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Dual Antiglutamate Therapy in Super-Refractory Status Epilepticus After Cardiac Arrest (SUPER-CAT Study) -
BACKGROUND AND OBJECTIVES: The SUPER-refractory status epilepticus (SE) after Cardiac Arrest Treatment (SUPER-CAT) study evaluated the efficacy and safety of dual antiglutamate therapy (combined AMPA and NMDA receptor blockade) in patients with super-refractory SE (SRSE) after cardiac arrest and without unfavorable prognostic indicators.
Diagnosing Lennox-Gastaut syndrome in adulthood: A scoping review of diagnostic challenges and age-related electroclinical evolution -
OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy typically diagnosed in childhood. The 2022 International League Against Epilepsy (ILAE) criteria provide a diagnostic framework built on pediatric data, but their applicability in adulthood is challenged by disease evolution, treatment effects, and missing pediatric records. This scoping review aimed to ide...
Outcomes of patients with post-stroke epilepsy: A scoping review on quality of life, readmissions, costs, seizure recurrence, and medication adherence -
OBJECTIVE: Post-stroke epilepsy (PSE) affects ≈10% of patients with stroke and is associated with adverse health and economic outcomes. We aimed to review published literature on health and economic outcomes for patients with PSE, with a specific focus on quality of life, hospital readmissions, healthcare costs, seizure recurrence, and medication adherence.
How does epilepsy self-management reduce seizure frequency? A causal mediational analysis of a program targeting rural and underserved people with epilepsy and prior negative health events -
OBJECTIVE: A recent clinical trial demonstrates that an epilepsy self-management program, self-management for people with epilepsy and a history of negative health events (SMART), improves seizure reduction. Understanding which aspects of SMART mediated this improvement allows refinement of epilepsy self-management programs for effective inclusion into epilepsy care.
Clinical characteristics and semiological pitfalls in patients with focal epilepsy and functional/dissociative seizures: A comparative analysis of correct and incorrect initial diagnoses -
OBJECTIVE: Both epilepsy and functional/dissociative seizures (FDS) can present with a wide variety of event manifestations which can appear similar in nature and contribute to misdiagnosis. Whereas many studies have addressed the misdiagnosis of FDS as epilepsy, research into the inverse, where epilepsy is mistaken for a functional disorder, remains limited. Accurate differentiation is vital, ...
Transcutaneous auricular vagus nerve stimulation in drug-resistant epilepsy: A randomized, sham-controlled crossover trial with exploratory EEG and MRI response phenotyping -
OBJECTIVE: Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive neuromodulation strategy for drug-resistant epilepsy, but clinical response is heterogeneous. We examined whether electroencephalographic (EEG) and structural magnetic resonance imaging (MRI) phenotypes were associated with active-specific clinical benefit from taVNS.
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