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Drosophila prickle mutants display comorbid neurological phenotypes and present with autism spectrum disorder-associated phenotypes -
Epilepsy affects approximately 30% of individuals with autism spectrum disorder (ASD). Consistent with these observations, while PRICKLE mutations are primarily linked with epilepsy, there is an enrichment of pathogenic DNA sequence variants in PRICKLE genes carried by individuals with ASD. Nonetheless, a connection between PRICKLE function and ASD warrants further investigation. Here, we show ...
Re-evaluating the neuroprotective landscape of Nigella sativa: Molecular mechanisms, nanomedicine, and clinical translation -
Nigella Sativa (NS) L., commonly known as black seed, and its major bioactive compound, thymoquinone (TQ), have long been used in traditional medicine and have recently gained increasing attention as potential neuroprotective agents. TQ exerts pleiotropic effects within the central nervous system through several interconnected mechanisms, including activation of the Nrf2/HO-1 antioxidant pathwa...
Emergency Department Visits for Falls and First-Time Seizure -
BACKGROUND AND OBJECTIVES: Unrecognized seizures occur in up to 77% of individuals with epilepsy, leading to delays in diagnosis with significant consequences including injury, mortality, impaired psychosocial functioning, and negative socioeconomic impacts. Falls are a common reason to present to the emergency department (ED) and may be a sentinel sign of an unrecognized seizure. Whether falls...
Cross-Subject Localization of Epileptogenic Zone for Drug-Resistant Epilepsy Based on the Causal Brain Network -
CONCLUSION: Causal brain network features extracted by FCCM are robust biomarkers for localizing the EZ.
Brain volumetric signatures of neighborhood disadvantage in focal epilepsy -
OBJECTIVE: Social disadvantage is an important determinant of health in focal epilepsy, but its neurobiological basis remains unclear. We examined whether brain morphometric alterations represent a structural signature of deprivation.
Prognosis of acute symptomatic seizures and impact of prolonged treatment with anti-seizure medication -
OBJECTIVES: Acute symptomatic epileptic seizures (ASySs) occur in temporal proximity to acute brain insults. Given their low risk of subsequent unprovoked seizures, current guidelines recommend either no treatment with anti-seizure medication (ASM) or early discontinuation, yet ASM treatment is often continued beyond hospital discharge. We aimed at investigating the cumulative 3-year risk and p...
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