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AAV-mediated GPR173 gene therapy attenuates long-term refractory epilepsy by enhancing synaptic GABA(A) receptor expression -
Approximately 30% of epilepsy patients are drug-resistant, and sustained seizure activity often reduces responsiveness to conventional therapies. This study aimed to evaluate the therapeutic efficacy and safety of adeno-associated virus (AAV)-mediated GPR173 gene therapy in two refractory epilepsy mouse models, including delayed-treatment epilepsy (DTE) and drug-resistant epilepsy (DRE), and to...
Effectiveness and Safety of Cannabis-Based Products for Refractory Epilepsy From Real-World Evidence -
PURPOSE: Cannabis-based products have emerged as a potential therapeutic option for refractory epilepsy; however, real-world evidence remains limited, particularly within public health systems. This study evaluated the effectiveness and safety of cannabis-based products among patients with refractory epilepsy treated through Brazil's public health system and explored factors associated with per...
Seizure-induced apnea causes sudden death independent of cortical spike wave discharge in mouse models of Tuberous Sclerosis Complex -
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of seizure-related mortality for people with epilepsy (PWE). Current evidence suggests that many cases of SUDEP are due to seizures that produce respiratory arrest, aka seizure-induced apnea. Patients with tuberous sclerosis complex (TSC) are at a significant risk of SUDEP, and mouse models of TSC have early mortality. Previous re...
Enhanced source localization accuracy through bidirectional deep brain stimulation (DBS) electrodes: A comparative study with non-invasive EEG methods -
Accurate neural source localization from electroencephalography (EEG) remains challenging for deep brain structures. This study investigates whether integrating bidirectional deep brain stimulation (DBS) electrodes with conventional scalp EEG can improve source localization accuracy, particularly under varying signal-to-noise ratio (SNR) conditions. While bidirectional DBS leads support both pa...
Psychiatric symptoms and quality of life in Saudi individuals with epilepsy receiving perampanel: A cross-sectional comparative study -
CONCLUSION: In this small Saudi cohort, PER treatment was not associated with a demonstrable increase in psychiatric symptom burden compared with controls, whereas titration speed and polytherapy appeared related to mood and quality‑of‑life measures. These findings are exploratory and suggest that cautious, gradual titration and careful use of polytherapy may be important when initiating PER, b...
Effects of music interventions on seizure outcomes in people with epilepsy: a systematic review and meta-analysis -
CONCLUSIONS: Music interventions show promising within‑study effects on seizure outcomes, but controlled evidence is inconclusive due to high heterogeneity and imprecision. High‑quality, adequately powered randomized trials with standardized interventions and matched active controls are needed.
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