Epilepsy News

PIWI-piRNA Axis in Epilepsy: Bridging Epigenetic Regulation, Neuroinflammation, and Neuronal Excitability - Epilepsy is a chronic neurological disorder characterized by recurrent seizures, neuroinflammation, and epigenetic instability, with around one-third of patients experiencing drug-resistant epilepsy. While ion channels and neurotransmitter imbalances have been thoroughly examined in relation to epilepsy, the significance of piRNAs and their interaction with PIWI proteins in gene regulation, tra...

Clinical application of artificial intelligence technology in epilepsy - Epilepsy is a prevalent neurological disorder, and its inherent complexity and significant interindividual variability pose substantial challenges for clinical diagnosis and treatment. Against this backdrop, the rapid development of artificial intelligence (AI) technology is driving a historic paradigm shift in the field of epilepsy diagnosis and management. This review analyses the application...

Napping characteristics and seizure frequency in toddlers and preschool-age children with epilepsy - This study examined the associations between napping characteristics and seizure frequency in toddlers and preschool-aged children with epilepsy. A secondary analysis was conducted using data from 139 children with epilepsy aged 1.5-6 years recruited from pediatric neurology clinics at a medical center in northern Taiwan. Sleep was objectively measured by 7-day actigraphy, with daily seizure fr...

Exploring the impact of controlled substance restrictions on epilepsy care in the United States: A neurologist survey - CONCLUSIONS: Respondents reported high rates of medication access issues related to controlled substance restrictions and low rates of ASM misuse. Controlled substance restrictions create practical barriers to reliably obtaining scheduled ASM prescriptions that can result in increased risk of morbidity and mortality. Controlled substance restrictions warrant reevaluation for PWE given the speci...

Impact of Antiseizure Medication on Thyroid Function in Children With Epilepsy: A Case-Control Study - Background Epilepsy, chronic monotherapy of antiseizure medications (ASMs), as well as the secondary disturbance of the thyroid axis, which includes both subclinical and clinical hypo- and hyperthyroidism, are crucial endocrine challenges during children's development. In this study, the levels of thyroid hormones in children with epilepsy who underwent chronic monotherapy were compared with th...

Epileptic seizures temporally associated with recombinant human growth hormone therapy in children: A case series of three patients - We report three pediatric patients who developed epileptic seizures while receiving recombinant human growth hormone therapy. Case 1 was a 12-year-old girl with a history of febrile seizures and epilepsy whose seizures recurred after discontinuation of antiepileptic medication during ongoing recombinant human growth hormone therapy. Case 2 was an 11-year-old boy born extremely preterm who devel...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.