Epilepsy News

Real-world effectiveness of cenobamate in drug-resistant and ultra-refractory epilepsy: A multicenter study - OBJECTIVE: To evaluate the real-world effectiveness, safety, and treatment retention of cenobamate (CNB) in patients with drug-resistant epilepsy (DRE), including ultra-refractory epilepsy (URE), high seizure burden, and extensive prior treatment history.

Exome sequencing of pashtun familial epilepsy in Pakistan reveals novel variants in LAMA5, KCNQ2 and GNAO1 - CONCLUSIONS: This study expands the mutational and phenotypic spectrum of epilepsy-associated genes in a highly consanguineous population and highlights the efficiency of integrating genomic, clinical, and computational approaches for variant interpretation. The findings also suggest a potential recessive contribution of genes traditionally associated with dominant inheritance, warranting furth...

Sulfonadyn Compounds: A Class of Aryl Sulfonamides That Inhibit Dynamin GTPase and Clathrin-Mediated Endocytosis and Are Antiepileptic in Animal Models - Synthetic modification of dansylcadaverine (1) and our previously identified dynamin I and clathrin-mediated endocytosis inhibitor S1-47 gave rise to new members of the sulfonadyns class of GTP-competitive dynamin inhibitors. Analogues in this class displayed high dynamin I, dynamin II, and clathrin-mediated endocytosis inhibition (inhibition of Tfn-A594 uptake in U2OS cells). Dynamin activity ...

A first in disease trial of the safety, tolerability, and anti-seizure effects of ES-481 in drug-resistant epilepsy - OBJECTIVES: ES-481 is a novel potent and selective antagonist of TARP-y8-dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES-481 as an add-on anti-seizure medication (ASM) in adults with drug-resistant epilepsy (DRE).

Clinical, Neuroimaging, and Functional Profile of Children With Hemiplegic Cerebral Palsy: A Cross-Sectional Study From a Tertiary Care Center - ObjectiveTo characterize the clinical profile, functional and developmental status, radiologic patterns, and comorbidity burden in children aged 1-14 years diagnosed with hemiplegic cerebral palsy (HCP) at a tertiary pediatric neurology center.MethodsThis cross-sectional study included 70 children with HCP. Functional assessments were done with the Gross Motor Function Classification System (GM...

Peri-operative management of a child with catecholamine-secreting neuroblastoma and Dravet syndrome undergoing tumour resection - Neuroblastoma is the most common extracranial solid tumour in children and accounts for approximately 15% of paediatric cancer-related deaths. Originating from the postganglionic sympathetic nervous system, it exhibits variable clinical behaviour. Catecholamine-secreting neuroblastoma is an uncommon but relevant cause of severe hypertension in children and poses major anaesthetic challenges, pa...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.