Epilepsy and Seizure News
Medical News Today
PubMed
Corpus callosotomy in Lennox-Gastaut syndrome: Effectiveness, safety, and predictors of outcome: A systematic review and meta-analysis -
BACKGROUND: Lennox-Gastaut syndrome (LGS) is a severe, drug-resistant developmental and epileptic encephalopathy for which corpus callosotomy (CC) can be a particularly effective option for seizure control. However, this benefit must be weighed against the tradeoff of permanent corpus callosum disconnection. Although use of CC declined with the rise of neuromodulation, interest has resurged wit...
Prevalence of epilepsy and seizures in frontotemporal dementia: a systematic review and meta-analysis -
Seizures and epilepsy are increasingly recognized in neurodegenerative diseases, yet their burden in frontotemporal dementia (FTD) remains poorly defined. We conducted a systematic review and meta-analysis to estimate the prevalence of epilepsy or seizures in FTD, assess comparative risk versus controls, and explore variation across clinical subtypes. MEDLINE/PubMed, Embase, Cochrane Library, L...
Idiopathic generalized epilepsy: biases and inconsistencies -
OBJECTIVES: Distinguishing Idiopathic Generalized Epilepsy (IGE) from focal epilepsy (FE) can be challenging when IGE cases present with asymmetric clinical or electroencephalographic (i.e., atypical) features. We aimed to identify factors that lead to discordance in IGE diagnoses among epileptologists.
Characterizing Epileptic Network Dynamics with Koopman Operator: Toward Surgical Targeting of Seizure Onset Zones -
Accurate localization of the seizure onset zone (SOZ) is essential for the surgical treatment of drug-resistant epilepsy, yet it remains challenging because seizures involve rapid and variable spatiotemporal reorganization of brain networks. In this study, we propose a Koopman-inspired dynamic graph (KDG) framework for SOZ localization from intracranial electroen cephalography (iEEG). Unlike co...
Invasive Neuromodulation of Drug-Resistant Epilepsy in Pediatric Populations: A Comprehensive Systematic Review and Meta-Analysis -
CONCLUSIONS: VNS, RNS, and DBS provide meaningful seizure reduction with favorable safety profiles in pediatric DRE, though seizure freedom remains uncommon. Treatment selection should be individualized on the basis of epilepsy characteristics, age, and practical considerations.
Pediatric developmental epileptic encephalopathies treated with cenobamate: Real-world outcomes across etiologies, syndromes, and seizure types -
OBJECTIVE: This study was undertaken to assess cenobamate (CNB) effectiveness, tolerability, and dosing in pediatric developmental and epileptic encephalopathies (DEEs), testing prespecified hypotheses on response by syndrome, etiology, electroencephalographic pattern, seizure type, CNB dose (mg/kg/day), and concomitant medication.
Science Daily