Epilepsy News

Evaluating diagnostic yield of ambulatory EEG for interictal epileptiform discharges and seizures - CONCLUSIONS: This study identified factors associated with diagnostic yield of aEEG for observing IEDs and seizures. At least 48-hours of aEEG was highest yield for seizures, and longer studies may be appropriate for people with lower seizure frequency. IEDs were less dependent on study length and were more associated with pre-aEEG certainty of epilepsy diagnosis.

Seizure freedom after vagus nerve stimulation in a patient with SCN3A-related network epilepsy and incomplete penetrance: A case report - Genetic-based epilepsies often present as distributed neural network disorders, challenging traditional focal versus generalized classifications. We report a 20-year-old male with drug-resistant epilepsy associated with a previously unreported SCN3A missense variant (c.5970C > G; p.Ser1990Arg). Despite failure of multiple anti-seizure medications and a non-localizing electroclinical profile, th...

Ten-year cognitive outcomes following epilepsy surgery: Temporal lobectomy versus selective amygdalohippocampectomy - OBJECTIVE: This study aimed to assess long-term memory outcomes in patients with temporal lobe epilepsy (TLE) who underwent anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SAH), compared to nonoperated TLE over a 10-year follow-up period.

Loss of microglial ATM drives synaptic pruning and cognitive impairment in epilepsy - Microglia are the resident immune cells of the central nervous system, highly sensitive to oxidative stress and essential for maintaining synaptic homeostasis. While epilepsy induces profound redox imbalance, how oxidative stress reshapes microglial function and disrupts synaptic integrity remains unclear. Here we show that epileptic seizures drive early loss of ataxia-telangiectasia mutated (A...

Childhood Absence Epilepsy with Coexisting Centrotemporal Spikes: Frequency, Electroclinical Course and Prognosis - CONCLUSION: Centrotemporal spikes were identified in 9% of patients with CAE. Focal seizures were not seen, suggesting that it reflects an EEG trait. Remission of the generalized epileptiform discharges correlates with ASM treatment and seizure outcome is excellent, despite persistence of centrotemporal spikes.

Altered EEG microstate dynamics reflect depressive symptoms in temporal lobe epilepsy - CONCLUSION: Higher depressive symptom burden in unilateral TLE is associated with increased temporal rigidity of the ictal hemisphere-aligned brain microstate, reflecting impaired disengagement of epileptogenic network configurations. These findings suggest that depressive symptoms in TLE may be associated with epilepsy-related disruptions in large-scale neural dynamics.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.