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Elevated body temperature affects spike-and-wave discharges and induces behavioural deficits in genetic absence epilepsy rats -
CONCLUSION: The increase in body temperature is associated with shorter duration of absence seizures, reduced locomotor activity, and anxiety-like symptoms in GAERS, suggesting thermoregulatory pathways may be involved in seizures and comorbidities. This may influence how people with absence epilepsy react to elevated temperatures, for example during heat waves.
Association of epilepsy duration and drug-resistant epilepsy duration with seizure outcomes after epilepsy surgery: a pediatric population-based study -
CONCLUSIONS: In this unselected population-based, pediatric, resective epilepsy surgery cohort, longer epilepsy duration is associated with worse seizure outcomes. Similarly, a prolonged duration of DRE was correlated with worse seizure outcomes. The findings emphasize the importance of early surgical referrals. Future multicenter studies are warranted to further clarify the relative prognostic...
Postapproval Study for Brain-Responsive Neurostimulation for Drug-Resistant Focal Epilepsy: Three-Year Efficacy and Interim Safety Results -
BACKGROUND AND OBJECTIVES: Neuromodulation therapies are approved for the treatment of focal epilepsy based on data from randomized controlled trials (RCTs). After approval of a responsive direct brain stimulation device (The RNS System for focal epilepsy), the Food and Drug Administration required a prospective study to evaluate whether real-world safety and effectiveness differed from outcome...
The Mechanism Underlying the Abnormal Expression of α-Synuclein in the Cortical Lesions of Patients With FCD Type IIb and TSC -
CONCLUSIONS: Our results showed that modulation of the mTOR/GLT-1 pathway ameliorated α-synucleinopathy and seizure activities in FCD, providing insights for understanding the epileptogenic mechanisms of FCD IIb and TSC.
International consensus recommendations for the diagnosis and treatment of Rasmussen syndrome: A modified Delphi procedure -
Rasmussen syndrome (RS) includes a well-described constellation of refractory focal seizures, often including epilepsia partialis continua, hemiplegia with progressive unilateral cortical atrophy, and cognitive/language decline. However, the precise early pathogenesis and reliable biomarkers remain elusive. In addition, we lack operational management guidelines, including diagnostic evaluation,...
Neuropharmacological, Analgesic, and Anti-Inflammatory Activities of Pothos scandens Acetone Extract With GC-MS-Based Phytochemical Profiling -
Pothos scandens, belonging to the Araceae family, locally known as "batilata," is traditionally used for treating various chronic diseases in folk medicine, such as epilepsy, seizures, convulsions, wounds, snakebites, skin issues, asthma, muscle problems, and diarrhea. This research examined the anxiolytic, antidepressant, analgesic, and anti-inflammatory potentials of the acetone extract of P....
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