Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Unraveling the Inflammatory Enigma: Is Neuroinflammation a Culprit or Consequence in Pharmacoresistant Epilepsy? -
CONCLUSION: These findings reveal a temporal dissociation in the roles of neuroinflammation: acute inflammation acts as a potent initiator of epileptogenesis, whereas chronic, sustained inflammation coincides with the drug-resistant phenotype. This study refines the prevailing view of neuroinflammation from a static pathogenic factor to a dynamic, phase-dependent modulator, supporting the ratio...
Expansion of the Clinical Spectrum of Autosomal Recessive Fatty Acyl-CoA Reductase 1 (FAR1) Deficiency: A Previously Unreported Association With Imperforate Anus-A Case Report - Peroxisomal fatty acyl-CoA reductase 1 (FAR1) deficiency is a rare single-enzyme peroxisomal disorder caused by biallelic pathogenic variants in FAR1, typically manifesting with severe neurodevelopmental delay, hypotonia, early-onset epilepsy, and congenital cataracts. We report a male infant born to first-cousin parents presenting with severe global developmental delay, refractory seizures, pr...
Clinical and Cytogenomic Characterization of Three Patients With Distal 1q43q44 Deletion: Twin Sisters With a de novo Deletion and a Patient With der(1)t(1;21)(q43;q22.3)mat - CONCLUSION: These findings further support the role of haploinsufficient genes within the distal 1q43q44 region, particularly AKT3, HNRNPU, and ZBTB18, to the core neurodevelopmental phenotype and highlight the value of high-resolution genomic analysis for patient characterization.
Cardiac Autonomic Modulation in Seizure Disorders With and Without Interictal Epileptiform Discharges: A Retrospective Heart Rate Variability Analysis Using Archived Digital EEG Recordings - Background Cardiac autonomic dysfunction is increasingly recognized in epilepsy and has been implicated in cardiovascular complications and sudden unexpected death in epilepsy (SUDEP). Heart rate variability (HRV) provides a non-invasive measure of cardiac autonomic modulation; however, the influence of interictal epileptiform discharges (IEDs) on resting HRV remains uncertain. This study compa...
Ertapenem-Associated Neurotoxicity in a Patient With Chronic Kidney Disease and Hypothyroidism: A Case Report - Carbapenems are broad-spectrum antibiotics used to treat infections caused by multidrug-resistant organisms and are associated with neurotoxicity, especially in high-risk groups. Although ertapenem generally has a lower risk of seizures, factors such as advanced age, pre-existing neurological conditions, renal impairment, and hypoalbuminemia can raise the likelihood of adverse effects. We repor...
Dyke-Davidoff-Masson Syndrome Underlying Hemiplegic Cerebral Palsy in an Adolescent: A Case Report - Dyke-Davidoff-Masson syndrome (DDMS) is a rare clinicoradiological syndrome involving unilateral cerebral hemiatrophy with compensatory calvarial changes. It typically presents with seizures, contralateral hemiparesis or hemiplegia, and developmental delay. The clinical manifestations may overlap with those of hemiplegic cerebral palsy, potentially delaying recognition of the underlying structu...
Expansion of the Clinical Spectrum of Autosomal Recessive Fatty Acyl-CoA Reductase 1 (FAR1) Deficiency: A Previously Unreported Association With Imperforate Anus-A Case Report - Peroxisomal fatty acyl-CoA reductase 1 (FAR1) deficiency is a rare single-enzyme peroxisomal disorder caused by biallelic pathogenic variants in FAR1, typically manifesting with severe neurodevelopmental delay, hypotonia, early-onset epilepsy, and congenital cataracts. We report a male infant born to first-cousin parents presenting with severe global developmental delay, refractory seizures, pr...
Clinical and Cytogenomic Characterization of Three Patients With Distal 1q43q44 Deletion: Twin Sisters With a de novo Deletion and a Patient With der(1)t(1;21)(q43;q22.3)mat - CONCLUSION: These findings further support the role of haploinsufficient genes within the distal 1q43q44 region, particularly AKT3, HNRNPU, and ZBTB18, to the core neurodevelopmental phenotype and highlight the value of high-resolution genomic analysis for patient characterization.
Cardiac Autonomic Modulation in Seizure Disorders With and Without Interictal Epileptiform Discharges: A Retrospective Heart Rate Variability Analysis Using Archived Digital EEG Recordings - Background Cardiac autonomic dysfunction is increasingly recognized in epilepsy and has been implicated in cardiovascular complications and sudden unexpected death in epilepsy (SUDEP). Heart rate variability (HRV) provides a non-invasive measure of cardiac autonomic modulation; however, the influence of interictal epileptiform discharges (IEDs) on resting HRV remains uncertain. This study compa...
Ertapenem-Associated Neurotoxicity in a Patient With Chronic Kidney Disease and Hypothyroidism: A Case Report - Carbapenems are broad-spectrum antibiotics used to treat infections caused by multidrug-resistant organisms and are associated with neurotoxicity, especially in high-risk groups. Although ertapenem generally has a lower risk of seizures, factors such as advanced age, pre-existing neurological conditions, renal impairment, and hypoalbuminemia can raise the likelihood of adverse effects. We repor...
Dyke-Davidoff-Masson Syndrome Underlying Hemiplegic Cerebral Palsy in an Adolescent: A Case Report - Dyke-Davidoff-Masson syndrome (DDMS) is a rare clinicoradiological syndrome involving unilateral cerebral hemiatrophy with compensatory calvarial changes. It typically presents with seizures, contralateral hemiparesis or hemiplegia, and developmental delay. The clinical manifestations may overlap with those of hemiplegic cerebral palsy, potentially delaying recognition of the underlying structu...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.