Epilepsy News

Tumor Recurrence or Radionecrosis: A Clinical Dilemma in Long-Term Survivors of Low-Grade Diffuse Glioma With Drug-Resistant Epilepsy - Low-grade diffuse gliomas with isocitrate dehydrogenase (IDH) mutations predominantly affect young adults and are frequently associated with prolonged survival, requiring extended neuro-oncological follow-up. In these patients, differentiating tumor recurrence from radionecrosis after radiotherapy remains a major diagnostic challenge because both entities may present with overlapping clinical m...

Effect of High-frequency Electrical Stimulation of Olfactory Bulb on Spontaneous Excitatory Postsynaptic Currents in Hippocampal CA1 Pyramidal Cells of Kindling Rats - CONCLUSION: These findings suggest that the OB may be a viable target for DBS in epilepsy treatment. HFS application may mitigate a seizure-induced increase in sEPSCs occurrence.

Assessing Electrocardiographic Parameters in the Patients With Drug-resistant Temporal Lobe Epilepsy: A Case-control Study - CONCLUSION: According to the findings of this study, shortened QTc interval at baseline ECGs, shortened RR interval, and increased HR during the seizure were the ECG elements that affected drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.

Education Research: Educational Informatics: Characterizing Child Neurology Resident Clinical Experiences Using Electronic Health Record Data - BACKGROUND AND OBJECTIVES: Gaps in preparedness for independent practice are common among recent graduates. Clinical experiences serve as the foundation for learning during residency, yet the breadth and variability of clinical exposure of child neurology residents remain poorly characterized. To inform programmatic curricular development and precision medical education (PME), we must better ch...

Prevalence and factors associated with intellectual impairment in children with epilepsy in two national referral hospitals in Uganda - CONCLUSIONS: Intellectual impairment is common among Ugandan children and adolescents with epilepsy and is associated with older age, school non-attendance, special-needs school placement, delayed speech, and anti-seizure medication polypharmacy. These findings underscore the need for routine assessment of intellectual functioning and targeted interventions, including academic support, speech t...

Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy - Epilepsy, a common neurological disorder is frequently linked to genetic variants in synaptic proteins. Here, we describe a de novo pathogenic missense variant in the gephyrin G-domain (G134R) identified in an individual with developmental delay, epileptic seizures, microcephaly, dysmorphic features and short stature. Functional analyses reveal that G134R disrupts higher-order oligomerization, ...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.