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Anaesthetic Management of a Patient with Dyke-Davidoff-Masson Syndrome Undergoing Robotic Thermocoagulative Hemispherotomy: A Case Report -
Dyke-Davidoff-Masson Syndrome (DDMS) is a rare neurological disorder characterized by cerebral hemiatrophy and compensatory calvarial changes, typically resulting from early-life cerebral insults. Patients may present with drug-resistant epilepsy (DRE), hemiparesis, and developmental delay. Due to its rarity and heterogeneous clinical presentation, diagnosis is often delayed or missed. We prese...
Safety and feasibility of oral zinc for patients with GNAO1-related disorders (ZINCGNAO1): an open-label, single-arm, single-centre, pilot trial in Germany -
BACKGROUND: GNAO1-related disorders (GNAO1-RD), caused by variants in GNAO1 encoding the Gαo protein, comprise a broad phenotypic spectrum including movement disorders (MD) and/or epilepsy and are typically associated with developmental delay and intellectual disability. Currently, only symptomatic treatments are available. Zinc can restore guanosine triphosphate hydrolysis and cellular interac...
Nanomedicine for epilepsy: Expanding beyond conventional drug targets -
Epilepsy remains a major neurological disorder characterized by unpredictable seizures and cumulative comorbidities that even endure with standard pharmacotherapy. Conventional antiepileptic drugs (AEDs) are constrained by two interrelated barriers: limited brain penetration due to the blood-brain barrier (BBB), which necessitates high systemic dosing and peripheral toxicity, and a narrow mecha...
Activating Sigma1R by fluoxetine suppresses neuronal ferroptosis in epilepsy by inhibiting MDM2-mediated GPX4 ubiquitination -
CONCLUSIONS: These findings reveal a novel molecular pathway (Sigma1R-JNK/p38 MAPK-MDM2-GPX4 axis) through which FLX inhibits ferroptosis, highlighting its therapeutic potential for epilepsy and other ferroptosis-related neurological disorders.
Quantitative electroencephalogram analysis in juvenile myoclonic epilepsy and its clinical significance -
CONCLUSIONS: The spatial and spectral patterns identified through EEG are consistent with previously reported MEG findings. This indicates that advanced EEG is similar to MEG in its ability to characterize neurophysiological activity. These findings highlight EEG as an efficient and accessible tool for the clinical assessment of JME across health-care settings.
Opposing associations of default mode network and subcortical network efficiency with IQ in children with drug-resistant epilepsy -
Paediatric drug-resistant epilepsy (DRE) is associated with IQ deficits only partially explained by clinical seizure variables (for example, age of onset, seizure burden, seizure location). Given that intelligence depends on efficient large-scale brain networks, structural connectomics provides a complementary mechanistic framework for explaining residual IQ variance. We tested whether brain-ne...
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