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Seizure and motor outcomes following subtotal hemispherotomy: A retrospective case series and systematic review -
CONCLUSION: SH preserved motor function in all patients. However, fewer than half of our patients remained seizure-free at long-term follow-up, a lower rate than reported in the literature. SH may be considered when preservation of motor function is a priority, provided that families are counseled that seizure outcomes may be inferior to those of complete hemispherotomy.
Temporal trends in GBD idiopathic epilepsy burden across 43 European countries, 1990-2023 -
CONCLUSIONS: Age-standardized DALY, YLL, and YLD rates for GBD idiopathic epilepsy declined on average across 43 European countries from 1990 to 2023. This overall improvement masked major national differences, particularly in burden from premature mortality. Country-specific monitoring remains important because the European average does not describe all national trajectories.
Predicting the risk of seizure recurrence after antiseizure medication withdrawal in children with epilepsy: An individualized and web-based clinical decision support model -
CONCLUSIONS: SE, FS, active epilepsy duration, and pre-withdrawal seizure-free duration independently predict recurrence in children with normal pre-withdrawal EEGs. Embedding this model into a web tool enables dynamic, evidence-based risk stratification in pediatric practice.
Full title: From neural excitability to volatile signatures: A mechanistic hypothesis for pre-ictal volatile organic compound signatures in epilepsy -
OBJECTIVE: Seizure unpredictability remains a major contributor to morbidity in epilepsy, and biomarkers capable of identifying pre-ictal states are critically needed. Volatile organic compounds (VOCs) have emerged as potential noninvasive indicators of seizure susceptibility, yet the biological mechanisms linking pre-ictal neural states to peripheral volatile signatures remain poorly understood.
Awareness, attitudes toward epilepsy, and first-aid knowledge of seizures among rural primary care doctors in Eastern China -
CONCLUSION: The awareness and attitudes of young rural primary care doctors toward epilepsy in the rural clinics were suboptimal. We recommend targeted training for young rural primary care doctors (covering first aid, novel ASMs, and patient counseling for marriage, dating, and pregnancy), combined with telemedicine integration to establish specialist support networks and optimize rural epilep...
Targeted gene therapy alleviates epilepsy and hyperexcitability in models of SCN2A deficiency -
Pathogenic SCN2A loss-of-function (LoF) variants can cause severe, refractory epilepsy with limited treatment options. Existing Scn2a-LoF mouse models exhibit few spontaneous seizures, limiting the dynamic range needed to assess therapeutic efficacy. We therefore generated gene-trap Scn2a-deficient mice on the seizure-prone DBA/2J background. These mice experienced hundreds of spontaneous absen...
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