Epilepsy News

What to know about epilepsy and seizure first aid - November is Epilepsy Awareness Month. Many people may already be aware of the condition from its prevalence in medical dramas, but that portrayal is often exaggerated and does not fully encapsulate ...

Understanding epilepsy: Seven ways to respond to an epileptic seizure - At the forefront of epilepsy research and treatment is the University of Alabama at Birmingham Epilepsy Center, a collaborative initiative between the UAB Department of Neurology and UAB Hospital, ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

First seizure clinic provides visit, pediatric epilepsy diagnosis in less than a week - Please provide your email address to receive an email when new articles are posted on . The model expedites access to specialists after a first seizure. The mean time between the referral and the ...

Why Early Detection of Seizures and Epilepsy Is so Important - For parents, a child having a seizure is one of the most frightening experiences imaginable. While many childhood seizures are brief and isolated, others are more serious and persistent. To make the ...

In vivo adenine base editing ameliorates Dravet syndrome phenotypes in a mouse model - Dravet syndrome (DS) is a severe neurodevelopmental disorder characterized by drug-resistant epilepsy, temperature-sensitive seizures, cognitive impairment, and a high incidence of sudden unexpected death in epilepsy (SUDEP). DS is caused by loss-of-function variants in SCN1A, which encodes the α subunit of the voltage-gated sodium channel (Na(v)1.1). Current approved treatments manage symptoms...

Prime editing of a pathogenic Scn1a allele ameliorates seizure phenotypes in a GEFS(+) mouse model - Generalized epilepsy with febrile seizures plus (GEFS^(+)) is an inherited epileptic disorder predominantly linked to autosomal-dominant, loss-of-function mutations in the sodium voltage-gated channel α subunit 1 (SCN1A) gene, which encodes the α subunit of the neuronal voltage-gated sodium ion channel type 1 (Na(V)1.1). Reduced Na(V)1.1 function in γ-aminobutyric acid (GABA)-ergic interneurons...

Beyond seizure control: Identifying deficits in cognitive networks in absence epilepsy - Cognitive impairments are common in absence epilepsy, yet the neural basis of these deficits remains largely unknown. Communication between the thalamic reuniens nucleus and the prefrontal cortex is critical for flexible behavior. Here, we identify a disruption of this pathway in mice with absence epilepsy. This dysfunction leads to impaired cognitive flexibility and altered cortical inhibition...

Inhibition of aerobic glycolysis suppresses ferroptosis via activation of the AMPK-FoxO3a pathway in epileptic rats - CONCLUSION: Inhibition of aerobic glycolysis attenuates seizure-induced ferroptosis through activation of the AMPK-FoxO3a pathway. These findings establish a mechanistic link between metabolic reprogramming and ferroptosis in epilepsy and suggest that targeting aerobic glycolysis may represent a promising therapeutic strategy for neuroprotection in epilepsy.

Insular morphological abnormalities in focal to bilateral tonic-clonic seizures - CONCLUSION: Our results supported brain network abnormalities related to FBTCS and highlighted the value of insula, particularly its subregions, in identifying FBTCS+ patients and predicting lateralization at the individual level.

5-(Benzofuran-2-yl)-3-(2-chloro-4-fluorobenzyl)-1,3,4-oxadiazol-2(3H)-one (GM-90663) Alleviates Dravet Syndrome via Inhibiting Monoamine Oxidase Activity - Dravet syndrome (DS) is a severe, catastrophic childhood epilepsy predominantly caused by loss-of-function mutations in the SCN1A gene, which encodes the voltage-gated sodium channel Na(v)1.1. In this study, we evaluated the therapeutic potential of 5-(Benzofuran-2-yl)-3-(2-chloro-4-fluorobenzyl)-1,3,4-oxadiazol-2(3H)-one (GM-90663), a novel small molecule designed to address the complex pathop...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.