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The role of SCN1A mutations in temporal lobe epilepsy: Genetic insights and clinical implications -
CONCLUSION: Current evidence suggests that SCN1A may act as a genetic modifier contributing to TLE susceptibility, pharmacoresistance, and clinical heterogeneity in certain contexts. Integration of genetic and molecular data may support improved phenotypic characterization and individualized management in selected patients. However, larger and well-designed studies incorporating multi-omics and...
Integrating weighted gene co-expression network analysis and machine learning reveal that NDUFA4L2 alleviates KA-induced HT22 cell neurotoxicity, apoptosis, oxidative stress, and mitochondrial dysf... -
Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy, with frequent seizures often leading to cognitive, emotional, and psychiatric issues. A prominent pathological change associated with TLE is hippocampal sclerosis (HS), characterized by neuronal loss, gliosis, and increased neuron fibre density. However, the pathogenesis of Temporal lobe epilepsy with hippocampal sclerosi...
Occurrence and clinical correlates of depressive symptoms in adults with epilepsy: A study in Georgia -
OBJECTIVE: To evaluate the occurrence, clinical correlates, and screening accuracy of depressive symptoms (DS) among adults with epilepsy in Georgia, a country with limited mental health resources.
Anatomo-clinical correlations in patients with lateral occipital seizures: A systematic review -
OBJECTIVE: Epilepsies presenting with lateral occipital seizures (LOS) pose diagnostic challenges due to their rarity and association with complex visual symptoms. We performed a systematic review to characterize the ictal semiology, electroencephalographic, imaging, and surgical features of LOS.
Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy -
OBJECTIVE: This study was undertaken to reliably estimate individual-specific resting-state cortical networks and determine whether language network topography can predict task-based language dominance in drug-resistant epilepsy.
Direct cortical stimulation-evoked symptoms in the human temporal pole: a cohort study -
CONCLUSIONS: Temporopolar DCS elicits heterogeneous symptoms, supporting its role as an integrative network node rather than a region with distinct stimulation-induced semiology.
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