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Case Report: Successful treatment of drug-resistant epilepsy with unilateral deep brain stimulation of the anterior nucleus of the thalamus -
CONCLUSION: Unilateral ANT-DBS can provide clinically meaningful seizure control in carefully selected patients whose predominant epileptogenic network is localized to one cerebral hemisphere. This approach may represent a feasible therapeutic option when anatomical or surgical constraints prevent conventional bilateral ANT electrode implantation. Further studies with larger patient cohorts and...
Chrysin Ameliorates Seizures, Seizure-induced Oxidative Stress, and Cognitive Impairment in Experimental Models of Epilepsy in Rats -
CONCLUSION: These findings support the anticonvulsant and neuroprotective effects of chrysin and highlight CH as a promising phytochemical candidate for managing epilepsy and its neurocognitive complications.
Structure-Activity Relationships and Mechanistic Insights of Racetam Derivatives in Epilepsy Management -
Epilepsy continues to affect millions globally, and despite advances in treatment, many patients still struggle with drug-resistant forms of the disorder. Among the newer therapeutic options, racetam derivatives have garnered attention for their distinctive mechanism of action-modulating synaptic vesicle protein 2A (SV2A)-which distinguishes them from traditional antiepileptic drugs (AEDs). Thi...
Disentangling the Genetic Relationship Between Sleep and Epilepsy -
OBJECTIVE: A bidirectional relationship between sleep and epilepsy is well recognised, yet the biological mechanisms linking them remain poorly understood. Both have a genetic basis, with genome-wide association studies (GWAS) capturing polygenic contributions. By leveraging GWAS summary statistics, we aimed to investigate their shared genetic architecture.
Optogenetic Stimulation of Insular Parvalbumin-Positive Interneurons Reveals CA3 Resonant Properties and Rebound Seizure Susceptibility -
Seizures in mesial temporal lobe epilepsy (MTLE) can spread to the insular cortex (IC) due to its connections with hippocampal and para-hippocampal areas. The contribution of specific cell types in the IC to ictogenesis remains however unclear. Therefore, we analyzed in the pilocarpine model of MTLE the effects of optogenetic activation of IC parvalbumin (PV)-positive interneurons on CA3 field ...
Psychological distress and seizure-related risks in forcibly displaced children: impending crisis triggered by wars and conflicts -
Seizure disorders, particularly epilepsy, are among the most prevalent and treatable neurological conditions, with high rates in forcibly displaced children. Although children represent around 40% of forcibly displaced people, limited research and data regarding this vulnerable group are available. Seizures and mental health disorders are very stigmatised conditions that generally remain undisc...
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