Epilepsy and Seizure News
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First seizure referral clinics or first seizure units in neurology: How long is too long? -
No abstract
Early neurocognitive outcomes following SEEG with radiofrequency thermocoagulation -
OBJECTIVE: Characterization of early neuropsychological outcomes following SEEG with radiofrequency thermocoagulation (RFTHC) is essential to guide patient expectations around return to work, study, and caregiving. The current study aimed to describe the early neurocognitive sequelae of SEEG.
Validation of the diagnosis of Lennox-Gastaut syndrome: Challenges and lessons learned -
OBJECTIVE: Lennox-Gastaut Syndrome (LGS) is a severe developmental and epileptic encephalopathy characterized by multiple seizure types, cognitive impairment, and distinct electroencephalographic (EEG) findings. However, evolving diagnostic criteria, heterogeneous clinical features, and inconsistent electronic health record (EHR) documentation complicate accurate diagnosis and cohort identifica...
Beyond neuroprotection: Context-dependent effects of GLP-1 receptor agonists on seizure susceptibility -
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely used in type 2 diabetes mellitus and obesity and are increasingly considered to exert neuroprotective effects. Recent large-scale clinical and real-world studies report a predominantly neutral to protective association between GLP-1 RA use and seizure- or epilepsy-related diagnoses. However, how these agents affect neuronal excita...
The translational asymmetry of corpus callosotomy: Two literatures that answered different questions -
Corpus callosotomy is an established palliative operation for drug-resistant epilepsy dominated by drop attacks, and it is performed in three extents: anterior, usually of the anterior two-thirds; total, in one or two stages; and selective posterior, which preserves the genu and rostral body. Meta-analysis finds no difference between them in overall seizure reduction, a difference in drop attac...
Symptom-related damage patterns in mesial temporal lobe epilepsy with hippocampal sclerosis -
OBJECTIVE: This study was undertaken to elucidate the neuroanatomical and network substrates underlying diverse seizure symptoms in mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) by applying multivariate support vector regression (SVR) to individualized structural symptom mapping and atrophy network mapping (ANM).
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