Epilepsy News

Age-stratified interictal epileptiform discharges in SCN1A-related epilepsy: Association with early sodium channel-blocking antiseizure medication exposure - CONCLUSION: Prolonged early exposure to SCBs was associated with the presence of IEDs in the 6-13-year age band in individuals with SCN1A-related epilepsy. These exploratory findings should be considered hypothesis-generating and require confirmation in prospective multicenter cohorts.

Design and optimization of nafimidone-inspired hybrid scaffolds targeting NaV1.2 for antiepileptic therapy with reduced cardiac liability - Epilepsy remains a major neurological disorder in need of safer and more effective antiepileptic agents. In this study, nineteen nafimidone-guided derivatives were designed, synthesized, and biologically evaluated to identify new anticonvulsant leads with improved efficacy, brain accessibility, and safety. Initial in vivo screening in the MES model identified compounds 11b and 12a among the mos...

Pediatric refractory status epilepticus: Predictors of in-hospital outcomes from a Chinese tertiary center - Refractory status epilepticus (RSE) is a life-threatening neurological emergency in children. However, real-world evidence on pediatric RSE remains limited. This study characterized treatment patterns, in-hospital outcomes, and predictors of clinical outcomes within a resource-constrained regional referral network. We performed a single-center retrospective cohort study of pediatric patients ad...

DYNAMIC BIOMARKERS FOR PREDICTING POST-TRAUMATIC EPILEPSY AFTER TRAUMATIC BRAIN INJURY - CONCLUSION: Late post-traumatic seizures and PTE after moderate TBI are associated with a persistent biomarker signature of neuroinflammation, neuroimmune activation and glial-axonal injury. A simple BioIndex based on IL-6, HMGB1 and NfL may serve as a practical laboratory tool for early risk stratification and individualized follow-up after moderate TBI.

Negative BOLD response to interictal discharges in epilepsy using intracranial EEG-fMRI - CONCLUSIONS: Positive BOLD responses provide superior localization of epileptogenic tissue compared to negative responses in intracranial EEG-fMRI. In contrast, negative BOLD clusters show greater spatial overlap with the DMN, suggesting they may reflect network deactivation at the time of IED events. These findings support prioritizing positive BOLD responses for clinical decision-making in pr...

Ethosuximide-induced lupus erythematosus: Unveiling a rare adverse reaction through systematic review - CONCLUSION: ESM-induced LE, though exceedingly rare, should be suspected in patients on ESM presenting with systemic autoimmune features. Its clinical and serological profiles overlap those of idiopathic systemic lupus erythematosus and classic DILE. Early recognition and prompt discontinuation of ESM typically result in rapid remission and may prevent unnecessary prolonged immunosuppression.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.