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Teratogenic risk of carbamazepine, levetiracetam, and lamotrigine treatment in pregnant women with epilepsy -
CONCLUSION: Levetiracetam and lamotrigine demonstrate favorable safety profiles, whereas carbamazepine carries a moderate teratogenic risk. Polytherapy risk is combination-dependent, and preconception seizure control is a key predictor of seizure outcomes during pregnancy.
Efficacy and safety of diazepam nasal spray in Japanese Pediatric patients with or at risk for status epilepticus: a phase 3, Multicenter, open-label clinical trial -
CONCLUSION: These findings support the favorable efficacy and safety profiles of diazepam nasal spray as a rescue therapy in pediatric patients with or at risk for SE.
Effect of Fenfluramine on convulsive seizures and rescue medication usage: A case series of adults within the Lennox-Gastaut syndrome spectrum -
CONCLUSION: Adjunctive FFA was tolerated without significant side effects and associated with a significant reduction in convulsive seizures in this limited cohort. Corresponding reduction in use of rescue medications and hospitalisations has the potential to impact on both patient and caregiver quality of life.
Severe Pediatric MOGAD-Associated ADEM With Persistent Neurological Morbidity and Later-Onset Epilepsy of Uncertain Etiology: A Case Report -
This report describes a 7-year-old boy with MOGAD presenting as severe ADEM with fever, encephalopathy, seizures, markedly elevated intracranial pressure, diffuse multifocal MRI abnormalities, and serum MOG-IgG positivity. He required intravenous corticosteroids, plasma exchange, IVIG, and tocilizumab, followed by rehabilitation and maintenance IVIG. Persistent sequelae included dysarthria, mem...
Neuroprotective Role of Flavonoids: Implications for Natural Epilepsy Therapy-A Systematic Review -
CONCLUSION: Flavonoids demonstrate significant multi-target neuroprotective potential in experimental models of epilepsy. This article focuses on various aspects, such as the mechanisms of action and neuroprotective benefits of various flavonoids against epilepsy. The article highlights the promising role of various flavonoids and the potential of nanotherapeutic flavonoids against epilepsy.
The microbiota-gut-brain axis in epilepsy: Mechanistic insights and emerging probiotic-based therapeutics -
Epilepsy is a chronic neurological disorder affecting more than 50 million people globally. Over one-third of patients remain pharmacoresistant to conventional antiepileptic therapy, creating a substantial healthcare and societal burden. Recently, the gut-brain axis has emerged as a novel and pivotal route in the pathophysiology and progression of epilepsy. The gut microbiota regulates brain fu...
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