Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

New genetic switch could improve gene therapy for drug-resistant epilepsy - Epilepsy affects more than 50 million people worldwide, making it one of the most common neurological disorders. Although medication helps many patients achieve seizure control, approximately ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

New tools map seizures in the brain, improve epilepsy treatment - Two new models could solve a problem that's long frustrated millions of people with epilepsy and the doctors who treat them: how to find precisely where seizures originate to treat exactly that part ...

Intermountain Health doctors perform 100th surgery using brain implants to improve epilepsy symptoms - SALT LAKE CITY (ABC4) — Intermountain Health neurologists are celebrating a major surgical milestone: the 100th use of an implantable device that reduces seizure activity in patients with focal ...

Automated seizure detection using wearable devices: updated systematic review and meta-analysis of tonic-clonic and focal seizure detection - INTRODUCTION: Wearable devices have emerged as promising tools for continuous seizure monitoring in patients with epilepsy. This study aimed to update the evidence on the diagnostic performance of non-invasive wearable sensors for seizure detection, extending the previous systematic review by Naganur et al., which included studies published up to November 10, 2021.

Peri-ictal magnetic resonance imaging findings in pediatric seizures: a scoping review on pearls and pitfalls from a heterogeneous population - CONCLUSIONS: Peri-ictal MRI abnormalities in children are most frequently described in PFS and SE, where recurring patterns of acute edema and later structural changes have been reported. However, existing evidence is heterogeneous and weighted toward early-life and acute symptomatic populations, limiting generalizability. Associations between early imaging changes and longer-term outcomes rema...

High-frequency, high-intensity electrical stimulation selectively activates human fast-spiking interneurons - Electrical brain stimulation has been used to treat epilepsy with therapeutic success, but without complete understanding of its cellular mechanisms of seizure suppression. Using acute human brain slices obtained from pharmaco-resistant epilepsy patients, we delivered high-frequency, high-intensity extracellular electrical stimulation while recording from neocortical layer 2/3 pyramidal neurons...

Expanding clinical variability in FBXW7-related neurodevelopmental disorder: a multicenter case series - CONCLUSIONS: This case series expands the phenotypic spectrum associated with FBXW7-related neurodevelopmental disorder and highlights variable expressivity and incomplete penetrance, including clinically relevant variants presenting with mild or atypical phenotypes. These findings support considering FBXW7 across a broad range of neurodevelopmental presentations and inform genetic counseling.

A continuous network physiology analysis of brain-heart interactions in epileptic seizures - The investigation of brain-heart interplay (BHI) has gained significant momentum in recent years, and has emerged as a pivotal area of neurophysiological research. The applications of BHI span cognitive neuroscience, sleep research, and neurological disorders, where the analysis of cortical and autonomic dynamics can provide a mechanistic overview of functional regulation. Epilepsy is known to ...

Transcranial focal current stimulation in super-refractory status epilepticus in a pregnant patient - Super-refractory status epilepticus (SRSE) during pregnancy is a rare, life-threatening condition with limited therapeutic options. Transcranial focal current stimulation (TFS) has shown benefit in refractory epilepsy, but its use in SRSE during pregnancy has not been reported. We describe a woman in her 20s at 12 weeks' gestation with longstanding focal drug-resistant epilepsy who developed SR...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.