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Geschwind syndrome in remitted bipolar affective disorder without MRI brain findings: A case report -
Geschwind Syndrome (GS) comprises a constellation of behavioural traits traditionally associated with temporal lobe epilepsy. These include hyper-religiosity, hypergraphia, altered sexuality, and circumstantial thought processes. Increasingly, GS features are also observed in other neuropsychiatric conditions. We present a 26-year-old female with bipolar affective disorder in remission who deve...
A Zebrafish Seizure Model of cblX Syndrome Reveals a Dose-Dependent Response to mTor Inhibition -
Mutations in the transcriptional co-factor HCFC1 cause methylmalonic aciduria and homocystinemia, cblX type (cblX) (MIM#309541), non-syndromic X-linked intellectual disability (XLID), and focal epilepsy. Zebrafish studies have revealed increased activation of the Akt/mTor signaling pathway after mutation of hcfc1a, one ortholog of HCFC1. mTOR hyperactivation is linked to seizures, and its inhib...
Exploring the Neural Pathways of Faith: A Review and Case Study on Hyperreligiosity in Epilepsy -
Religious experiences represent a universal and timeless phenomenon that has accompanied humanity since its origins. In recent decades, neuroscience has explored the relationship between temporal lobe epilepsy (TLE) and hyperreligiosity phenomena, describing sudden convictions, states of ecstasy, and spiritual conversions associated with epileptic seizures. This article offers a narrative revie...
2-Linoleoylglycerol decreased seizure through the regulation of 5-hydroxytryptamine 1A receptor and G protein-coupled receptor 55 interaction in mice -
CONCLUSION: These results suggest that 2-LG exerts an antiseizure effect through interactions between the 5-HT1A receptor and GPR55.
Immune biomarkers for epilepsy in autism: indications of cytokine alterations in an exploratory cross-sectional pediatric study -
CONCLUSION: These findings raise the possibility that immune system alterations may be associated with EP in children with ASD and could potentially aid diagnosis, although larger studies are needed to confirm these findings.
Functional Neurological Disorder Presenting as Apparent Drug-Resistant Seizures: A Case Report on Emphasizing the Role of Early Diagnosis -
Functional neurological disorder (FND) is a complex and frequently misdiagnosed condition characterized by neurological symptoms such as motor events, sensory deficits, or altered consciousness caused by brain network dysfunction rather than structural abnormalities. Despite its prevalence, FND remains stigmatized and underrecognized, mainly due to its historical association with psychological ...
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