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Congenital Long QT Syndrome Type 2: Delayed Diagnosis After a Decade of Seizure-Like Episodes -
BACKGROUND: Congenital long QT syndrome (LQTS) is typically diagnosed in youth. Recognition in advanced age is rare and may be delayed when arrhythmic syncope mimics epilepsy.
Myelin oligodendrocyte glycoprotein antibody-associated isolated seizures in children: a retrospective single-center case series -
CONCLUSION: Myelin oligodendrocyte glycoprotein antibody-associated isolated seizures is a rare and frequently underrecognized phenotype within the spectrum of MOGAD. For school-age children presenting with epileptic seizures, particularly focal motor seizures, along with elevated ESR and CSF pleocytosis, early testing for MOG antibody is recommended in the absence of clinical or radiological e...
Psychiatric comorbidities in pediatric epilepsy: a single-center retrospective study highlighting the burden of depressive symptoms -
INTRODUCTION: Epilepsy in the pediatric population is frequently associated with psychiatric comorbidities. Depression is of particular clinical significance given its elevated incidence and substantial impact on quality of life, treatment adherence, and psychosocial functioning. The prevalence of depression in children with epilepsy ranges from 7% to 14%, considerably higher than the 1-5% repo...
Viral Infection-Induced Epilepsy and the Gut Microbiome Crosstalk -
Viral infections of the central nervous system (CNS) pose a significant risk for seizures, and in some cases, long-term epileptogenesis. Seizure development following viral infection involves diverse CNS mechanisms, with emerging evidence that peripheral factors, including gut microbiome composition and immune-inflammatory responses, also contribute. The gut microbiome is a multifaceted ecosyst...
Epilepsy in paediatric neurofibromatosis type 1: clinical features and associated factors in a single-centere cohort -
CONCLUSIONS: In our cohort, epilepsy occurred in 4.74% of patients. Most had favorable seizure outcomes. Epilepsy was associated with cerebrovascular anomalies and neurodevelopmental comorbidities but not with NBOs or intracranial tumours. These findings suggest that children with NF1 and cerebrovascular abnormalities may warrant particular vigilance for seizures, while those with epilepsy shou...
Advances in neurological disease models and optimization of the laboratory animal environment for reproducible research -
Animal models of neurological diseases have evolved from phenotype-based systems to integrated platforms that link genetics, molecular signaling, synaptic physiology, neural circuits, behavior, and therapeutic responses. Simultaneously, increasingly precise phenotyping has revealed that experimental outcomes are strongly influenced by age, microbiological status, diet, housing, stress, previous...
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