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Vagus Nerve Stimulation Exerts Disease-Modifying Effects in Epileptic Rats by Enhancing Hippocampal Adenosine Signalling -
CONCLUSIONS: VNS exerts disease-modifying effects in epileptic rats by enhancing hippocampal adenosine signalling. These effects are associated with VNS-evoked adenosine release, inhibition of ADK overexpression, and restoration of A1R-mediated anticonvulsant signalling.
Neuroradiologic Findings in Patients With SCN2A Disease: A Systematic Review and Retrospective Multicenter Cohort Study -
BACKGROUND AND OBJECTIVES: SCN2A disease spans a broad clinical spectrum from self-limited (familial) neonatal-infantile epilepsy to severe developmental and epileptic encephalopathies. Systematic characterization of the spectrum of neuroradiologic abnormalities in SCN2A disease has not been performed. This study aimed to delineate MRI findings across SCN2A phenotypes, their frequency and evolu...
Prediction of Post-Cardiac Arrest Seizures Using Heart Rate Variability -
CONCLUSIONS: Heart rate variability changed before post-cardiac arrest seizures, with 18 minutes before onset appearing optimal for prediction.
Clinical and neuropsychological course of young adult patient with anti-GAD-65 autoimmune encephalitis: A case report -
Objective: Among autoimmune limbic encephalitis syndromes, glutamic acid decarboxylase 65 (GAD65) antibody-associated syndromes represent a relatively rare and clinically heterogeneous subtype characterized by prominent temporal lobe involvement and diverse neurological manifestations. GAD65 is an intracellular antigen involved in gamma-aminobutyric acid (GABA) synthesis, and associated autoant...
Enhancing quality of mental health service for veterans with seizures -
Psychiatric disorders are commonly identified in people with seizures (PWS). Comorbid mood, anxiety, and trauma- and stressor-related disorders are highly prevalent and not consistently recognized or treated promptly. Veterans with seizures are particularly vulnerable to neuropsychiatric comorbidities, including a higher prevalence of posttraumatic stress disorder and traumatic brain injury. In...
Emerging role of targeted therapy in drug-resistant epilepsy in patients with glioma -
PURPOSE OF REVIEW: Seizures are among the most frequent and disabling manifestations of gliomas, and in some patients remain drug-resistant despite optimal antiseizure medication and standard antitumour treatments. This review examines the clinical evidence that targeted therapies may improve seizure control in patients with glioma.
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