Epilepsy and Seizure News
Understanding epilepsy: Seven ways to respond to an epileptic seizure -
At the forefront of epilepsy research and treatment is the University of Alabama at Birmingham Epilepsy Center, a collaborative initiative between the UAB Department of Neurology and UAB Hospital, ...
What to know about epilepsy and how to recognize a seizure -
In today’s Health Headlines, what you need to know about epilepsy — including how to recognize a seizure, how to help someone who’s having one, and how people with seizures can maximize quality of ...
What to know about epilepsy and seizure first aid -
November is Epilepsy Awareness Month. Many people may already be aware of the condition from its prevalence in medical dramas, but that portrayal is often exaggerated and does not fully encapsulate ...
What are the main causes of epilepsy? -
Medically reviewed by Diana Apetauerova, MD Key Takeaways Epilepsy is often linked to genetic factors, brain injuries, infections, or developmental disorders. Seizures are sudden bursts of electrical ...
EPILEPSY AWARENESS: Local neurologist explains condition & seizure first aid -
COLUMBUS, Ga. (WRBL) — Local experts say epilepsy is not a condition to be afraid of. Piedmont Columbus Regional pediatric neurologist Pierre Fequiere treats patients with epilepsy every day and knows ...
Understanding epilepsy: Types of seizures, symptoms and first aid -
Epilepsy is a common neurological disorder that affects millions of people worldwide. Characterized primarily by seizures, epilepsy can present in a variety of ways depending on the individual and the ...
New tools map seizures in the brain, improve epilepsy treatment -
Two new models could solve a problem that's long frustrated millions of people with epilepsy and the doctors who treat them: how to find precisely where seizures originate to treat exactly that part ...
Neurofeedback News
Medical News Today
PubMed
Inhibition of the SGLT2/NHE-1/NLRP3 Signaling Axis Attenuates Neuroinflammation and Oxidative Stress to Ameliorate Seizures and Cognitive Impairment in Epileptic Mice -
CONCLUSION: Our findings unveil the SGLT2/NHE-1/NLRP3 axis as a master regulator that integrates oxidative stress and neuroinflammation in epilepsy. Notably, we identify this as a neuron-intrinsic pathway, and its targeted inhibition of this axis restores redox homeostasis and attenuates neuroinflammation, leading to improved seizure control and cognitive function. This study provides a novel m...
Retrospective comparison of interictal cardiac biomarkers of SUDEP or near-SUDEP with PNES patients -
Interictal QTc-interval changes and heart rate variability (HRV) are reported in people succumbing to sudden unexpected death in epilepsy (SUDEP). We evaluated cardiac biomarkers recorded during video-EEG monitoring in nine SUDEP/near-SUDEP cases and compared them to 9 age- and gender-matched people with psychogenic nonepileptic episodes (PNES) treated with anti-seizure medications (ASMs). QT-i...
Integrated genotype-phenotype function analysis reveals distinct pathogenic mechanisms for cognitive impairment in KCNQ2-related disorders -
OBJECTIVE: Pathogenic variants of KCNQ2 lead to a spectrum of disorders including self-limited familial neonatal-infantile epilepsy (SeL(F)NIE), developmental and epileptic encephalopathies (DEEs), and neurodevelopmental disorders (NDDs) with intellectual disability (ID). This study aimed to delineate the clinical progression and underlying pathogenesis of these disorders. Particularly, we unra...
mHealth adherence in pediatric epilepsy: Outcomes of a sequential, multiple assignment, randomized trial (SMART) -
OBJECTIVE: Nonadherence to antiseizure medications in pediatric epilepsy affects ~60% of youth. The aim of this multisite two-stage sequential, multiple assignment, randomized trial (SMART) was to evaluate the effectiveness of mHealth intervention strategies for improving adherence in caregivers of young children with epilepsy, particularly those who are underserved. It was hypothesized that pa...
'Pseudo-ataxic' negative myoclonic status in developmental and epileptic encephalopathy with spike-wave activation in sleep: Utility of ACTH therapy beyond west syndrome -
CONCLUSION: This case demonstrates for the first time the potential of ACTH in refractory DEE-SWAS with negative myoclonic status epilepticus, wherein conventional immunomodulation fails. The sustained clinical and electrographic improvement highlights the broader neuro-modulatory mechanisms of ACTH and supports its consideration in treatment algorithms. Larger prospective studies are warranted...
Clinical outcomes and learning curve of MRgLITT system for drug-resistant epilepsy in China: A single-center retrospective study -
OBJECTIVE: Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive technique that allows for real-time magnetic resonance imaging (MRI) monitoring and precise ablation of epileptogenic lesions. This study reports our initial clinical experience with a domestically developed MRgLITT system in patients with drug-resistant epilepsy (DRE) and evaluates its eff...
Science Daily