Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Positioning Cenobamate in the Treatment Algorithm of Focal Epilepsy: Seizure Control and Benefits Beyond Seizures -
This work integrates the opinion on the current use of cenobamate (CNB) of an expert panel structured across seven thematic domains: efficacy, patient profiles, titration and dosing, pharmacokinetic interactions, safety, parallel effects, and therapeutic positioning. According to personal experience and scientific evidence, experts unanimously regarded CNB as likely more efficacious than other ...
Efficacy of Lactobacillus reuteri as an adjunctive therapy for seizure control and quality of life in pediatric drug-resistant epilepsy: A prospective interventional study - CONCLUSIONS: In this single-arm before-after study, statistically significant within-participant changes in HRQOL and seizure frequency were observed during the 12-week period following adjunctive L. reuteri supplementation. However, the absolute magnitude of these changes was modest and their clinical significance remains uncertain. Because there was no concurrent placebo control group, the ob...
Combining responsive neurostimulation with resection or ablation for treatment of epilepsy: a multicenter experience - CONCLUSIONS: Combined RNS with resection or ablation might provide meaningful seizure control in complex drug-resistant epilepsy with acceptable safety profiles. These findings describe current practice and support further investigation of hybrid surgical strategies in patients with challenging seizure networks as a potential treatment strategy.
More Than a Daughter: Margaret A. Lennox-Buchthal (1913-2001), Epileptologist - In a 2010 book chapter on the pioneering encephalographer Mary A.B. Brazier, PhD (1904-1995), a photo of a smiling woman is labeled "Margaret Lennox-Buchthal, wife of Fritz, daughter of William Lennox." Yet, like most women, Margaret Lennox-Buchthal, MD (1913-2001), was more than a wife and a daughter. She was an assistant professor at the Yale School of Medicine and associate professor at the ...
AI for Poststroke Epilepsy: Scoping Review of Imaging-Based Prediction Models and Implications for African Settings - CONCLUSIONS: Imaging-based AI for predicting PSS and PSE has progressed rapidly, but important methodological and geographical gaps remain. Limited external validation, heterogeneous reporting, and the absence of African development and validation cohorts restrict confidence in the generalizability of existing models. Future research should prioritize the development of explainable imaging-base...
Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities - CONCLUSIONS: In the periglioma human cortex, seizures arise from progressively recruited neuronal assemblies sculpted together with HFOs, providing new insights into the microphysiological processes of glioma-related ictogenesis and requiring consideration of the preictal fast and focal neuronal activity.
Efficacy of Lactobacillus reuteri as an adjunctive therapy for seizure control and quality of life in pediatric drug-resistant epilepsy: A prospective interventional study - CONCLUSIONS: In this single-arm before-after study, statistically significant within-participant changes in HRQOL and seizure frequency were observed during the 12-week period following adjunctive L. reuteri supplementation. However, the absolute magnitude of these changes was modest and their clinical significance remains uncertain. Because there was no concurrent placebo control group, the ob...
Combining responsive neurostimulation with resection or ablation for treatment of epilepsy: a multicenter experience - CONCLUSIONS: Combined RNS with resection or ablation might provide meaningful seizure control in complex drug-resistant epilepsy with acceptable safety profiles. These findings describe current practice and support further investigation of hybrid surgical strategies in patients with challenging seizure networks as a potential treatment strategy.
More Than a Daughter: Margaret A. Lennox-Buchthal (1913-2001), Epileptologist - In a 2010 book chapter on the pioneering encephalographer Mary A.B. Brazier, PhD (1904-1995), a photo of a smiling woman is labeled "Margaret Lennox-Buchthal, wife of Fritz, daughter of William Lennox." Yet, like most women, Margaret Lennox-Buchthal, MD (1913-2001), was more than a wife and a daughter. She was an assistant professor at the Yale School of Medicine and associate professor at the ...
AI for Poststroke Epilepsy: Scoping Review of Imaging-Based Prediction Models and Implications for African Settings - CONCLUSIONS: Imaging-based AI for predicting PSS and PSE has progressed rapidly, but important methodological and geographical gaps remain. Limited external validation, heterogeneous reporting, and the absence of African development and validation cohorts restrict confidence in the generalizability of existing models. Future research should prioritize the development of explainable imaging-base...
Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities - CONCLUSIONS: In the periglioma human cortex, seizures arise from progressively recruited neuronal assemblies sculpted together with HFOs, providing new insights into the microphysiological processes of glioma-related ictogenesis and requiring consideration of the preictal fast and focal neuronal activity.
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.