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Clinical outcomes and risk factors in pediatric epilepsy associated with focal cortical dysplasia: a retrospective cohort study of 628 imaging-confirmed cases -
CONCLUSION: Children with FCD show marked clinical heterogeneity, and their prognosis is closely associated with neurodevelopmental deficits, lesion extent, and electrophysiological characteristics. Early identification of these high-risk factors, together with cluster-based stratified management, may be of substantial importance for improving patient outcomes.
Prevalence, treatment gap and factors associated with epilepsy: findings from the Ningxia neuro-epidemiologic study (NNES) in northwestern China -
BACKGROUND AND OBJECTIVES: Prior estimates of epilepsy prevalence in Ningxia have varied substantially across studies, largely reflecting methodological heterogeneity in survey scope, case definitions, and diagnostic criteria. This population-based study used a standardized protocol to estimate the prevalence, treatment gap, seizure characteristics, and factors associated with epilepsy in Ningxia.
Amygdala-HPA axis interactions in temporal lobe epilepsy with anxiety comorbidity -
Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy and is frequently associated with various psychiatric and psychological comorbidities, among which anxiety is one of the most common and clinically significant symptoms. Anxiety not only significantly reduces patients' quality of life and treatment adherence but may also increase susceptibility to seizures, thereby exacerbat...
Cenobamate in Focal-Onset Refractory and Super-Refractory Status Epilepticus: A Multicenter Cohort Study With Matched Analysis -
BACKGROUND AND OBJECTIVES: Cenobamate (CNB) is an antiseizure medication (ASM) with demonstrated efficacy in drug-resistant focal epilepsy, but its role in status epilepticus (SE) remains unclear. Emerging evidence suggests that it may achieve early clinically meaningful seizure control at relatively low doses, with an acceptable safety profile, supporting its potential utility as an urgent adj...
Robust Epilepsy Diagnosis in Neonates Via Spatio-Temporal Graph Learning and Balanced Test-Time Training -
Timely diagnosis of neonatal epilepsy is critical for mitigating long-term neurodevelopmental deficits. However, while neonates exhibiting extensive seizure burden are readily identified, accurately diagnosing epileptic infants with sparse or no overt seizure onset during monitoring remains a formidable challenge using electroencephalogram (EEG) signals alone. Current automated systems predomin...
Early seizure risk after stereotactic radiosurgery for brain metastases: a multicenter analysis of LINAC- and gamma knife-treated cohorts -
CONCLUSIONS: Early post-SRS seizures are an uncommon complication in patients without a history of epilepsy. Seizure risk appears mainly driven by intracranial disease burden, reflected by total irradiated volume and number of lesions at diagnosis, whereas technical SRS parameters do not seem to affect seizure incidence.
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