Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Researchers uncover novel pathway that causes epilepsy - Researchers have uncovered a novel biological pathway that can lead to seizures when disrupted. The findings also provide a new approach to improve the diagnosis of epilepsy, for which a genetic cause ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

EU epilepsy care gap leaves 40% with treatable seizures - As the EU turns global brain health commitments into national action, member states remain far apart on epilepsy care ...

Evaluation of metformin for epilepsy prevention or seizure control in people without evidence of diabetes: retrospective cohort study - Background Metformin demonstrates antiepileptogenic (primary prevention) and antiseizure (symptom control) properties in animal models of epilepsy. It is unclear whether these effects translate to ...

Genotypic and phenotypic heterogeneity in tubulinopathies: insights from a Turkish multicenter cohort - CONCLUSION: Our findings underscore the profound genetic and phenotypic heterogeneity of tubulin-related disorders. The identification of rare variants and specific complications, such as SUDEP, highlights the necessity for comprehensive clinical monitoring and standardized management guidelines to optimize outcomes for this complex patient population.

"Severe intellectual disability with cardiac and dermatologic involvement due to homozygous METTL23 frameshift mutation: a case report of two Turkish sisters" - CONCLUSION: These cases represent one of the most severe phenotypic presentations of METTL23-related intellectual disability reported to date. The co-occurrence of profound intellectual impairment, epilepsy, systemic involvement (mitral valve prolapse), and dermatologic findings (nummular eczema) suggests that the homozygous form of this frameshift mutation may be associated with a more severe ...

Evaluating diagnostic yield of ambulatory EEG for interictal epileptiform discharges and seizures - CONCLUSIONS: This study identified factors associated with diagnostic yield of aEEG for observing IEDs and seizures. At least 48-hours of aEEG was highest yield for seizures, and longer studies may be appropriate for people with lower seizure frequency. IEDs were less dependent on study length and were more associated with pre-aEEG certainty of epilepsy diagnosis.

Seizure freedom after vagus nerve stimulation in a patient with SCN3A-related network epilepsy and incomplete penetrance: A case report - Genetic-based epilepsies often present as distributed neural network disorders, challenging traditional focal versus generalized classifications. We report a 20-year-old male with drug-resistant epilepsy associated with a previously unreported SCN3A missense variant (c.5970C > G; p.Ser1990Arg). Despite failure of multiple anti-seizure medications and a non-localizing electroclinical profile, th...

Ten-year cognitive outcomes following epilepsy surgery: Temporal lobectomy versus selective amygdalohippocampectomy - OBJECTIVE: This study aimed to assess long-term memory outcomes in patients with temporal lobe epilepsy (TLE) who underwent anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SAH), compared to nonoperated TLE over a 10-year follow-up period.

Loss of microglial ATM drives synaptic pruning and cognitive impairment in epilepsy - Microglia are the resident immune cells of the central nervous system, highly sensitive to oxidative stress and essential for maintaining synaptic homeostasis. While epilepsy induces profound redox imbalance, how oxidative stress reshapes microglial function and disrupts synaptic integrity remains unclear. Here we show that epileptic seizures drive early loss of ataxia-telangiectasia mutated (A...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.