Epilepsy News

Multidisciplinary management and nursing care for pediatric patients with febrile infection-related epilepsy syndrome in the acute phase: A case series - RATIONALE: This case series discusses the nursing care and clinical outcomes of 3 pediatric patients with febrile infection-related epilepsy syndrome (FIRES) and acute-phase complications, focusing on critical care interventions such as seizure management, respiratory support, and nutritional therapy.

Beyond seizures: understanding adaptive functioning in drug-resistant epilepsy in patients undergoing palliative surgery - PURPOSE: To evaluate clinical predictors of adaptive functioning in pediatric patients with drug-resistant epilepsy (DRE) and the impact of corpus callosotomy and vagus nerve stimulation (VNS) using the Vineland Adaptive Behavior Scales (VABS) during long-term follow-up.

Antiseizure properties of new selenobenzimidazole derivatives: A pre-clinical study in a neonatal model of epilepsy - This study aimed to evaluate the anti-seizure potential of new selenobenzimidazole compounds and identify their potential molecular targets. The primary research question was whether these novel benzimidazolic derivatives could effectively control seizures and mitigate their severity. The research combined an in vivo animal model of neonatal epilepsy with in silico molecular target prediction. ...

First-episode psychosis and mood disorder onset in individuals with epilepsy - BACKGROUND: Psychiatric disorders represent a major burden for patients with epilepsy (PwE). This study examined how demographic, epilepsy-related, and clinical risk factors contribute to the onset of mood and psychotic disorders in epilepsy.

Cenobamate in older adults with drug-resistant epilepsy: Real-world tolerability, efficacy, and predictors of discontinuation - CONCLUSION: CNB is effective and generally well-tolerated in older adults, with most reaching therapeutically meaningful doses. However, an elevated comorbidity burden and advancing age (≥70 years) increase the risk of discontinuation due to adverse effects, underscoring the need for individualized, cautious titration in this vulnerable population.

Deep brain stimulation in pediatric drug-resistant epilepsy: Implications for the developing connectome - Epilepsy is increasingly recognized as a disorder of brain networks, and intracranial neuromodulation has emerged as a therapeutic strategy for individuals with drug-resistant epilepsy (DRE). In pediatric populations, however, ongoing brain development raises important questions regarding safety, efficacy, and long-term consequences of chronic neuromodulation. In this review, we examine the eme...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.