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KCNA3 Gene Polymorphism Affects the Efficacy and Plasma Concentration of Perampanel in Patients With Refractory Epilepsy -
CONCLUSIONS: The KCNA3 rs2821557 polymorphism is an important predictor of the therapeutic efficacy of PER in controlling epileptic seizures and a determinant of the attainment of therapeutic plasma PER concentrations.
The Spatial Divergence of Hypometabolism and Atrophy in Mesial Temporal Lobe Epilepsy: Combining (18)F-FDG PET and Structural MRI for Predicting Postoperative Seizure Freedom -
Surgical failure in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) may reflect insufficient disruption of epileptogenic networks. We investigated whether integrating quantitative spatial patterns of regional atrophy and hypometabolism, along with clinical features, could provide complementary prognostic information for postoperative seizure freedom. T1-weighted MRI, ^(18)F-FDG-PET, ...
Electroclinical Dissociation in Generalized Epilepsy: A Video-EEG Case From Sub-Saharan Africa -
CONCLUSION: Diagnostic evaluation of FDS should rely on a positive "rule-in" framework as recommended by international guidelines. Even when epileptiform discharges appear on EEG during clinical events, a lack of physiological congruence between electrographic patterns and semiology confirms electroclinical dissociation.
The ketogenic diet ameliorates behavioral abnormalities in a PTZ-induced zebrafish larvae model via modulating neurotransmitter balance -
CONCLUSION: We established a PTZ-induced amphibian epilepsy model with KD intervention. KD exerts anti-epileptic effects, likely mediated partially by rebalancing central nervous system neurotransmitter homeostasis, providing a valuable translational platform for further mechanism research.
Concomitant Antiseizure Medications' Influence on Valproic Acid and Levetiracetam Pharmacokinetics in Pediatric Patients -
CONCLUSION: Concomitant enzyme-inducing ASM significantly reduced dose-normalized trough concentrations of VPA and LEV, while neutral co-medications had no effect, highlighting the importance of TDM in pediatric combination therapy.
Post-Stroke Epileptogenesis as a Dynamic Network Process: State-Dependent Biomarkers, Longitudinal Monitoring, and the Concept of an Irritable Brain State -
Post-stroke epilepsy (PSE) is one of the most common long-term neurological complications of stroke and represents a major contributor to disability, reduced quality of life, and increased healthcare burden. Although numerous risk factors and biomarkers have been proposed, many current risk models still emphasize lesion-related predictors and do not fully account for the temporal evolution of p...
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