Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Case Report: Post-stroke hemorrhagic infarction in a status epilepticus Beagle dog -
This case describes the acute neuropathology of a 4.5-year-old male Beagle that presented with status epilepticus and a simultaneous post-stroke hemorrhagic infarction. The clinical course involved 5 days of refractory cluster and generalized seizures, during which the patient remained in a "grave" borderline threshold on the Modified Glasgow Coma Scale. Initial hematobiochemical analysis revea...
Clozapine for treatment-resistant schizophrenia with epilepsy: A case report - CONCLUSION: We report a case of TRS with comorbid epilepsy in which CLOZ therapy was both effective and safe.
Thalamocortical network dynamics in focal epilepsy: SEEG investigation - Thalamic neuromodulation is clinically effective in drug-resistant epilepsy, suggesting critical contributions of the thalamus to the epileptogenic process. However, the underlying electrophysiologic mechanisms remain poorly characterized. Converging evidence implicates the thalamus in shaping large-scale functional interactions across the cortex. We hypothesized that ictal changes in thalamic ...
Passive neuromodulation: an energy-driven mechanism for closed-loop suppression of epileptic seizures - For decades, electrical neuromodulation has been used as a therapeutic mechanism to disrupt and desynchronize pathological neural activity in various neurological disorders. Despite notable progress, however, patient outcomes remain highly variable, particularly in medically intractable epilepsy where surgery still provides the greatest chance of seizure freedom. Here we propose passive neuromo...
Gut Microbiome Alterations in Canine Idiopathic Epilepsy: A Pairwise Case-Control Study - CONCLUSION: Our findings suggest a relationship between gut microbiomes and IE. However, the specific mechanism needs to be further investigated.
Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy - Up to 30% of patients with epilepsy have intractable seizures, yet the mechanisms of focal ictogenesis remain unclear. Tissue involvement in ictal regions is heterogeneous, with different regions playing distinct roles in ictogenesis, seizure propagation, and resistance to spread. These roles are reflected in electrophysiologic differences between the seizure focus and the ictal penumbra, where...
Clozapine for treatment-resistant schizophrenia with epilepsy: A case report - CONCLUSION: We report a case of TRS with comorbid epilepsy in which CLOZ therapy was both effective and safe.
Thalamocortical network dynamics in focal epilepsy: SEEG investigation - Thalamic neuromodulation is clinically effective in drug-resistant epilepsy, suggesting critical contributions of the thalamus to the epileptogenic process. However, the underlying electrophysiologic mechanisms remain poorly characterized. Converging evidence implicates the thalamus in shaping large-scale functional interactions across the cortex. We hypothesized that ictal changes in thalamic ...
Passive neuromodulation: an energy-driven mechanism for closed-loop suppression of epileptic seizures - For decades, electrical neuromodulation has been used as a therapeutic mechanism to disrupt and desynchronize pathological neural activity in various neurological disorders. Despite notable progress, however, patient outcomes remain highly variable, particularly in medically intractable epilepsy where surgery still provides the greatest chance of seizure freedom. Here we propose passive neuromo...
Gut Microbiome Alterations in Canine Idiopathic Epilepsy: A Pairwise Case-Control Study - CONCLUSION: Our findings suggest a relationship between gut microbiomes and IE. However, the specific mechanism needs to be further investigated.
Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy - Up to 30% of patients with epilepsy have intractable seizures, yet the mechanisms of focal ictogenesis remain unclear. Tissue involvement in ictal regions is heterogeneous, with different regions playing distinct roles in ictogenesis, seizure propagation, and resistance to spread. These roles are reflected in electrophysiologic differences between the seizure focus and the ictal penumbra, where...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.