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Cathodal transcranial direct current stimulation in pediatric epileptic syndromes: mechanisms, limitations, and future research horizons -
INTRODUCTION: Drug-resistant epilepsy affects approximately 20 to 30% of children with epilepsy, with particularly devastating outcomes in developmental and epileptic encephalopathies (DEEs). Cathodal transcranial direct current stimulation (c-tDCS) has emerged as a promising noninvasive neuromodulation approach warranting systematic evaluation.
Cervical Sympathetic Blockade for Psychogenic Nonepileptic Seizures Associated With Post-traumatic Stress Disorder: A Case Report and Neurobiological Framework -
Psychogenic nonepileptic seizures (PNES), also termed functional seizures, are episodes that resemble epileptic seizures but occur without the abnormal ictal electrical activity characteristic of epilepsy. PNES is frequently associated with trauma exposure, post-traumatic stress disorder (PTSD), and abnormalities in autonomic regulation. Emerging evidence suggests that altered interactions amon...
Neurosurgical Outcomes of Epilepsy Surgery Between 2017 and 2025: A Retrospective ESSQ-19 Study From a Tertiary Care Center -
Introduction Epilepsy is a common neurological disorder. Despite being on anti-epileptic drug therapy, a subset of patients continue to experience seizures. In such patients with drug-resistant epilepsy, surgery remains a viable treatment option. Patient-reported satisfaction provides an important perspective on post-epilepsy surgery outcomes. This study aimed to descriptively assess postoperat...
Association of depression and epilepsy in rural northern Rwanda: a prospective longitudinal study with a patient-centered approach -
CONCLUSIONS: Kinyarwanda PHQ-9 and HDRS versions were successfully deployed for screening and diagnosing depression symptoms in PwE in rural settings. Treatment of epilepsy and co-morbid depression improved clinical outcomes. Implementation of depression screening in routine health practice in Rwanda is warranted.
Prevalence and potential risk factors associated with idiopathic epilepsy in Golden Retrievers -
CONCLUSIONS AND CLINICAL IMPORTANCE: Golden retrievers have an increased risk of IE, often presenting with cluster seizures. The association between IE and gastrointestinal disease might lead to new therapeutic strategies, but further investigations are needed.
Efficacy of Levetiracetam Combined with Sodium Valproate (Oral) in the Treatment of Senile Epilepsy and Its Effects on Cognitive Function, Inflammatory Factors and Neurotransmitters -
CONCLUSION: Levetiracetam combined with sodium valproate demonstrated superior comprehensive efficacy in the treatment of senile epilepsy. This regimen effectively improved seizure control, cognitive function, inflammatory status, and neurotransmitter balance, supporting its value as a reliable therapeutic option for elderly patients with epilepsy under routine clinical conditions and standardi...
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