Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Patients engage with epilepsy monitor in real time, improving seizure detection - A team has built an AI-based interface that enables real-time communication between patients and epilepsy monitoring devices. As part of a small clinical study at the University of Pennsylvania in ...

Seizure action plans: More than management tools for epilepsy - Newswise — Historically, seizure action plans have focused on certain high-risk groups — such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters ...

Seizure or epilepsy? Understanding the critical difference could save lives - A sudden episode of shaking, confusion, or loss of awareness can be frightening - but does it mean epilepsy? Understanding the difference between a seizure and epilepsy is crucial for timely treatment ...

Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? - Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...

Machine Learning Framework for Integration of Video and EEG Reveals Distinct Seizure Phenotypes in Mouse Models of Epilepsy - Video-electrocorticogram (VEEG) recordings are the gold-standard diagnostic tool for detecting and characterizing seizures in rodent models of seizure and epilepsy. Manual/visual scoring remains the prevailing strategy despite significant limitations. Alternatively, automated and semi-automated analyses have been applied to either EEG or video features alone but integrating these disparate data...

A homozygous GABRA2 variant associated with infantile spasms evolving to Lennox-Gastaut syndrome alters receptor gating - Variants in GABA(A) receptor subunits are increasingly implicated in developmental and epileptic encephalopathies. Although GABRA2 variants have been associated with early-onset epilepsy, the functional consequences of individual variants, particularly those located outside canonical ligand-binding and transmembrane pore-forming regions, remain incompletely understood. We identified a homozygou...

Seizure Management in Palliative Care: An Exploratory Cross-sectional Survey of Physician Practices in Germany - CONCLUSION: Seizure management in palliative care in Germany reflects the specific requirements of patients with serious illness and partly deviates from established epilepsy guidelines. Findings point to a shift towards individualized approaches, including prioritization of BZD-ASM, flexible routes of administration, and increased off-label use. This highlights the need for tailored guidelines...

Protective effects of Matricaria chamomilla L. extract against PTZ-induced epilepsy: Targeting neuroinflammations, glial reactivity and neurofilaments - CONCLUSIONS: In rats, MCE demonstrated neuroprotective and antiseizure effects against seizures brought on by PTZ. These effects may be associated with normalization of hippocampal electrical activity, reduction of oxidative stress and inflammatory markers, attenuation of glial activation, and restoration of NFL expression.

CNPY3 variants associated with a recessive developmental and epileptic encephalopathy affect inflammasome and TLR function - BACKGROUND: Canopy FGF signalling regulator 3 (CNPY3) is an endoplasmic reticulum (ER)-resident chaperone essential for toll-like receptor (TLR) folding, trafficking and inflammasome activation. In rare paediatric cases, biallelic CNPY3 variants have been associated with developmental and epileptic encephalopathy (DEE), but available data remain sparse.

Open-Loop Deep Brain Stimulation Versus Closed-Loop Responsive Neurostimulation in Drug-Resistant Bitemporal Epilepsy: A Narrative Review - Drug-resistant bitemporal epilepsy presents a therapeutic challenge when resective surgery is not feasible due to bilateral seizure onset or eloquent cortex involvement. Neuromodulation has emerged as an alternative, with open-loop deep brain stimulation (DBS) and closed-loop responsive neurostimulation (RNS) as implantable strategies. Comparative indications for modality selection remain uncle...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.