Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Epilepsy and Seizure News
Seizure action plans: Management and educational tools in epilepsy care -
Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
Medical News Today
PubMed
Lateralizing value of memory recognition index difference scores (RIDS) in patients with right versus left temporal lobe epilepsy -
CONCLUSIONS: The current findings support the utility and adequate accuracy of the WMS-IV RIDS in improving neuropsychological lateralization in patients with TLE.
Corpus Callosotomy in LIS1 Lissencephaly: Postoperative Ketogenic Diet-Related Metabolic Derangements and Feeding Intolerance - Classic lissencephaly from PAFAH1B1 (LIS1) haploinsufficiency presents with early, drug-resistant epilepsy; palliative strategies such as corpus callosotomy (CC) and vagus nerve stimulation (VNS) can be effective but are challenging to coordinate in children maintained on ketogenic dietary therapy (KDT). We report the case of a 6-year-old girl with de novo PAFAH1B1 deletion who underwent total ...
Expanding the phenotypic and genotypic spectrum of KCNT1-related epilepsies - The KCNT1 gene encodes for a sodium-activated potassium channel involved in neuronal excitability. Since its initial description in 2012 in patients with Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) and in Sleep-related Hypermotor Epilepsy (SHE), the associated phenotypic spectrum has broadened-encompassing other focal epilepsies and Developmental and Epileptic Encephalopathies (DE...
Acquired pharmacoresistance in temporal lobe epilepsy is driven by Na(v)1.6-mediated subicular hyperexcitability - Pharmacoresistance to anti-seizure medications (ASMs) remains a major unmet challenge in temporal lobe epilepsy (TLE), and occurs diversely, as classified to primary or acquired manner. The pathophysiological underpinnings of acquired pharmacoresistance remain elusive. Here, using a hippocampal kindling mouse model, we established that prolonged lamotrigine (LTG) treatment-either during or afte...
Considerations for an awake craniotomy in a paediatric patient - Awake craniotomy facilitates real-time assessment of neurological function and maximises the extent of tumour resection, reducing the risk of postoperative deficits. Awake craniotomy is uncommonly performed in young children. To our knowledge, we report the youngest case of awake craniotomy in medical literature, involving a 6-year-old child. He had a right frontoparietal tumour and a 4-year hi...
Ganglioglioma and gangliocytoma: a review for pathologists - Ganglioglioma and gangliocytoma are rare, predominantly low-grade neuroepithelial tumors that commonly present with epilepsy in children and young adults. Advances in molecular profiling have improved understanding of their pathogenesis, highlighting key roles for the mitogen-activated protein kinase/ERK signaling pathway. Diagnosis relies on a combination of clinical, radiologic, and histopath...
Corpus Callosotomy in LIS1 Lissencephaly: Postoperative Ketogenic Diet-Related Metabolic Derangements and Feeding Intolerance - Classic lissencephaly from PAFAH1B1 (LIS1) haploinsufficiency presents with early, drug-resistant epilepsy; palliative strategies such as corpus callosotomy (CC) and vagus nerve stimulation (VNS) can be effective but are challenging to coordinate in children maintained on ketogenic dietary therapy (KDT). We report the case of a 6-year-old girl with de novo PAFAH1B1 deletion who underwent total ...
Expanding the phenotypic and genotypic spectrum of KCNT1-related epilepsies - The KCNT1 gene encodes for a sodium-activated potassium channel involved in neuronal excitability. Since its initial description in 2012 in patients with Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) and in Sleep-related Hypermotor Epilepsy (SHE), the associated phenotypic spectrum has broadened-encompassing other focal epilepsies and Developmental and Epileptic Encephalopathies (DE...
Acquired pharmacoresistance in temporal lobe epilepsy is driven by Na(v)1.6-mediated subicular hyperexcitability - Pharmacoresistance to anti-seizure medications (ASMs) remains a major unmet challenge in temporal lobe epilepsy (TLE), and occurs diversely, as classified to primary or acquired manner. The pathophysiological underpinnings of acquired pharmacoresistance remain elusive. Here, using a hippocampal kindling mouse model, we established that prolonged lamotrigine (LTG) treatment-either during or afte...
Considerations for an awake craniotomy in a paediatric patient - Awake craniotomy facilitates real-time assessment of neurological function and maximises the extent of tumour resection, reducing the risk of postoperative deficits. Awake craniotomy is uncommonly performed in young children. To our knowledge, we report the youngest case of awake craniotomy in medical literature, involving a 6-year-old child. He had a right frontoparietal tumour and a 4-year hi...
Ganglioglioma and gangliocytoma: a review for pathologists - Ganglioglioma and gangliocytoma are rare, predominantly low-grade neuroepithelial tumors that commonly present with epilepsy in children and young adults. Advances in molecular profiling have improved understanding of their pathogenesis, highlighting key roles for the mitogen-activated protein kinase/ERK signaling pathway. Diagnosis relies on a combination of clinical, radiologic, and histopath...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.