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Right amygdala ablation reduces maladaptive negative interpretation bias and symptoms in a patient with post-traumatic stress disorder -
Negative interpretation bias - the tendency to perceive ambiguous stimuli as threatening - is a core cognitive distortion underlying post-traumatic stress disorder (PTSD). The amygdala, a key structure in fear processing, is implicated in PTSD-related hypervigilance and heightened fear perception, yet direct causal evidence linking amygdala function to negative interpretation bias remains limit...
Cortistatin neurons in the prelimbic cortex regulate seizure susceptibility in female mice via BDNF-TrkB signaling -
The risk of developing psychiatric disorders, particularly stress-related disorders such as major depressive disorder (MDD) and post-traumatic stress disorder (PTSD), is increased three fold in patients with epilepsy. While this increased risk may arise as a consequence of living with epilepsy, shared neurobiological mechanisms, particularly dysregulation of GABAergic signaling, may also contri...
Lipoxygenase (LOX) signaling in epilepsy: Pathophysiology and therapeutic prospects -
Epilepsy is a devastating neurological disorder affecting about 1-2% of the global population and is characterized by recurrent, unprovoked seizures that can severely impair quality of life. Despite the availability of antiseizure medications, nearly one-third of individuals with epilepsy continue to experience drug-resistant seizures, underscoring the need for novel therapeutic strategies. Gro...
The seizure embedding map: A spatio-temporal transformer for comparing patients by ictal intracranial EEG features at scale -
Planning invasive treatment for medication-resistant epilepsy depends on interpreting intracranial EEG (iEEG) recordings to identify seizure onset patterns and locations. Clinicians currently rely on multimodal data, experience and literature to recommend treatments. Referencing a new patient's seizures against past cases remains subjective because implant strategies, electrode placements, and ...
Healthcare resource utilization and persistence in children and adults with Dravet syndrome receiving fenfluramine: a retrospective analysis using United States claims data -
CONCLUSIONS: High fenfluramine treatment persistence indicates that children and adults with DS tend to continue with fenfluramine treatment, regardless of their concomitant ASM regimen. Significant reductions in HCRU in were observed in individuals receiving fenfluramine ≥6 months; however, further research is warranted in this area.
Early Electroencephalographic Changes After Ketogenic Diet Initiation Are Associated With Clinical Response in Pediatric Drug-Resistant Epilepsy -
CONCLUSION: Early reduction in IED index on routine sleep EEG is associated with favorable clinical response to the ketogenic diet. Routine EEG assessment may offer supportive electrophysiological information during early follow-up of KD therapy in pediatric drug-resistant epilepsy.
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