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Circumstantial, but Compelling: Multimodal Phase 1 Data and the Seizure Onset Zone -
No abstract
Antiseizure Networks -
Epilepsy is increasingly recognized as a disorder of brain networks rather than a solely focal disease. Beyond the seizure focus, connected brain networks can exert inhibitory control over seizure initiation and propagation resulting in antiseizure effects. Here, we present data from animal and human studies on antiseizure networks and integrate recent results from lesion-, stimulation- and neu...
DNM1-related disorder is characterized by recurrent variants and phenotypic homogeneity -
CONCLUSION: A harmonized cohort of individuals with DNM1 -related disorder was analyzed to define mutational hotspots and reveal novel genotype-phenotype correlations. Due to the homogeneous phenotype, disease mechanism, and high proportion of recurrent variants, DNM1 represents an attractive target for targeted therapy development.
Febrile Seizures in Children in a Low-Resource Setting: A Hospital-Based Cross-Sectional Study from Eastern Libya -
CONCLUSION: In this hospital-based study from a resource-limited setting, FSs, predominantly simple FSs, were common among young children. A family history of epilepsy and elevated white blood cell counts were associated with complex FSs, highlighting the importance of risk stratification and context-appropriate management in low-resource health care environments.
Near-Sudden Unexpected Death in Epilepsy Rescued by Bystander Use of an Automated External Defibrillator: A Case of Nonconvulsive Seizure -
CONCLUSION: All healthcare providers caring for people with epilepsy should be aware of SUDEP to help prevent epilepsy-related deaths.
Surgical resection as salvage therapy for super-refractory status epilepticus: a report of two cases -
CONCLUSION: Emergency epilepsy surgery may represent a life-saving therapeutic option for selected patients with SRSE and identifiable structural lesions. Our findings support the inclusion of surgical evaluation in SRSE treatment protocols when pharmacological interventions fail. Multimodal imaging and prompt surgical decision-making are crucial for successful outcomes.
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