Epilepsy News

Development and psychometric validation of a screening tool of psychosocial risk factors in patients with epilepsy: the ARisE study protocol - Introduction Epilepsy is one of the most common neurological chronic diseases worldwide. While medications can control seizures, about one-third of people with epilepsy have drug-resistant epilepsy ...

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Focal treatment-resistant epilepsy symptoms improved with antiseizure medication - Please provide your email address to receive an email when new articles are posted on . Monthly seizure frequency percentage reduction was 68.73% for the entire study cohort. For those followed up in ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? - Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...

First seizure clinic provides visit, pediatric epilepsy diagnosis in less than a week - Please provide your email address to receive an email when new articles are posted on . The model expedites access to specialists after a first seizure. The mean time between the referral and the ...

Characterizing Higher-order Functional Brain Networks with Simplicial Complexes and Temporal Dynamics - While conventional approaches characterize brain functional connectivity using static, pairwise interactions, higher-order interactions among multiple regions and their temporal organization are also essential for understanding complex brain dynamics. Here, we propose a temporal higher-order functional brain network framework (THFBN) that integrates simplicial complexes with temporal dynamical ...

Volume-based stereotactic radiofrequency thermocoagulation for focal cortical dysplasia: A potentially safer alternative to resection in insulo-opercular and central regions - OBJECTIVE: Deep white matter infarction caused by injury to the medullary arteries is a crucial cause of postoperative neurological deficits following surgical resection of focal cortical dysplasia (FCD) in the central and insulo-opercular cortices. Volume-based radiofrequency thermocoagulation (v-RFTC) is a less-invasive ablation technique that may reduce the risk of white matter infarction. T...

Epilepsy in Alkuraya-Kucinskas syndrome: A longitudinal clinical characterization - No abstract

Hemimegalencephaly with accelerated myelination in the affected hemisphere - Hemimegalencephaly is an uncommon malformation of cortical development characterized by congenital enlargement and dysplasia of part or all of one cerebral hemisphere. It usually presents in early life with developmental delay, hemiparesis, and drug-resistant seizures. We report the case of a 7-month-old boy with recurrent seizures beginning in the neonatal period. Electroencephalography demons...

Seizure due to Lamotrigine Underexposure During High-Volume CRRT for Hyperammonaemia: A Case Report - CONCLUSION: This case underscores the clinical significance of extracorporeal clearance of antiseizure medications during CRRT in patients with UCDs. Drug selection should consider both ammonia-modifying and dialysability profiles. Therapeutic drug monitoring and pre-emptive dose adjustment, or the addition of a second intravenously available agent, should be considered when high-volume dialysi...

Functional and pharmacological characterization of the SCN2A variant p.C258R with mixed gain and loss of function causing developmental and epileptic encephalopathy type 11 - Pathogenic variants in SCN2A cause dysfunction of the Na(V)1.2 voltage-gated sodium channel and are associated with neurodevelopmental disorders with or without epilepsy. Treatment of epilepsy in these patients is challenging and depends on whether the variant results in a gain (GoF) or loss of function (LoF). We describe a patient with the de novo SCN2A variant p.C258R presenting with therapy-...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.