Epilepsy News

Peroxynitrite-Activated Valproic Acid Precursor for Monitoring Oxidative Stress and Reducing Epileptic Seizures in an Epilepsy Model - Epilepsy is a chronic neurological disorder characterized by recurrent seizures, which poses a significant threat to human health. Increasing evidence indicates that the pathological mechanism of epilepsy is closely related to the presence of peroxynitrite (ONOO^(-)). To address this issue, we have developed a dual-molecule release precursor, DVN, with different functional components, which con...

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS - OBJECTIVE: Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross-network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.

Spontaneous Splenic Rupture in a Patient With Combined Congenital Factor XIII and Factor VII Deficiencies: A Case Report - Spontaneous (atraumatic) splenic rupture (SSR) is an uncommon and potentially fatal emergency, most frequently linked to infection, cancer, or hematologic disorders. Although clotting factor XIII (FXIII) and factor VII (FVII) deficiencies are uncommon bleeding disorders on their own, their coexistence and association with spontaneous splenic rupture have not been reported before. A 26-year-old ...

Mental health of children with epilepsy in Ukraine during the war - OBJECTIVE: The ongoing conflict in Ukraine has created a severe humanitarian crisis, disproportionately affecting vulnerable populations such as children with chronic conditions. We set out to determine information about mental health in children with epilepsy in Ukraine affected by the conflict.

Chronic sleep deprivation promotes drug-resistant epilepsy via the BMAL1-mTOR-P-gp axis - OBJECTIVE: The interplay between chronic sleep deprivation and drug-resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt-like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation-induced DRE.

Lateralizing and localizing value of postictal signs: A systematic review - To present a concise and comprehensive review of the lateralizing and localizing value of postictal signs in focal epilepsy and to provide guidance in the interpretation of the signs for presurgical evaluation of drug-resistant epilepsy. We performed a systematic literature review following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines to identify th...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.