Epilepsy News

Obstructive sleep apnea and epilepsy comorbidity: possible complications and treatment options - Epilepsy is one of the most prevalent neurological disorders, affecting approximately 50 million individuals globally. Sleep plays a crucial role in the progression of epilepsy, particularly concerning serious complications such as Sudden Unexpected Death in Epilepsy (SUDEP). The sleep patterns of individuals with epilepsy can be significantly disrupted by obstructive sleep apnea (OSA), which a...

Aberrant Potassium Handling by Astrocytes and Epileptic Seizures: A Synthetic Update - Excessive extracellular accumulation of K^(+) plays a key role in the induction and propagation of seizures associated with temporal lobe epilepsy (TLE), and astrocytes are largely responsible for K^(+) clearance from the extracellular space. Here, we review the TLE-related changes in the content and/or activity of proteins contributing to K^(+) transport across the astrocytic cell membranes. S...

Traumatic Brain Injury and Delusional Disorder: A Narrative Synthesis with Psychopharmacologic Implications - CONCLUSIONS: Post-TBI delusional syndromes highlight the role of structural brain injury in the development of psychosis. Careful diagnostic evaluation and individualized, low-dose psychopharmacologic strategies are essential. Further research is needed to guide evidence-based treatment in this population.

Celiac disease presenting As recurrent encephalopathy and seizures - CONCLUSION: The child remained seizure-free over two years with significant clinical improvement, highlighting gluten-sensitive epilepsy as an important, treatable extraintestinal manifestation of pediatric celiac disease.

Clinical and genetic analysis of PRRT2 gene mutations in a cohort of 21 pediatric patients: a case series - CONCLUSIONS: This study expands the known mutational spectrum of PRRT2 by identifying a novel missense variant (c.811C > T) associated with refractory epilepsy and providing functional evidence for the pathogenic intronic variant c.880-34G > A. The findings highlight the time-dependent evolution of PRRT2-related phenotypes and underscore that PRRT2 mutations are not invariably associated with a...

Incidence, Risk Factors, and Clinico-Radiological Correlations of Early Post-traumatic Seizures: A Prospective Analysis at a Tertiary Care Center in India - Background Post-traumatic epilepsy (PTE) is a major cause of acquired epilepsy. Early post-traumatic seizures (EPTS), occurring within the first seven days following traumatic brain injury (TBI), are known to worsen secondary brain damage and adversely affect patient outcomes. Despite the recognized burden, the incidence and risk factors of EPTS in the Indian population remain poorly characteri...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.