Epilepsy News

Cost-effectiveness of vagus nerve stimulation therapy for drug-resistant epilepsy across healthcare settings: a structured narrative review - Drug-resistant epilepsy (DRE) is associated with substantial healthcare utilization, impaired quality of life (QOL), and considerable societal costs. Vagus nerve stimulation (VNS) has become an established adjunctive treatment for patients who are not suitable candidates for resective epilepsy surgery or who fail to achieve adequate seizure control with pharmacotherapy. This structured narrativ...

GRIN-related epilepsy in Chinese pediatric patients: a retrospective study of clinical, genetic, and mutant protein structural features in a tertiary center cohort - CONCLUSIONS: Localized conformational alterations within specific NMDAR micro-domains provide insights into pathogenic clinical phenotypes. However, the observed divergence suggests that geometric deviations alone may not account for clinical severity in a linear fashion. Our findings highlight the potential for in silico modeling to complement clinical phenotyping, but emphasize that precision...

Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats - Temporal lobe epilepsy (TLE) is the most prevalent form of drug-resistant epilepsy and is driven by persistent neuroinflammatory cascades wherein interactions between inflammatory mediators and hormones play a crucial role. Kisspeptin (Kiss1), a neuropeptide known to modulate synaptic transmission in the hippocampus, has an unclear role in pathophysiology of epilepsy. To investigate this, a lit...

Canonical and non-canonical STAT3 pathways in epilepsy: Mechanistic insights and translational challenges - Epileptogenesis is a multifactorial cascade involving neuroinflammation, glial activation, neuronal hyperexcitability, abnormal synaptic plasticity, and cell death. Understanding the epileptogenic changes is critical for improving therapeutic outcomes. Despite extensive knowledge of inflammatory pathways in epilepsy, the role of signal transducer and activator of transcription 3 (STAT3) remains...

Efficacy and safety of MR guided-laser interstitial thermal therapy versus resective surgery for MRI-positive focal cortical dysplasia type II and tuberous sclerosis complex: A systematic review an... - CONCLUSION: Both resective surgery and MRgLITT are effective treatment options for epilepsy caused by MRI-positive FCD II and TSC, demonstrating comparable efficacy in seizure control and safety. Postoperative seizure outcomes were not influenced by patient age group.

Remarkable seizure reduction with trofinetide treatment in an adult with Rett syndrome: A case report - No abstract

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.