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Structured EEG report complements the prognostic stratification of status epilepticus -
CONCLUSIONS: Current clinical scores demonstrate limited accuracy in the risk stratification of SE due to high etiological variability. In contrast, structured EEG interpretation significantly enhances prognostic specificity and provides distinct predictive value for LOS. Future efforts should focus on integrating EEG parameters with existing clinical scores to harmonize and improve risk strati...
Optimal perampanel dose as the treatment for refractory partial-onset seizures: Network meta-analysis based on pivotal randomized double-blind clinical trials -
BACKGROUND: Intractable epilepsy with partial-onset seizures (POS), affecting more than 20% of individuals with epilepsy, is one of the most common neurological conditions worldwide. Perampanel (PER), an antiepileptic drug (AED), is widely used in the treatment of refractory POS. However, the optimal dose of PER remains undetermined. This network meta-analysis (NMA) aims to determine the optima...
A randomized feasibility pilot trial of a remotely delivered physical activity intervention for adults with epilepsy -
CONCLUSION: A remotely delivered daily steps-based physical activity intervention is feasible for people with epilepsy and shows promising immediate and sustainable effects on physical activity behaviors.
CaMKIIbeta insufficiency disrupts cortical networks, producing aberrant low-gamma oscillations and seizure susceptibility -
OBJECTIVE: Pathogenic variants in the calcium/calmodulin-dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear. Building on our previous clinical report of a patient carrying the CaMKIIβ P213L variant and our prior characterization of the corresponding mous...
Genetic spectrum and risk factor analysis for drug-resistant of early-onset epilepsy -
CONCLUSIONS: Genetic etiology underlies most early-onset epilepsy cases. Abnormal muscle tone, epileptiform discharges on EEG, and definitive genetic diagnosis are risk factors for DRE, guiding early intervention.
Microcephaly, seizures and developmental delay caused by two novel mutations in the PNKP gene: a case report -
CONCLUSIONS: This is the third report of MCSZ in a non-consanguineous Chinese mainland family. Our results offer additional evidence for clinical variability associated with disorders stemming from mutations in the PNKP gene, which complicates disease diagnosis. This underscores the significance of genetic testing to identify the underlying causes of these conditions. Furthermore, these finding...
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