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Right vagal nerve stimulation for epilepsy - case series and systematic review of the literature -
CONCLUSION: This study presents an updated systematic review and institutional case series to better characterize the safety and efficacy of R-VNS. Although traditionally avoided due to cardiac concerns, symptomatic cardiac complications with R-VNS were not regularly documented compared to L-VNS. Instances of unreliable heart rate detection limited the value of cardiac auto-stimulation and shou...
The impact of predator stress on electroshock seizure threshold: insights into GABAergic, glutamatergic, and serotonergic pathways in mice -
CONCLUSION: This study shows that predator stress is associated with increased seizure susceptibility and with downregulation of hippocampal GABAAα1R and 5-HT1AR expression, together with enhanced NF-κB activation and reduced ERK signaling. Pharmacological modulation of GABAergic, glutamatergic, and serotonergic pathways reversed the stress-induced reduction in seizure threshold in this model, ...
Upregulation of Salt-Inducible Kinase 2 Promotes Seizure Susceptibility in Epilepsy -
Salt-inducible kinase 2 (SIK2) is a serine/threonine kinase implicated in several neurological disorders; however, its role in epilepsy remains unclear. In this study, temporal lobe cortex tissues from patients with temporal lobe epilepsy and control subjects, as well as tissues from epilepsy model mice, were analyzed to investigate the expression and function of SIK2. Western blotting and immu...
Syncope due to loss of ventricular capture during sleep misdiagnosed as epilepsy: A case report -
No abstract
Medication Barriers in Pediatric Patients With Epilepsy -
CONCLUSIONS: Screening for medication barriers was feasible for a large cohort of patients in a sustainable and repeatable manner, and barriers were common. Future improvement initiatives may focus on improving common barriers.
Formononetin attenuates neuroinflammation and confers neuroprotection in a pentylenetetrazol-induced kindling model of epilepsy in mice -
Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures, generally associated with an imbalance of neurotransmitters, neuroinflammation, and oxidative stress. Formononetin, a naturally occurring isoflavone found in several medicinal plants, has been previously explored for its anti-inflammatory and antioxidant effects in preclinical studies. These properties s...
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