Epilepsy and Seizure News
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Nursing a Patient With Amyotrophic Lateral Sclerosis Stage 4B With Epilepsy: A Case Study -
Amyotrophic lateral sclerosis (ALS) is a rare motor neuron disease characterised by progressive muscle weakness, which can eventually lead to death. So far there is no effective cure for it. This case report discusses the nursing of a patient with stage 4B amyotrophic lateral sclerosis complicated with epilepsy and sudden disturbance of consciousness during his stay in an intensive care unit (I...
Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy -
Real-time visualization of oxidative stress in living systems poses a formidable challenge in epilepsy research, primarily due to the scarcity of tools capable of selectively distinguishing structurally similar reactive oxygen species (ROS) with high specificity. Here, we present a dual-functional fluorescent probe, HH, capable of independently detecting hydrogen peroxide (H(2)O(2)) and hydroxy...
Effect of high altitude on the pharmacokinetics and pharmacodynamics of valproate in epileptic rats -
CONCLUSION: High altitude not only exacerbate seizure severity but also significantly alter the PK and PD of VPA in epileptic rats. This study suggests that epilepsy patients rapidly entering high altitude regions may require an appropriate increase in dosage and enhanced PK/PD monitoring during VPA treatment to ensure clinical efficacy.
Shared Genetic Architecture of Epilepsy and Glioma Revealed by Mendelian Randomization: Identifying Prognostic Biomarkers and Therapeutic Targets -
CONCLUSION: These results reveal a common genetic architecture between glioma and epilepsy, offering candidate biomarkers and therapeutic strategies for the management of GRE.
Thyroid dysfunction and migraine across racial and age groups: A multinational cohort study -
CONCLUSION: In this large, multinational real-world study, both hypothyroidism and hyperthyroidism were independently associated with increased migraine prevalence across diverse racial and age groups. These results highlight thyroid dysfunction as an important comorbid condition in migraine and support further prospective and mechanistic investigation.
Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review -
Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p-tau) and amyloid-β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence of dementia. However, the prevalence, distribution, a...
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