Epilepsy News

Seizure freedom on subtherapeutic levels of valproic acid - Valproic acid (VPA) is a well-established antiseizure medication typically prescribed to maintain serum levels between 50 and 100 μg/mL. This case report presents a 25-year-old male with idiopathic generalized epilepsy who achieved long-term seizure freedom while on significantly subtherapeutic VPA levels. The patient initially maintained seizure control on a 750 mg once-daily regimen, with a m...

Glymphatic System Dysfunction in Epilepsy: Clinical and Translational Perspectives - Epilepsy has traditionally been viewed as a disorder involving neuronal hyperexcitability and brain network dysfunction. However, growing evidence indicates that recurrent seizures are associated with widespread disturbances in brain homeostasis, including metabolic stress, neuroinflammation, vascular dysregulation, and sleep disruption. These processes extend beyond neurons and involve brain-w...

Diagnostic Dilemma in an Infant With Sound-Triggered Motor Events: Reflex Epilepsy Versus Exaggerated Startle-A Case Report - Auditory-triggered motor events in infancy present a significant diagnostic challenge due to overlap between epileptic and non-epileptic startle phenomena. We report the case of a term female infant with neonatal-onset seizures and subsequent development of reproducible sound-triggered jerky movements, raising diagnostic uncertainty between exaggerated startle reflex and reflex auditory epileps...

Ultra-rapid prolactin normalization with cabergoline in a premenopausal woman with epilepsy and giant prolactinoma - Giant prolactinomas are rare pituitary tumors characterized by extremely high prolactin levels and extensive extrasellar invasion. While dopamine agonists are usually effective, they may require months to normalize prolactin. We report a 47-year-old premenopausal woman presenting with new-onset temporal epilepsy and secondary amenorrhea. Assessments revealed marked hyperprolactinemia (mean seru...

Postictal psychosis concealed during long-term video-electroencephalographic monitoring and unmasked after discharge: A case report - CONCLUSION: The present case highlights a diagnostic pitfall caused by overlooking PIP occurring during LTVEM, particularly in patients in whom the psychotic content is directed against the hospital and medical staff. The absence of overt behavioral disturbances does not exclude PIP. Close multidisciplinary collaboration between epileptologists and psychiatrists is essential to ensure the patie...

Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy - Electroencephalography (EEG) can provide important diagnostic and prognostic information for the management of adult stroke patients. However, its integration into routine clinical practice remains variable. During the acute phase, routine and continuous EEG (cEEG) allow the detection of nonconvulsive seizures and status epilepticus (SE), especially in patients exhibiting impaired consciousness...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.