Epilepsy News

Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model - Maternal inflammatory response (MIR) during early mouse gestation induces a cascade of physiological and behavioral changes associated with autism spectrum disorder (ASD). We have shown that mild MIR causes chronic systemic and brain inflammation, mTOR pathway activation, mild brain overgrowth with regionally specific volumetric changes, sensory processing dysregulation, and repetitive behavior...

Age-related trajectories in Epileptogenesis and neurological function in an experimental model of post-traumatic epilepsy - Post-traumatic epilepsy (PTE) is a debilitating long-term consequence of traumatic brain injury (TBI), yet the influence of age on epileptogenesis and neurological recovery remains insufficiently understood. Despite the high prevalence of TBI in the elderly, few studies have systematically compared long-term outcomes across age groups. In this study, we investigated age-dependent differences in...

Insights from zebrafish models of glutamatergic and GABAergic dysregulation in neurological and psychiatric disorders - The zebrafish (Danio rerio) has emerged as a valuable model system in neuroscience due to their genetic tractability, conserved neuroanatomy, sensitivity to pharmacological manipulations, and suitability for high-throughput screening. Among the many applications of zebrafish in neurobiology, the investigation of glutamatergic (glutamate-based) and GABAergic (gamma-aminobutyric acid-based) signa...

Scalp fast oscillations predict seizure recurrence following a first unprovoked seizure - CONCLUSION: Gamma-range SFOs (≥40 Hz) detected using standard EEG protocols are independently associated with seizure recurrence after FUS and outperform conventional EEG markers. These findings support SFOs as a clinically accessible biomarker for early epilepsy risk stratification, warranting prospective validation in larger and more diverse cohorts.

Predicting the efficacy of classic ketogenic diet therapy in children with refractory epilepsy using dynamic changes in the glucose-ketone index (GKI) - CONCLUSION: A GKI > 9.63 on the first day of CKD therapy may serve as an early-warning indicator of poor treatment response. The early treatment phase-from the second day of halving carbohydrate intake to the first day of CKD-represents a critical window for metabolic transition. Monitoring dynamic changes in GKI and blood ketone may facilitate timely adjustment of intervention strategies.

Infertility treatment in women with epilepsy: A systematic review - CONCLUSION: Available evidence suggests that ART is feasible in women with epilepsy, with most patients maintaining stable seizure control. Hormonal therapy may affect ASM pharmacokinetics and seizure threshold, thereby warranting close monitoring. Larger prospective studies are needed to better define ASM-specific effects and optimize care.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.