Epilepsy News

Acute catatonia and psychosis in the context of seizure exacerbation in epilepsy: a case report - CONCLUSION: The working discharge diagnosis was catatonic disorder due to another medical condition (epilepsy), with psychotic features of indeterminate classification. Clinicians should resist anchoring on temporal associations between seizure activity and psychiatric symptoms. EEG findings must be interpreted in their pharmacological context; pharmacokinetic interactions should inform antipsy...

An updated estimate of the proportion of neurocysticercosis among people with epileptic seizures: a systematic review and Bayesian meta-analysis - CONCLUSION: This study provides an updated estimate of NCC proportion among PWES between 1990 and 2023, with implications for burden estimation, and highlights its decline in endemic regions. However, substantial between-study heterogeneity indicates context-specific differences; therefore, the pooled estimates should be interpreted cautiously and not as universally generalizable. Further resea...

Clobazam in pediatric drug-resistant epilepsy: from pharmacology to clinical practice - CONCLUSION: Clobazam demonstrates consistent efficacy as adjunctive therapy in pediatric drug-resistant epilepsy, with the strongest evidence supporting its use in LGS. Individualized treatment informed by CYP2C19 genotyping and therapeutic drug monitoring can optimize clinical outcomes. This review provides a comprehensive reference for the rational clinical use of clobazam.

Long-term seizure outcomes and factors associated with response to adjunctive everolimus in TSC-associated epilepsy - CONCLUSION: Adjunctive everolimus was associated with sustained long-term seizure reduction in this real-world cohort. In exploratory analyses, fewer involved organ systems and fewer baseline ASMs were associated with favorable treatment response. These findings require validation in larger prospective cohorts.

CARM1 as a therapeutic target: The future of disease-modifying therapies for epilepsy - Epilepsy is a chronic neurological condition characterised by persistent or recurrent spontaneous seizures caused by aberrant and hyper-synchronisation of neurons. It is one of the leading causes of neurological problems affecting over 50 million people all around the globe, and at present, disease-modifying therapeutic agents are not widely available. This intricate set of molecular processes,...

Neuronal monocarboxylate transporter 2 is downregulated and aggravates seizures in a rat model of infantile epileptic spasms - Infantile epileptic spasms syndrome (IESS) is an age-dependent epileptic encephalopathy of the developing brain, yet its underlying mechanisms remain unclear. Monocarboxylate transporter 2 (MCT2) maintains cerebral metabolic homeostasis via energy substrate transport, but its role in IESS epileptogenesis is unknown. We found that MCT2 was predominantly expressed in neurons and downregulated in ...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.