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Implantation of Deep Brain Stimulator Through Polyetheretherketone (PEEK) Cranioplasty -
CONCLUSIONS: This case series highlights how PEEK cranioplasties can be drilled through for therapeutic procedures, such as DBS electrode implantation, without compromising their structure. These cases illustrate the versatility, safety, and adaptability of PEEK implants for additional necessary interventions.
Subtle Hippocampal Subfield Volumetric Alterations in Clinically Diagnosed MRI-Negative Temporal Lobe Epilepsy -
CONCLUSION: These results imply that selective CA4-DG atrophy is a defining characteristic of the MRI-negative TLE phenotype, thereby corroborating the "dentate gate" failure hypothesis. Quantitative volumetry provides a crucial diagnostic tool in settings with limited resources, where advanced techniques like 3-T MRI or invasive monitoring are not accessible. This objective structural marker, ...
Microglial pathological synaptic pruning in epilepsy: pathophysiology and therapeutic potential -
Epilepsy affects around 70 million people worldwide, and roughly one-third of them respond poorly to standard antiepileptic drugs. Current treatments are directed almost entirely at neurons, leaving the contribution of non-neuronal cells largely unaddressed. Microglia, the resident immune cells of the central nervous system, both support neuronal survival and shape neural circuits by pruning sy...
Decades of Epilepsy Surgery Follow-up: What's Known and What's Not? -
No abstract
A comprehensive review of deep brain stimulation for drug-resistant epilepsy -
CONCLUSION: DBS represents an important therapeutic option for DRE, expanding the scope of neuromodulation beyond traditional surgical approaches. Optimal outcomes depend on individualized target selection based on seizure semiology, network characteristics, and anatomical considerations. As clinical experience and technological advances continue to evolve, further studies are required to refin...
Vagus nerve stimulation as an add-on therapy in patients with epilepsy: a prospective, multicenter, real-world study in China -
CONCLUSIONS: VNS is an effective and safe adjunctive treatment for epilepsy, reducing seizure frequency and significantly improving quality of life, with a cumulative effect over time.
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