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TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala -
CONCLUSIONS AND IMPLICATIONS: Together, these findings uncover a central role for TRPM3 in amygdala function and identify this ion channel as a modulator of fear memory and seizure susceptibility.
Hippocampal LTP shifts from NMDAR dependence to mGluR/VGCC-supported mechanisms following juvenile status epilepticus in rats -
Hippocampal long-term potentiation (LTP) can persist in the chronic epileptic state, but the mechanisms supporting this residual plasticity remain poorly understood. In particular, it is unclear whether LTP retains canonical N-methyl-D-aspartate receptor (NMDAR) dependence or shifts to alternative induction mechanisms. We addressed this question in male rats during the chronic phase following j...
Transcranial rotating permanent magnet stimulation for focal continuous spike-and-wave during sleep: First-in-human pediatric pilot study -
OBJECTIVE: Continuous spike-and-wave during sleep (CSWS) is an epileptic encephalopathy characterized by sleep-potentiated epileptiform activity and neurocognitive deterioration. Available therapies are frequently ineffective or poorly tolerated. We evaluated the safety, tolerability, and acute electrophysiologic effects of transcranial rotating permanent magnet stimulation (TRPMS), a novel wea...
Valproate-Associated Hyperammonemic Encephalopathy Despite Nontoxic Serum Levels and Preserved Liver Function: A Case Report -
Valproate-associated hyperammonemic encephalopathy (VHE) is a potentially serious adverse effect that may occur despite nontoxic serum valproate concentrations and preserved liver function. We report a 49-year-old man with intellectual disability and long-standing drug-resistant epilepsy treated with valproate, phenytoin, phenobarbital, cenobamate, levetiracetam, and several psychotropic medica...
Managing Drug-Resistant Epilepsy and Severe Feeding Difficulties in Miller-Dieker Syndrome: The Role of Enteral Ketogenic Diet -
Miller-Dieker syndrome (MDS) is a rare genetic disorder characterized by classical lissencephaly, severe neurodevelopmental impairment, and early-onset drug-resistant epilepsy. Feeding difficulties and aspiration pneumonia significantly contribute to morbidity and mortality. Evidence regarding ketogenic diet (KD) therapy in patients with severe neurological impairment requiring exclusive entera...
High frequency stimulation in thalamic reticular nucleus blocks the effect of pentylenetetrazole -
High-frequency stimulation (HFS) is an alternative and promising treatment for intractable epilepsy; however, the optimal targets remain unknown. The thalamic reticular nucleus (TRN) occupies a key position in the modulation of cortico-thalamic and thalamo-cortical pathways. HFS-TRN retarded the generalization of PTZ-induced seizures. To explore the mechanism underlying HFS-TRN, we recorded TRN...
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