Epilepsy News

Seizures Temporally Associated With SSRI Treatment: A Two-Case Report Exploring Agomelatine as a Treatment Alternative - Selective serotonin reuptake inhibitors (SSRIs) are widely used as first-line treatments for major depressive disorder (MDD) and anxiety disorders, with common adverse effects, including sexual dysfunction, anxiety, insomnia, and appetite changes, although seizures have also been reported, particularly in the presence of risk factors such as older age, family history of epilepsy, neurological c...

Early Psychiatric Manifestations of Lafora Disease: A Case Report - Lafora disease is a rare genetic progressive myoclonic epilepsy characterized by the onset of epileptic seizures and myoclonus during adolescence, followed by a rapid progression toward neurodegeneration. However, an often underrecognized aspect of this condition is the presence of psychiatric manifestations, particularly depressive and psychotic disorders, which may emerge prior to or concurre...

Beneficial effects of turmeric oil and sunflower seed oil in the rapid kindling rat model of epileptogenesis - CONCLUSIONS: Both vehicle and turmeric oil exerted anti-ictogenic effects in the rapid kindling model, without attenuating kindling-induced gliosis. Notably, turmeric oil showed modest short-term persistence of its anti-ictogenic effects after washout, consistent with either a transient residual pharmacological action or a limited modulation of seizure progression within this paradigm, but not ...

Clinical characteristics and factors associated with preoperative neurodevelopment in children with Rasmussen encephalitis: A single-centre retrospective study of 51 patients - CONCLUSION: Preoperative neurodevelopmental status in children with RE was heterogeneous, with overall scores in the borderline range. Contralateral independent epileptiform discharges were independently associated with lower FSDQ/IQ, although the underlying mechanisms and clinical significance of this association remain uncertain. These findings support close developmental monitoring and indiv...

Beyond seizure control: A qualitative study on the behavioural profiles of self-management in adolescents with epilepsy in western China - CONCLUSION: Recognizing the four distinct self-management profiles among AWEs enables clinicians to develop tailored, stepped intervention strategies that align with each patient's behavioral characteristics, potentially improving early risk identification, transitional care coordination, and long-term quality of life.

Prolonged postictal hypercapnia is associated with delayed recovery of consciousness after generalized convulsive seizure - BACKGROUND: Postictal impairment of breathing and arousal is a significant contributor in many SUDEP cases. Central CO(2) chemoreception, which mediates ventilatory response, is often blunted after generalized convulsive seizures (GCS). It is plausible that the central chemoreceptors that mediate arousal in response to hypercapnia are similarly impaired after GCS, thereby contributing to delaye...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.