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Shoulder instability and associated shoulder injuries in patients with epilepsy -
CONCLUSION: In patients with epilepsy, shoulder dislocations predominantly occur during generalized seizures, with anteroinferior dislocations being the most frequent, while posterior dislocations are significantly more prevalent compared to the general population. Recurrent dislocations were associated with significantly larger humeral and posterior glenoid defects, indicating progressive bone...
Effect of immunotherapy on seizure severity and spike-wave index in epileptic encephalopathy with spike-wave activation in sleep: The value of EEG spikes in monitoring treatment response -
CONCLUSION: IVIg therapy was associated with significant and sustained electrophysiological improvement and is accompanied by clinical improvement in children with EE-SWAS and DEE-SWAS. However, changes in SWI were not significantly correlated with functional, behavioral, or seizure outcomes, suggesting a dissociation between electrophysiological and clinical responses. These findings indicate ...
Genetic heterogeneity, movement disorders, and white matter abnormalities in pediatric developmental and epileptic encephalopathies: A retrospective cohort study from a National Neurodegenerative a... -
Developmental and epileptic encephalopathies (DEEs) are severe neurodevelopmental disorders characterized by early-onset seizures, developmental impairment, and heterogeneous neurological features. We retrospectively analyzed 37 children meeting strict DEE criteria from the Iranian Neurodegenerative and Leukodystrophy Registry (2016-2024), focusing on movement disorders and white matter (WM) ab...
Living with Dravet syndrome: quality of life and caregiver burden among family caregivers in Europe. Results from the QoL4DRAVET study -
CONCLUSIONS: Caregiving burden in DS is long-term, multidimensional, and shaped by both gendered caregiving roles and national contexts. These findings underscore the necessity for integrated, gender-sensitive, and policy-informed support strategies that cater to caregivers' psychological, social, and occupational needs throughout their life course.
Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway -
Pyroptosis is an inflammatory type of programmed cell death that may contribute to epilepsy initiation and progression through neuroinflammation. Fatty acid binding protein 5 (FABP5), a lipid chaperone, has been implicated in chronic inflammation. However, whether FABP5 regulates pyroptosis and its pathological role in epilepsy remains uncharacterized. Here, FABP5 was upregulated in astrocytes ...
Misinformation about seizures and epilepsy on the web: The need for systematic quality management -
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