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Platelet-to-lymphocyte ratio as an indicator of idiopathic epilepsy in dogs -
CONCLUSIONS AND CLINICAL IMPORTANCE: Platelet-to-lymphocyte ratio shows promise as a biomarker for diagnosing IE in dogs and distinguishing it from structural brain diseases, including those with seizures.
Neurodevelopmental Assessment, EEG Findings and Epilepsy in Children With Autism Spectrum Disorder: A Retrospective Study -
CONCLUSION: EEG abnormalities and epilepsy are highly prevalent in children with ASD. Abnormal EEG findings and pathogenic genetic variants were strong independent predictors of epilepsy in our cohort. EEG should be strongly considered in children with ASD, particularly those with seizures, developmental regression, unexplained paroxysmal events or pathogenic genetic variants. Prospective studi...
L-2-Hydroxyglutaric Aciduria Due to the Homozygous Variant c.905C>T in L2HGDH Without Cognitive Deficits or Gait Disturbance: A Case Report -
L-2-hydroxyglutaric aciduria (L2HGA) is a rare, slowly progressive, autosomal recessive neurometabolic disorder caused by mutations in the L2HGDH gene and characterized by psychomotor developmental delay, cognitive impairment, epilepsy, dystonia, cerebellar ataxia, tremor, dysarthria, pyramidal signs, macrocephaly, leukoencephalopathy, and elevated L-2-hydroxyglutaric acid levels. To date, no c...
Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography -
CONCLUSIONS: Overall, we found that ASMs altered the effective connectivity within the seizure network more than within non-involved regions, whereas functional connectivity was altered more often within non-involved regions. This study is the first study revealing with high spatiotemporal resolution that ASMs can alter brain effective and functional connectivity in multiple different ways.
Thalamic Volume Asymmetry as a Potential Predictor of Vagus Nerve Stimulation Outcomes in Refractory Epilepsy -
Vagus nerve stimulation is an established treatment for refractory epilepsy, but predictors of treatment response remain unclear. Given that left-sided vagus nerve stimulation preferentially modulates the left thalamus and that epileptic networks induce thalamic structural damage, we investigated whether preoperative thalamic volume asymmetry predicts vagus nerve stimulation outcomes. This retr...
Cenobamate: a new drug that may change the concept of drug-resistant focal epilepsy -
CONCLUSION: Considering the response rates obtained, cenobamate may change the concept of drug-resistant epilepsy. Failure of any 2 drugs will no longer be sufficient to define this condition; rather, it will require failure of the most efficacious drug.
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