Epilepsy News

Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States - OBJECTIVE: National prescribing trends for antiseizure medication (ASM) in children with epilepsy over the past decade are unclear. Despite the 2021 SANAD II trials supporting lamotrigine and valproate for focal and generalized epilepsies, respectively, it is unknown if their use increased. This study evaluated ASM prescriptions in the U.S. before and after publication of high-quality clinical ...

Diosmetin's impact on epileptic seizures: a study on inflammatory pathways and neuronal health - This study investigated the anti-seizure potential of diosmetin (DM), a naturally occurring active compound, and explored its molecular mechanisms. A pentetrazole (PTZ)-induced chemical kindling mouse model was employed to assess seizure severity, cognitive function, motor coordination, and anxiety-like behaviors. Hippocampal neuronal injury was examined by hematoxylin-eosin and Nissl staining....

Brivaracetam-associated manic episode in a patient with bipolar disorder: A case report - CONCLUSION: This case suggests that, despite its generally favorable psychiatric tolerability, BRV may be associated with the emergence of symptoms in patients with bipolar disorder. These findings highlight the importance of careful psychiatric risk assessment and close monitoring when initiating BRV in individuals with underlying mood vulnerability.

Clinical characteristics and molecular genetic analysis of 73 cases of tuberous sclerosis complex caused by TSC1/2 gene mutations in children - CONCLUSION: The clinical phenotype of TSC is highly heterogeneous, with complex genotype-phenotype associations. The identification of 14 novel variants expands the known mutational spectrum of TSC, and the detailed genotype-phenotype analysis provides valuable insights for early diagnosis, genetic counseling, and personalized therapeutic strategies in pediatric populations. Early TSC1/TSC2 gen...

Target Trial Emulation Meta-Analysis of Benzodiazepines For Out-of-Hospital Status Epilepticus in Adults - CONCLUSIONS: Traditional meta-analysis was found to overestimate benzodiazepine efficacy by 3.9 percentage points due to open-label design bias. Intramuscular midazolam demonstrated superior effectiveness compared to intravenous lorazepam and diazepam for status epilepticus in adults.

Clinical Predictors of Drug-Resistant Epilepsy in Adults: An Analytical Observational Study - Background Drug-resistant epilepsy (DRE) remains a significant clinical challenge, with many adults experiencing persistent seizures despite adequate trials of antiseizure medications. Early identification of factors associated with DRE is essential for timely intervention and optimized management. Objectives The research aimed to examine the demographic, clinical, and behavioral factors involv...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.