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Predictive Value of Unilateral Hand Automatism and Brain Positron Emission Tomography Scan in Temporal Lobe Epilepsy Surgery Outcomes -
CONCLUSION: This study showed that unilateral upper-limb automatisms in MTLE occur mostly ipsilaterally to the epileptogenic zone, and that the right hand is more sensitive and specific when automatisms occur. Left upper-limb automatism with contralateral dystonia is associated with a higher likelihood of an ipsilateral left epileptogenic focus. The brain PET scan best predicted surgical outcom...
Effect of concurrent anti-seizure medications on the efficacy of the ketogenic diet in children with epilepsy -
No abstract
Anticonvulsant Potential and Network Pharmacology Analysis of Pimenta dioica (L.) Merr -
The present study evaluated the anticonvulsant property of hydro-alcoholic leaf extract of Pimenta dioica (L.) Merr. (Allspice), a plant known for its diverse biological properties. Phytochemical screening and ATR-IR spectral analysis confirmed the presence of various metabolites, including flavonoids, tannins, phenolic compounds, and carbohydrates. The acute toxicity study revealed no toxic ef...
Factors Associated with Poor Health-Related Quality of Life Among Patients with Epilepsy at Mulago National Referral Hospital -
CONCLUSION: Poor HRQOL is common among adults with epilepsy receiving tertiary care in Uganda and is associated with seizure burden, depressive symptoms, stigma, and social characteristics. Integrating psychosocial screening for depression with HADS, stigma with SSE, and psychosocial support into routine epilepsy care may improve patient-centred outcomes.
Electrographic-only seizures and status epilepticus in neonates with Tuberous Sclerosis Complex -
CONCLUSION: Epilepsy in TSC may present in neonatal period as electrographic-only seizures, including status epilepticus, and may occur before term age. This underscores the importance of early EEG monitoring -even in asymptomatic neonates with suspected or confirmed TSC- to enable timely diagnosis and intervention.
Neuroprotective effects of platinum nanoparticle-based microreactors in a pilocarpine-induced rat model of epilepsy -
Epilepsy is a neurological disorder characterized by recurrent seizures resulting from excessive and synchronous electrical activity in the brain. Hyperexcitability leads to increased intracellular calcium, oxidative stress, and neuronal damage, promoting neurodegeneration and long-term reorganization of brain circuits. Approximately 30% of individuals diagnosed with epilepsy do not respond ade...
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