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Seizure-Induced Resolution of Depressive and Psychotic Symptoms in a Pregnant Patient: A Case of Spontaneous Neuromodulation -
Many individuals with epilepsy often develop major depressive disorder (MDD), creating a complex interplay that exacerbates outcomes for affected individuals. The relationship between these disorders may be mediated by overlapping neurobiological mechanisms, including disturbances in the limbic system, neurotransmitter imbalances, and the psychosocial stressors of chronic illness. While the co-...
Refractory epilepsy from lead poisoning -
CONCLUSIONS: This case highlights the importance of considering lead toxicity in unexplained encephalopathy or refractory seizures in children, with early recognition to prevent irreversible neurological sequelae.
Hilbert-domain sub-band feature framework for EEG-based seizure detection -
Epilepsy is a chronic neurological disease in which the brain's activity deviates from normal. The classification and analysis of EEG signals is the first step in diagnosing epilepsy. Various machine learning algorithms have been used in the past to classify epileptic EEG recordings. The proposed approach for EEG seizure detection is based on processing signals in the Hilbert domain. In this st...
AAV-mediated GPR173 gene therapy attenuates long-term refractory epilepsy by enhancing synaptic GABA(A) receptor expression -
Approximately 30% of epilepsy patients are drug-resistant, and sustained seizure activity often reduces responsiveness to conventional therapies. This study aimed to evaluate the therapeutic efficacy and safety of adeno-associated virus (AAV)-mediated GPR173 gene therapy in two refractory epilepsy mouse models, including delayed-treatment epilepsy (DTE) and drug-resistant epilepsy (DRE), and to...
Effectiveness and Safety of Cannabis-Based Products for Refractory Epilepsy From Real-World Evidence -
PURPOSE: Cannabis-based products have emerged as a potential therapeutic option for refractory epilepsy; however, real-world evidence remains limited, particularly within public health systems. This study evaluated the effectiveness and safety of cannabis-based products among patients with refractory epilepsy treated through Brazil's public health system and explored factors associated with per...
Seizure-induced apnea causes sudden death independent of cortical spike wave discharge in mouse models of Tuberous Sclerosis Complex -
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of seizure-related mortality for people with epilepsy (PWE). Current evidence suggests that many cases of SUDEP are due to seizures that produce respiratory arrest, aka seizure-induced apnea. Patients with tuberous sclerosis complex (TSC) are at a significant risk of SUDEP, and mouse models of TSC have early mortality. Previous re...
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