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Cenobamate-associated weight loss (Cenobaweight study) -
CONCLUSIONS: A larger than expected number of patients in two centers had significant unintentional weight loss associated with CNB use. In a subset, the effect appeared to be reversible with minor dose reduction, even with severe weight loss. Systematic weight assessment should be considered in all patients on CNB, especially with telehealth. Clinicians should rule out contributing etiologies ...
MulPi: A Multi-class and Patient-independent Epileptic Seizure Classifier with Co-designed Input-stationary Computing-in-SRAM -
Unprovoked seizures have threatened epilepsy patients over 70 million. Automated classification to detect and predict seizures could bring seizure-free lives to epilepsy patients, delivering them from fatal danger and increasing the quality of life. Authentic detection and prediction of seizures require 1) multi-class (Mul) and 2) patient-independent (Pi) classification. Recent implementable ch...
Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations -
Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifests as cardiac disorders. Patients with epilepsy (PWE), particularly those with poorly controlled seizures, have a higher prevalence of cardiac pathologies com...
The Importance of Impedance: A Case of Responsive Neurostimulation Failure Characterized by Concurrent Stereoelectroencephalography -
Epilepsy neuromodulation treatment failure is a significant challenge, with multiple possible causes. The responsive neurostimulation (RNS) system delivers stimulation from a single current source, and the relative flow of the electrical current through each stimulating contact is inversely proportional to the relative impedance of each contact. Current shunting through low-impedance contacts (...
Concordant interictal stereoelectroencephalographic high-frequency oscillations and magnetoencephalography predict better surgical outcomes in focal epilepsy -
OBJECTIVE: This study was undertaken to investigate the concordance between magnetoencephalographic (MEG) and interictal stereoelectroencephalographic (SEEG) high-frequency oscillations (HFOs) and their impact on surgical outcomes.
Relative roles of HCN4 and synaptic excitation in pyramidal neuron firing rates in a hyperactive Rheb-mTOR condition -
OBJECTIVE: De novo somatic mutations in mTOR pathway genes during fetal development lead to focal malformation of cortical development (FMCD) and epilepsy. This FMCD is characterized by misplacement of enlarged pyramidal neurons displaying increased mTOR activity. Whether these neurons display enhanced excitability has remained an open question. Several lines of evidence in experimental murine ...
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