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Outcomes of patients with functional/dissociative seizures after neurobehavioral therapy -
CONCLUSIONS: The results of this study suggest that manualized NBT effectively reduces seizure frequency and improves symptom comorbidities and quality of life for patients with FDS. This study supports the value of psychotherapy as a primary or adjunct treatment modality for patients with FDS.
Understanding the lived experience of epilepsy through creative engagement workshops: Insights beyond patient-generated questions -
CONCLUSIONS: Patient-generated questions identify information needs, whereas creative engagement methods illuminate the emotional and social experiences in daily life underlying those needs. This richer understanding can guide the development of more authentic and patient-centred care. The development of online versions of the creative workshops is now underway, aiming to extend access to the b...
Concordance between magnetoencephalography and intracranial EEG and association with surgical outcomes in MRI-negative epilepsy -
CONCLUSIONS: MEG identified localizing interictal abnormalities in approximately two-thirds of this selected cohort of patients with MRI-negative DRE. When MEG was localizing and an iEEG-defined SOZ was identified, lobar-level concordance was common. Because MEG could inform invasive evaluation, these findings reflect concordance within an MEG-informed clinical workflow rather than independent ...
Shunt outcomes following multidisciplinary ventriculoperitoneal shunt placement with general surgery involvement -
CONCLUSIONS: In a multicenter cohort, VPS placement with concurrent abdominal GS procedures was associated with lower 90-day VPS reoperation, conversion to alternative CSF diversion, and mechanical shunt complications, without increases in mortality, infection, or other 90-day complications. These findings support consideration of a multidisciplinary approach to distal catheter placement when G...
Assessment of Compliance With the National Institute for Health and Care Excellence Guidance in the Management of Patients Referred Following a First Suspected Seizure: A Retrospective Clinical Audit -
Introduction A first suspected seizure requires timely specialist assessment and appropriate investigation to establish an accurate diagnosis, identify seizure mimics, assess the risk of recurrence, and provide appropriate safety advice. The National Institute for Health and Care Excellence (NICE) guidance recommends urgent specialist assessment following a first suspected seizure, alongside ap...
Quantifying Interictal Spike Asymmetry on Scalp EEG to Lateralize the Seizure-Onset Zone in Temporal Lobe Epilepsy -
BACKGROUND AND OBJECTIVES: Accurate lateralization of the seizure focus in temporal lobe epilepsy (TLE) is critical for surgical planning. Our current approach of capturing multiple seizures often misses bilateral disease because of seizure-onset variability. Interictal spike rate asymmetry is a promising marker of TLE laterality. However, visual analysis has low interrater reliability and cann...
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