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Inhibition of the SGLT2/NHE-1/NLRP3 Signaling Axis Attenuates Neuroinflammation and Oxidative Stress to Ameliorate Seizures and Cognitive Impairment in Epileptic Mice -
CONCLUSION: Our findings unveil the SGLT2/NHE-1/NLRP3 axis as a master regulator that integrates oxidative stress and neuroinflammation in epilepsy. Notably, we identify this as a neuron-intrinsic pathway, and its targeted inhibition of this axis restores redox homeostasis and attenuates neuroinflammation, leading to improved seizure control and cognitive function. This study provides a novel m...
Retrospective comparison of interictal cardiac biomarkers of SUDEP or near-SUDEP with PNES patients -
Interictal QTc-interval changes and heart rate variability (HRV) are reported in people succumbing to sudden unexpected death in epilepsy (SUDEP). We evaluated cardiac biomarkers recorded during video-EEG monitoring in nine SUDEP/near-SUDEP cases and compared them to 9 age- and gender-matched people with psychogenic nonepileptic episodes (PNES) treated with anti-seizure medications (ASMs). QT-i...
Integrated genotype-phenotype function analysis reveals distinct pathogenic mechanisms for cognitive impairment in KCNQ2-related disorders -
OBJECTIVE: Pathogenic variants of KCNQ2 lead to a spectrum of disorders including self-limited familial neonatal-infantile epilepsy (SeL(F)NIE), developmental and epileptic encephalopathies (DEEs), and neurodevelopmental disorders (NDDs) with intellectual disability (ID). This study aimed to delineate the clinical progression and underlying pathogenesis of these disorders. Particularly, we unra...
mHealth adherence in pediatric epilepsy: Outcomes of a sequential, multiple assignment, randomized trial (SMART) -
OBJECTIVE: Nonadherence to antiseizure medications in pediatric epilepsy affects ~60% of youth. The aim of this multisite two-stage sequential, multiple assignment, randomized trial (SMART) was to evaluate the effectiveness of mHealth intervention strategies for improving adherence in caregivers of young children with epilepsy, particularly those who are underserved. It was hypothesized that pa...
'Pseudo-ataxic' negative myoclonic status in developmental and epileptic encephalopathy with spike-wave activation in sleep: Utility of ACTH therapy beyond west syndrome -
CONCLUSION: This case demonstrates for the first time the potential of ACTH in refractory DEE-SWAS with negative myoclonic status epilepticus, wherein conventional immunomodulation fails. The sustained clinical and electrographic improvement highlights the broader neuro-modulatory mechanisms of ACTH and supports its consideration in treatment algorithms. Larger prospective studies are warranted...
Clinical outcomes and learning curve of MRgLITT system for drug-resistant epilepsy in China: A single-center retrospective study -
OBJECTIVE: Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive technique that allows for real-time magnetic resonance imaging (MRI) monitoring and precise ablation of epileptogenic lesions. This study reports our initial clinical experience with a domestically developed MRgLITT system in patients with drug-resistant epilepsy (DRE) and evaluates its eff...
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