Epilepsy News
Recent news about epilepsy, seizures and treatments.
News Feeds
Medical News Today
PubMed
Optimal perampanel dose as the treatment for refractory partial-onset seizures: Network meta-analysis based on pivotal randomized double-blind clinical trials -
BACKGROUND: Intractable epilepsy with partial-onset seizures (POS), affecting more than 20% of individuals with epilepsy, is one of the most common neurological conditions worldwide. Perampanel (PER), an antiepileptic drug (AED), is widely used in the treatment of refractory POS. However, the optimal dose of PER remains undetermined. This network meta-analysis (NMA) aims to determine the optima...
A randomized feasibility pilot trial of a remotely delivered physical activity intervention for adults with epilepsy - CONCLUSION: A remotely delivered daily steps-based physical activity intervention is feasible for people with epilepsy and shows promising immediate and sustainable effects on physical activity behaviors.
CaMKIIbeta insufficiency disrupts cortical networks, producing aberrant low-gamma oscillations and seizure susceptibility - OBJECTIVE: Pathogenic variants in the calcium/calmodulin-dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear. Building on our previous clinical report of a patient carrying the CaMKIIβ P213L variant and our prior characterization of the corresponding mous...
Genetic spectrum and risk factor analysis for drug-resistant of early-onset epilepsy - CONCLUSIONS: Genetic etiology underlies most early-onset epilepsy cases. Abnormal muscle tone, epileptiform discharges on EEG, and definitive genetic diagnosis are risk factors for DRE, guiding early intervention.
Microcephaly, seizures and developmental delay caused by two novel mutations in the PNKP gene: a case report - CONCLUSIONS: This is the third report of MCSZ in a non-consanguineous Chinese mainland family. Our results offer additional evidence for clinical variability associated with disorders stemming from mutations in the PNKP gene, which complicates disease diagnosis. This underscores the significance of genetic testing to identify the underlying causes of these conditions. Furthermore, these finding...
Autoimmune Epilepsy Temporally Associated With Lyme Disease: A Report of Two Cases - The relationship between Lyme-associated illness and immune-mediated seizure disorders remains incompletely characterized. Infection-triggered neurologic immune syndromes are well described in some settings, but evidence linking Borrelia burgdorferi to autoimmune epilepsy remains limited and is based primarily on isolated reports. We describe two previously healthy patients, a 25-year-old male ...
A randomized feasibility pilot trial of a remotely delivered physical activity intervention for adults with epilepsy - CONCLUSION: A remotely delivered daily steps-based physical activity intervention is feasible for people with epilepsy and shows promising immediate and sustainable effects on physical activity behaviors.
CaMKIIbeta insufficiency disrupts cortical networks, producing aberrant low-gamma oscillations and seizure susceptibility - OBJECTIVE: Pathogenic variants in the calcium/calmodulin-dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear. Building on our previous clinical report of a patient carrying the CaMKIIβ P213L variant and our prior characterization of the corresponding mous...
Genetic spectrum and risk factor analysis for drug-resistant of early-onset epilepsy - CONCLUSIONS: Genetic etiology underlies most early-onset epilepsy cases. Abnormal muscle tone, epileptiform discharges on EEG, and definitive genetic diagnosis are risk factors for DRE, guiding early intervention.
Microcephaly, seizures and developmental delay caused by two novel mutations in the PNKP gene: a case report - CONCLUSIONS: This is the third report of MCSZ in a non-consanguineous Chinese mainland family. Our results offer additional evidence for clinical variability associated with disorders stemming from mutations in the PNKP gene, which complicates disease diagnosis. This underscores the significance of genetic testing to identify the underlying causes of these conditions. Furthermore, these finding...
Autoimmune Epilepsy Temporally Associated With Lyme Disease: A Report of Two Cases - The relationship between Lyme-associated illness and immune-mediated seizure disorders remains incompletely characterized. Infection-triggered neurologic immune syndromes are well described in some settings, but evidence linking Borrelia burgdorferi to autoimmune epilepsy remains limited and is based primarily on isolated reports. We describe two previously healthy patients, a 25-year-old male ...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.