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Integrating Therapeutic Drug Monitoring and Metabolomics to Explore Interindividual Variability in Lamotrigine Response in Epilepsy -
CONCLUSION: Higher LTG plasma concentrations were associated with better seizure control, and VPA co‑administration enhances LTG exposure and efficacy. The distinct amino acid profile in high-concentration responders suggests amino acid metabolism and redox balance may modulate LTG efficacy.
Assessing the efficacy and safety of transcranial magnetic stimulation and vagus nerve stimulation for drug-resistant epilepsy: A systematic review -
CONCLUSION: Evidence reported that both TMS and VNS greatly improve seizure control in patients with drug-resistant epilepsy, potentially enhancing quality of life and reducing seizure frequency. A large amount of our findings support the integration of neuromodulation techniques into future treatment regimens for drug-resistant epilepsy, which might be accompanied by calls for future clinical ...
Wearable Technologies for Clinical Assessment and Monitoring in Pediatric Neurodevelopmental Disorders : A Narrative Review -
Pediatric neurodevelopmental disorders (NDDs) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision : intellectual disabilities, communication disorders, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), specific learning disorder, and motor disorders together with closely associated pediatric neurological conditions...
Multi-omics identifies RNF149 as a key molecular marker mediating neuron-glia interaction in temporal lobe epilepsy -
Epilepsy is a complex central nervous system disease with a high incidence and a significant social health burden. Although there are many antiepileptic drugs, about 30% of patients are insensitive to existing drug treatments, and it is urgently required to identify reliable molecular markers and therapeutic targets. Traditional research has focused on a single omics level, and it is difficult ...
Computational neuroelectrophysiology and artificial intelligence for drug-resistant epilepsy: Recent advances, current challenges, and future directions -
Drug-resistant epilepsy (DRE) affects approximately 30% of epilepsy patients, with surgical cure rates below 70%. This challenge drives a fundamental paradigm shift from localizing a discrete epileptogenic zone (EZ) toward characterizing and modulating the 
dysfunctional brain networks that initiate and propagate seizures. This review critically synthesizes how computational neuroelectrophy...
Cortical evolutionary lineage as an organising principle for seizure semiology: implications for intracranial EEG and presurgical hypothesis generation -
CONCLUSIONS: Cortical evolutionary lineage may offer a biologically grounded and testable framework for understanding seizure semiology. Rather than replacing localisationist or network-based models, it may help to anchor them within a broader account of how cortical structure, connectivity, and function are organised across evolutionary gradients.
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