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Behavioral and spectral electroencephalographic biomarkers of epileptogenesis, disease progression, and drug resistance in a longitudinal lithium-pilocarpine model of temporal lobe epilepsy -
Temporal lobe epilepsy (TLE) is linked to progressive alterations in brain network dynamics, leading to behavioral comorbidities and emergence of drug resistance; yet the underlying mechanistic and synaptic substrates remain incompletely understood. Here, we performed longitudinal phase-specific characterization of network dysfunction in TLE employing a lithium-pilocarpine-induced model in 7-we...
Neurosurgical management of childhood-onset epilepsy in periventricular nodular heterotopia: A systematic review of effectiveness and outcomes -
Epilepsy associated with periventricular nodular heterotopia (PVNH) frequently begins in childhood and often proves refractory to medication. Surgical management is challenging, as lesions are frequently deep-seated or bilateral, and seizure onset often involves networks extending beyond the heterotopic tissue itself, with the precise contribution of the nodules varying between patients. This s...
Medication adherence in epilepsy: Validation of the short medication adherence scale (SMAS-7) and mediation analysis of quality-of-life pathways -
CONCLUSION: The SMAS-7 is a valid, reliable, and clinically useful tool for assessing medication adherence in adults with epilepsy. When each predictor was considered individually, medication adherence showed partial indirect associations linking financial wellbeing, mental health burden, and AED adverse effects with QOL; however, these associations were attenuated to near zero in a mutually ad...
A potential therapeutic role of unilateral anterior thalamic deep brain stimulation in epileptic spasms: A case report -
OBJECTIVE: Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is an established palliative therapy for drug-resistant focal epilepsy; however, its efficacy for epileptic spasms (ES) and the clinical utility of unilateral stimulation remain unclear. To address these issues, we report a case of drug-resistant focal epilepsy with ES treated with unilateral ANT-DBS.
Seizure prophylaxis versus epilepsy prevention after acquired brain injury: a cross-sectional clinicaltrials.gov registry analysis, 2000-2026 -
CONCLUSIONS: The seizure management pipeline after acquired brain injury registered on ClinicalTrials.gov is concentrated in brain tumor/neurosurgery and TBI, with sparse representation of hemorrhagic stroke and few completed pharmacologic trials targeting late epilepsy prevention. The registry findings support a clearer separation of the objectives of acute seizure prophylaxis, treatment of ac...
Targeting glycine transporter type 1 (GlyT1) in epilepsy: Pathophysiological rationale and therapeutic perspectives -
Glycine transporter type 1 (GlyT1) plays a crucial role in regulating extracellular glycine concentrations, thereby maintaining the balance between excitatory and inhibitory neurotransmission in the central nervous system. GlyT1 is expressed predominantly in astrocytes, as well as in neurons, throughout most regions of the mammalian brain, and dysregulation of glycinergic transmission has been ...
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