Epilepsy News

GABA(A) Receptors and Drug-Resistant Epilepsy: Why It's Time to Think Outside the Pore - Drug-resistant epilepsy (DRE) represents a major clinical hazard, characterised by persistent uncontrolled seizures that elevate risks of trauma, cognitive deterioration, psychiatric comorbidity, and sudden unexpected death in epilepsy, while cumulative medication exposure, healthcare burden, and functional impairment substantially worsen long-term morbidity and quality of life. In DRE, disrupt...

Status Epilepticus Is Detected Earlier than Seizures on cEEG in Critically Ill Adults - CONCLUSIONS: SE events were detected significantly earlier than short seizures. If confirmed in larger cohorts, and supported by additional data on the relationship between timely seizures/SE detection, treatment and outcome, these findings may aid in optimizing EEG resource allocation.

ApoE impairs microglial efferocytosis by targeting Gas6/MerTK in a mouse model of acute seizure - Epilepsy, a neurological condition, is characterized by frequent, spontaneous seizures. Both apolipoprotein E (ApoE) and TAM (Tyro3, Axl and MerTK) receptors, the key efferocytosis receptors, have been associated with the pathological mechanisms underlying epilepsy. Nevertheless, little is known about how they interact or the molecular mechanisms. Here, we explored how ApoE and microglial effer...

Kainic acid pig model of hippocampal epilepsy - Translational large-animal models that can accommodate human-scale implantable devices are essential for advancing neuromodulation therapies in epilepsy. This study establishes a kainic acid (KA)-induced porcine model of mesial temporal lobe epilepsy (mTLE) using clinical imaging, stereotactic surgery, and a fully implantable neural stimulator-recorder (INSR) device designed for humans. Seven p...

Abnormal protein glycosylation in epileptogenesis: evidence from experimental models and clinical insights - Epilepsy is a brain disease caused by transient changes in the patients' clinical status due to excessive neuronal discharge or depolarization. Despite the increasing understanding of potential risk factors for epileptic seizures, there is still no method to prevent the onset of epilepsy in high-risk populations, and clear diagnostic criteria remain lacking. Currently, the clinical diagnosis of...

The electroencephalographic patterns in the acute phase of febrile infection related epilepsy syndrome in children - CONCLUSIONS: "Migratory Zig-Zag Pattern", the relatively characteristic acute-phase ictal EEG finding may serve as an specific electrophysiological feature suggestive of FIRES in children. When combined with other ancillary examinations, they may assist in the early clinical diagnosis of FIRES and guide early immunomodulatory interventions to improve clinical outcome.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.