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Seizure detection devices in outpatient epilepsy care: High demand, low use, and the need for specialized counseling -
OBJECTIVE: To determine real-world uptake of seizure detection devices (SDDs), quantify patient demand, and identify factors associated with their adoption in routine outpatient epilepsy care.
Bridging computational and clinical strategies for presurgical identification of epileptogenic networks -
OBJECTIVE: About one third of epilepsy patients are drug-resistant. Resective epilepsy surgery remains a key treatment option but depends critically on accurate identification of the seizure onset zone (SOZ), which is still guided mainly by subjective visual inspection of electrophysiological signals. Network-based metrics derived from intracranial EEG have recently shown promise for SOZ identi...
The effectiveness of adding on or switching antiseizure medications after the first fails to control focal epilepsy: A systematic review of randomized controlled trials -
Focal epilepsy constitutes 60-70% of epilepsy, and up to half of patients do not achieve seizure freedom with their first antiseizure medication (ASM). When the first ASM fails, evidence guiding whether to switch or add-on another ASM and which ASMs to use is limited. This review synthesized evidence from randomized controlled trials (RCTs) on the comparative effectiveness of subsequent ASMs af...
Chorea-athetosis-like hyperkinetic seizures in temporal lobe epilepsy: insights from stereo-EEG in three patients -
CONCLUSIONS: Chorea-athetosis-like hyperkinetic seizures in TLE appear to be cortically driven, with seizures arising from temporal cortex and propagating through a temporo-insular-orbitofrontal network before recruiting basal ganglia-thalamic structures. These findings highlight the importance of adequate SEEG coverage of temporal and insular regions to avoid misdiagnosis and to optimize presu...
Age-dependent axonal dysfunctions and altered sharp-wave ripple oscillations in Scn1a +/- mice -
Mice with Scn1a haploinsufficiency replicate symptoms of Dravet syndrome (DS), a rare childhood disease characterized by febrile seizures at an early age. As adults, patients with DS suffer from epilepsy, motor dysfunction, psychological disorders, and cognitive disabilities. Patients with DS carry loss-of-function variants in the SCN1A gene, which encodes the voltage-gated sodium channel subun...
A novel mutation in SETD1A is associated with early-onset epilepsy-a rare case report -
SET Domain Containing 1A (SETD1A) is a histone H3K4 methyltransferase implicated in neurodevelopmental disorders. Pathogenic variants in this gene are associated with schizophrenia, intellectual disability, and epilepsy. Here, whole-exome sequencing and Sanger sequencing were performed on a 4-year-old Chinese girl with early-onset epilepsy and her unaffected parents. A novel de novo heterozygou...
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