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Effectiveness and safety of cannabidiol in adult patients with epilepsy: A multicenter, retrospective study -
OBJECTIVE: Cannabidiol (CBD) has demonstrated promising effectiveness and tolerability as adjunctive treatment in patients with severe childhood epilepsies. This study investigated the effectiveness and tolerability of CBD in adults with a history of Dravet syndrome (DS), Lennox-Gastaut syndrome (LGS), or tuberous sclerosis complex (TSC).
CSNK2B-associated epilepsy: family report and literature review -
CONCLUSIONS: This study expanded the mutational and phenotypic spectrum of CSNK2B-related disorders by identifying a novel pathogenic nonsense mutation. Protein-level mutation location appeared to be more informative than mutation type in relation to epilepsy severity. We noticed that the composition of intradomain mutations may play a part in predicting DRE susceptibility. Further large-scale ...
TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala -
CONCLUSIONS AND IMPLICATIONS: Together, these findings uncover a central role for TRPM3 in amygdala function and identify this ion channel as a modulator of fear memory and seizure susceptibility.
Hippocampal LTP shifts from NMDAR dependence to mGluR/VGCC-supported mechanisms following juvenile status epilepticus in rats -
Hippocampal long-term potentiation (LTP) can persist in the chronic epileptic state, but the mechanisms supporting this residual plasticity remain poorly understood. In particular, it is unclear whether LTP retains canonical N-methyl-D-aspartate receptor (NMDAR) dependence or shifts to alternative induction mechanisms. We addressed this question in male rats during the chronic phase following j...
Transcranial rotating permanent magnet stimulation for focal continuous spike-and-wave during sleep: First-in-human pediatric pilot study -
OBJECTIVE: Continuous spike-and-wave during sleep (CSWS) is an epileptic encephalopathy characterized by sleep-potentiated epileptiform activity and neurocognitive deterioration. Available therapies are frequently ineffective or poorly tolerated. We evaluated the safety, tolerability, and acute electrophysiologic effects of transcranial rotating permanent magnet stimulation (TRPMS), a novel wea...
Valproate-Associated Hyperammonemic Encephalopathy Despite Nontoxic Serum Levels and Preserved Liver Function: A Case Report -
Valproate-associated hyperammonemic encephalopathy (VHE) is a potentially serious adverse effect that may occur despite nontoxic serum valproate concentrations and preserved liver function. We report a 49-year-old man with intellectual disability and long-standing drug-resistant epilepsy treated with valproate, phenytoin, phenobarbital, cenobamate, levetiracetam, and several psychotropic medica...
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