Epilepsy News

Accelerated Brain Atrophy in Epilepsy: A Prospective Population-Based Study - OBJECTIVE: Previous longitudinal neuroimaging studies suggest that epilepsy is a progressive disorder. To date, these findings have relied largely on populations from tertiary centers, resulting in ascertainment bias, as severely affected individuals are more likely to be rescanned. We aimed to determine rates of progressive brain atrophy in a prospective, population-based cohort.

Structural insights enable drug discovery for the neuronal NBCn2 carbonate transporter - NBCn2 (SLC4A10), a member of the SLC4 solute carrier (SLC) family, is a sodium-dependent (bi)carbonate transporter that regulates acid extrusion in various brain regions. Mutations in NBCn2 cause severe neurodevelopmental disorders in humans, and knock out studies suggest that its role in regulating neuronal excitability could hold therapeutic potential for seizure disorders such as epilepsy. D...

Genetic backround of developmental and epileptic encephalopathies is wider than monogenic aetiologies: Clinical and prognostic implications - No abstract

Temporal light modulation from LED lighting and seizure risk: A focused review of visible flicker, invisible modulation, and evidence gaps - Critically assess whether light emitting diode (LED) lighting temporal light modulation (TLM) is linked to seizure risk while distinguishing established evidence on visible flicker in photosensitive epilepsy from weaker evidence on prolonged exposure to invisible or supra-critical flicker fusion (CFF) modulation. The review also lists desired data: modulation depth at 100/120 Hz, waveform and d...

Epilepsy with eyelid myoclonia beyond the classical phenotype: Longitudinal electroclinical observations in a pediatric cohort - OBJECTIVE: Epilepsy with eyelid myoclonia is a childhood-onset generalized epilepsy syndrome with variable recognition of eyelid myoclonia, eye-closure sensitivity, and photosensitivity during follow-up. We aimed to characterize longitudinal clinical and electroencephalographic features in pediatric epilepsy with eyelid myoclonia, focusing on delayed recognition, reflex electroencephalographic ...

Long-Term Audiogenic Kindling Induces Pronounced Downregulation of the GABAergic System in the Hippocampus of Krushinsky-Molodkina Rats - Downregulation of inhibitory GABAergic transmission is closely connected with the development and progression of epilepsy; however, further studies are still needed to provide the complex and detailed picture of corresponding pathological alterations and their contribution to epileptogenesis. In the present study, we performed the comprehensive analysis of GABAergic system in the hippocampus of...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.