Epilepsy News

AI decodes epilepsy signals in brain waves before seizures appear - Epilepsy isn't always easy to diagnose. Seizures often don't occur during routine brain-wave recordings (EEGs), leaving doctors without the direct observation they need to make a clear diagnosis.

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

AI detects early warning signs of epilepsy without visible seizures - Epilepsy isn't always easy to diagnose. Seizures often don't occur during routine brain-wave recordings (EEGs), leaving doctors without the direct observation they need to make a clear diagnosis.

Understanding epilepsy: Seven ways to respond to an epileptic seizure - At the forefront of epilepsy research and treatment is the University of Alabama at Birmingham Epilepsy Center, a collaborative initiative between the UAB Department of Neurology and UAB Hospital, ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

EPILEPSY AWARENESS: Local neurologist explains condition & seizure first aid - COLUMBUS, Ga. (WRBL) — Local experts say epilepsy is not a condition to be afraid of. Piedmont Columbus Regional pediatric neurologist Pierre Fequiere treats patients with epilepsy every day and knows ...

The cumulative impact of seizures: the science underlying how seizures beget seizures - Seizures are symptoms of epilepsy but spontaneous seizure recurrence can also be considered a biomarker of disease progression. The temporary imbalance between excitatory and inhibitory drive that culminates in a hyperexcitable, hypersynchronous state clinically observed as seizure, initiates an insidious cascade of neurochemical, structural, genetic, epigenetic, and neuroinflammatory processes...

Hippocampal Long Axis Differentiation in Memory and Seizure Networks - The structure-function gradient along the hippocampal long axis is recognized but poorly understood. Rodent recordings mainly sample the dorsal hippocampus (posterior), while surgical recordings in epilepsy patients typically sample from the ventral hippocampus (anterior), because of greater known involvement in seizure networks. These divergent recording practices imply that the mechanisms of ...

Case report: Whole-exome sequencing reveals a novel variant in a patient with epilepsy presenting with fever - Epilepsy is a prevalent neurological disorder characterized by recurrent seizures and significant impacts on quality of life. This case report describes a 2-year-old male patient presenting with epilepsy associated with fever, in whom whole-exome sequencing (WES) revealed a novel de novo variant in the KCNMA1 gene, resulting in the amino acid substitution p.Leu187His. This variant is classified...

Case Report: Atypical hepatobiliary manifestations associated with erythrocyte membrane instability in glucose transporter type 1 deficiency syndrome - CONCLUSION: This case expands the phenotypic spectrum of GLUT1DS by linking erythrocyte membrane instability to recurrent hemolysis and rarely reported hepatobiliary complications. Functional evaluation of erythrocyte membrane integrity may facilitate recognition of atypical systemic manifestations of GLUT1DS and supports the need for multidisciplinary surveillance beyond neurological care.

Regional excitability, not epileptic pathology, drives stimulation-evoked interictal spike increases - OBJECTIVE: Interictal spikes have been proposed as a biomarker for both localizing seizure onset zones (SOZ) and tracking changes in seizure risk with neurostimulation in patients with drug-resistant epilepsy. Electrical stimulation can modulate spike rates acutely, and it has been proposed that measuring this modulation can help localize the SOZ. However, it is unclear whether stimulation-indu...

Sleep increases firing rate modulation during interictal epileptiform discharges in mesial temporal structures - Epileptic seizures and interictal epileptiform discharges are strongly influenced by sleep and circadian rhythms. However, human data on the effect of sleep on neuronal behaviour during interictal activity have been lacking. We analysed EEG from eight epileptic patients implanted with macro and micro electrodes in mesial temporal structures. Sleep staging was performed on polysomnography and vi...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.