD finger protein 24 (Phf24) gene. PHF24 is widely expressed in the soma of neurons and neuropil in the wild-type rat brain and spinal cord but...
In silico and in vivo studies reveal that Theiler's murine encephalomyelitis virus induces upregulation of miR-155-5p in the hippocampus -
MicroRNAs (miRNAs) are perceived as master regulators of gene expression in the cells. Their involvement has been demonstrated in the etiopathogenesis of many neurological disorders, including central nervous system (CNS) infection, neuroinflammation, seizures and epilepsy. Here, we evaluated the role of miRNAs in the Theiler's murine encephalomyelitis virus (TMEV) model. Using in silico modeli...
Are enlarged perivascular spaces a predictor of early post-traumatic seizures after traumatic brain injury?- A pilot study -
CONCLUSION: Our findings suggest that ePVS may not be reliable biomarkers for predicting EPTS (after TBI). However, future longitudinal studies that track ePVS changes over time could better illuminate their relationship with PTE development. This approach may reveal critical mechanisms influencing seizure risk and identify potential intervention points for at-risk patients, ultimately enhancin...
An increase in cerebrospinal fluid macrophage migration inhibitory factor levels in pediatric patients with acute neuroinflammatory diseases: A preliminary study -
CONCLUSIONS: CSF MIF levels were elevated in pediatric patients with acute neuroinflammatory diseases. This is the first study to compare differences in CSF MIF levels among neuroinflammatory diseases and to show relationships between MIF and related cytokines.
Ramadan fasting and seizure activity in adults with epilepsy: A systematic review and meta-analysis -
CONCLUSION: While many patients remained seizure-free during Ramadan, high study variability highlights the need for standardized research. With proper medical supervision, fasting may be safely practiced for selected epilepsy patients.
Assessing the impact of e-learning in caregiver training on paediatric epilepsy awareness and buccal Midazolam administration: A Scottish quality improvement study -
Caregiver training is vital for drug administration in medical emergencies. Most training, in the UK, for paediatric epilepsy is delivered by specialist nurses, covering awareness and buccal Midazolam administration, the preferred management for paediatric status epilepticus. Training is predominately delivered face-to-face due to limited evidence supporting online methods. This project outline...
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