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Infant Abusive Head Trauma Induces Seizures and Cellular Stress in a Pre-Clinical Mouse Model -
Abusive head trauma (AHT) occurs when a child is grasped and shaken with such force that the brain moves within the skull. AHTs are not isolated events; repetition occurs in 30-50% of cases, with affected children experiencing ∼10 episodes. While many AHTs appear asymptomatic, there is often underlying cellular and neurological damage. Notably, seizures following AHT may be solely electrographi...
Tau accumulation increases the susceptibility to effective seizures of electroconvulsive therapy -
Electroconvulsive therapy (ECT) is a very valuable treatment for mood disorders. While previous studies have examined predictors of ECT responsiveness, there is a scarcity of neuroimaging studies examining these predictors. In previous studies, it has been reported that epilepsy is significantly more common in patients with Alzheimer's disease, and it has been suggested that tau accumulation is...
The second unprovoked seizure in a cohort of treated patients with a first unprovoked seizure -
OBJECTIVES: To evaluate the rate of a second unprovoked seizure in antiseizure medications (ASMs)-treated patients following a first unprovoked seizure and to identify potential risk factors associated with its occurrence.
Determinants of accuracy in frame-based stereoelectroencephalography: the role of experience, workflow, and selective use of guiding devices -
CONCLUSION: Frame-based sEEG implantation demonstrates high accuracy and safety. Deviations were predominantly minor and clinically acceptable, Accuracy appears primarily determined by surgical experience and workflow standardization rather than adjunctive devices. Selective cannula use may be reasonable in technically demanding trajectories, but routine application does not confer measurable b...
Mapping the cognitive landscape: a pilot study of domain-specific outcomes following frontal lobe resection in children with epilepsy -
CONCLUSION: This pilot study demonstrates the feasibility and clinical value of domain-specific cognitive assessment, revealing heterogeneous outcomes not captured by global measures. The exploratory findings generate specific hypotheses regarding the roles of ASM management, developmental timing, baseline cognition, and surgical laterality. These results provide a foundation for larger, prospe...
Case Report: Epilepsy-related pure word deafness in the elderly: an underreported presentation? -
We describe a rare case of epilepsy-related PWD in the elderly. A 61-year-old right-handed man presented with status epilepticus. Although electroencephalogram revealed no epileptiform discharges, brain magnetic resonance imaging (MRI) showed hyperintensity in the left temporoparietal lobe and thalamic pulvinar on diffusion-weighted imaging (DWI). Cerebrospinal fluid revealed no pleocytosis and...
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