Epilepsy News

Folic acid supplementation and prevention of adverse offspring outcomes among women with epilepsy: An observational study - OBJECTIVE: Folic acid (FA) is essential for fetal development, while the benefits and optimal dose in pregnant women with epilepsy (PWWE) remain unclear. This study explores effects of FA supplementation, dose, and initiation time on offspring outcomes in PWWE.

Increased interval between seizure clusters across time in pediatric patients treated with the immediate-use seizure medication diazepam nasal spray - OBJECTIVE: Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti-seizure medication. Benzodiazepine-containing immediate-use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters. Diazepam nasal spray is approved by the U.S. Food and D...

Fully Automated EEG Source Imaging Using Structured Sparsity for Single and Multiple Synchronous Epileptic Activities - Accurate localization of epileptic zones from high-resolution electroencephalography (HR-EEG) data can be challenging, especially when multiple synchronous zones are involved, and is highly dependent on the chosen EEG Source Imaging (ESI) method. Since a given scalp-level electrical pattern can result from multiple source configurations, ESI methods address this ill-posed inverse problem by imp...

Stereo-electroencephalography-guided cross-electrode radiofrequency thermocoagulation in focal epilepsy: A review of current methodologies and outcomes - Advances in stereo-electroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RFTC) have led to the development of cross-electrode RFTC, which has been shown to result in significantly larger lesions and higher seizure-freedom rates compared to standard RFTC methods. Given the novelty of cross-electrode RFTC, herein we review the reported surgical techniques and treatment-relat...

Green-synthesized Matricaria chamomilla silver nanoparticles enhance anticonvulsant and neuroprotective effects through GABAergic and antioxidant pathways in an acute seizure rat model - Epilepsy is a major chronic neurological disorder with significant treatment limitations, particularly in drug-resistant cases, highlighting the need for novel and affordable neuroprotective strategies. This study investigates the anticonvulsant and neuroprotective effects of ethanolic extract of Matricaria chamomilla (German chamomile) and its green-synthesized silver nanoparticles (MC-AgNPs) ...

Recurrent spatial disorientation and amnestic episodes associated with lung adenocarcinoma: a serum- and CSF-negative paraneoplastic case - Recurrent seizure-like episodes with preserved motor function and negative conventional investigations pose a significant diagnostic challenge, particularly in elderly patients. We report an elderly patient presenting with recurrent, stereotyped episodes of spatial disorientation and amnesia. Extensive evaluation, including brain MRI, cerebrospinal fluid analysis, electroencephalography, serum ...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.