Neurofeedback News
Medical News Today
PubMed
Deep learning discriminates seizures from normal brain oscillations in the electroencephalogram of a rat model of post-traumatic epilepsy -
This study used machine learning to objectively identify seizures in the electroencephalogram of a model of post-traumatic epilepsy based on fluid percussion injury in male rats. We applied transfer learning to a neural-network trained and tested on three potentially distinct electroencephalographic phenotypes: (1) late-onset convulsive seizures associated with rare post-traumatic epilepsy, (2)...
Long-read genome sequencing increases diagnostic yield in a short-read sequencing unsolved developmental epileptic encephalopathy (DEE) cohort -
Developmental epileptic encephalopathy (DEE) comprises neurodevelopmental disorders with early-onset seizures and developmental impairment. Despite >900 implicated genes, many patients remain undiagnosed after short-read sequencing (SRS). We assessed long-read genome sequencing (LR-GS) in 38 previously unsolved infantile-onset DEE probands (10 singletons, 28 trios). Variant detection included s...
Old drugs, new indications: Effectiveness of amantadine for epileptic encephalopathy in paediatric patients with spike-wave activation in sleep or refractory absence seizures -
CONCLUSION: Amantadine is an effective and safe treatment for drug-resistant generalised epilepsy, especially in patients with D/EE-SWAS.
A cohort approach to focal cortical dysplasia type II: A 10-year management overview at an adult epilepsy referral centre -
CONCLUSIONS: FCD type II is not always associated with drug-resistant epilepsy. Diagnosis does not rule out the presence of functional seizures. Because of the need for neurophysiological and protocolised neuroimaging tests, these patients should be managed at expert units within referral centres. Surgery achieves clinical improvement in most cases, with complete seizure freedom in approximatel...
Phenotype and genotype of AKT3-related disorders -
OBJECTIVES: To systematically define and elucidate the relationship between clinical manifestations and genetic features of somatic and germline AKT3 variants.
Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus -
CONCLUSIONS AND RELEVANCE: Results of this cross-sectional study suggest that acute neuroaxonal injury, as reflected by elevated NfL levels, was substantially greater in cNORSE than in the cohorts with eSE and in controls without status epilepticus. The rapid early rise in NfL highlights a narrow therapeutic window, emphasizing the need for prompt, effective, and potentially neuroprotective int...
Science Daily