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Genetic Etiologies of Epilepsies With Status Epilepticus: Insights From the Italian Pediatric Status Epilepticus Group Cohort -
BACKGROUND AND OBJECTIVES: Genetic factors are major contributors to pediatric epilepsy, but their role in status epilepticus (SE) remains incompletely defined. We aimed to characterize the clinical and genetic landscape of pediatric epilepsy complicated by SE in a large cohort, and to identify clinical features associated with genetic etiologies.
MuGEP: Multiplex Graph-Based Brain Network Modeling for Epileptic Seizure Prediction Using Intracranial EEG -
Accurate seizure prediction in advance is crucial for patients with epilepsy, as it helps prevent harm and improve life quality. Intracranial electroencephalogram (iEEG), enabling precise characterization of epileptogenic and propagation networks from deep brain tissue, is a reliable foundation for epilepsy research. While deep learning models have shown success in automating seizure prediction...
Expanding the scope of pediatric epilepsy surgery: Access, indications, and outcomes in a modern cohort -
OBJECTIVE: Expanded indications, diagnostic tools, and treatment options have transformed the landscape of modern pediatric epilepsy surgery. Published real-world experiences from large surgical cohorts are still needed. To close this gap, we evaluated access, indications, treatment, and outcomes in a contemporary pediatric epilepsy surgery program.
The Complexity and Challenges of Developing Effective Epilepsy Therapies: Lessons to be Learned from Comparing Cenobamate, Carisbamate, and Padsevonil -
Most of the about 30 clinically approved antiseizure medications (ASMs) have been discovered using animal seizure models. Thus, such models are commonly considered highly predictive of clinical antiseizure efficacy. However, this has recently been questioned by the apparent dichotomy in clinical antiseizure efficacy between the novel ASMs padsevonil and the alkyl-carbamate cenobamate, both of w...
The Multifaceted Roles of GPR120 in Central Nervous System Disorders: Mechanistic Insights and Therapeutic Implications -
G protein-coupled receptor 120 (GPR120), also known as free fatty acid receptor 4 (FFAR4), is a receptor for ω-3 polyunsaturated fatty acids (ω-3 PUFAs), mainly including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). It is widely expressed in the central nervous system on microglia, astrocytes, and neurons, where it regulates neuroinflammation and homeostasis. This review summariz...
Clinical Analysis of SYNGAP1 Variant-Related Neurodevelopmental Disorders in Chinese Children -
This study aims to characterize the clinical phenotypes of children with SYNGAP1-related neurodevelopmental disorders (SRDs), explore the genotype-phenotype correlation, and guide optimal clinical management. Clinical data of 99 Chinese children with SRDs were retrospectively collected, including genetic results, clinical features, electroencephalogram (EEG), cranial imaging, and treatment resp...
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