Epilepsy News

Assessment of Compliance With the National Institute for Health and Care Excellence Guidance in the Management of Patients Referred Following a First Suspected Seizure: A Retrospective Clinical Audit - Introduction A first suspected seizure requires timely specialist assessment and appropriate investigation to establish an accurate diagnosis, identify seizure mimics, assess the risk of recurrence, and provide appropriate safety advice. The National Institute for Health and Care Excellence (NICE) guidance recommends urgent specialist assessment following a first suspected seizure, alongside ap...

Quantifying Interictal Spike Asymmetry on Scalp EEG to Lateralize the Seizure-Onset Zone in Temporal Lobe Epilepsy - BACKGROUND AND OBJECTIVES: Accurate lateralization of the seizure focus in temporal lobe epilepsy (TLE) is critical for surgical planning. Our current approach of capturing multiple seizures often misses bilateral disease because of seizure-onset variability. Interictal spike rate asymmetry is a promising marker of TLE laterality. However, visual analysis has low interrater reliability and cann...

Curcuminoid supplementation alters proteomic profiles and clinical outcomes in canine primary epilepsy: A pilot study - CONCLUSION: Curcuminoid supplementation was safe, well tolerated, and demonstrated a clinical response rate of 50% in dogs with PES. These findings provide preliminary molecular evidence of enhanced antioxidant capacity, mTOR/TLR2 modulation, and metabolic reprogramming. As pilot observations, definitive neuroprotective conclusions require confirmation in larger controlled trials with direct ne...

Seizures and epilepsy in MOG antibody-associated disease: from cortical neuroimmunology to clinical practice - Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder distinct from multiple sclerosis (MS) and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD). Seizures are an important but incompletely characterized manifestation. Their reported prevalence is strongly age-dependent-approximately 30% in pediatric-onset ve...

First-trimester trace-element profiles in pregnant women with epilepsy: An exploratory prospective association between selenium and subsequent seizure recurrence - CONCLUSION: Pregnant women with epilepsy showed a distinct first-trimester trace-element profile. Lower first-trimester selenium was prospectively associated with subsequent seizure recurrence; however, this exploratory finding requires external validation before any predictive or clinical interpretation.

AAV-mediated Modulation of Dorsal Raphe Serotonergic Neurons Recapitulates Fenfluramine Efficacy in a Rat Model of Dravet Syndrome - Dravet Syndrome (DS) is a catastrophic developmental and epileptic encephalopathy (DEE) primarily caused by SCN1A haploinsufficiency. It is characterized by refractory hyperthermia-induced seizures, neurodevelopmental delay, and an elevated risk of sudden unexpected death in epilepsy (SUDEP) compared to other childhood epilepsies. While the small molecule fenfluramine (FFA) provides profound cl...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.