Epilepsy News

Self-limited epilepsy with centrotemporal spikes (SeLECTS) with spike-and-wave activation in sleep (SWAS): clinical characteristics and electroencephalogram outcomes at the 2-year follow-up - CONCLUSIONS: In this study, we identified five independent risk factors for persistent SWAS and developed a predictive nomogram. This model demonstrates excellent predictive performance and may serve as a valuable clinical tool for predicting EEG outcomes and guiding clinical management in children with SeLECTS and SWAS.

Comparison of postoperative recovery indicators between stereoelectroencephalography and subdural grid electrode implantation for drug-resistant epilepsy - CONCLUSIONS: Compared with SDG, SEEG was associated with reduced blood loss, earlier resumption of oral intake, and fewer antiemetic administrations. These findings suggest that SEEG may offer early postoperative recovery after intracranial electrode implantation.

Atrial fibrillation as an independent predictor of early epileptic seizures after acute ischemic stroke - CONCLUSIONS: EES after AIS are independently associated with cortical involvement, hemorrhagic transformation, atrial fibrillation, hypertension, and advanced age. Recognition of these factors may support early EEG monitoring and individualized management of patients at increased seizure risk.

Uridine-responsive epileptic encephalopathy: Precision treatment across the age spectrum - a case series - CONCLUSIONS: CAD deficiency should be considered in patients with refractory epilepsy and unexplained anaemia. Early genetic diagnosis and initiation of uridine therapy can result in significant neurological and haematological improvement. Securing access to uridine is essential to improve outcomes in this otherwise devastating disorder.

Interictal spectral EEG features associated with thalamocortical dysfunction and seizure burden in childhood absence epilepsy - CONCLUSION: CAE is associated with distinct interictal spectral alterations, including reduced β/θ ratio and increased frontal theta and alpha power, which correlate with seizure burden. These findings suggest potential electrophysiological correlates of thalamocortical dysfunction that warrant validation in larger prospective studies.

Brain-age defines a structural signature of outcomes after vagus nerve stimulation in children - CONCLUSION: Developmental structural differences can be summarized using a robust, single-metric biomarker that reflects both disease burden and treatment responsiveness. BrainAGEgap may support individualized prognostic assessment and improve clinical decision-making in pediatric DRE undergoing neuromodulation.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.