Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...

Frequent Cannabis Use Tied to Greater Seizure Burden in Drug-Resistant Epilepsy - Frequent cannabis users with drug-resistant epilepsy have more convulsive seizures and require more antiseizure medications, but researchers caution that the findings do not establish causation.

Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring - NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...

Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? - Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...

Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial - CONCLUSIONS: The results of this Phase IIb pilot study suggest that a supervised aerobic exercise intervention for adults with epilepsy is feasible, acceptable, and appropriate to implement among participants who enroll. Recruitment remains the primary challenge to progressing this line of research and may represent a broader field-level barrier. Future trials should focus on improving how adul...

Comparison of the efficacy and safety of lacosamide and oxcarbazepine monotherapy in young children aged 1 month to 4 years with focal epilepsy: An ambispective cohort study based on real-world cli... - CONCLUSION: In real-world clinical practice in China, LCM monotherapy demonstrated efficacy and safety comparable to those of OXC in young children with focal epilepsy, suggesting that LCM may represent an alternative option for off-label use in this age group. Its potential benefit for language development warrants further investigation.

Pioneering Epilepsy Surgery in Cameroon: Outcomes from the First Prospective Cohort of Surgical Patients with Drug-Resistant Epilepsy - CONCLUSION: Epilepsy surgery was feasible in our resource-limited setting and was associated with encouraging short-term seizure and quality-of-life outcomes in carefully selected patients with MRI-visible, electroclinically concordant DRE who were able to complete presurgical evaluation. Larger multicentre studies with longer follow-up are needed to determine the durability and generalizabilit...

The postsynaptic scaffold protein ABLIM1 regulates seizure susceptibility by maintaining GluA2 membrane localization in chronic epilepsy - Temporal lobe epilepsy (TLE), the most common form of drug-resistant epilepsy (DRE) in adults, is a frequent chronic neurological disorder. Nevertheless, the precise pathophysiological mechanisms underlying TLE remain largely undefined. Our findings demonstrate that Actin-binding LIM protein 1 (ABLIM1) is broadly expressed in the adult mouse brain, with high expression in the hippocampus. The p...

Valproate use in low- and middle-income countries: Balancing reproductive safety, seizure control, and access to safer antiseizure medicines - Valproate is highly effective for genetic generalized epilepsies but carries substantial dose-dependent risks of major congenital malformations and adverse neurodevelopment after in utero exposure. Guidelines therefore recommend avoiding it in individuals with pregnancy potential when effective alternatives are available. This dilemma is concentrated in generalized epilepsies; focal epilepsies ...

Stereoelectroencephalography-based anatomo-electro-clinical subtyping reveals network-specific organization in parietal lobe epilepsy - CONCLUSION: SEEG-based subtyping reveals network-organized seizure semiology and improves the localization precision of the seizure onset zone (SOZ) in PLE.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.