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Functional ultrasound assessment of cerebral blood flow and brain connectivity in a pilocarpine-induced acute epileptic seizures in mice -
CONCLUSION: These results demonstrated that CBV exhibited heterogeneous changes across the whole brain, and the overall brain functional network connectivity underwent modifications during acute seizure state of TLE in mice.
A novel de novo QRICH1 variant causing Ververi-Brady syndrome with infantile epileptic spasms syndrome: clinical and genetic analysis -
CONCLUSION: QRICH1 variants underlie Ververi-Brady syndrome. Here we describe a patient with QRICH1-related Ververi-Brady syndrome presenting with IESS. Combined treatment with ACTH and vigabatrin was followed by seizure freedom, electroencephalographic (EEG) improvement, and developmental gains in this patient. This report expands the genotypic and phenotypic spectrum of the disorder.
Refractory hypokalemia associated with levetiracetam: a case report -
Levetiracetam (LEV) is frequently prioritized in epilepsy management due to its minimal drug-drug interactions and perceived metabolic neutrality. However, its potential involvement in severe electrolyte disturbances remains scarcely documented. We describe a 36-year-old male admitted for status epilepticus and initiated on a dose-escalated LEV regimen (2000 mg/day). The clinical course was com...
Hybrid CNN transformer framework for EEG-based epileptic seizure detection -
Early diagnosis and early intervention are important in the treatment of epilepsy, so detecting epileptic seizures from EEG signal is very important. However, the non-stationary nature of EEG signals, inter-subject variability and artefacts arising from noise are major challenges to the development of a robust, generalisable and real-time automated seizure detection system. Many current deep le...
Brain network construction and analysis for epilepsy: A methodology review -
Epilepsy is increasingly understood as a network disorder, prompting widespread application of graph-theoretic methods to electrophysiological and neuroimaging data. The resulting methodological landscape-spanning functional, structural, and effective connectivity, together with dynamic and multimodal extensions-has grown fragmented. Following PRISMA guidelines, we screen Web of Science, IEEE X...
Real-time EEG-based epileptic seizure prediction using artificial intelligence: A systematic review -
CONCLUSION: Despite high accuracy, the lack of prospective validation and standardised deployment metrics remains a major barrier to clinical translation. We propose an operational framework requiring standardised evaluation (PS/PI/EXT), explicit end-to-end latency budgets, and prospective FAR reporting per 24 h, to ensure clinical viability and patient outcomes.
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