Epilepsy News

Seizure outcomes after laser interstitial thermal therapy for pediatric extratemporal lobe epilepsy - CONCLUSIONS: This study demonstrated that LITT is a safe and effective treatment option for pediatric ETLE and may achieve acceptable rates of seizure freedom with a minimally invasive approach. Concordance between noninvasive imaging (particularly PET) with LITT targets was associated with favorable outcomes, underscoring the importance of thorough preoperative evaluations to determine appropr...

Every Second Counts: The School Nurse as a Health Educator - A Cross Sectional Observational Study - Background Schools are key environments for children's daily lives, where urgent events such as syncope, hypoglycemia, seizures, and minor trauma can occur. In Italy, the absence of school nurses and the lack of mandatory first aid training for all teachers place initial emergency management largely on educational staff, whose preparation is variable. Enhancing first aid culture and readiness i...

Bridging the outcome documentation gap in epilepsy surgery: Validating large language model agents for automated Engel and International League Against Epilepsy scoring from clinical notes - OBJECTIVE: Timely and accurate classification of postepilepsy surgery outcomes using Engel and International League Against Epilepsy (ILAE) scales is essential for clinical follow-up, yet electronic health record documentation often lacks the structured detail needed for reliable scoring. This study aimed to validate large language model (LLM) agents for autonomous extraction of standardized po...

SEEG-guided therapeutic decision-making in drug-resistant epilepsy: retrospective analysis and clinical framework - CONCLUSIONS: SEEG is a safe and effective tool not only for localizing the EZ but also for structuring therapeutic decision-making in drug-resistant epilepsy. SEEG findings enable patient stratification into individualized treatment pathways and support a dynamic, staged approach in which RF-TC may serve as both a therapeutic and decision-modulating tool. This framework highlights the evolving ...

Rotenone in Drug-Resistant Epilepsy Models: Powerful Tool or Problematic Paradigm? - The rotenone adjuvant kindling paradigm replicates key clinical features of drug-resistant epilepsy (DRE), including broad-spectrum pharmacoresistance, neuroinflammation, and oxidative stress, by combining mitochondrial complex I inhibition with pentylenetetrazol (PTZ) or corneal kindling. PTZ, a GABA(A) receptor antagonist, induces seizures by reducing inhibitory neurotransmission and is widel...

Antiseizure Medication Trials Before Referral in Pediatric Patients Undergoing Epilepsy Surgery - CONCLUSION: In this population-based cohort, most children underwent more ASM trials than recommended before referral for epilepsy surgery. Greater ASM exposure was associated with more severe epilepsy phenotypes. These findings reinforce the importance of timely recognition of drug-resistant epilepsy and consideration of surgical evaluation alongside escalation of ASM trials.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.