Epilepsy News

Beyond the Onset: The Diagnostic Value of Late Significant Patterns in Scalp Ictal EEG - PurposeThis study aimed to systematically assess ictal scalp electroencephalography (EEG) evolution by examining both ictal onset characteristics and late significant patterns (LSPs) in adults with focal epilepsy. We aimed to investigate their individual and collective descriptive roles in seizure lateralization and localization, as well as their correlation with seizure semiology, interictal E...

Contusion Volume is a Cross-cohort Predictor of Delayed Seizures after Traumatic Brain Injury - OBJECTIVE: Predicting specific cognitive, psychiatric, and health-related sequelae in patients after acute traumatic brain injury (TBI) remains an important but challenging clinical problem. Acute phase computed tomography (CT) scans acquired show hemorrhagic contusions, a common type of traumatic pathology. However, whether CT-measured contusions predict long-term sequelae is uncertain.

Antiepileptic and antiepileptogenic effects of Lagenaria siceraria aqueous extract (Curcubitaceae) in PTZ-induced kindling in rats - Lagenaria siceraria (Curcubitaceae) is a plant traditionally used in Cameroon to treat epilepsy and other central nervous system disorders. The present study investigated the antiepileptogenic and antiepileptic effects of Lagenaria siceraria in PTZ-induced kindling in rats. Kindling was induced in male rats aged of 2-3 months using a challenging dose of PTZ (70 mg/kg, i.p.) followed by the admi...

A Novel De Novo Frameshift Variant of TBL1XR1 Leads to Neurodevelopmental Disorders and Treatment Experience - CONCLUSION: Our results expanded the pathogenic variant spectrum and treatment of TBL1XR1-related neurodevelopmental disorders.

Thalamo-Lesional Connectivity Signatures of Bilateral Tonic-Clonic Seizures in Focal Cortical Dysplasia-Related Epilepsy - OBJECTIVES: Focal cortical dysplasia (FCD) is the most common etiology of drug-resistant epilepsy in children. Focal to bilateral tonic-clonic seizures (FBTCS) mark a high risk of drug-resistant epilepsy and involve thalamocortical circuitry in their generation and propagation. Using FCD as a model of focal epilepsy, we examined the integrity of thalamocortical circuitry to characterize thalamo...

Towards Interpretable Seizure Detection: An Excitation/Inhibition Dynamic Polynomial Network Framework for Electroencephalography - Epilepsy is a prevalent neurological disorder characterized by recurrent seizures, and electroencephalogram (EEG) signals provide a direct measure of brain activity for detection. Although deep learning achieves high accuracy, it often lacks physiological interpretability. We propose the Excitation/Inhibition Dynamic Polynomial Network (E/I-DynPolyNet), a biologically grounded framework for int...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.