Epilepsy News

Bath-related sudden death in pregnancy associated with post-hemorrhagic epilepsy: An autopsy case report - Sudden unexpected death is a rare but clinically important event in pregnant women with epilepsy. This case report describes a fatal bathtub drowning in a pregnant woman with epilepsy secondary to pregnancy-related intracerebral hemorrhage. A 31-year-old woman at 6 months' gestation was found submerged in a bathtub filled with 41 °C water, and resuscitation attempts were unsuccessful. At age 29...

Cysticercosis and neurocysticercosis in Eastern Zambia: A cross-sectional, community-based study - CONCLUSION: Our findings demonstrate that cysticercosis and NCC are prevalent in this rural community in the Eastern Province of Zambia. Most of the patients with NCC had calcified lesions, and people with NCC more often had epileptic seizures and headache than those without NCC; only a few people had neurological deficits.

Midline thalamic neurons show early hypersynchrony during absence seizures in mouse models - Generalized seizures reflect a pathological state of sudden, global neuronal hypersynchrony. The mechanisms that support the initiation and maintenance of such synchrony remain unknown. Using simultaneous single-unit and electrocorticographic recordings in two mouse models of absence epilepsy, we evaluated the activity of approximately 2,000 individual neurons across 26 brain structures. By doi...

Clinical characteristics and treatment analysis of children with glucose transporter type 1 deficiency syndrome: a report of two cases - CONCLUSIONS: A decreased CSF glucose level and a low CSF-to-blood glucose ratio are key diagnostic clues for GLUT1-DS. Early initiation of a KD yielded favorable short-term clinical outcomes in both cases, highlighting the importance of prompt metabolic and genetic screening.

Factors associated with drug-resistant epilepsy in children with epilepsy: a retrospective cohort study - CONCLUSIONS: In this retrospective cohort, seizure type, history of status epilepticus, neurodevelopmental disorder, structural etiology, and older age at onset were independently associated with DRE after excluding treatment‑related variables. These findings suggest that true baseline independently associated variables of DRE are limited, and the diagnosis of DRE itself-failure of two adequate...

Association of first-month beta-hydroxybutyrate levels with subsequent ketogenic diet response in children with drug-resistant epilepsy: a prospective cohort study - CONCLUSION: Continuous first-month BHB showed no clear monotonic association with 3-month seizure reduction; an exploratory 3.0 mmol/L cutoff analysis similarly did not distinguish subsequent responders from non-responders. These findings describe the prognostic value of first-month BHB measured after individualized KDT titration and should not be interpreted as evidence regarding the benefit o...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.