Epilepsy News

Outcome trajectories after pediatric epilepsy surgery vary by biopsychosocial phenotypes - OBJECTIVE: The aims of this study were to examine whether there are distinct biopsychosocial phenotypes among children with drug-resistant epilepsy (DRE) and to determine whether these phenotypes are related to the longitudinal trajectories of child, parent, and family outcomes after epilepsy surgery compared to medical treatment.

Comparative risk of epilepsy with SGLT2 inhibitors versus incretin-based therapies in type 2 diabetes - OBJECTIVE: This study was undertaken to compare the risk of seizures and epilepsy among patients with type 2 diabetes (T2D) initiating sodium-glucose cotransporter-2 inhibitors (SGLT2is), glucagonlike peptide-1 receptor agonists (GLP-1 RAs), or dipeptidyl peptidase-4 (DPP-4) inhibitors using nationwide real-world data.

Expanding the electroclinical spectrum of TANC2-related disorders: Lennox-Gastaut syndrome and related developmental epileptic phenotypes - OBJECTIVE: Neurodevelopmental disorders (NDDs) and epilepsy are often associated. Increasing evidence highlights a pivotal role for pathogenic variants in genes encoding synaptic scaffolding proteins. Within this group, TANC2 has recently been implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures; however, its full clinical spectru...

Single-center longitudinal experience with MRgLITT in pediatric neurosurgery: technical evolution, expanding indications, and advanced MRI-driven planning - CONCLUSIONS: The integration of robotic precision and 3T real-time monitoring has lowered procedural risks, allowing MRgLITT to progressively emerge as a first-line option in selected complex cases (thalamic and infratentorial) previously considered high-risk or inaccessible. The low permanent morbidity rate (3.2%) confirms the safety of this technological evolution.

Real-world use of Cenobamate in pediatric drug-resistant epilepsy: A European multicenter retrospective study - Pediatric drug-resistant epilepsy (DRE) remains a significant clinical challenge, with few effective pharmacological options. This European multicenter retrospective study assessed the real-world efficacy, tolerability, and retention of off-label cenobamate (CNB) in 108 children and adolescents with DRE (median age: 13.83 years, range 3.9-19.8). Overall, 57/108 patients (52.8%) achieved a ≥50% ...

Long-term mortality after status epilepticus: A 5-year analysis study - OBJECTIVE: To describe 5-year mortality after status epilepticus (SE) and identify factors associated with long-term survival. We also validated the prognostic performance of the Age, Consciousness, Duration (ACD) score and evaluated long-term survival across etiological categories defined by the Lattanzi classification of acute symptomatic SE.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.