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Probiotics and seizure susceptibility in preclinical epilepsy models: mechanistic insights from a systematic review and meta-analysis -
The gut microbiota can affect neuronal excitability, inflammation, and oxidative balance via the gut-brain axis, shaping seizure susceptibility. To translate these findings into clinical approaches, a synthesis of preclinical microbiome-based evidence is needed. This systematic review and meta-analysis examined the putative anticonvulsant, anti-inflammatory, antioxidant, and neuroprotective eff...
Investigating the role of cortical microglia in a mouse model of viral infection-induced seizures -
Microglia, resident immune sentinels in the brain, are crucial in responding to tissue damage, infection, damage signals like purines (ATP/ ADP), and clearing cellular debris. It is currently unknown how microglial reactivity progresses and contributes to seizure development following Theiler's Murine Encephalomyelitis Virus (TMEV) infection. Previously, it has been demonstrated that purinergic...
Diagnosis of the first seizure-like events in children from third-tier cities in southwestern China: a retrospective cohort study -
CONCLUSIONS: Although we aimed to identify risk factors applicable to resource-limited areas, we found that only high seizure frequency, abnormal video-EEG findings and structural brain MRI abnormalities independently predicted a subsequent diagnosis of epilepsy. These findings underscore the need for targeted paediatrician training, as well as increased financial investment in resource-limited...
Ido1 and Ido2 deficiencies attenuate kainic acid-induced ictogenesis -
Insults to the brain in the form of injury, infection and exposure to seizurogenic chemicals can induce seizures (ictogenesis). Seizure episodes during any of these events is one of the biggest risk factors for the development of treatment-resistant epilepsy, making the acute ictogenic period a critical time for intervention. Indoleamine-2,3-dioxygenases (Ido1 & Ido2) modulate systemic and cent...
Senescence markers in peripheral blood mononuclear cells in pediatric drug-resistant epilepsy -
CONCLUSION: We observed no evidence of established stress-induced premature or replicative senescence in drug-resistant epilepsy patients. However, elevated proinflammatory cytokines and high p21/p16 expression in the drug-resistant group may suggest ongoing seizures cause cellular stress which could increase susceptibility to senescence in drug-resistant pediatric epilepsy patients over time.
Synthesis and Pd(0)-Catalyzed Arylation of Naphthalen-2-yl 5-Bromofuran-2-Carboxylate Derivatives: Anticonvulsant Evaluation via In Vivo and In Silico Studies -
A series of naphthalene-2-yl 5-bromofuran-2-carboxylate (5a-5h) was synthesized using a palladium-catalyzed approach. The in vivo experiments and in silico studies were used to assess the anticonvulsant potential of the synthesized library of compounds. We tested the in vivo anticonvulsant activity using the acute 6 Hz model and pentylenetetrazol (PTZ) seizure models, antiepileptic potential of...
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