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Lived experiences and acceptability challenges among caregivers of people with epilepsy in Limpopo and Mpumalanga, South Africa -
CONCLUSION: Caregiving for PWE in rural South Africa is a demanding and socially shaped experience that extends beyond seizure management to include emotional labor, social negotiation, and structural hardship. Interventions to improve epilepsy outcomes should include caregiver education, stigma reduction, family-centered psychosocial support, and stronger community- and primary healthcare-base...
Caregiver burden and associated factors among primary caregivers of children with epilepsy in southwestern Uganda -
CONCLUSION: Caregiver burden is highly prevalent among caregivers of children with epilepsy in rural Southwestern Uganda and is influenced by both caregiver characteristics and child-related clinical factors. Integrating caregiver-focused psychosocial support into epilepsy care services may help reduce caregiver burden and improve outcomes for children and their families in resource-limited set...
Expanding the phenotypic Spectrum of ZNF711: Autism and epilepsy in two siblings -
Zinc Finger Protein 711 (ZNF711) is a Krüppel-type zinc finger transcription factor highly expressed in the brain and whose mutations have been associated with neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, and epilepsy. While most pathogenic variants previously described affect the C-terminal DNA-binding domain, we report two siblings carrying a rare he...
Fenfluramine for seizures in Dravet syndrome and Lennox-Gastaut syndrome: Mechanisms, clinical evidence, safety, and practical integration -
Developmental and epileptic encephalopathies such as Dravet syndrome and Lennox-Gastaut syndrome remain highly drug resistant and are associated with substantial neurodevelopmental, behavioral, and caregiver burdens. Fenfluramine, repurposed at low antiseizure doses, is approved as adjunctive therapy for both syndromes and has a distinct multimodal mechanism that combines serotonergic modulatio...
Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management -
Epilepsy is a common neurological disorder with a substantial global burden. Despite major advances in diagnosis and therapy, nearly one-third of patients remain resistant to antiseizure medications, highlighting persistent gaps in understanding epileptogenesis and disease progression. Here, we review epidemiological evidence, time-dependent seizure patterns, and pathogenic mechanisms that cont...
The Role of Emergent Brain CT Scans in the Management of Epilepsy Patients Presenting With Breakthrough Seizures -
Background and purpose Approximately 1-3% of global emergency department (ED) visits are for acute seizures. The role of neuroimaging with non-contrast computed tomography (CT) has been well described for first-time unprovoked seizures. However, current guidelines provide limited or non-specific recommendations for the utility of routine neuroimaging in patients with a known history of epilepsy...
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