Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Modifiable Factors Responsible for Most Epilepsy Relapses - In patients with newly diagnosed epilepsy, nearly 70% of seizure relapses are linked to potentially modifiable factors, including poor adherence and inadequate ASM dosing, rather than drug resistance.

New tools map seizures in the brain, improve epilepsy treatment - Two new models could solve a problem that's long frustrated millions of people with epilepsy and the doctors who treat them: how to find precisely where seizures originate to treat exactly that part ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

Neurologic sequelae of cerebral malaria and other forms of severe malaria in children - CONCLUSION: Neurologic sequelae, particularly epilepsy, are more common in CM than other forms of severe malaria, but occur rarely in non-cerebral severe malaria.

Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy - Temporal lobe epilepsy (TLE) most commonly presents clinically with unilateral or bilateral hippocampal seizure onsets. Antiseizure medications are often ineffective, and epilepsy surgery outcomes are variable. TLE often occurs after exposure to risk factors; this latent period provides the opportunity for preventative treatments, however, there are currently no clinically approved anti-epilept...

Brivaracetam as viable monotherapy option for focal and generalized epilepsy - CONCLUSION: In this retrospective real-world cohort, BRV monotherapy was associated with favorable short-term seizure outcomes and good tolerability. Particularly favorable outcomes were observed after conversion from LEV. Although long-term retention decreased over time, a substantial proportion of patients continued to benefit from BRV monotherapy over a two-year period, despite BRV being the...

Explanatory models of epilepsy: key deterrents to seeking biomedical care and effective epilepsy management in Uganda - CONCLUSION: The prevailing explanatory models might account for the observation that the PWE, including those on anti-seizure medication, often engage in non-allopathic care that can impact reaching or maintaining biomedical treatment. Effective epilepsy management requires a multi-pronged approach involving the utilization of contextually tailored epilepsy literacy programs and collaboration w...

Rest-activity patterns across development in two mouse models of autism and epilepsy - OBJECTIVE: Sleep disturbances are common in individuals with autism spectrum disorder (ASD) and epilepsy and are increasingly recognized as comorbidities that affect disease severity and quality of life. This study investigated rest-activity patterns across development in two genetic mouse models relevant to ASD and epilepsy: synapsin 2 (Syn2) and contactin-associated protein-like 2 (Cntnap2) k...

Altered autonomic balance drives the increase in cardiac output and arterial pressure during convulsive seizures in nonanesthetized sheep - OBJECTIVE: Preclinical and human studies suggest that ictal and interictal modulation of the sympathetic and parasympathetic systems contributes to cardiovascular changes that may induce sudden unexpected death in epilepsy. We therefore investigated the effects of convulsive seizures on cardiovascular and autonomic function in nonanesthetized sheep.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.