Epilepsy and Seizure News
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Voxel-based morphometry in mesial temporal lobe epilepsy surgery: an exploratory Moroccan pilot study -
CONCLUSION: Implementing this VBM workflow was feasible within a newly established Moroccan epilepsy surgery programme. The findings are preliminary, descriptive, and hypothesis-generating; they do not establish disease mechanisms or postoperative reorganization. Larger, adequately powered longitudinal studies using dedicated repeated-measures models and multimodal quantitative MRI are required.
Reduced inhibition of hippocampal adult-born granule cells by parvalbumin interneurons after TBI -
Traumatic brain injury (TBI) is one of the leading causes of acquired temporal lobe epilepsy. TBI drives hippocampal circuit rearrangements that may contribute to increased seizure risk, such as altered inhibitory circuit function and aberrant post-traumatic neurogenesis. In the hippocampal dentate gyrus, adult-born dentate granule cells (DGCs) acquire inhibitory synaptic inputs from parvalbumi...
Parvalbumin interneurons and dentate gyrus homeostatic dysregulation shape epileptogenesis in Angelman syndrome model mice -
Understanding how neural circuits transition from seizure-resistant to seizure-prone is essential for developing improved epilepsy therapies. Here, we study this process by leveraging the heightened susceptibility to seizure kindling of Angelman syndrome (AS) model mice, which lack the maternal Ube3a (mUbe3a) allele. We identify parvalbumin-expressing (PV+) interneurons as critical gatekeepers;...
Perampanel improves cognitive function in epilepsy by targeting AMPA receptor subunit GluR2-mediated endoplasmic reticulum stress and synaptic plasticity -
CONCLUSION: GluR2-mediated ERS may involve the improved effects of Perampanel in cognitive function of epilepsy patients by promoting synaptic plasticity.
mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis -
Tuberous sclerosis complex (TSC) is a genetic neurodevelopmental disorder characterized by focal brain malformations called cortical tubers, which are associated with severe, intractable epilepsy¹. Tubers are thought to result from somatic second-hit mutations that disrupt the TSC1 or TSC2 genes in neural progenitor cells, driving hyperactive mTORC1 signalling². Glial abnormalities are commonly...
Development and psychometric validation of a screening tool of psychosocial risk factors in patients with epilepsy: the ARisE study protocol -
INTRODUCTION: Epilepsy is one of the most common neurological chronic diseases worldwide. While medications can control seizures, about one-third of people with epilepsy have drug-resistant epilepsy and continue to experience seizures. Psychosocial burdens are a major concern, as they are linked to seizure worsening and vice versa. Early identification of risk factors for psychosocial burdens c...
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