Epilepsy News

DYNAMIC BIOMARKERS FOR PREDICTING POST-TRAUMATIC EPILEPSY AFTER TRAUMATIC BRAIN INJURY - CONCLUSION: Late post-traumatic seizures and PTE after moderate TBI are associated with a persistent biomarker signature of neuroinflammation, neuroimmune activation and glial-axonal injury. A simple BioIndex based on IL-6, HMGB1 and NfL may serve as a practical laboratory tool for early risk stratification and individualized follow-up after moderate TBI.

Negative BOLD response to interictal discharges in epilepsy using intracranial EEG-fMRI - CONCLUSIONS: Positive BOLD responses provide superior localization of epileptogenic tissue compared to negative responses in intracranial EEG-fMRI. In contrast, negative BOLD clusters show greater spatial overlap with the DMN, suggesting they may reflect network deactivation at the time of IED events. These findings support prioritizing positive BOLD responses for clinical decision-making in pr...

Ethosuximide-induced lupus erythematosus: Unveiling a rare adverse reaction through systematic review - CONCLUSION: ESM-induced LE, though exceedingly rare, should be suspected in patients on ESM presenting with systemic autoimmune features. Its clinical and serological profiles overlap those of idiopathic systemic lupus erythematosus and classic DILE. Early recognition and prompt discontinuation of ESM typically result in rapid remission and may prevent unnecessary prolonged immunosuppression.

Myelodysplasia From Valproic Acid Resolved by Cessation - Myelodysplastic neoplasms (MDS) are clonal blood disorders that cause ineffective hematopoiesis, low blood counts, and a risk of progression to acute myeloid leukemia. Chemotherapy and radiation usually drive these changes, but a small set of medications, including valproic acid (VPA), can also produce reversible myelodysplastic features. We report a case of VPA-induced myelodysplasia in a midd...

Effects of carbamazepine and phenytoin in Krushinsky-Molodkina rats: further validation of the audiogenic kindling model of epilepsy - In the present study, we evaluated the effects of the clinically approved anti-seizure medications (ASMs) carbamazepine (CBZ) and phenytoin (PHT) on brainstem audiogenic seizures (AGS) and limbic seizures in Krushinsky-Molodkina (KM) audiogenic rats. In order to analyze the effects of ASMs on the standard AGS, KM rats received single intraperitoneal injection of CBZ (50 mg/kg), PHT (25 mg/kg), ...

Epi-Spec2State: Convolutional state space model via spectrogram image sequences for prediction-oriented seizure state classification in EEG signals - CONCLUSION: The proposed Epi-Spec2State can effectively capture the complex spatiotemporal dependencies in EEG signals. Its ability to handle diverse EEG types highlights its potential to support seizure state analysis and pre-seizure warning in clinical practice.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.