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STRADA deficiency impairs cortical interneuron development in humans and mice -
Polyhydramnios, Megalencephaly, and Symptomatic Epilepsy syndrome (PMSE/STRADA-related disease) is a rare neurodevelopmental disorder characterized by megalencephaly, early-onset drug-resistant epilepsy, neurocognitive impairment, and high early mortality, often due to status epilepticus. PMSE is caused by a multiexon deletion in the STRADA/LYK5 gene, encoding STRADA protein, which regulates th...
Stiripentol in Dravet syndrome: preventing prolonged seizures, reducing mortality, and improving value in care -
Dravet syndrome (DS) is a rare and severe developmental and epileptic encephalopathy that begins in infancy. Although nonconvulsive seizures may occur, the syndrome is marked by frequent, prolonged convulsive seizures followed by neurodevelopmental plateau, slowing, or regression. Stiripentol (STP) is an anti-seizure medication (ASM) approved for adjunctive use in DS in countries across Europe,...
Clinical, neurophysiological, and radiological correlates of treatment response in elderly patients with epilepsy -
CONCLUSION: Comprehensive clinical assessment, supported by neurophysiological and radiological findings, may help optimize the diagnosis and effective management of epilepsy in elderly patients.
The impact of rising global temperatures on neurological diseases -
CONCLUSION: While research is expanding, neurological diseases remain an understudied frontier of the climate crisis. Targeted scientific investigation and robust public health strategies are imperative to mitigate the emerging neurological risks of a warming planet.
Caution with self-reported ADHD symptoms in adults with epilepsy: discrepancy between subjective perception and objective cognitive performance -
CONCLUSION: Subjective ADHD symptoms show limited overlap with objectively measured cognitive impairment in people with epilepsy. Attention and executive dysfunction appear to be driven primarily by epilepsy-related factors rather than reported ADHD symptoms, underscoring the need for comprehensive clinical assessment.
After the Spasms: Long-Term Outcomes Following Pulsatile Dexamethasone Therapy for Infantile Epileptic Spasms Syndrome: A Retrospective Observational Study -
CONCLUSIONS: Pulsatile dexamethasone for IESS treatment shows long-term outcomes comparable with other corticosteroids; patients achieving seizure freedom in the examined population received 4-7 pulses. Majority of seizure relapses occur within the first year after therapy, highlighting the importance of close follow-up, and early relapse in structural IESS may warrant prompt referral for epile...
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