Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Beyond a Single Etiology: Tachy-Brady Syndrome and Possible Coexisting Focal Epilepsy Presenting as Transient Loss of Consciousness -
Transient loss of consciousness has overlapping cardiac and neurologic causes, and distinguishing syncope from seizure can be difficult. The co-occurrence of a primary cardiac rhythm disorder with a possible coexisting epileptic process is infrequently reported, as most cases instead describe one condition mimicking or triggering the other. We present a case of a 77-year-old woman with hyperten...
An evaluation of cytokine responses and antiseizure medication levels during mild upper respiratory infections in children with epilepsy - CONCLUSION: The findings of this study suggest that mild upper respiratory tract infections do not cause clinically significant alterations in serum valproate or carbamazepine levels.
Structural optimization and anticonvulsant evaluation of aminoalkyl indole derivatives - A series of twenty-two novel aminoalkyl indole derivatives were rationally designed and synthesized via Friedel-Crafts acylation followed by nucleophilic substitution, targeting the cannabinoid receptor 2 (CB2R) as a novel approach for anticonvulsant therapy. Systematic structural optimization of the indole C-3 cycloheptanecarbonyl moiety and the N-1 aminoalkyl side chain was conducted to balan...
Astrocytic circular RNA SLC8A1 boosted CEBPB/NLRP3-triggered pyroptosis by stabilizing PTBP1 to drive neuroinflammation in temporal lobe epilepsy - CONCLUSION: Our findings identify a novel circSLC8A1/PTBP1/CEBPB signaling axis that mediates astrocytic inflammation and pyroptosis in TLE. Targeting circSLC8A1 may represent a promising therapeutic strategy for epilepsy.
The role of Vagus nerve stimulation in epilepsy with eyelid myoclonia - A case series - CONCLUSIONS: From this small case series of patients with EEM, four (33.3%) were responders to VNS, with improvement noted in multiple seizure types. This indicates the potential role of VNS for patients with EEM.
Quality of life and depressive symptoms in older adults: findings from an integrated epilepsy self-management data set - CONCLUSIONS: Among OAWE, depressive symptoms are strongly linked to reduced QOL. These findings underscore the importance of integrated mental health screening and intervention for OAWE.
An evaluation of cytokine responses and antiseizure medication levels during mild upper respiratory infections in children with epilepsy - CONCLUSION: The findings of this study suggest that mild upper respiratory tract infections do not cause clinically significant alterations in serum valproate or carbamazepine levels.
Structural optimization and anticonvulsant evaluation of aminoalkyl indole derivatives - A series of twenty-two novel aminoalkyl indole derivatives were rationally designed and synthesized via Friedel-Crafts acylation followed by nucleophilic substitution, targeting the cannabinoid receptor 2 (CB2R) as a novel approach for anticonvulsant therapy. Systematic structural optimization of the indole C-3 cycloheptanecarbonyl moiety and the N-1 aminoalkyl side chain was conducted to balan...
Astrocytic circular RNA SLC8A1 boosted CEBPB/NLRP3-triggered pyroptosis by stabilizing PTBP1 to drive neuroinflammation in temporal lobe epilepsy - CONCLUSION: Our findings identify a novel circSLC8A1/PTBP1/CEBPB signaling axis that mediates astrocytic inflammation and pyroptosis in TLE. Targeting circSLC8A1 may represent a promising therapeutic strategy for epilepsy.
The role of Vagus nerve stimulation in epilepsy with eyelid myoclonia - A case series - CONCLUSIONS: From this small case series of patients with EEM, four (33.3%) were responders to VNS, with improvement noted in multiple seizure types. This indicates the potential role of VNS for patients with EEM.
Quality of life and depressive symptoms in older adults: findings from an integrated epilepsy self-management data set - CONCLUSIONS: Among OAWE, depressive symptoms are strongly linked to reduced QOL. These findings underscore the importance of integrated mental health screening and intervention for OAWE.
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.