Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Apoptosis and Glial Marker Profiles in Hippocampus and Amygdala of Medically Intractable Temporal Lobe Epilepsy -
Medically intractable temporal lobe epilepsy is associated with potential neuronal and glial damage in key brain structures, including the hippocampus and amygdala. This study aimed to examine apoptosis, caspase expression, and glial activation markers in these regions, and to evaluate their associations with clinical variables. Hippocampal and amygdala tissues from 17 patients with medically i...
Post-neonatal epilepsy in newborns with neurologic conditions: a retrospective cohort study from a tertiary center - CONCLUSION: Regular surveillance of epilepsy in high-risk newborns may aid in early diagnosis and treatment initiation.
De Novo 2.2 Mb 19q13.42-q13.43 Microdeletion Encompassing U2AF2: Support for a Haploinsufficiency Model - U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential pre-mRNA splicing factor involved in the early stages of pre-mRNA splicing. To date, multiple individuals have been reported with predominantly heterozygous missense variants presenting intellectual disability, speech and motor delays, seizures, hypotonia, and thin or hypoplastic corpus callosum. Here, we describe a patient with a ...
Journal club: Seizure-related biomarkers of sudden unexpected death in epilepsy (SUDEP) in drug-resistant focal epilepsy (REPO(2)MSE): a prospective, multicentre case-control study - No abstract
Neuromodulation and sudden unexpected death in epilepsy: A systematic review of SUDEP rates across VNS, DBS, and RNS therapies - CONCLUSIONS: All three neuromodulation modalities are associated with SUDEP rates of 1.7-2.8 per 1000 patient-years, below expected DRE rates. VNS has the strongest evidence for a temporal decline in SUDEP risk. Prospective registries with standardised SUDEP surveillance are needed to establish causality.
Pyruvate dehydrogenase autoantibodies in autoantibody-negative patients with seizures are associated with reduced pyruvate dehydrogenase activity - OBJECTIVE: We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Post-neonatal epilepsy in newborns with neurologic conditions: a retrospective cohort study from a tertiary center - CONCLUSION: Regular surveillance of epilepsy in high-risk newborns may aid in early diagnosis and treatment initiation.
De Novo 2.2 Mb 19q13.42-q13.43 Microdeletion Encompassing U2AF2: Support for a Haploinsufficiency Model - U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential pre-mRNA splicing factor involved in the early stages of pre-mRNA splicing. To date, multiple individuals have been reported with predominantly heterozygous missense variants presenting intellectual disability, speech and motor delays, seizures, hypotonia, and thin or hypoplastic corpus callosum. Here, we describe a patient with a ...
Journal club: Seizure-related biomarkers of sudden unexpected death in epilepsy (SUDEP) in drug-resistant focal epilepsy (REPO(2)MSE): a prospective, multicentre case-control study - No abstract
Neuromodulation and sudden unexpected death in epilepsy: A systematic review of SUDEP rates across VNS, DBS, and RNS therapies - CONCLUSIONS: All three neuromodulation modalities are associated with SUDEP rates of 1.7-2.8 per 1000 patient-years, below expected DRE rates. VNS has the strongest evidence for a temporal decline in SUDEP risk. Prospective registries with standardised SUDEP surveillance are needed to establish causality.
Pyruvate dehydrogenase autoantibodies in autoantibody-negative patients with seizures are associated with reduced pyruvate dehydrogenase activity - OBJECTIVE: We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.