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Seizure freedom after vagus nerve stimulation in a patient with SCN3A-related network epilepsy and incomplete penetrance: A case report -
Genetic-based epilepsies often present as distributed neural network disorders, challenging traditional focal versus generalized classifications. We report a 20-year-old male with drug-resistant epilepsy associated with a previously unreported SCN3A missense variant (c.5970C > G; p.Ser1990Arg). Despite failure of multiple anti-seizure medications and a non-localizing electroclinical profile, th...
Ten-year cognitive outcomes following epilepsy surgery: Temporal lobectomy versus selective amygdalohippocampectomy -
OBJECTIVE: This study aimed to assess long-term memory outcomes in patients with temporal lobe epilepsy (TLE) who underwent anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SAH), compared to nonoperated TLE over a 10-year follow-up period.
Loss of microglial ATM drives synaptic pruning and cognitive impairment in epilepsy -
Microglia are the resident immune cells of the central nervous system, highly sensitive to oxidative stress and essential for maintaining synaptic homeostasis. While epilepsy induces profound redox imbalance, how oxidative stress reshapes microglial function and disrupts synaptic integrity remains unclear. Here we show that epileptic seizures drive early loss of ataxia-telangiectasia mutated (A...
Childhood Absence Epilepsy with Coexisting Centrotemporal Spikes: Frequency, Electroclinical Course and Prognosis -
CONCLUSION: Centrotemporal spikes were identified in 9% of patients with CAE. Focal seizures were not seen, suggesting that it reflects an EEG trait. Remission of the generalized epileptiform discharges correlates with ASM treatment and seizure outcome is excellent, despite persistence of centrotemporal spikes.
Altered EEG microstate dynamics reflect depressive symptoms in temporal lobe epilepsy -
CONCLUSION: Higher depressive symptom burden in unilateral TLE is associated with increased temporal rigidity of the ictal hemisphere-aligned brain microstate, reflecting impaired disengagement of epileptogenic network configurations. These findings suggest that depressive symptoms in TLE may be associated with epilepsy-related disruptions in large-scale neural dynamics.
Neuropsychiatric adverse events with anti-seizure medications in patients with epilepsy: A systematic review and meta-analysis -
CONCLUSION: ASM use in patients with epilepsy is accompanied by a range of NPAEs, with risk varying across distinct types of ASMs. These findings support considering NPAEs in ASM selection and routine monitoring in patients with epilepsy. The observational nature of the included studies, residual confounding, heterogeneity in comparator groups, outcome definitions, and limited data on dose, dur...
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