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EGR3 deletion attenuates developmental and epileptic encephalopathy in Kcna1-null mice -
KCNA1 encodes the α-subunit of the voltage-gated potassium channel KV1.1. Mutations in KV1.1's pore domain result in developmental and epileptic encephalopathy (DEE), where early life seizures and a culprit lesion synergistically disrupt neurodevelopmental trajectories, resulting in intellectual disability that often presents with disturbances in sleep, sociability and sensory processing. Abnor...
Entropy of the resting state cortex in epilepsy -
Epilepsy has long been conceptualised as a disorder in which aberrant brain dynamics extend beyond the epileptogenic zone. Evidence demonstrates that loss of entropy is a generic feature of pathological dynamics in the brain, including the ictal state. However, the impact of recurrent seizures on entropy in the interictal state remains unknown. Resting state magnetoencephalography (MEG) scans a...
Home video-only recording in epilepsy care: clinical applications, technological platforms, and future directions -
Home video-only recordings (HVR) of seizures are an important adjunct in diagnosing and managing epilepsy alongside video-EEG (vEEG) monitoring. HVR demonstrates high levels of accuracy, sensitivity, and specificity, making them useful for distinguishing between epileptic seizures and non-epileptic spells. HVR effectively monitors patients experiencing spells (such as movement abnormalities lik...
Resilience as a mediating mechanism between psychological distress and quality of life in epilepsy -
CONCLUSION: These findings identify resilience as a potential mechanism linking stress to HRQoL in epilepsy and support a multidimensional understanding of overall well-being that encompasses both psychological and clinical determinants. Interventions targeting stress reduction and resilience enhancement may contribute to improved patient-reported outcomes.
Abnormal ECG Findings in Children Undergoing Seizure Evaluation -
CONCLUSIONS: The identification of cardiac abnormalities in children undergoing evaluation for a possible seizure disorder allows not only optimization of seizure management but also guides differential diagnosis, specific cardiological interventions, and avoidance of antiseizure medication that might exacerbate cardiac arrhythmias. It is crucial to pay attention to the ECG channel of the elect...
Longitudinal EEG, Seizure, and Developmental Patterns in Children With CDKL5 Deficiency Disorder in the First 2 Years of Life -
BACKGROUND AND OBJECTIVES: Although there is near-universal early-onset epileptic encephalopathy in cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD), it has been observed clinically that EEGs are initially only mildly abnormal and worsen in the first 2 years of life. This study aimed to identify specific EEG patterns, ictal and interictal, in individuals with CDD during the firs...
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