Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...

EPILEPSY AWARENESS: Local neurologist explains condition & seizure first aid - COLUMBUS, Ga. (WRBL) — Local experts say epilepsy is not a condition to be afraid of. Piedmont Columbus Regional pediatric neurologist Pierre Fequiere treats patients with epilepsy every day and knows ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

Neuroprotective activity of the α7-nAChR positive allosteric modulator PNU-120596 on short term outcomes after traumatic brain injury - Traumatic brain injury (TBI) often leads to long-lasting neurological, cognitive, and behavioral impairments. Despite its high global burden, no disease-modifying therapies currently exist to mitigate secondary injury processes that contribute to chronic neurological deficits. Activation of α7 nicotinic acetylcholine receptors (α7-nAChRs), which are expressed on neurons, glia, and immune cells,...

A neural mass modelling framework for evaluating EEG source localisation of seizure activity - This study addresses the challenge of objectively evaluating electroencephalography and magnetoencephalography (EEG/MEG) source localisation algorithms in the absence of an experimentally verifiable ground truth, specifically for the characterisation of ictal dynamics. 
Approach. A simulation framework is presented for generating biologically plausible ictal dynamics and their corresponding...

Functional and effective connectivity methods from SEEG for characterizing epileptogenic networks in refractory epilepsy: a comprehensive review and future directions - Brain Connectivity Analysis based on Stereoelectroencephalography (SEEG) has been increasingly explored as a tool for studying Epileptogenic Networks and supporting therapies for Refractory Epilepsy. In this Review, we summarize recent methodologies and findings on SEEG-based Functional and Effective Connectivity, which aim to define the dependence and influence between spatially distributed ne...

Established and emerging neuromodulation for drug-resistant epilepsy - Drug-resistant epilepsy concerns approximately 30% of epilepsy patients. Surgical interventions might not be an option, especially in case of generalized or multifocal seizures or if there is a high risk of neurological defects caused by the resection. Currently widely approved neuromodulation approaches consist of invasive methods: vagus nerve stimulation (VNS), deep brain stimulation (DBS) an...

Status epilepticus in patients with known epilepsy presenting to the emergency department: Predictors and mortality risk - CONCLUSION: SE occurred in nearly one-quarter of epilepsy patients presenting to the ED and was strongly associated with increased in-hospital mortality. These findings may assist clinicians in identifying patients at increased risk of SE and support early risk stratification and appropriate monitoring, particularly among older patients and those presenting with metabolic abnormalities or suspe...

Diagnostic accuracy of artificial intelligence models for seizure outcome prediction after epilepsy surgery: A systematic review and meta-analysis - Drug-resistant epilepsy (DRE) affects approximately one-third of individuals with epilepsy. Although surgery offers the best chance of durable seizure freedom in appropriately selected patients, postoperative outcomes remain difficult to predict. Artificial intelligence (AI) has been proposed to improve individualized presurgical prediction, but its diagnostic performance has not been quantitat...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.