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Concomitant Antiseizure Medications' Influence on Valproic Acid and Levetiracetam Pharmacokinetics in Pediatric Patients -
CONCLUSION: Concomitant enzyme-inducing ASM significantly reduced dose-normalized trough concentrations of VPA and LEV, while neutral co-medications had no effect, highlighting the importance of TDM in pediatric combination therapy.
Post-Stroke Epileptogenesis as a Dynamic Network Process: State-Dependent Biomarkers, Longitudinal Monitoring, and the Concept of an Irritable Brain State -
Post-stroke epilepsy (PSE) is one of the most common long-term neurological complications of stroke and represents a major contributor to disability, reduced quality of life, and increased healthcare burden. Although numerous risk factors and biomarkers have been proposed, many current risk models still emphasize lesion-related predictors and do not fully account for the temporal evolution of p...
Anti-Inflammatory and Antioxidant Strategies in Epilepsy: From Molecular Mechanisms to Threshold Management -
Epilepsy is a multifactorial disorder, yet routine management still focuses on neuronal excitation and insufficient inhibition, with antiseizure medications (ASMs) as the primary therapeutic strategy. This approach fails in roughly one-third of patients who develop drug-resistant epilepsy (DRE). Converging evidence links DRE with neuroinflammation, oxidative stress (OS), and mitochondrial dysfu...
Antiepileptic Drug Adherence in Patients with Epilepsy in Saudi Arabia: A Multicentre Cross-Sectional Study -
Background: Medication adherence is essential for optimal seizure control in epilepsy. However, non-adherence to antiepileptic drugs (AEDs) remains common and contributes to poor clinical outcomes. Evidence on adherence patterns and determinants in Saudi Arabia is limited. This study aimed to evaluate AED adherence and identify factors associated with adherence among patients with epilepsy in S...
4-Phenylbutyrate Rescue in GABRA1 Variants Associated with Developmental Epileptic Encephalopathies: From Cell and Mouse Models to Humans -
Disease variants in GABR genes encoding γ-aminobutyric acid type A receptor (GABA(A)R) subunits are major causes of developmental and epileptic encephalopathies (DEEs). There is no effective treatment for these DEEs, although the GABA(A)R is a major target for antiseizure drugs. We previously identified the therapeutic effect of 4-phenylbutyrate (PBA) in Gabrg2^(+/Q390X) knockin DEE mice and in...
Unraveling the neuroprotective and anti-seizure potential of Calendula officinalis L. extracts in PTZ-induced experimental epilepsy in rats -
To examine the potential neuroprotective and anti-seizure effects of Calendula officinalis L. extracts (COE) in PTZ-induced seizures in rats as well as its effects on hippocampal electrophysiological alterations and signaling pathways implicated in epileptogenesis. A recording electrode was stereotaxically inserted in the CA1 hippocampus area of 36 male rats. Rats were randomly allocated into 3...
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