Epilepsy and Seizure News
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The MID1IP1/S100A10-mGluR5 Axis in Seizures: Immune-Metabolic Crosstalk and Enhanced Therapeutic Efficacy of Benfotiamine/Phenytoin Combination -
CONCLUSION: The MID1IP1/S100A10-mGluR5 axis drives seizure pathogenesis through metabolic-immune crosstalk. BFT and PHT target complementary nodes of this pathway, demonstrating enhanced efficacy in preclinical models.
Ketogenic diet for pediatric drug-resistant epilepsy: sleep, children's psychosocial functioning, and maternal mental health -
CONCLUSIONS: A 12-week KDT was associated with improvements in children's sleep quality and psychosocial functioning, as well as maternal sleep quality and mental health, suggesting benefits beyond seizure control.
A systematic review of highly purified cannabidiol in developmental and epileptic encephalopathies and complex treatment-resistant epilepsies: Nonseizure outcomes -
CONCLUSION: This SLR mainly identified observational studies with moderate to high bias risk. The available evidence suggests CBD may improve various nonseizure outcomes in patients with DEEs and complex TREs, while underscoring the need for rigorous confirmatory studies.
Multi-generational mitochondrial complex V deficiency due to the recurrent ATP5F1A c.620G>A (p.Arg207His) pathogenic variant: A novel family and a review of the literature -
ATP5F1A encodes part of the catalytic core of mitochondrial complex V, which is responsible for the majority of ATP production. Mitochondrial complex V deficiency, nuclear type 4A (MC5DN4A; MIM#620358) is due to monoallelic pathogenic variants in ATP5F1A. MC5DN4A is a neonatal-onset disorder with features including growth faltering, developmental delay, epilepsy, and a biochemical phenotype ind...
Imaging fast neural circuit activity in brain and nerve with Electrical Impedance Tomography (fnEIT) : review and neurophysiological applications -
Neural Engineering has become topical with widespread publicity for projects such as implanted devices for recording and intelligent stimulation of the cerebral cortex. Unfortunately, the brain has many billions of neurones, with thousands of synaptic connections, and functions with millisecond-scale graded depolarisation; there are substantial limitations in sampling this adequately, even with...
Pediatric Continuous EEG Monitoring Utilization: An 8-Year Cohort Study Using the Pediatric Health Information System Database -
CONCLUSIONS: CEEG utilization has increased over time but remains variable across hospitals and indications. Comparative effectiveness approaches that leverage variation could determine optimal CEEG practices.
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