Epilepsy and Seizure News
Many people have seizures. Here's why it doesn’t always mean epilepsy -
One of the most common causes of epilepsy is a structural brain abnormality. “Epilepsy can result from structural issues in the brain, such as brain tumors, brain injuries, brain infections or ...
Late-Onset Epilepsy a Distinct Neurodegenerative Subtype? -
Emerging clinical and autopsy evidence points to late-onset epilepsy as a potentially distinct, neurodegeneration-related form of epilepsy, with many cases still unexplained.
'I just felt like me': West MI woman's journey from epilepsy to seizure-free life -
Taylor Hyma's journey from enduring drug-resistant epilepsy to becoming seizure-free after brain surgery highlights hope and challenges for patients.
‘First Seizure Clinic’ for Pediatric Epilepsy a Model of Success -
A dedicated pediatric “one-stop” First Seizure Clinic cuts wait times to under a week and enables earlier diagnoses, giving families faster answers and more streamlined care.
Supporting someone with epilepsy: How you can help during a seizure | Health Smart -
"First thing is safety. Lower them to the ground, turn them to the side so they don't choke and time the seizure. If it goes beyond 3 to 4 minutes, call 911 immediately and don’t put anything in the ...
First seizure clinic speeds time to diagnosis with pediatric epilepsy -
Children referred to a first seizure clinic (FSC) see a neurologist epilepsy specialist within one week, according to a study presented at the annual meeting of the American Epilepsy Society, held ...
GLP-1 drugs linked to lower epilepsy risk in diabetes patients -
Research last month suggested that starting GLP-1 receptor agonist treatment in people with epilepsy and type 2 diabetes was associated with reduced risks of seizure recurrence, hospitalization, and ...
Durham family, desperate to help 3-year-old with severe epilepsy, fundraising for seizure alert dog -
Doctors diagnosed Finley with epilepsy. No one else in the Mullen family has the seizure disorder, and Ashley and Will worked to learn as much as possible about it and document Finley’s ...
Praxis claims efficacy success in phase 2 seizure trial, setting up approval talks with FDA -
“SCN2A and SCN8A DEEs are devastating conditions with extremely high mortality due to the debilitating seizure burden they impose on patients, and there are currently no approved treatment options,” ...
Going beyond seizure control: evidence for cost-effectiveness of epilepsy surgery -
Over 10 million people with epilepsy qualify as surgical candidates worldwide, with 1.4 million new potential surgical candidates added each year.1 The actual number of epilepsy surgeries performed ...
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Prevalence, comorbidities, and mortality of epilepsy in an older Chinese population: The Shanghai Aging Study -
OBJECTIVE: To investigate the prevalence, comorbidities, and 13-year mortality of epilepsy among older community-dwelling adults.
Cardiorespiratory cross-frequency coupling biomarker for sudden unexpected death in epilepsy -
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) often follows generalized tonic-clonic seizures during sleep, likely resulting from impaired brainstem cardiorespiratory function. We used ictal electrocardiogram (ECG)-based cross-frequency phase-amplitude coupling (PAC) to detect cardiorespiratory disruptions, comparing SUDEP to non-SUDEP cohorts. Leveraging respiratory modulation of ECG ...
Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning -
OBJECTIVE: Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers. Approximately 60% of patients fail to have their ETs identified through noninvasive preoperative evaluations, creating an urgent clinical need...
Astrocyte S1P1 regulates mitochondrial autophagy in inflammation and neuronal injury after epilepsy -
CONCLUSION: S1P1-PHB2 axis plays a crucial role in the neuroinflammation and neurodamage caused by epilepsy. S1P1, through PHB2, promotes mitochondrial autophagy, increases oxidative stress and releases pro-inflammatory cytokines, thereby leading to neural damage. By using the S1P1 antagonist W146 to inhibit autophagy and inflammatory responses, these effects can be alleviated.
Cost-effectiveness of fenfluramine as add-on treatment in the management of Dravet Syndrome: A real-world multicenter study -
OBJECTIVE: Dravet syndrome (DS) is a rare disease with a high clinical and socioeconomic impact on patients, society, and the healthcare system. The recent approval of therapies such as fenfluramine (FFA) has transformed the treatment landscape; however, data on their cost-effectiveness are still scarce. This study evaluates the real-world cost-effectiveness of adding FFA to existing therapies ...
Atypical GNAO1 variants in severe childhood speech disorders: clinical, genetic, and molecular insights -
CONCLUSIONS: Our results broaden the clinical and mechanistic spectrum of GNAO1-related disorders, showing that severe speech disorders and ID can occur as defining features even in the absence of seizures or movement disorders. These findings highlight the importance of including GNAO1 in genetic testing for children with severe speech disorders.
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