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CT-based radiomic markers to predict late-onset seizures after traumatic brain injury -
Post-traumatic epilepsy (PTE) is a major long-term complication of traumatic brain injury (TBI), but early risk prediction remains imprecise. Radiomics enables quantitative analysis of subtle abnormalities on non-contrast head CT (NCCT) that are not readily visible on routine imaging and may improve early risk stratification. This pilot study assessed the performance of radiomic features from a...
Alcohol and seizures -
Alcohol-related seizures are a frequent neurological emergency, yet their management is often inconsistent. This article provides a practical, clinically orientated framework for evaluating and treating these seizures across different clinical settings. It reviews the neurobiological mechanisms linking alcohol use, withdrawal and seizure susceptibility; outlines a structured diagnostic work-up ...
Real-world clinical experience with intravenous perampanel in Japanese patients at perceived high risk for early postoperative or acute symptomatic seizures: A single-center retrospective observati... -
CONCLUSION: This retrospective observational study suggests feasibility and acceptable tolerability of PER-IV; however, preventive effects cannot be determined in this uncontrolled study without systematic EEG monitoring. PER-IV is a feasible and well-tolerated option in patients at increased risk of early postoperative or acute symptomatic seizures who are temporarily unable to take oral antis...
Altered structural connectivity in epilepsy with myoclonic atonic seizures -
CONCLUSIONS: A specific altered cortico-subcortical network including pericentral motor areas and probably reticular formation, was identified in our EMAS sample. This supports the Doose's original hypothesis of a brainstem-cortical network involvement in EMAS. These changes were not explained by differences in FA or ADC but decrease in the NoF. The role of sustained seizure activity, antiseizu...
Adjunctive cenobamate in children and adolescents - real-world data from a retrospective multicenter study -
CONCLUSION: Our study provides evidence that cenobamate is an effective and well-tolerated ASM in children and adolescents, including in the younger pediatric population. Our findings support the administration of cenobamate in children with focal, drug-resistant epilepsy as adjunctive therapy alongside the use of more established ASMs.
Pulsed focused ultrasound for seizure suppression: Mechanisms, models, and clinical translation -
Focused ultrasound (FUS) has emerged as a versatile, non-invasive therapeutic platform for drug-resistant epilepsy, offering both thermal effects for the permanent ablation of epileptogenic foci and non-thermal mechanical mechanisms for the reversible neuromodulation of neural activity, all without the need for surgical implantation. Pulsed focused ultrasound (pFUS) achieves seizure control thr...
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