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Do preclinical seizure models predict success or failure in anti-seizure drug development? A retrospective analysis of 89 compounds with divergent clinical outcomes for epilepsy -
Anti-seizure medication (ASM) discovery remains a major challenge despite over 30 commercially available options. One persistent obstacle for any promising candidate compound to successfully move from preclinical study to clinical approval has been the ambiguity in preclinical model selection. Which models are most predictive of clinical response and failure? For decades, the maximal electrosho...
Sphenoidal Meningioma with Focal Seizures Masquerading as Immune Reconstitution Inflammatory Syndrome in HIV Patient -
Seizures in adults with HIV can result from structural lesions, opportunistic infections, immune reconstitution inflammatory syndrome (IRIS) or medication effects, making accurate diagnosis challenging. We report a 47-year-old woman with HIV who developed recurrent focal-onset seizures evolving to bilateral tonic-clonic seizures beginning approximately 4 weeks after initiation of antiretroviral...
The challenge of drug-related seizures: is identifying the cause only part of the battle? -
No abstract
Case Report: Longitudinal evaluation of cerebrospinal fluid Alzheimer's disease core biomarkers in a case of refractory late-onset epilepsy of unknown etiology -
In recent years, late-onset epilepsy of unknown etiology (LOEU) has increasingly been recognized as a risk factor for Alzheimer's disease (AD) and other forms of dementia. We present a case of refractory LOEU with progressive cognitive decline, longitudinally evaluated over more than 20 years using neuropsychological tests, cerebrospinal fluid (CSF) AD core biomarkers (Aβ42/40 ratio, p-tau), el...
Seizure-Related Burn Injuries in People with Epilepsy: A Narrative Review with Emphasis on Low- and Middle-Income Countries -
Epilepsy is a neurological disease characterized by an enduring predisposition to recurrent seizures. Approximately 1% of the global population is affected by epilepsy, making it the second most common neurological disease after stroke. Individuals with epilepsy are at heightened risk for both seizure-related and unrelated injuries, including soft tissue injuries, head injury, dental and tongue...
"A Father and Daughter Presentation of Autosomal Dominant Sleep-Related Hypermotor Epilepsy Via a DEPDC5 Deletion in Exon 28" -
Sleep-related hypermotor epilepsy (SHE) is a form of focal epilepsy that can be caused by a pathogenic autosomal-dominant DEP domain containing Protein 5 (DEPDC5) variant. Given its variable clinical presentation and etiology, SHE can be challenging to diagnose and treat effectively. This case describes a father-daughter pair who experienced sleep-related seizures with similar semiologies and w...
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