Epilepsy News

Efficacy of Levetiracetam in Patients With Pediatric Epilepsy: A Systematic Review and Meta-Analysis - BACKGROUND AND OBJECTIVES: Levetiracetam (LEV) is widely used in pediatric epilepsies because of its favorable pharmacokinetics, ease of administration, and perceived tolerability. However, its comparative efficacy relative to established antiseizure medications (ASMs) in children remains uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to eva...

The relationship of cucurbitacin E with epileptic seizures, circadian rhythm, and genetics in a pentylenetetrazole-induced mouse model of epilepsy - CONCLUSION: These findings demonstrate that CuE exerts anticonvulsant effects through integrated chronomodulatory and antioxidant mechanisms, supporting its potential as a multi-target therapeutic strategy for epilepsy management.

Rapamycin and Minocycline Treatment Does Not Rescue Behavioral and Molecular Changes Induced by Early-Life Seizures in Female Mice - Early-life seizures lead to long-term behavioral deficits, stimulate cytokine release, and disrupt the intracellular PI3K/AKT/mTOR signaling pathway. This study examined whether inhibiting the mTOR pathway, neuroinflammatory signaling, or both reduces behavioral comorbidities in adulthood. Female C57BL/6J mice received kainic acid on postnatal day 10 to induce status epilepticus. Three hours la...

Localizing value of cutaneous ictal phenomena: A systematic review - CONCLUSIONS: Ictal cutaneous symptoms offer distinct localizing utility in epilepsy. Piloerection and pallor serve as reliable "red flags" for temporal lobe involvement, whereas flushing is indicative of a posterior quadrant origin. Despite the limitations of current evidence-primarily retrospective case reports-these autonomic signs provide valuable supporting data for multimodal localization ...

Electroclinical characteristics, genetic findings, and complex epilepsy surgery outcomes in children with low-grade epilepsy-associated tumors: A comprehensive view - OBJECTIVE: To evaluate outcomes in relation to epilepsy characteristics and genetic findings in pediatric patients with isolated low-grade epilepsy-associated tumors (LEAT) and LEAT plus focal cortical dysplasia type IIIb (FCD IIIb) who underwent epilepsy surgery.

Case Report: Recurrent pathogenic mutation c.110G>A in DHDDS gene - Recent studies have demonstrated the close association of mutations in the dehydrodolichyl diphosphate synthase (DHDDS) gene with neurodevelopmental disorders and the onset of epilepsy. This report describes a female patient harboring a de novo heterozygous variant c.110G>A (p.Arg37His) in the DHDDS gene, characterized by childhood-onset myoclonus-like movement disorder (at age 6) and late-onse...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.