Epilepsy and Seizure News
Seizure action plans: Management and educational tools in epilepsy care -
Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
The Campaign for a National Plan for Epilepsy Needs Your Help -
A future neurologist appeals for your support for the National Plan for Epilepsy to coordinate research and care to enable earlier diagnosis, better treatment, and hopefully a cure.
Patients engage with epilepsy monitor in real time, improving seizure detection -
A team has built an AI-based interface that enables real-time communication between patients and epilepsy monitoring devices. As part of a small clinical study at the University of Pennsylvania in ...
Seizure action plans: More than management tools for epilepsy -
Newswise — Historically, seizure action plans have focused on certain high-risk groups — such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters ...
Epilepsy Advocacy Network provides resources, plans fundraiser -
One in 26 people will develop epilepsy in their lifetime, and one 1 in 10 people will have a seizure. November is just around the corner, and that is Epilepsy Awareness Month. Carrie Jones and Kim ...
Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring -
NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...
First seizure clinic provides visit, pediatric epilepsy diagnosis in less than a week -
Please provide your email address to receive an email when new articles are posted on . The model expedites access to specialists after a first seizure. The mean time between the referral and the ...
Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? -
Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...
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Patient counseling across neurologic subspecialties-a single academic center study -
BACKGROUND AND OBJECTIVES: Counseling is a routine part of neurologic care, but little is known about how commonly it is documented. We sought to characterize counseling in routine neurologic care by determining the proportion of visits with documented counseling, describe forms of counseling, and investigate factors that predict documentation of counseling.
Immunometabolic synaptopathy: linking metabolic syndrome to epileptogenesis through trained immunity and parvalbumin interneuron vulnerability -
CONCLUSION: Immunometabolic synaptopathy integrates cross-context evidence into a testable hypothesis of metabolically associated seizure susceptibility. The complete pathway to spontaneous epilepsy has not been demonstrated end-to-end and requires longitudinal, cell- and pathway-specific validation.
Endothelial cell-specific TGM2 deficiency promotes progression of temporal lobe epilepsy by disrupting S1P metabolism and intercellular communication -
CONCLUSIONS: This study establishes a link between TGM2 and BBB function, metabolic pathways, and intercellular communication in TLE, providing an experimental basis for developing TLE therapeutic strategies targeting this pathway.
The clinical spectrum of MECP2 variants in males: a multicenter Turkish cohort of 22 probands, with implications for diagnosis and variant interpretation -
CONCLUSIONS: In this diagnostically ascertained series, phenotypes observed among males carrying MECP2 variants were graded rather than uniformly severe. Fourteen of the 21 probands carry variants of uncertain significance, in whom causation is not established, so the range that may be attributed to MECP2 rests on seven individuals carrying variants classified as pathogenic or likely pathogenic...
Neuroplastin Suppresses Seizures by Downregulating Endophilin A1 to Promote Internalization of GluA1-AMPA Receptors: Therapeutic Implications of Arbutin -
Status epilepticus (SE) is a critical neurological disorder characterized by an imbalance between excitatory and inhibitory neurotransmission. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate fast excitatory synaptic transmission, whereas internalization of GluA1-containing AMPARs regulates neuronal excitability. Although neuroplastin (Np) modulates neuronal excit...
Mechanisms of Seizure Generation and SUDEP in Cortical Dysplasia: A Role for Cortical Up and Down States -
Sudden unexpected death in epilepsy (SUDEP) remains the primary cause of epilepsy-related mortality, yet the preictal brain dynamics that distinguish fatal from nonfatal seizures are not well understood. Identifying the network mechanisms determining these outcomes is critical for developing SUDEP risk biomarkers. Using a neuron-specific PTEN knockout mouse model of cortical dysplasia-which exh...
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