Epilepsy and Seizure News
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Seizure improvement following intravenous immunoglobulin in drug-resistant mesial temporal lobe epilepsy associated with systemic lupus erythematosus -
No abstract
SeizureBiomeDB: a unified database of gut microbiome alterations in pediatric and adult epilepsy -
MOTIVATION: The gut microbiome plays a critical role in health, immunity, metabolism, and brain function. Growing evidence links it to neurological health via the gut-brain axis. Seizure disorders are associated with distinct microbial changes that vary by epilepsy type and developmental stage, yet data are scattered across numerous published studies. To address this, we developed SeizureBiomeD...
Glucose Transporter Deficiency Syndrome Type 1 (Glut1-DS): New Insights From a Brazilian Cohort of Patients -
Glucose transporter deficiency syndrome type 1 (Glut1-DS) is a rare neurometabolic disorder caused by pathogenic variants in SLC2A1, characterized by epilepsy, neurodevelopmental delay, movement disorders, dysarthria, intellectual disability, and postnatal microcephaly. We aimed to characterize the natural history of a Brazilian cohort of patients with Glut1-DS. Brazilian patients of all ages w...
A CNN-BiLSTM-GRU and attention-integrated hybrid network for epileptic seizure detection -
INTRODUCTION: Epilepsy is a common neurological disease, and accurate seizure detection is essential for clinical monitoring and scientific treatment. This study aims to construct an effective intelligent detection model to achieve precise automatic identification of epileptic EEG signals and assist clinical medical decisions.
Determinants of health-related quality of life in pediatric epilepsy: the impact of treatment tolerability and epilepsy type -
CONCLUSION: In this cohort, HRQOL was more strongly associated with treatment-related adverse effects than with most seizure-related variables. Treatment tolerability appears to represent an important and modifiable correlate of well-being. Routine assessment of adverse effects may enhance patient-centered care.
Pathophysiological frameworks and emerging preventative strategies in SUDEP -
Sudden Unexpected Death in Epilepsy (SUDEP) represents a leading cause of epilepsy-related mortality, reflecting a severe disruption of systemic physiology that remains challenging to address using standard clinical protocols. Although generalized tonic-clonic seizures (GTCS) and pharmacoresistance are established risk indicators, current clinical risk stratification frequently lacks the predic...
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