Epilepsy and Seizure News
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Case Report: longitudinal imaging in a patient with SMART syndrome after cranial radiotherapy -
CONCLUSION: This longitudinal case supports the hypothesis that SMART syndrome may represent a spectrum of radiation-induced cortical vulnerability, with possible recurrence and earlier, milder manifestations. Its coexistence with these cavernous malformations is compatible with a shared substrate of chronic radiation-induced microvascular injury. We propose a multimodal diagnostic framework th...
Clinical outcomes and unmet therapeutic needs in new-onset refractory status epilepticus: evidence from a retrospective cohort -
CONCLUSIONS: NORSE defines a distinct and severe clinical syndrome within status epilepticus, characterized by older age, female predominance and adverse outcomes. Beyond the clinical severity of NORSE, our findings show that cohort composition is highly sensitive to the temporal operationalization of consensus criteria. Standardized application of diagnostic timing may therefore be essential f...
Potential Role of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) Abnormalities in Epileptogenesis: Multimodal Mechanisms and Therapeutic Targets -
Epilepsy is a prevalent neurological disorder characterized by an incompletely understood etiology and a substantial unmet therapeutic need, particularly for drug-resistant forms. This review examines the potential role of mitochondria-associated endoplasmic reticulum membranes (MAMs) as emerging signaling hubs in epileptogenesis. We systematically analyze how MAMs regulate core cellular proces...
Corpus callosotomy in Lennox-Gastaut syndrome: Effectiveness, safety, and predictors of outcome: A systematic review and meta-analysis -
BACKGROUND: Lennox-Gastaut syndrome (LGS) is a severe, drug-resistant developmental and epileptic encephalopathy for which corpus callosotomy (CC) can be a particularly effective option for seizure control. However, this benefit must be weighed against the tradeoff of permanent corpus callosum disconnection. Although use of CC declined with the rise of neuromodulation, interest has resurged wit...
Prevalence of epilepsy and seizures in frontotemporal dementia: a systematic review and meta-analysis -
Seizures and epilepsy are increasingly recognized in neurodegenerative diseases, yet their burden in frontotemporal dementia (FTD) remains poorly defined. We conducted a systematic review and meta-analysis to estimate the prevalence of epilepsy or seizures in FTD, assess comparative risk versus controls, and explore variation across clinical subtypes. MEDLINE/PubMed, Embase, Cochrane Library, L...
Idiopathic generalized epilepsy: biases and inconsistencies -
OBJECTIVES: Distinguishing Idiopathic Generalized Epilepsy (IGE) from focal epilepsy (FE) can be challenging when IGE cases present with asymmetric clinical or electroencephalographic (i.e., atypical) features. We aimed to identify factors that lead to discordance in IGE diagnoses among epileptologists.
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