Epilepsy News

Fenfluramine in refractory SCN1A-related 'genetic epilepsy with febrile seizures plus' - A child with SCN1A-related 'genetic epilepsy with febrile seizures plus' (GEFS+) presented in infancy with recurrent febrile and afebrile seizures, frequently progressing to generalised tonic-clonic status epilepticus. Despite a severe seizure burden and typical Dravet-like triggers, neurodevelopment remained entirely normal and a familial SCN1A variant supported a diagnosis of GEFS+. The varia...

Rapid hippocampal kindling of mice as a model of sudden unexpected death in temporal lobe epilepsy - Sudden unexpected death in epilepsy (SUDEP) is the leading cause of seizure-related death in people with epilepsy. Yet, its mechanisms remain poorly understood. While most epilepsy syndromes have no known genetic component, animal SUDEP models are often of rare monogenetic mutations. Here, we present a novel non-genetic mouse model of SUDEP, relevant to temporal lobe epilepsy, the most common s...

Evaluation of EEG findings in pediatric patients presenting with dizziness - CONCLUSION: While the prevalence of epilepsy in the general population is approximately 1%, the rate of epileptiform activity among children presenting with dizziness was found to be 11.6% in this study. This suggests that dizziness may be a manifestation of underlying epileptic activity in certain cases. Therefore, EEG may provide significant diagnostic and therapeutic value in the evaluation ...

Cortical wiring cost abnormalities in mesial temporal lobe epilepsy with hippocampal sclerosis: implications for postoperative seizure recurrence - CONCLUSIONS: Abnormalities of cortical wiring costs were observed in mTLE-HS, particularly in patients with postoperative seizure recurrence. These abnormalities may reflect increased long-range connectivity and short-range reorganization within gray matter, offering novel insights into the underlying pathophysiology of this illness and providing potential for outcome prediction.

In Vivo Longitudinal Mapping of Brain Iron Accumulation After Pilocarpine-Induced Status Epilepticus - Iron accumulations have been identified in resected tissue from patients with refractory temporal lobe epilepsy. These deposits are linked to ferroptosis, a form of nonapoptotic cell death in which iron catalyzes the formation of reactive oxygen species, leading to lipid peroxidation. Experimentally, this process has recently been associated with seizures based on the increased levels of specif...

The Neurology of Menopause - PURPOSE OF REVIEW: Menopause is a neuroendocrine process with important implications for neurological health. This review examines the complex, multidirectional relationships between menopause and major central nervous system conditions, including stroke, migraine, epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.