Epilepsy and Seizure News
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Analysis of Risk Factors Affecting Epilepsy Seizure Frequency with Statistical Models -
CONCLUSION: While our study found that stress, sleep deprivation, fasting/prolonged hunger, and excessive physical activity may increase seizure frequency, it was also determined that some additional, unidentified environmental or genetic factors affect seizure frequency. The limited sample size, heterogeneity of the patient population, and reliance on patients' subjective assessments constitut...
Clozapine-Associated Generalized Seizure at Therapeutic Dose Without Prior Epilepsy: A Case Report -
CONCLUSION: Clozapine may precipitate seizures at therapeutic doses in patients with latent epileptiform susceptibility. When therapeutic drug monitoring is unavailable, careful clinical assessment, EEG evaluation, and exclusion of alternative causes are essential. Dose reduction with anticonvulsant therapy may permit safe continuation of clozapine.
Ethnopharmacological relevance of Chinese medicinal materials and natural products in epilepsy: a critical multi-target review integrating neurons, glia and inflammatory signaling -
Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures, substantial comorbidity, and persistent pharmacoresistance in approximately one-third of affected patients. Chinese medicinal materials, including botanical drugs, selected animal-derived medicinal materials, extracts, and defined natural metabolites, have long been used as adjunctive approaches for seiz...
Nucleus-specific thalamic involvement in seizure networks differentiates neuromodulation outcomes -
Closed-loop neuromodulation via responsive neurostimulation (RNS) of the thalamus has emerged as a promising therapy for drug-resistant epilepsy (DRE), particularly in patients with broad or multifocal onset. However, response to thalamic RNS is inconsistent, and there is a crucial need to identify factors that distinguish responders from non-responders. Given the heterogeneous composition of t...
Developing a Specialized Dravet Syndrome Ontology for Rare Disease Informatics and AI Applications -
Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy whose clinical and research representation requires integration of heterogeneous knowledge spanning seizures, development, behavior, SUDEP/autonomic risk, genetics, comorbidities, electrophysiology, pharmacology, and drug responsiveness. We report the development of a DS-focused ontology created by expert-guided special...
Monogenic epilepsies exhibit distinct sleep endophenotypes -
Monogenic epilepsies are 1.6 times more likely to be treatment-resistant compared to other epilepsies, emphasizing the need for additional therapeutic strategies. Sleep dysfunction beyond sleep-related breathing disorders is common yet insufficiently characterized and treated in monogenic epilepsies. We therefore sought to study sleep phenotypes across these epilepsies, examine associations wit...
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