Todd's Paralysis Simulating Acute Ischemic Stroke: A Case Report -
Todd's paralysis is a transient focal neurological deficit following epileptic seizures that may closely mimic an acute ischemic stroke, posing a diagnostic challenge in the emergency department. We report the case of a 32-year-old woman with a history of epilepsy who presented with persistent expressive aphasia and right hemiparesis after experiencing multiple generalized tonic-clonic seizures...
Single-nucleus transcriptomics-based drug screening platform for focal cortical dysplasia -
Focal cortical dysplasias (FCDs) are a major cause of drug-resistant epilepsy, yet their molecular and pathological complexity has limited the development of effective antiseizure medications. Here, we performed single-nucleus RNA sequencing on 49 human neocortical specimens spanning FCDI-III. We identified prominent transcriptional alterations in non-neuronal populations, particularly astrocyt...
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes -
New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
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