Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring - NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...

Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...

[What is 'Epilepsy,' a brain disorder that affects 1 in 100 people? A gentle guide to symptoms, types, and treatment goals] - Are you feeling vague anxiety or have questions about epilepsy, such as 'What should I do if I suddenly lose consciousness?' or 'Are convulsions the same thing as epilepsy?'Epilepsy is a very common ...

Alternating hemiplegia of childhood - a systematic review - CONCLUSIONS: Alternating hemiplegia of childhood is a complex multisystem disorder requiring early diagnosis, continuous monitoring, and multidisciplinary care. Disease-modifying treatments remain urgently needed.

Adeno-Associated Virus Vector-Mediated Expression of Neuroligin 2 in the Mouse Hippocampus Attenuates the Progression of Pentylenetetrazol-Induced Seizures - Gene therapy can target specific brain regions and may be an effective therapeutic tool for drug-resistant epilepsy. Neuroligin 2 (NL2) is a postsynaptic cell-adhesion protein involved in the formation of inhibitory synapses. Since epileptic seizures are attributed to excessive brain neuronal activity, we hypothesized that NL2-mediated inhibitory signaling suppresses seizures. Male C57BL/6J mic...

Ketogenic Diet-Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy - CONCLUSION: Together, these results suggest that synaptic and mitochondrial protein alterations in this region are associated with cortical molecular adaptations observed under ketogenic diet administration in absence epilepsy.

Indoor environmental conditions and interictal epileptiform discharge frequency during pediatric video-EEG monitoring - CONCLUSIONS: Pediatric epilepsy patients exhibit marked, highly individualized bidirectional sensitivities to ambient temperature and humidity despite a uniform group-level circadian rhythm in cortical excitability. These findings underscore the importance of personalized environmental monitoring in epilepsy management.

Initial experience of bortezomib in cryptogenic new-onset refractory status epilepticus: a case series - CONCLUSIONS: Bortezomib may represent a promising therapeutic option in immunotherapy-refractory NORSE. Larger prospective multicenter studies are needed to establish its efficacy, safety, and optimal timing of administration.

Hyperfunction of PSD-95 leads to hyperexcitability and cognitive abnormalities in MEF2C haploinsufficiency - Myocyte enhancer factor 2C (MEF2C) is a transcription factor critical for brain circuit development and cognitive behavior. The loss of one copy of MEF2C leads to MEF2C haploinsufficiency syndrome (MCHS), a neurodevelopmental disorder characterized by intellectual disability, epilepsy, and behavioral phenotypes associated with autism spectrum disorders. Given that numerous genes are regulated b...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.