Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Pyruvate dehydrogenase autoantibodies in autoantibody-negative patients with seizures are associated with reduced pyruvate dehydrogenase activity -
OBJECTIVE: We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Corpora amylacea and glymphatic system in temporal lobe epilepsy patients: Clinicopathological correlation - OBJECTIVE: Corpora amylacea (CA), now called wasteosomes, are basophilic inclusions associated with aging, neurodegeneration, and impaired glymphatic waste clearance. Their presence is well described in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and related to hippocampal neuronal loss and longer epilepsy duration. Here, we assessed CA deposition in TLE patients submitted to epi...
Ketogenic diet therapy for children with super-refractory status epilepticus in intensive care: International clinical practice recommendations - OBJECTIVE: We aimed to create practical recommendations to support healthcare teams starting ketogenic diet therapy (KDT) for children with super-refractory status epilepticus in intensive care settings.
Hemispheric surgery for hemimegalencephaly and hemispheric cortical dysplasia in infants below 12 months of age-A single-center experience - OBJECTIVE: Infants with early drug-resistant epilepsy caused by hemimegalencephaly (HME) and hemispheric cortical dysplasia (HCD) pose substantial surgical and critical care challenges and have poor seizure outcome prognosis. This study evaluated the safety, complications, and seizure outcomes of hemispheric surgeries in infants younger than 12 months with HME and HCD.
Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug-resistant focal epilepsy - CONCLUSION: While CSP lengthening may merely reflect higher stimulation intensities, rMT increases align with CNB's suggested modulation of sodium channels.
Epilepsy associated with SYNGAP1 gene variants: clinical features of six cases and a literature review - CONCLUSIONS: Myoclonic seizures, absence seizures, and eyelid myoclonia are common in SYNGAP1-related epilepsy. Valproate is generally effective, but combination therapy is often required. Neurodevelopmental impairment shows limited improvement despite seizure control.
Corpora amylacea and glymphatic system in temporal lobe epilepsy patients: Clinicopathological correlation - OBJECTIVE: Corpora amylacea (CA), now called wasteosomes, are basophilic inclusions associated with aging, neurodegeneration, and impaired glymphatic waste clearance. Their presence is well described in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and related to hippocampal neuronal loss and longer epilepsy duration. Here, we assessed CA deposition in TLE patients submitted to epi...
Ketogenic diet therapy for children with super-refractory status epilepticus in intensive care: International clinical practice recommendations - OBJECTIVE: We aimed to create practical recommendations to support healthcare teams starting ketogenic diet therapy (KDT) for children with super-refractory status epilepticus in intensive care settings.
Hemispheric surgery for hemimegalencephaly and hemispheric cortical dysplasia in infants below 12 months of age-A single-center experience - OBJECTIVE: Infants with early drug-resistant epilepsy caused by hemimegalencephaly (HME) and hemispheric cortical dysplasia (HCD) pose substantial surgical and critical care challenges and have poor seizure outcome prognosis. This study evaluated the safety, complications, and seizure outcomes of hemispheric surgeries in infants younger than 12 months with HME and HCD.
Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug-resistant focal epilepsy - CONCLUSION: While CSP lengthening may merely reflect higher stimulation intensities, rMT increases align with CNB's suggested modulation of sodium channels.
Epilepsy associated with SYNGAP1 gene variants: clinical features of six cases and a literature review - CONCLUSIONS: Myoclonic seizures, absence seizures, and eyelid myoclonia are common in SYNGAP1-related epilepsy. Valproate is generally effective, but combination therapy is often required. Neurodevelopmental impairment shows limited improvement despite seizure control.
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.