Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...

Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring - NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

In people with epilepsy, sleeping after a seizure may trigger more seizures - Add Yahoo as a preferred source to see more of our stories on Google. A new study suggests that the memory-forming stage of sleep could be key for understanding epileptic seizures. . | Credit: ...

Decoding epilepsy in brain waves - Neurologists often use EEGs to help diagnose epilepsy, but routine recordings offer only about a 20-minute snapshot of brain activity. Without a seizure captured during that window, clinicians must ...

Patient-Specific Non-Invasive Epileptogenic Zone Localization via High-Resolution Time-Frequency Representations and CNN Deep Learning - Stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation is the mainstream treatment for drug-resistant epilepsy (DRE), yet non-invasive patient-specific localization of potential epileptogenic zone (EZ) prior to SEEG electrode implantation remains a critical unmet clinical need, hindered by limited automation, suboptimal accuracy, and poor cross-patient generalizability. To ...

A de novo NR2F1 c.330 C > A variant in Bosch-Boonstra-Schaaf optic atrophy syndrome presenting with early-onset developmental and epileptic encephalopathy - CONCLUSION: The novel NR2F1 variant was classified as likely pathogenic according to ACMG guidelines, confirming the diagnosis of BBSOAS. The ARF3 variant, identified as a secondary finding of uncertain clinical significance, is unlikely to account for the patient's phenotype; however, reporting this variant may facilitate future interpretation of ARF3-associated disease. This is the first repo...

Development of Phenoxyacetic Acid Hybrids With COX-2 Inhibitory Activity as Potential Anti-Neuroinflammatory Agents - This research employs a molecular hybridization strategy to repurpose the pyrazoline scaffold 6a, 6c, 7a-c, 11a, and 12b, transforming it into a high-efficiency conjugate designed to tackle the multifaceted pathology of neuroinflammation and epilepsy. By integrating a selective phenoxyacetic acid moiety. Our findings identified compound 7c as a potential lead candidate for the development of no...

Monthly or menstrual? A scoping review of catamenial epilepsy and non-menstrual seizure rhythms - OBJECTIVE: Despite the reported high prevalence of catamenial epilepsy (CE), the condition remains poorly defined, with lack of consensus on what entails a menstrual-related seizure exacerbation. Emerging evidence of multiday cycles of seizure activity, including about-monthly cycles, present in both men and women, further confound the existence of CE. Issues of misdiagnosis, attribution bias, ...

Early Ictal Dynamics in Childhood Absence Epilepsy: Scalp EEG Detection of Direct Current Shifts and High-Frequency Oscillations - IntroductionAbsence seizures are characterized by the appearance of generalized spike-and-wave complexes (SWCs) on scalp electroencephalography (EEG), but the EEG-level physiological changes that precede the onset of SWCs remain poorly understood. Advances in scalp wide-band EEG have enabled the simultaneous visualization of ultraslow and high-frequency activity, providing an opportunity to exa...

Unraveling the Inflammatory Enigma: Is Neuroinflammation a Culprit or Consequence in Pharmacoresistant Epilepsy? - CONCLUSION: These findings reveal a temporal dissociation in the roles of neuroinflammation: acute inflammation acts as a potent initiator of epileptogenesis, whereas chronic, sustained inflammation coincides with the drug-resistant phenotype. This study refines the prevailing view of neuroinflammation from a static pathogenic factor to a dynamic, phase-dependent modulator, supporting the ratio...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.