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Recent news about epilepsy, seizures and treatments.
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Data-Driven Clinical Phenotyping of Adult Epilepsy Using Latent Class Analysis: A Regional Cohort Study from Southern Kazakhstan -
Background/Objectives: Adult epilepsy is clinically heterogeneous, and individual clinical predictors may not fully capture the multidimensional burden associated with drug-resistant epilepsy (DRE). This study aimed to identify latent clinical phenotypes in adults with epilepsy and examine their cross-sectional associations with DRE and broader disease burden. Methods: This regional observation...
Resting-State fMRI Functional Connectivity Alterations in Drug-Resistant Epilepsy Compared to Well-Controlled Epilepsy and Healthy Controls - Background/Objectives: Epilepsy is a chronic brain disease characterized by recurrent epileptic seizures. It affects roughly 50 million people worldwide and around one third of the patients have drug-resistant epilepsy (DRE). The current study aimed to find differences in the whole-brain functional connectivity (FC) in patients with DRE compared to patients with well-controlled epilepsy (WCE) a...
A Rare EEG Finding of Eye Closure Sensitivity in a Child with Genetic Generalized Epilepsy: A Case Report - Background: Eye-closure sensitivity (ECS) is a rare reflex epilepsy phenomenon characterized by epileptiform discharges on electroencephalogram (EEG), triggered by eye closure. It has been reported in all genetic generalized epilepsies (GGEs), particularly in adolescents and adults. However, pediatric cases remain uncommon in the literature. Case Presentation: We report a 10-year-old previously...
Impact of medical and surgical treatment on stigma among people with epilepsy: A systematic review - OBJECTIVE: The stigma surrounding epilepsy affects medication adherence, psychosocial well-being, and quality of life. While medical and surgical interventions aim for seizure control, their impact on stigma remains unclear. We appraised published literature examining the relationship between epilepsy treatment and stigma.
Electroclinical phenotypes-genetic characterization of developmental and epileptic encephalopathies in a cohort study - OBJECTIVE: Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype-phenotype characterizations and prognosis with genetically deter...
Patient-independent automated pediatric seizure monitoring based on expert-labeled electrographic ictal data as core reference knowledge - CONCLUSION: A curated set of expert-labeled ictal EEG segments served as the core reference knowledge for the proposed seizure detector in recognizing seizure occurrence in unseen patients. Because the proposed approach analyzes individual channels in parallel, it may be clinically applicable to continuous seizure monitoring, particularly in wearable seizure detection systems with a limited num...
Resting-State fMRI Functional Connectivity Alterations in Drug-Resistant Epilepsy Compared to Well-Controlled Epilepsy and Healthy Controls - Background/Objectives: Epilepsy is a chronic brain disease characterized by recurrent epileptic seizures. It affects roughly 50 million people worldwide and around one third of the patients have drug-resistant epilepsy (DRE). The current study aimed to find differences in the whole-brain functional connectivity (FC) in patients with DRE compared to patients with well-controlled epilepsy (WCE) a...
A Rare EEG Finding of Eye Closure Sensitivity in a Child with Genetic Generalized Epilepsy: A Case Report - Background: Eye-closure sensitivity (ECS) is a rare reflex epilepsy phenomenon characterized by epileptiform discharges on electroencephalogram (EEG), triggered by eye closure. It has been reported in all genetic generalized epilepsies (GGEs), particularly in adolescents and adults. However, pediatric cases remain uncommon in the literature. Case Presentation: We report a 10-year-old previously...
Impact of medical and surgical treatment on stigma among people with epilepsy: A systematic review - OBJECTIVE: The stigma surrounding epilepsy affects medication adherence, psychosocial well-being, and quality of life. While medical and surgical interventions aim for seizure control, their impact on stigma remains unclear. We appraised published literature examining the relationship between epilepsy treatment and stigma.
Electroclinical phenotypes-genetic characterization of developmental and epileptic encephalopathies in a cohort study - OBJECTIVE: Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype-phenotype characterizations and prognosis with genetically deter...
Patient-independent automated pediatric seizure monitoring based on expert-labeled electrographic ictal data as core reference knowledge - CONCLUSION: A curated set of expert-labeled ictal EEG segments served as the core reference knowledge for the proposed seizure detector in recognizing seizure occurrence in unseen patients. Because the proposed approach analyzes individual channels in parallel, it may be clinically applicable to continuous seizure monitoring, particularly in wearable seizure detection systems with a limited num...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.