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Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG-Guided Radiofrequency Thermocoagulation-A Seizure-Onset Pattern-Based Stratified Analysis -
CONCLUSION: In this cohort, LVFA-present SOPs are strongly associated with favorable RFTC outcomes and may represent a prerequisite for postoperative scalp EEG normalization. Postoperative EEG is a sensitive objective endpoint that complements Engel classification. Systematic PET evaluation in larger cohorts may further refine candidate selection in MRI-negative patients.
Altered oligodendroglial cell development and increased myelination in SCN2A gain-of-function-linked epilepsy -
Gain-of-function variants in SCN2A, encoding the voltage-gated sodium channel Na(V)1.2, cause developmental and epileptic encephalopathies characterized by seizures, developmental delay, and white matter abnormalities. While Na(V)1.2 is known to regulate neuronal excitability, its role in oligodendroglial cells is unclear. Here, we show that Na(V)1.2 is expressed in early oligodendrocyte lineag...
Tumor-related epilepsy and preoperative cognitive performance in glioma: a preliminary study -
CONCLUSION: Seizure presentation was associated with better preoperative TMT-A performance after adjustment for selected demographic and tumor-burden factors. The persistence of this association across sensitivity analyses suggests that TRE may capture clinically relevant aspects of the tumor-brain context that are not fully reflected by conventional demographic, pathological, and molecular cha...
Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial -
CONCLUSIONS: The results of this Phase IIb pilot study suggest that a supervised aerobic exercise intervention for adults with epilepsy is feasible, acceptable, and appropriate to implement among participants who enroll. Recruitment remains the primary challenge to progressing this line of research and may represent a broader field-level barrier. Future trials should focus on improving how adul...
Comparison of the efficacy and safety of lacosamide and oxcarbazepine monotherapy in young children aged 1 month to 4 years with focal epilepsy: An ambispective cohort study based on real-world cli... -
CONCLUSION: In real-world clinical practice in China, LCM monotherapy demonstrated efficacy and safety comparable to those of OXC in young children with focal epilepsy, suggesting that LCM may represent an alternative option for off-label use in this age group. Its potential benefit for language development warrants further investigation.
Pioneering Epilepsy Surgery in Cameroon: Outcomes from the First Prospective Cohort of Surgical Patients with Drug-Resistant Epilepsy -
CONCLUSION: Epilepsy surgery was feasible in our resource-limited setting and was associated with encouraging short-term seizure and quality-of-life outcomes in carefully selected patients with MRI-visible, electroclinically concordant DRE who were able to complete presurgical evaluation. Larger multicentre studies with longer follow-up are needed to determine the durability and generalizabilit...
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