Epilepsy News
Recent news about epilepsy, seizures and treatments.
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EEG Functional Connectivity Methods for Seizure-related Disorders -
EEG functional connectivity analysis is increasingly used to study neurological disorders. However, the lack of standardization in connectivity estimation limits its clinical translation. This work addresses the need for more guidance in connectivity pipeline design by evaluating numerous techniques in two seizure-related disorders to identify optimal approaches. Retrospective EEG data were ana...
Reconstruction and validation of a short version of the scale for suspicion of psychogenic non-epileptic seizures in a Japanese cohort - CONCLUSION: In our Japanese cohort, the original 15-item scale did not show reproducibility, so a shortened version with a two-factor structure was developed and evaluated. The new SS-PNES-short had high sensitivity but low specificity for identifying FDS. The addition of epilepsy-specific factors may improve the specificity of SS-PNES.
Spike-wave detection in ultra-long-term EEG recordings from patients with absence seizures - CONCLUSIONS: Patient-specific CNN-based detectors demonstrated excellent performance, and cross-patient detectors performed comparably.
Phenotype and genotype of people with epilepsy and GABAA receptor gene variants: Genetic and clinical characterization of six children in China - CONCLUSION: Clinical phenotypic heterogeneity in epilepsy associated with GABA(A) receptor variants is significant and may relate to variant type and location. This study expands the spectrum of known pathogenic variants in a Chineses cohort and provides a reference for clinical diagnosis and genetic counseling. The findings underscore the need for large-scale collaborative studies to further r...
Exploring DHODH inhibition with silibinin as a promising approach to treat drug resistance in epilepsy - Mitochondrial dysfunction and excessive production of reactive oxygen species (ROS) are key contributors to the pathogenesis of drug resistant epilepsy (DRE). Recent findings suggest DHODH, a mitochondrial enzyme may influence neuronal excitability by affecting intrinsic firing set points. Dysregulated DHODH activity may elevate set points, contributing to persistent hyperexcitability in epilep...
Levetiracetam for Seizure Prophylaxis after Traumatic Brain Injury: A Severity-Stratified Cohort Study of 51,000 Patients - OBJECTIVES: The objective of this study was to evaluate the effectiveness and adverse effect profile of prophylactic levetiracetam in preventing epilepsy after traumatic brain injury (TBI).
Reconstruction and validation of a short version of the scale for suspicion of psychogenic non-epileptic seizures in a Japanese cohort - CONCLUSION: In our Japanese cohort, the original 15-item scale did not show reproducibility, so a shortened version with a two-factor structure was developed and evaluated. The new SS-PNES-short had high sensitivity but low specificity for identifying FDS. The addition of epilepsy-specific factors may improve the specificity of SS-PNES.
Spike-wave detection in ultra-long-term EEG recordings from patients with absence seizures - CONCLUSIONS: Patient-specific CNN-based detectors demonstrated excellent performance, and cross-patient detectors performed comparably.
Phenotype and genotype of people with epilepsy and GABAA receptor gene variants: Genetic and clinical characterization of six children in China - CONCLUSION: Clinical phenotypic heterogeneity in epilepsy associated with GABA(A) receptor variants is significant and may relate to variant type and location. This study expands the spectrum of known pathogenic variants in a Chineses cohort and provides a reference for clinical diagnosis and genetic counseling. The findings underscore the need for large-scale collaborative studies to further r...
Exploring DHODH inhibition with silibinin as a promising approach to treat drug resistance in epilepsy - Mitochondrial dysfunction and excessive production of reactive oxygen species (ROS) are key contributors to the pathogenesis of drug resistant epilepsy (DRE). Recent findings suggest DHODH, a mitochondrial enzyme may influence neuronal excitability by affecting intrinsic firing set points. Dysregulated DHODH activity may elevate set points, contributing to persistent hyperexcitability in epilep...
Levetiracetam for Seizure Prophylaxis after Traumatic Brain Injury: A Severity-Stratified Cohort Study of 51,000 Patients - OBJECTIVES: The objective of this study was to evaluate the effectiveness and adverse effect profile of prophylactic levetiracetam in preventing epilepsy after traumatic brain injury (TBI).
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.