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Electroencephalogram Utilization, Epileptiform Findings, and Associated Factors Among Children with Epilepsy in Southwestern Uganda: A 5-Year Retrospective Record Review -
OBJECTIVE: Epilepsy is the most common neurological condition in children in Low and Middle Income Countries (LMIC). Although the diagnosis remains majorly clinical, EEG is fundamental in assessment and management of epilepsy. However, its uptake remains low in LMIC. We aimed to determine the proportion of children with epilepsy who have had an EEG, the proportion of epileptiform EEGs, and the ...
Moderate-intensity treadmill exercise improved the anticonvulsant efficacy of topiramate and attenuated anxiety and depressive-like side effects in epileptic rats by upregulating 5-HT1A receptors i... -
CONCLUSION: The current findings demonstrate that adjunctive moderate-intensity treadmill exercise potentiates the anticonvulsant efficacy of topiramate and effectively counteracts its depressive-like side effects and anxiety. This behavioral improvement was correlated with exercise-mediated upregulation of 5-HT1A receptors, suggesting a potential mechanistic link. These findings provide a prec...
Prevalence and clinical correlates of autoimmune and infection-related antibodies in unexplained seizures in western China -
CONCLUSION: Combined detection of neural autoantibodies, systemic autoimmune antibodies, and infection-related serological markers facilitates etiological diagnosis and identification of candidates for early immunotherapy in patients with unexplained seizures in western China.
Epigenetic ageing is accelerated in drug-resistant epilepsy and dynamically modulated during ketogenic diet therapy -
BACKGROUND: The ketogenic diet (KD) is an established treatment for drug-resistant epilepsy. Beyond seizure reduction, many patients report improved energy, cognition, and well-being. DNA methylation (DNAm)-based epigenetic clocks provide molecular indices of biological ageing and may capture short-term adaptations induced by dietary therapy.
Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics -
OBJECTIVE: To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status.
Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy -
OBJECTIVE: The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome-wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS.
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