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Neuropathological Findings Following Failure of Laser Interstitial Thermal Therapy for an Epileptogenic Cerebral Cavernous Malformation -
We describe the case of a 32-year-old woman with focal drug-resistant epilepsy, who underwent surgical resection of a cerebral cavernous malformation (CCM), previously treated with laser interstitial thermal therapy (LITT), after experiencing seizure recurrence. Histological findings after LITT have been rarely described. We report and discuss neuropathological findings to explain post-LITT sei...
Auricular acupuncture attenuates neuronal damage in kainic acid-induced epilepsy related to mGluR5 and GABA(A) receptor alpha1 subunit modulation -
Epilepsy affects over 50 million people worldwide, with more than one-third developing drug-resistant forms. While acupuncture is increasingly utilized for seizure management, its molecular mechanisms remain poorly understood. This study investigated the neuroprotective effects of auricular electroacupuncture (EA) in a kainic acid (KA)-induced rat model of epilepsy. Rats received EA at the hear...
Morin, a bioflavonoid from a traditional medicinal plant, attenuates inflammasome-associated neuroinflammation in drug-resistant epilepsy -
Morin, a bioflavonoid abundant in Morus alba (Moraceae) and traditionally used in Ayurveda and Chinese medicine for the treatment of convulsions and inflammation, modulates neuroinflammatory pathways relevant to epilepsy. This study investigated the effects of morin on inflammasome-associated neuroinflammation, assessed using downstream markers such as caspase-1 and IL-1β, in a rotenone-lamotri...
Sleep disruption and neuropsychiatric features in Angelman syndrome: insights into underlying neurobiology -
Sleep disorders are a core feature of Angelman syndrome (AS), affecting approximately 80% of individuals. They typically manifest as insomnia and disrupted sleep-wake cycles and contribute substantially to the burden experienced by affected individuals and their families. AS is caused by loss of function of the ubiquitin protein ligase E3A (UBE3A) gene, which encodes the E3 ubiquitin ligase E6A...
Early infantile developmental and epileptic encephalopathy: clinical spectrum, diagnosis, outcomes, and evolving treatment strategies -
Early infantile developmental and epileptic encephalopathy (EIDEE) is among the most severe epilepsy syndromes, with onset before three months of age and an estimated incidence of approximately 10 per 100,000 live births. The 2022 International League Against Epilepsy classification unified the historically distinct Ohtahara syndrome and early myoclonic encephalopathy under a single diagnostic ...
Patient-Specific Non-Invasive Epileptogenic Zone Localization via High-Resolution Time-Frequency Representations and CNN Deep Learning -
Stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation is the mainstream treatment for drug-resistant epilepsy (DRE), yet non-invasive patient-specific localization of potential epileptogenic zone (EZ) prior to SEEG electrode implantation remains a critical unmet clinical need, hindered by limited automation, suboptimal accuracy, and poor cross-patient generalizability. To ...
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