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Factors associated with drug-resistant epilepsy in children with epilepsy: a retrospective cohort study -
CONCLUSIONS: In this retrospective cohort, seizure type, history of status epilepticus, neurodevelopmental disorder, structural etiology, and older age at onset were independently associated with DRE after excluding treatment‑related variables. These findings suggest that true baseline independently associated variables of DRE are limited, and the diagnosis of DRE itself-failure of two adequate...
Association of first-month beta-hydroxybutyrate levels with subsequent ketogenic diet response in children with drug-resistant epilepsy: a prospective cohort study -
CONCLUSION: Continuous first-month BHB showed no clear monotonic association with 3-month seizure reduction; an exploratory 3.0 mmol/L cutoff analysis similarly did not distinguish subsequent responders from non-responders. These findings describe the prognostic value of first-month BHB measured after individualized KDT titration and should not be interpreted as evidence regarding the benefit o...
Understanding MEG Source Profiles in Tuberous Sclerosis -
CONCLUSIONS: This study demonstrates a localization concordance between MEG and sEEG that is related to postsurgical seizure outcomes in patients with TSC. However, no correlation between MEG source number, laterality (unilateral vs. bilateral), and surgical outcomes was found, supporting the continued use of MEG as a presurgical epilepsy tool in this patient population, no matter the number of...
Sustained Seizure Freedom After Stereo-Electroencephalography Without Definitive Intervention: Evidence for Network Modulation by Invasive EEG -
Stereo-electroencephalography (sEEG) is a diagnostic technique used to localize seizure-onset networks in drug-resistant epilepsy, typically guiding resection, ablation, or neuromodulation. Sustained seizure freedom after diagnostic implantation alone is rarely described. We describe two patients who achieved long-term remission after sEEG monitoring without definitive surgical intervention. A ...
The Impact of Plasmapheresis on Serum Concentrations of Antiseizure Medications: A Systematic Review -
Seizures are an important neurological manifestation of several autoimmune and antibody-mediated disorders and often require treatment with antiseizure medications (ASMs). Therapeutic plasma exchange (TPE) is frequently used to treat these antibody-mediated conditions by removing circulating pathogenic factors. However, TPE is non-selective and may also remove protein-bound ASMs, particularly t...
Rotavirus-associated mild encephalitis with a reversible splenial lesion of the corpus callosum -
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