Epilepsy News

Glioma-related epilepsy in patients with oligodendroglioma, IDH-mutant, and 1p/19q-codeleted: A single-institute study - CONCLUSIONS: The current study offered valuable insights into GRE in patients with oligodendroglioma, IDH-mutant, and 1p/19q-codeleted. Younger age, left hemisphere tumor, and a better Karnofsky performance score were associated with a higher incidence of preoperative GRE. Although preoperative GRE showed no significant prognostic value for survival outcomes, it was the sole independent risk fa...

Impact of vitamin D supplementation and status on seizure frequency and quality of life in drug-resistant epilepsy: A systematic review and meta-analysis - CONCLUSION: Vitamin D supplementation is a safe adjunctive therapy that may reduce seizure frequency in drug-resistant epilepsy, though further large-scale trials are needed to confirm its efficacy and define optimal use.

Ketogenic diet therapy for epilepsy in conjunction with concurrent inflammatory bowel disease: Case series and recommendations - The combined occurrence of ketogenic diet therapy (KDT) and inflammatory bowel disease (IBD) has not been previously described. Seven patients from 6 institutions were identified from 2005 to 2025. Five were receiving KDT when the IBD diagnosis was made, with two subjects with Crohn's disease subsequently starting KDT to improve their refractory seizures. The mean age at the combined KDT/IBD pr...

Tongue Wounds Following Convulsive Seizures: Bridging Neurology and Oral Medicine Practice - CONCLUSION: Post-convulsive oral wounds represent clinically significant and potentially severe manifestations of epilepsy that require more than isolated local management. We propose an interdisciplinary clinical algorithm integrating acute surgical care, neurological evaluation, and preventive dental strategies. This approach supports early diagnosis, reduces recurrence, and promotes improved...

The Neurotoxic Mechanisms of Valproic Acid and Their Association With Neurodevelopmental Disorders: A Narrative Review - Valproic acid (VPA), which is an anticonvulsant and mood stabilizer, has been applied in treating several neurological and psychiatric conditions. However, severe neurotoxic side effects may result from its use, especially when taken at certain developmental stages of a child's brain. Consequently, the present narrative review aimed not only to summarize what is presently known about the neurot...

Exosome-based therapy for epilepsy: a systematic review and meta-analysis of preclinical studies - CONCLUSION: Exosome therapy improves seizure phenotypes and protects cognitive function in epilepsy models by suppressing neuroinflammation to promote neuronal survival, providing evidence for further mechanistic and clinical translation studies.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.