Epilepsy News
Recent news about epilepsy, seizures and treatments.
News Feeds
Medical News Today
PubMed
Exploring DHODH inhibition with silibinin as a promising approach to treat drug resistance in epilepsy -
Mitochondrial dysfunction and excessive production of reactive oxygen species (ROS) are key contributors to the pathogenesis of drug resistant epilepsy (DRE). Recent findings suggest DHODH, a mitochondrial enzyme may influence neuronal excitability by affecting intrinsic firing set points. Dysregulated DHODH activity may elevate set points, contributing to persistent hyperexcitability in epilep...
Levetiracetam for Seizure Prophylaxis after Traumatic Brain Injury: A Severity-Stratified Cohort Study of 51,000 Patients - OBJECTIVES: The objective of this study was to evaluate the effectiveness and adverse effect profile of prophylactic levetiracetam in preventing epilepsy after traumatic brain injury (TBI).
Adjunctive transcranial DC stimulation in the management of refractory drug-resistant focal epilepsy in POLG mitochondrial disease: A case series - CONCLUSION: Our findings support further exploration of tDCS as a potential adjunctive therapy for complex neurological challenges in mitochondrial disorders.
Adolescent diagnosis of pyridoxine-dependent epilepsy - Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive metabolic epilepsy classically presenting with refractory neonatal seizures that respond to pharmacological doses of pyridoxine (vitamin B6). Although traditionally regarded as a neonatal disorder, later presentations are increasingly recognised. We report an adolescent patient with long-standing treatment-resistant epilepsy and ...
Prenatal alcohol exposure differently affects seizure susceptibility and severity depending on its mechanism of induction: role of excitatory synapses and parvalbumin-positive interneurons - BACKGROUND: Prenatal alcohol exposure (PAE) leads to several neurological developmental deficits, including seizure predisposition. It is speculated that alcohol would interfere with the development of GABAergic neurons, which would fail to control neocortical excitability.
Robust multi-centre interictal EEG biomarker for distinguishing epilepsy from mimickers - CONCLUSIONS: Low-dimensional, clinically interpretable EEG features support robust epilepsy-versus-mimicker classification within and across centres when recording-length confounds are controlled.
Levetiracetam for Seizure Prophylaxis after Traumatic Brain Injury: A Severity-Stratified Cohort Study of 51,000 Patients - OBJECTIVES: The objective of this study was to evaluate the effectiveness and adverse effect profile of prophylactic levetiracetam in preventing epilepsy after traumatic brain injury (TBI).
Adjunctive transcranial DC stimulation in the management of refractory drug-resistant focal epilepsy in POLG mitochondrial disease: A case series - CONCLUSION: Our findings support further exploration of tDCS as a potential adjunctive therapy for complex neurological challenges in mitochondrial disorders.
Adolescent diagnosis of pyridoxine-dependent epilepsy - Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive metabolic epilepsy classically presenting with refractory neonatal seizures that respond to pharmacological doses of pyridoxine (vitamin B6). Although traditionally regarded as a neonatal disorder, later presentations are increasingly recognised. We report an adolescent patient with long-standing treatment-resistant epilepsy and ...
Prenatal alcohol exposure differently affects seizure susceptibility and severity depending on its mechanism of induction: role of excitatory synapses and parvalbumin-positive interneurons - BACKGROUND: Prenatal alcohol exposure (PAE) leads to several neurological developmental deficits, including seizure predisposition. It is speculated that alcohol would interfere with the development of GABAergic neurons, which would fail to control neocortical excitability.
Robust multi-centre interictal EEG biomarker for distinguishing epilepsy from mimickers - CONCLUSIONS: Low-dimensional, clinically interpretable EEG features support robust epilepsy-versus-mimicker classification within and across centres when recording-length confounds are controlled.
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.