Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring - NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...

Seizure or epilepsy? Understanding the critical difference could save lives - A sudden episode of shaking, confusion, or loss of awareness can be frightening - but does it mean epilepsy? Understanding the difference between a seizure and epilepsy is crucial for timely treatment ...

Focal treatment-resistant epilepsy symptoms improved with antiseizure medication - Please provide your email address to receive an email when new articles are posted on . Monthly seizure frequency percentage reduction was 68.73% for the entire study cohort. For those followed up in ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

First seizure clinic provides visit, pediatric epilepsy diagnosis in less than a week - Please provide your email address to receive an email when new articles are posted on . The model expedites access to specialists after a first seizure. The mean time between the referral and the ...

In people with epilepsy, sleeping after a seizure may trigger more seizures - Add Yahoo as a preferred source to see more of our stories on Google. A new study suggests that the memory-forming stage of sleep could be key for understanding epileptic seizures. . | Credit: ...

Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? - Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...

An updated estimate of the proportion of neurocysticercosis among people with epileptic seizures: a systematic review and Bayesian meta-analysis - CONCLUSION: This study provides an updated estimate of NCC proportion among PWES between 1990 and 2023, with implications for burden estimation, and highlights its decline in endemic regions. However, substantial between-study heterogeneity indicates context-specific differences; therefore, the pooled estimates should be interpreted cautiously and not as universally generalizable. Further resea...

Clobazam in pediatric drug-resistant epilepsy: from pharmacology to clinical practice - CONCLUSION: Clobazam demonstrates consistent efficacy as adjunctive therapy in pediatric drug-resistant epilepsy, with the strongest evidence supporting its use in LGS. Individualized treatment informed by CYP2C19 genotyping and therapeutic drug monitoring can optimize clinical outcomes. This review provides a comprehensive reference for the rational clinical use of clobazam.

Long-term seizure outcomes and factors associated with response to adjunctive everolimus in TSC-associated epilepsy - CONCLUSION: Adjunctive everolimus was associated with sustained long-term seizure reduction in this real-world cohort. In exploratory analyses, fewer involved organ systems and fewer baseline ASMs were associated with favorable treatment response. These findings require validation in larger prospective cohorts.

CARM1 as a therapeutic target: The future of disease-modifying therapies for epilepsy - Epilepsy is a chronic neurological condition characterised by persistent or recurrent spontaneous seizures caused by aberrant and hyper-synchronisation of neurons. It is one of the leading causes of neurological problems affecting over 50 million people all around the globe, and at present, disease-modifying therapeutic agents are not widely available. This intricate set of molecular processes,...

Neuronal monocarboxylate transporter 2 is downregulated and aggravates seizures in a rat model of infantile epileptic spasms - Infantile epileptic spasms syndrome (IESS) is an age-dependent epileptic encephalopathy of the developing brain, yet its underlying mechanisms remain unclear. Monocarboxylate transporter 2 (MCT2) maintains cerebral metabolic homeostasis via energy substrate transport, but its role in IESS epileptogenesis is unknown. We found that MCT2 was predominantly expressed in neurons and downregulated in ...

Electroclinical and neuroradiological evolution in pediatric and adult patients with Rasmussen encephalitis - CONCLUSION: RE demonstrated heterogeneous electroclinical and neuroradiological evolution across pediatric and adult patients. The coexistence of an older age profile and a predominance of left hemisphere involvement may suggest age-related phenotypic variability. Early MRI abnormalities may precede overt hemispheric atrophy, highlighting the importance of longitudinal evaluation for timely dia...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.