Epilepsy News

Physical exercise combined with prednisolone attenuates serum TNF-alpha expression in a rat model of epileptic seizures: an experimental and in silico study of candidate regulatory microRNAs - OBJECTIVES: Epilepsy is frequently associated with neuroinflammation, in which tumor necrosis factor-alpha (TNF-α) promotes excitotoxicity and neuronal hyperexcitability. We evaluated whether physical exercise, alone or combined with prednisolone, modulates peripheral TNF-α mRNA expression in a pentylenetetrazol (PTZ)-induced seizure model, and applied in silico approaches to identify candidate...

Engineering a chitosan-based nanoemulsion for non-invasive CNS-targeting approach: dual neuroprotection against epileptic and depressive disorders - The frequent comorbidity of epilepsy and depression presents a major therapeutic challenge, with current therapies limited by systemic side effects and poor blood-brain barrier penetration. This study aimed to develop a non-invasive, dual-therapy topical nanoemulsion for combined (additive), rather than formally demonstrated synergistic, neuroprotection. A Quality-by-Design optimized chitosan-l...

How I do it: meningioangiomatosis of the sylvian fissure. The need for a tailored functional neurosurgery - CONCLUSION: To underline the efficacy of the disconnection surgery and the pivotal role of intraoperative electrophysiologic assessment for tailoring the surgical resection at the presumed ictal onset zone.

SV2A Attenuates Interictal anxiety in Pharmacoresistant Epilepsy via the SYT3-GluA2 Axis - CONCLUSION: SV2A plays a pivotal role in interictal anxiety associated with PRE. PRE downregulates SV2A and weakens the SV2A-SYT3 interaction, thereby driving aberrant LTP and the emergence of anxiety-like behavior.

"Destructive epilepsy", epilepsy metaphors of people with epilepsy: A qualitative study - CONCLUSIONS: Bycategorizing metaphors,this studysuggests that epilepsy is not merely a chronic physical disease but also reveals its psychosocial aspects and impact on individuals with epilepsy through their personal experiences. Metaphors are a powerful tool for understanding the inner world ofpatients with epilepsyand the emotional burdens that cannot be expressed in the clinic. The use of th...

What shapes health-related quality of life in drug-resistant epilepsy? Clinical, emotional, and cognitive predictors - CONCLUSION: HRQoL in DRE is influenced by clinical, emotional, and cognitive factors. Beyond seizure burden, mood disturbances, alexithymia, and neuropsychological performance are linked to HRQoL, underscoring the need for a holistic, patient-centered approach that addresses emotional and cognitive functioning alongside seizure control.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.