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Assessing metabolic progression in temporal lobe epilepsy: biological and methodological considerations -
CONCLUSION: Ipsilateral mesial temporal regions are one of the areas most sensitive to epileptic seizures. Assessment of metabolic progression is affected by methodological factors, such as brain atrophy (and the correction thereof) and data variability. Normalized CMRglu values and AIs have greater statistical power than absolute CMRglu values implying no need for quantitative PET studies.
When seizure counts are not seizures: Measurement error and its implications for epilepsy management and driving policy -
No abstract
Clinical and Evolutionary Aspects of CDKL5-Related Developmental Epileptic Encephalopathy: A Case Report -
Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficiency Disorder (CDD) is a rare genetic condition characterized by early-onset, pharmacoresistant epilepsy and severe global developmental delay. We report the case of a five-month-old infant who developed epileptic spasms at three months of age. Despite multiple antiepileptic therapies, seizures remained refractory. The clinical course was marked by p...
Dravet syndrome: diverse seizure phenotypes with various triggers and developmental outcome- A case series from a LMIC -
Dravet syndrome (DS) is a severe childhood epilepsy characterised by drug-resistant seizures, developmental delays, and behavioural disturbances, often linked to de novo mutations in the SCN1A gene. This retrospective case series from Aga Khan University Hospital, Karachi, describes five patients with varying ages of seizure onset and difficult-to-control seizures despite conventional antiseizu...
Prophylactic anti-seizure medication for post-traumatic seizures in Chinese PICUs: current practices and knowledge gaps -
OBJECTIVE: To evaluate current practices and asses knowledge gaps in the use of prophylactic anti-seizure medication (ASM) for managing pediatric post-traumatic epilepsy (PTE) in Mainland China, with a particular focus on clinical decision-making of pediatric intensive care unit (PICU) physicians.
Prenatal exposure to Antiseizure Medications for all indications and the risk of neurodevelopmental disorders in offspring: a nationwide population-based cohort study in South Korea -
CONCLUSION: In this nationwide Korean cohort, prenatal ASM exposure was associated with dose-dependent risks of ASD and ID. These findings underscore the importance of preconception counseling and early pregnancy management for all women receiving ASMs, beyond those with epilepsy.
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