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After the Spasms: Long-Term Outcomes Following Pulsatile Dexamethasone Therapy for Infantile Epileptic Spasms Syndrome: A Retrospective Observational Study -
CONCLUSIONS: Pulsatile dexamethasone for IESS treatment shows long-term outcomes comparable with other corticosteroids; patients achieving seizure freedom in the examined population received 4-7 pulses. Majority of seizure relapses occur within the first year after therapy, highlighting the importance of close follow-up, and early relapse in structural IESS may warrant prompt referral for epile...
Impact of Epileptiform Abnormalities on Functional Phenotype in a Cohort of Autism Spectrum Disorder Patients With or Without Epilepsy: A Monocentric Retrospective Study -
CONCLUSION: These findings highlight the potential influence of epileptiform activity on cognitive and behavioral outcomes in ASD. Further longitudinal research is warranted to elucidate the prognostic implications of EAs in ASD and better characterize its impact on functional profile.
The ongoing dilemma of immunotherapy in antibody-negative suspected autoimmune encephalitis-associated epilepsy: A retrospective cohort study -
OBJECTIVES: This study evaluates immunotherapy in drug-resistant epilepsy (DRE) patients with concern for autoimmune encephalitis-associated epilepsy (AEAE) but negative neural antibody testing (-Ab).
Beyond Seizure Suppression: Caffeic Acid Phenethyl Ester and 10-Hydroxy-2-Decenoic Acid Improve Anxiety-like and Cognitive Behaviors in PTZ-Challenged Zebrafish -
Epilepsy is associated with recurrent seizures and behavioral and cognitive disturbances, highlighting the importance of assessing behavioral outcomes alongside seizure severity. Caffeic acid phenethyl ester (CAPE) has shown neuroprotective activity, whereas evidence for the neurobehavioral effects of 10-hydroxy-2-decenoic acid (10-HDA) remains limited. This study investigated their individual ...
How to Implement a Ketogenic Diet Therapy in Developing Countries: Colombian Consensus on Ketogenic Diet Therapy Use in the Management of Adults with Drug-Resistant Epilepsy -
CONCLUSIONS: Evidence around KDT shows it can be implemented safely as an adjunctive treatment for adults with drug-resistant epilepsy and is reasonable to consider following the failure of two adequate antiseizure medications. Structured implementation may reduce seizure frequency, improve quality of life, and reduce the pharmacological burden. Multicenter prospective studies are needed to fur...
Harnessing Neurogenic Potential of Glial Cell Types as an Emerging Strategy for Treating Epilepsy -
In every third case of epilepsy, anti-seizure drugs are ineffective, so the search for new therapies for this disease is ongoing. In recent years, new methods for generating cells with desired properties, as well as for the targeted expression of genes in specific cell types in situ within the brain, were designed. These methods allowed researchers to consider the idea of transforming resident ...
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