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Targeting oxidative stress pathways in epilepsy: mechanistic insights into the role of ascorbic acid -
Epilepsy, a neurological disease, is linked to oxidative stress generated due to the synchronous firing of neurons during seizures and use of antiseizure medications (ASMs). Among commonly prescribed ASMs, carbamazepine, valproate, and levetiracetam have been implicated in modulating oxidative stress-related signaling pathways, including Nrf2, NF-κB, and MAPK. Ascorbic acid, a potent antioxidan...
The Ketogenic Diet Fails to Mitigate Seizures and Neuroinflammatory Responses in a Mouse Model of Virus-Induced Epilepsy -
OBJECTIVE: The ketogenic diet (KD) is a high-fat, low-carbohydrate intervention widely used to treat drug-resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota-dependent mechanisms. Additionally, recent studies suggest that the anticonvulsant effects of KD require the gut microbiota, with taxa such as Akkermansia and Parabacteroides contribu...
Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model -
Stress is a commonly reported seizure precipitant and may contribute to the development of psychiatric comorbidities in epilepsy, yet how chronic stress interacts with epileptic circuits remains poorly understood. We investigated the impact of chronic restraint stress on physiological, behavioral, and synaptic outcomes in a mouse model of Dravet syndrome, specifically corticotropin-releasing fa...
Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model of SCN2A -Related Disorders -
SCN2A -related disorders result from pathogenic variants in the gene encoding for the voltage-gated sodium channel Nav1.2. Collectively, these disorders result in variable age of onset epilepsy, autism spectrum disorder, and epileptic encephalopathies. While the mechanisms of haploinsufficiency resulting in autism spectrum disorder have been explored in detail, few studies report the impact of ...
Quantifying cognitive effort's impact on suppression of epilepsy-associated after discharges -
Epilepsy affects over 50 million people worldwide, with approximately 30% of patients experiencing seizures that are resistant to medication, significantly impacting their quality of life. In this study, we analyze a unique dataset of intracranial electroencephalography (iEEG) recordings from patients undergoing functional brain mapping prior to epilepsy surgery. During this procedure, electrod...
Assessment of Routine, On-Demand Electroencephalograms for Seizure Detection in the Intensive Care Unit of a Major Saudi Tertiary Center -
CONCLUSION: Routine EEGs play a vital role in investigating altered mental status in ICU patients, particularly for seizure evaluation. Age, ICU admission due to status epilepticus, and a history of epilepsy are significant factors associated with seizure occurrence on EEG. Future studies should validate these findings and explore the comparative effectiveness of routine and continuous EEGs in ...
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