Epilepsy and Seizure News
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Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model -
OBJECTIVE: γ-Aminobutyric acidergic (GABAergic) parvalbumin-positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage-gated channels. Specifically, the Kv3.1 voltage-gated potassium channel, which is h...
Meduna and the origins of the idea that seizures can be therapeutic -
Electroconvulsive therapy (ECT) has been well discussed in psychiatry as one of the oldest, yet still enduring and effective treatments for several psychiatric disorders, including depression, catatonia, mania, and psychoses. However, the intellectual history of ECT is much less known in the field of epilepsy, in spite of the fact that the therapy's origins are squarely in epilepsy neuropatholo...
Sleep macro-architecture in sleep-deprivation-sensitive and sleep-deprivation-insensitive juvenile myoclonic epilepsy: A polysomnographic study -
OBJECTIVE: Sleep deprivation (SD) triggers seizures in only a subset of patients with juvenile myoclonic epilepsy (JME). We compared sleep macro-architecture between SD-sensitive and SD-insensitive JME patients and healthy controls.
Extracellular matrix and perineuronal nets in neural plasticity, memory, and epileptogenesis -
In the mature brain, the extracellular matrix (ECM) molecules derived from neurons and glia accumulate in spatially distinct extracellular compartments, including a diffuse interstitial matrix and condensed perineuronal nets (PNNs), where they regulate receptor mobility, ion homeostasis, cell-surface signaling, structural stabilization, and experience-dependent synaptic remodeling. PNNs, in par...
Editorial: The network theory of epilepsy at twenty -
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Anterior shoulder dislocation after tonic-clonic seizure -
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