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Effects of carbamazepine and phenytoin in Krushinsky-Molodkina rats: further validation of the audiogenic kindling model of epilepsy -
In the present study, we evaluated the effects of the clinically approved anti-seizure medications (ASMs) carbamazepine (CBZ) and phenytoin (PHT) on brainstem audiogenic seizures (AGS) and limbic seizures in Krushinsky-Molodkina (KM) audiogenic rats. In order to analyze the effects of ASMs on the standard AGS, KM rats received single intraperitoneal injection of CBZ (50 mg/kg), PHT (25 mg/kg), ...
Epi-Spec2State: Convolutional state space model via spectrogram image sequences for prediction-oriented seizure state classification in EEG signals -
CONCLUSION: The proposed Epi-Spec2State can effectively capture the complex spatiotemporal dependencies in EEG signals. Its ability to handle diverse EEG types highlights its potential to support seizure state analysis and pre-seizure warning in clinical practice.
Cenobamate and Trazodone Combination Suppresses Seizures, EEG Alterations, Preserves Neuronal Architecture and Normalizes the BDNF/TrkB Expression in PTZ-Kindled Mice -
Polytherapy is increasingly needed to overcome the limitations of monotherapy in epilepsy and its comorbidities. Therefore, we investigated the effect of cenobamate (CNB, 30 mg/kg) and trazodone (TZ, 10 mg/kg), alone and in combination, in PTZ-kindling model, where mice received 11 doses of pentylenetetrazole (PTZ, 40 mg/kg) every other day for three weeks. Behavioral seizure scoring, electroen...
A Young Child With Global Developmental Delay and Epilepsy Secondary to a Novel Variant of KBG Syndrome -
KBG syndrome is a rare neurodevelopmental disorder caused by changes in the ANKRD11 gene (ankyrin repeat domain-containing protein 11). It is typically inherited in an autosomal dominant pattern. This syndrome is characterized by a distinct constellation of clinical findings, including short stature, distinctive craniofacial manifestations, skeletal abnormalities, and abnormal patterns of hair ...
Neuromodulation by electrical stimulation timing during picture naming task based on high gamma dynamics -
CONCLUSIONS: A strong relationship exists between the HGA and the ECS-timing. Short ECS disrupts brain functions and networks when appropriately aligned with the HGA. Combining HGA dynamics with ECS reveals the functional distribution and physiological dynamics during naming tasks.
Machine learning-based lateralization and localization of seizure onset in focal cortical dysplasia patients using ictal scalp EEG -
INRODUCTION: This study aimed to develop and evaluate a machine learning framework for classifying seizure onset zone lateralization and localization in patients with focal cortical dysplasia using ictal scalp electroencephalography (EEG).
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