Epilepsy News

TSPO-PET Imaging Accurately Localizes Seizure Foci in Drug-Resistant Epilepsy Preoperative Evaluations - A review indicates that TSPO-PET imaging identifies seizure foci in drug-resistant epilepsy even when standard magnetic resonance scans appear normal.

Wearable Tech Advances in Epilepsy Seizure Detection - A narrative review published in Acta Epileptologica on March 2, 2026, synthesizes the current state of wearable digital health technologies in epilepsy management.

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Seizure action plans: More than management tools for epilepsy - Newswise — Historically, seizure action plans have focused on certain high-risk groups — such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters ...

Side-to-side and other complex head movements as ictal signs in epilepsy: A video-EEG case series and review of literature - Side-to-side head shaking is often considered a distinctive clinical sign that differentiates functional seizures from epileptic seizures; however, it may also occur as an ictal phenomenon in focal epilepsy. We retrospectively reviewed all video-telemetry reports of patients with drug-resistant focal epilepsy undergoing presurgical evaluation between 2015 and 2025. All reports were electronical...

Chemogenetic activation of parvalbumin interneurons in the piriform cortex alleviates hippocampal focal seizures - OBJECTIVE: The anterior piriform cortex (APC) is a limbic area closely associated with temporal lobe epilepsy (TLE) but is understudied. Our previous study demonstrated that in the APC, parvalbumin-expressing (PV^(+)) interneurons provide strong inhibition and help maintain excitation-inhibition balance. Here, we examined whether and how APC^(PV) neurons can ameliorate seizure symptoms in TLE.

Clinical characterization and in silico structural analysis of microtubule-related gene variants in eleven patients - CONCLUSION: This study delineates the diverse clinical spectrum across patients harboring MTs variants: TUBA1A variants were predominantly observed in individuals with cortical malformations and potential developmental regression, TUBB2A with severe static neurodevelopmental delay and drug-resistant epilepsy, TUBB4A with motor impairment (with systemic lupus erythematosus noted in one individua...

Visualization of super-selective Wada with computed tomography perfusion: toward a novel option in preoperative functional mapping - INTRODUCTION: The Wada test has long been a well-established method for evaluating hemispheric dominance and functional localization; however, it has not been established as a visualizable functional imaging modality. Recently, the super-selective Wada test (ssWada) has emerged as a technique enabling more localized functional evaluation. By selectively catheterizing distal cerebral arterial br...

CD44 Predisposes the Epileptogenesis of Cortical Tubers by Regulating CASK and Acts as a Potential Biomarker to Identify Epileptogenic Tuber in Tuberous Sclerosis Complex - CONCLUSION: CD44 activation predisposes cortical tubers to epileptogenesis, and could be a potential biomarker for identifying Epi tubers and predicting surgical outcomes in TSC patients.

Delayed diagnosis of tuberous sclerosis complex in a young adult with long-term refractory epilepsy: a case report - CONCLUSIONS: TSC may manifest insidiously for years with refractory epilepsy as its only prominent clinical feature. Comprehensive screening consisting of thorough cutaneous examination, standardized cranial imaging and molecular genetic testing is mandatory for early identification of this disorder. Individualized antiseizure regimens combined with mechanistic target of rapamycin (mTOR) inhibi...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.