Neurofeedback News
Medical News Today
PubMed
[(18)F]FDG PET/MRI in Pediatric Focal Epilepsies -
We hypothesized that [^(18)F]FDG PET/MRI would improve presurgical lesion detection compared with MRI alone in pediatric patients with focal epilepsy. We analyzed surgical outcomes and the presurgical evaluation pipeline. Methods: We included pediatric patients undergoing [^(18)F]FDG PET/MRI between January 2017 and October 2021. Eligible patients were 18 y or younger, had a diagnosis of focal ...
Antiseizure medication-induced hyponatraemia -
Hyponatraemia is a well-documented side effect of antiseizure medication (ASM). Its management involves balancing the risks of untreated hyponatraemia against the risks of upsetting seizure control by altering the ASM. The first consideration is to exclude other causes of hyponatraemia. The management should be informed by the degree of hyponatraemia, the severity of symptoms and the patient's ...
Latent profiles of emotional well-being in adolescents with epilepsy and correlations with family function and peer relationships -
CONCLUSION: EWB among adolescents with epilepsy is generally lower than that of their healthy peers and exhibits heterogeneity. Healthcare professionals should prioritize adolescents in the "moderate positive-high negative" and "low positive-moderate negative" groups, implementing targeted interventions to enhance their EWB. Future research should further explore the factors influencing these d...
Olfactory Mucosa MSCs-Derived Exosomal RPL6 Attenuates Seizure-Induced Neuronal Damage via FGF2-Mediated Oxidative Stress and Mitophagy -
Evidence suggests that olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) can benefit epilepsy treatment in both clinical patients and mouse models, although their precise mechanism remains unclear. Given the advantages of exosomes in precise cellular regulation, ease of storage, and long-term stability, this study investigated the role of OM-MSCs-derived exosomes (OM-MSCs-exos) in statu...
Glymphatic-meningeal lymphatic dysfunction in epilepsy: Novel mechanistic insights and therapeutic avenues -
Despite advances in pharmacotherapy, approximately one-third of individuals with epilepsy develop drug-resistant epilepsy (DRE), accounting for a disproportionate share of the global disease burden. Emerging evidence implicates dysfunction of the meningeal lymphatic system-a critical regulator of waste clearance and immune surveillance-in the pathogenesis of DRE. This suggests that impaired lym...
Thalamic 5-HT(2A) Receptor Activation Reduces GABA Uptake, Increases Tonic GABA(A) Inhibition and Induces Absence Seizures in Wistar Rats -
Renewed interest in psychedelic therapeutics has brought serotonin 5-HT(2A) receptors (5-HT(2A)Rs) back into focus. Given the role of the thalamus in sensory integration and network synchronization, we examined the expression, developmental regulation, and functional impact of thalamic 5-HT(2A)Rs, with particular emphasis on their interaction with extrasynaptic GABA(A) receptors and the generat...
Science Daily