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Vagus nerve stimulation for refractory status epilepticus: A systematic review -
CONCLUSION: VNS implantation may be considered a treatment option for patients with acute-to-subacute SRSE who do not respond to medical treatment. However, functional disability remains substantial, and the likelihood of long-term seizure freedom is uncertain. Given the potential for publication bias and the exploratory nature of the subgroup analyses, the findings of this review should be int...
Memory performance, hippocampal volumes and memory fMRI in frontal versus temporal lobe epilepsy -
CONCLUSION: These findings reveal similarities but also underline task- and material-specific differences in memory performance and functional integrity between TLE and FLE.
Neuroinflammatory PET in Epilepsy: Prospects for Epileptogenic Zone Localization and Presurgical Planning -
Neuroinflammatory PET offers a direct in vivo means of quantifying neuroinflammatory processes through molecular targets expressed by activated glia, including the 18 kDa translocator protein (TSPO), monoamine oxidase B, and the P2X7 receptor. This review synthesizes current evidence for neuroinflammatory PET in epileptogenic zone (EZ) localization across these and emerging targets. TSPO PET de...
Cannabidiol Attenuates Seizure Progression and Recognition Memory Deficit Induced by Hippocampal HCN(1) Knockdown in the Kindling Model of Epilepsy in Male Rats -
Epilepsy is a neurological disorder characterized by excessive neuronal firing, frequently originating in the hippocampus. Hyperpolarization-activated cyclic nucleotide-gated channel-1 (HCN(1)) regulates neuronal excitability and resting membrane potential, yet its role in seizure progression remains unclear. Cannabidiol (CBD), an effective anticonvulsant, may exert part of its effects through ...
Long-Term Outcome of Patients With Posterior Predominant Gliosis Secondary to Perinatal Insult: An Ambispective Cohort Study -
CONCLUSIONS: These results depict the long-term effects of posterior gliosis on epilepsy, neurodevelopment, and also highlights its socioeconomic impact. Neonatal hypoglycemia being the most common cause, this study thus also emphasizes the need for its primary prevention and multidisciplinary care of those affected.
Full recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease -
Encephalitis and cerebral abscesses are rare, serious complications of deep brain stimulation (DBS) surgery. We report on two patients with Parkinson's disease (PD) who developed a critical condition with focal neurological symptoms and decreased consciousness, after an initially uncomplicated subthalamic nucleus DBS implantation. Because of the clinical and radiological suspicion of encephalit...
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