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Late-Onset Seizures: Etiology and Demographics in US Tertiary Care Epilepsy Centers -
BACKGROUND AND OBJECTIVES: Adults older than age 55 years have the highest incidence rate and are the fastest-growing population among people with epilepsy. The aim of this study was to characterize the etiologies of new-onset seizures in older adults and to examine how seizure etiology varies across demographic groups. We used data from 7 US epilepsy centers from 2021 to 2025 and compared find...
WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy -
The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic transmission and plasticity. Recent research highli...
Management of ring chromosome 20 syndrome: Narrative review and consensus recommendations -
Ring chromosome 20 (ring 20) is a rare genetic condition usually presenting as developmental and epileptic encephalopathy. The disease is caused by fusion of the long and short arms of chromosome 20. Patients are symptomatic even if there is no loss of genetic material. Epilepsy in ring 20 is usually drug-resistant, with seizures often significantly debilitating and severely impacting quality o...
Folic acid supplementation and prevention of adverse offspring outcomes among women with epilepsy: An observational study -
OBJECTIVE: Folic acid (FA) is essential for fetal development, while the benefits and optimal dose in pregnant women with epilepsy (PWWE) remain unclear. This study explores effects of FA supplementation, dose, and initiation time on offspring outcomes in PWWE.
Increased interval between seizure clusters across time in pediatric patients treated with the immediate-use seizure medication diazepam nasal spray -
OBJECTIVE: Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti-seizure medication. Benzodiazepine-containing immediate-use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters. Diazepam nasal spray is approved by the U.S. Food and D...
Fully Automated EEG Source Imaging Using Structured Sparsity for Single and Multiple Synchronous Epileptic Activities -
Accurate localization of epileptic zones from high-resolution electroencephalography (HR-EEG) data can be challenging, especially when multiple synchronous zones are involved, and is highly dependent on the chosen EEG Source Imaging (ESI) method. Since a given scalp-level electrical pattern can result from multiple source configurations, ESI methods address this ill-posed inverse problem by imp...
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