Epilepsy News

Complications of deep brain stimulation for drug-resistant epilepsy: an analysis from the MAUDE database - CONCLUSIONS: The MAUDE database helps to more clearly define the risks and complications arising from DBS implantation to treat DRE. These results will help in assessing the risks, treatment alternatives, and outcomes associated with DBS device therapy for DRE. This will facilitate enhancements in the effectiveness of the device, better management of complications, and provide more comprehensiv...

Accuracy of the rapid-response electroencephalography's Automated Seizure Burden Estimator: A follow-up validation study of version 8 (AccuRASE II) - OBJECTIVE: Ceribell Inc.'s point-of-care electroencephalographic (EEG) system and artificial intelligence-based Automated Seizure Burden Estimator (ASBE; ClarityPro) have US Food and Drug Administration clearance for diagnosing electrographic status epilepticus (ESE). The AccuRASE study using ASBE version 6 (V6) showed high negative predictive value (NPV) but limited sensitivity and positive pr...

Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts - OBJECTIVE: This study was undertaken to evaluate the predictive, stratification, and prognostic utility of polygenic risk scores (PRSs) for epilepsy in three Taiwanese cohorts comprising more than 7000 cases among more than 600 000 individuals, thereby addressing the limited evidence on PRS performance in non-European populations.

Stroke or Seizure? Diagnostic Role of Neuroimaging in Acute Neurologic Mimics - CONCLUSIONS: A multimodal approach integrating vascular imaging, perfusion distribution, DWI/ADC, ASL, clinical timing, and EEG findings can improve diagnostic accuracy in the stroke-seizure differential without delaying treatment in true acute ischemic stroke.

Responsive Neurostimulation in Patients with a History of Viral Brain Infections-A Single-Center Experience - Drug-resistant epilepsy (DRE) secondary to viral brain infections (VBI) may have multiple seizure foci, making it not amenable to surgical resection but could respond to responsive neurostimulation (RNS). We aimed to evaluate characteristics of DRE patients with a VBI history who did or did not respond to RNS therapy; 9 patients met criteria. Four out of 9 patients were responders to RNS therap...

Timing, Composition, and Clinical Correlates of Immunotherapy Response in GAD65 Antibody-Associated Epilepsy: A Literature-Derived Patient-Level Analysis of 375 Published Cases - OBJECTIVE: Glutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy often presents as chronic focal epilepsy, usually with temporal lobe predominance, marked drug resistance, and inconsistent response to first-line immunotherapy. We assembled a large, harmonized, and literature-derived patient-level cohort to examine whether immunotherapy timing and regimen composition were associate...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.