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Thalamic interictal epileptic and non-epileptic events during NREM sleep in patients with focal epilepsy: a Stereo-EEG study -
BACKGROUND: Thalamic recordings are increasingly incorporated into stereo-electroencephalography (SEEG) evaluations of drug-resistant focal epilepsy to guide neuromodulation targeting. Human thalamic electrophysiology, however, is poorly defined, limiting the distinction between pathological and physiological activity. Here, we characterised interictal epileptic and non-epileptic events during ...
The TeleEPI Feasibility Study -
CONCLUSION: We expect to gain valuable insights into the feasibility and clinical utility of telemedicine in the care of epilepsy patients through both the TeleEPI project and clinical study.
Exploring human GABA transporter 3 binders for epilepsy through quantum reactivity analysis, molecular dynamics, machine learning prediction, and network pharmacology -
CONTEXT: Drug-resistant epilepsy (DRE) remains a major therapeutic challenge, affecting millions of patients globally who do not respond to conventional antiepileptic medications. Recent evidence highlights GABA transporter 3 (GAT3), a glial subtype responsible for regulating extracellular GABA levels, as a promising molecular target for seizure control. Despite its therapeutic potential, selec...
A Brain-Permeable Selenocyanate Near-Infrared (NIR) Probe Platform for H2S Dynamics Imaging: Insights into Redox Homeostasis and Antiepileptic Therapy -
The spatiotemporal dynamics of hydrogen sulfide (H(2)S) in the living brain remain elusive, primarily due to the lack of molecular probes that can concurrently resist biothiol interference, cross the blood-brain barrier (BBB), and yield reliable in vivo signals.This work presents a selenocyanate-based sensing trigger relying on a specific H(2)S-initiated cascade cyclization that exhibits superi...
Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic-clonic seizures -
OBJECTIVE: Most therapies for drug-resistant epilepsy (DRE) focus on focal-onset seizures, the most common seizure types. Studying primary generalized tonic-clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment difficulties. While vagus nerve stimulation (VNS) therapy is globally established in DRE with focal-onset seizures, approved indications vary by region. This stud...
Integrating Therapeutic Drug Monitoring and Metabolomics to Explore Interindividual Variability in Lamotrigine Response in Epilepsy -
CONCLUSION: Higher LTG plasma concentrations were associated with better seizure control, and VPA co‑administration enhances LTG exposure and efficacy. The distinct amino acid profile in high-concentration responders suggests amino acid metabolism and redox balance may modulate LTG efficacy.
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