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Vagus nerve stimulation as an add-on therapy in patients with epilepsy: a prospective, multicenter, real-world study in China -
CONCLUSIONS: VNS is an effective and safe adjunctive treatment for epilepsy, reducing seizure frequency and significantly improving quality of life, with a cumulative effect over time.
Enhanced hippocampal miR-32-5p promotes neuronal hyperexcitability and epileptic seizures by targeting KCC2 -
MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression at the post-transcriptional level and are involved in the pathogenesis of epilepsy. Although miRNA-32-5p (miR-32-5p) is known to be significantly upregulated at seizure onset in patients, its function and mechanism in neuron hyperexcitability and epileptic seizures remain unclear. In this study, we demonstrated elevated le...
Current Clinical Evidence on Nose-to-Brain Drug Delivery -
Intranasal delivery is increasingly recognised as a promising strategy for direct drug transport to the brain via the nose-to-brain pathway, bypassing the blood-brain barrier and improving therapeutic efficacy. This approach has shown potential in the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, and acute psychiatric cond...
Clinical significance of subclinical seizures in epilepsy presurgical evaluation: A systematic review and meta-analysis -
OBJECTIVE: Subclinical seizures (SCSs) remain an understudied aspect of presurgical evaluation in patients with drug-resistant epilepsy (DRE), with uncertain prevalence, distribution among epilepsy types, and predictive value for surgical outcomes. This systematic review and meta-analysis aims to explore the occurrence of SCSs, their concordance with the seizure-onset zone (SOZ), and their asso...
Clinical subtypes and sleep-wake evolution pattern in epilepsy manifesting as sleep-related seizures -
OBJECTIVE: Epilepsy manifesting as sleep-related seizures (EpSRS) represents a common but heterogeneous group. This study aimed to identify distinct clinical subtypes of EpSRS and explore alterations in sleep-wake seizure rhythms over the disease course.
Seizure Action Plans Beyond the Neurology Clinic: What Emergency, School, and Primary Care Teams Need to Know for Children With Epilepsy -
Most seizures in children with epilepsy occur outside the neurology clinic. Seizure action plans (SAPs) are designed to extend the neurologist's management plan into these settings. Early SAPs primarily targeted caregivers, while current plans target not only caregivers but also teachers, other medical providers, and anyone else who may be able to intervene on behalf of these children. Some stu...
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