Epilepsy News

Circuit-Selective FAAH Inhibition Suppresses Experimental Absence Seizures - CONCLUSION: FAAH inhibition represents a mechanistically distinct and circuit-selective strategy to suppress absence seizures, likely through elevation of endogenous AEA and targeted modulation of thalamocortical networks. These findings support further translational development of FAAH inhibitors as potential therapies for CAE.

Activation of lateral septum dorsal GABAergic neurons alleviates epilepsy in mice - Temporal lobe epilepsy (TLE) represents a common neurological disorder characterized by seizures arising from imbalances between neuronal excitation and inhibition (E-I). Correction of such imbalances has been shown to influence epileptogenesis. The hippocampal CA3 region possesses a high density of kainate receptors (KARs), implicated in the induction of epileptic seizures, and contains a high...

Depression and anxiety in adults with epilepsy. Systematic literature review and meta-analysis - CONCLUSION: Depressive and anxiety symptoms are frequent in PWE, supporting systematic screening and integrated mental health care within epilepsy management.

Nailfold videocapillaroscopy reveals early microvascular changes in pediatric epilepsy - CONCLUSION: Chronic ASMs exposure, particularly valproic acid, may lead to subtle but measurable alterations in microcirculation. NVC may serve as a practical, non-invasive method for the early detection of endothelial dysfunction in pediatric epilepsy and could aid long-term vascular monitoring in this population.

High Theta (4-10 Hz) power as a biomarker of inhibition during epileptogenesis in an animal model of mesial temporal lobe epilepsy - Theta oscillations (4-10 Hz) are a prominent electrophysiological feature of the hippocampus and are highly dependent on the activity of interneurons and GABAergic signaling. In mesial temporal lobe epilepsy (MTLE), theta oscillations are disrupted in the hippocampus and extra-hippocampal structures. We studied here the time-sensitive changes of hippocampal theta oscillations during epileptogen...

Thalamic glutamatergic neurons regulate seizure onset and generalization in temporal lobe epilepsy - Temporal lobe epilepsy (TLE) is a common form of epilepsy in adults. The anterior nucleus of the thalamus (ANT) is a potential therapeutic target due to its role in epileptic networks. Using calcium imaging, we show that glutamatergic neurons in the anterodorsal thalamic nucleus (AD), a subarea of the ANT, are activated during hippocampal seizures. Chemogenetic inhibition of AD glutamatergic ne...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.