Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring - NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...

Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...

[What is 'Epilepsy,' a brain disorder that affects 1 in 100 people? A gentle guide to symptoms, types, and treatment goals] - Are you feeling vague anxiety or have questions about epilepsy, such as 'What should I do if I suddenly lose consciousness?' or 'Are convulsions the same thing as epilepsy?'Epilepsy is a very common ...

Indoor environmental conditions and interictal epileptiform discharge frequency during pediatric video-EEG monitoring - CONCLUSIONS: Pediatric epilepsy patients exhibit marked, highly individualized bidirectional sensitivities to ambient temperature and humidity despite a uniform group-level circadian rhythm in cortical excitability. These findings underscore the importance of personalized environmental monitoring in epilepsy management.

Initial experience of bortezomib in cryptogenic new-onset refractory status epilepticus: a case series - CONCLUSIONS: Bortezomib may represent a promising therapeutic option in immunotherapy-refractory NORSE. Larger prospective multicenter studies are needed to establish its efficacy, safety, and optimal timing of administration.

Hyperfunction of PSD-95 leads to hyperexcitability and cognitive abnormalities in MEF2C haploinsufficiency - Myocyte enhancer factor 2C (MEF2C) is a transcription factor critical for brain circuit development and cognitive behavior. The loss of one copy of MEF2C leads to MEF2C haploinsufficiency syndrome (MCHS), a neurodevelopmental disorder characterized by intellectual disability, epilepsy, and behavioral phenotypes associated with autism spectrum disorders. Given that numerous genes are regulated b...

Spectrally-resolved transfer entropy in resting-state SEEG reveals epileptogenic and non-epileptogenic communication in adults and children with refractory epilepsy - Objective. To characterise directed, frequency-resolved communication between seizure onset zone (SOZ) and non-involved zone (NIZ) regions in resting-state stereo-electroencephalography (SEEG) from adults and children with drug-resistant epilepsy (DRE).Approach. We analysed retrospective SEEG from 21 adults and 18 paediatric patients who underwent focal resective surgery. Channels were grouped ...

Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation - Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) can reduce seizures in patients with drug-resistant epilepsy. However, seizure freedom is rare, and there is no early response biomarker to predict long-term seizure suppression. To evaluate a candidate short-term biomarker of therapeutic response to DBS, we studied 18-min trials of ANT stimulation in patients with drug-...

Acute Intrapartum Seizure in a Pregnant Woman with Epilepsy Receiving Divalproex: Maternal-Fetal Consequences and Emergency Obstetric Management-A Case Report - CONCLUSION: Careful multidisciplinary management of epilepsy during pregnancy is essential. Breakthrough seizures during labor may lead to acute fetal compromise and require emergency delivery. Close antenatal, intrapartum, and postpartum monitoring is crucial to optimize maternal and neonatal outcomes.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.