Epilepsy and Seizure News
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Ohtahara syndrome in early infancy: A case report and review of the literature -
RATIONALE: Ohtahara syndrome (OS), also known as early infantile epileptic encephalopathy, is a rare and severe neurologic condition characterized by early-onset intractable seizures, tonic spasms, and a characteristic suppression-burst pattern on electroencephalography. Early diagnosis and management are particularly challenging in resource-limited settings where access to genetic and metaboli...
Clinically Meaningful Reduction in Seizure Frequency in Patients with Tuberous Sclerosis Complex Treated with Cannabidiol -
CONCLUSION: When anchored to a CGIC rating of 'slightly improved' or better, the threshold for a clinically important response in seizure reduction was 33%, suggesting that a cut-off of 50% may overlook patients who are achieving meaningful improvements in their overall condition, as perceived by their caregivers. This exploratory analysis may help physicians to ascertain the level of improveme...
A Novel Variant of Congenital Disorder of Glycosylation Presenting with Psychomotor Retardation, Restricted Diffusion in the Brainstem and Corpus Callosal Malformation: A Case Report -
CONCLUSION: This case expands the radiological spectrum of ALG9-related CDG and highlights the importance of advanced neuroimaging and molecular diagnostics in children with unexplained developmental delay and epilepsy.
Tau spread plays an etiopathogenic connection between seizures and Alzheimer's disease -
Patients with Alzheimer's disease (AD) display heightened seizure susceptibility, in which neuronal hyperactivity during seizures correlates with exacerbated Tau pathology and cognitive impairment. This study integrated public transcriptomic datasets with machine learning approaches, suggesting Tau spread as a key biological association between seizure activity and AD. We validated activity-dep...
Bilateral cerebellar high-frequency rTMS for refractory epilepsy: a randomized, single-blind, sham-controlled study -
CONCLUSION: Active cerebellar rTMS was associated with reduced seizure frequency, improved responder rates, and suppressed IEDs in refractory epilepsy with no obvious discomfort. The optimal efficacy duration was approximately 2 months, with greater IED suppression in patients with higher baseline levels.
Risk factors for seizures in patients with brain metastases: integrating clinical features and molecular markers -
CONCLUSIONS: Our findings suggest an association between seizure risk and molecular status of the primary tumor, specifically BRAF mutations in melanoma and HER2+ breast cancer subtype. Additionally, we found an improved OS in BM patients experiencing seizures at onset of disease. These findings are exploratory and warrant confirmation in larger cohorts; this could help refine seizure-risk esti...
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