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Cardiac repolarization abnormalities and SUDEP risk in epilepsy -
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, yet its mechanisms remain complex and multifactorial. Cardiac repolarization abnormalities are proposed biomarkers, but evidence is scarce, especially in low- and middle-income countries where epilepsy is highly prevalent.
Sudden unexpected death in epilepsy: An Italian expert consensus statement on risk, mechanisms, prevention, and therapeutic strategies -
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature mortality in people with epilepsy, particularly in those with tonic-clonic seizures (TCSs), developmental and epileptic encephalopathies (DEEs), and drug-resistant epilepsy. Although awareness of SUDEP has increased, major uncertainties remain regarding individualized risk stratification, mechanistic interpre...
Predictors of Seizure Occurrence After Mild Cognitive Impairment and Alzheimer's Disease in Older Adults in the Veterans Affairs Healthcare System: A Retrospective Cohort Study -
CONCLUSION: Our study showed that seizure risk is elevated in MCI and AD, with specific comorbidities associated with risk of seizure occurrence and cognitive decline, suggesting potentially actionable targets for risk stratification and clinical monitoring.
Response to: "Early benzodiazepine treatment and electrographic seizures after febrile status epilepticus" -
We appreciate Inui et al.'s comments regarding the divergent prognostic outcomes of patients with electrographic seizures (ESz) between our studies. The poorer prognosis in their cohort compared to ours likely stems from three key differences. First, baseline disease severity significantly differed. Our cohort predominantly consisted of milder cases, such as febrile seizures, with only 17.2% re...
Chronic posthypoxic myoclonus: Lance-Adams syndrome -
Lance-Adams syndrome (LAS) is a rare condition described as chronic intentional myoclonus following prolonged hypoxia. With limited cases of the condition, no standardised diagnostic criteria, and features overlapping acute myoclonus status epilepticus (MSE), diagnosis and management are challenging.Our case is a man in his 20s, who was admitted to the intensive care unit following two in-hospi...
Comparative analysis of the effects of Δ9-tetrahydrocannabinol and cannabidiol on pilocarpine-induced status epilepticus in mice -
There is growing interest in using cannabis and its active ingredients for epilepsy treatment. The main components of cannabis are cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), with some formulations of CBD approved for treating epilepsies refractory to traditional pharmacological treatments. However, it remains unclear whether the acute administration of THC or CBD can reverse a seizure...
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