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Investigating the effect of probiotics on seizure-related symptoms in children with medication-resistant epilepsy: a randomized clinical trial -
INTRODUCTION: Antiseizure Medications (ASMs) can be beneficial for many patients with epilepsy; however, some individuals with medication-resistant epilepsy (MRE) may not experience effective seizure control. Although effective alternative diets and non-pharmacological interventions have received much attention, there are limited studies in this regard. Therefore, this study was conducted to in...
In Vivo Characterization of Synthetic Cannabidiol Analogs for Seizure Suppression in Zebrafish -
Epilepsy affects over 70 million people worldwide, nearly 20% of whom experience pharmacoresistant forms, particularly in pediatric populations. Cannabidiol (CBD) shows promise for the treatment of neurological disorders, including refractory epilepsy, but its low potency necessitates high dosing, leading to side effects that include drowsiness, gastric issues, and potential hepatotoxicity. Reg...
Disrupted inhibitory interneuron development in SCN1A Dravet syndrome revealed by patient-derived subpallial organoids -
OBJECTIVE: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy caused by loss-of-function variants in SCN1A, with seizures typically emerging during the first year of life. Although DS pathophysiology has largely been attributed to inhibitory network dysfunction underlying seizures, early developmental alterations in inhibitory interneurons remain poorly understood.
Surgical re-evaluation patterns among pediatric vagus nerve stimulation non-responders: a single-center retrospective study -
CONCLUSION: Nearly half of pediatric patients treated with VNS failed to achieve seizure reduction, yet few underwent re-evaluation for further surgical management despite favorable outcomes among those who did. Structured follow-up pathways are needed to ensure timely surgical re-assessment of pediatric VNS non-responders within comprehensive epilepsy programs.
Developmental and cell type-specific contributions of thalamic serotonin 2A receptors to absence seizures -
OBJECTIVE: Serotonin 2A receptors (5-HT(2A)Rs) play a complex role in focal and generalized seizures due to their diverse cellular and regional distribution. Although systemic activation of 5-HT(2A)Rs suppresses absence seizures (ASs) in Genetic Absence Epilepsy Rats From Strasbourg (GAERS) rats, the contribution of thalamic receptors and their cell-type specificity remains unclear. Here, we pe...
Prefrontal Cortex 5-HT1A Receptor-Coupled Inwardly Rectifying Potassium Channels Decreased Seizure Susceptibility in Rat Models With Autism Spectrum Disorder -
Dysregulation of serotonin 1A receptor (5-HT1A), a G protein-coupled inhibitory receptor, is implicated in the pathogenesis of both autism spectrum disorder (ASD) and epilepsy. The prefrontal cortex (PFC) is particularly vulnerable to the factors that affect neuronal and synaptic development, with abnormal PFC development leading to increased epilepsy susceptibility. This study used 8-OH-DPAT t...
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