Epilepsy News

Prolonged intervals persist beyond epileptologist referral in corpus callosotomy: A referral odyssey analysis - CONCLUSION: Prolonged intervals occurred both before and after epileptologist referral, particularly during the period before comprehensive inpatient evaluation, suggesting that referral alone may be insufficient and that comprehensive inpatient evaluation may be important in streamlining the pathway to CC.

The association between epilepsy self-management and perceived stigma in adults with epilepsy: a cross-sectional study - OBJECTIVE: To investigate the association between epilepsy self-management and perceived stigma among adults with epilepsy and to identify demographic and clinical factors associated with perceived stigma.

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single-center cohort of 80 patients - OBJECTIVE: Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.

Localization and anticipation of seizure onset and propagation using network architecture of pathological high-frequency oscillations - OBJECTIVE: In focal epilepsies, seizures originate from a presumed seizure onset zone (SOZ) and propagate through a network of dynamically interconnected brain regions. Accurate identification of the SOZ and propagation pathways is critical for surgical planning in patients with drug-resistant epilepsy. We tested the hypothesis that pathological high-frequency oscillation (pHFO) network propert...

Apoptin-Derived Peptide Alleviates Temporal Lobe Epilepsy (TLE) by Limiting Neuronal Ca(2+) Overload Through the HSPA1A-AP2B1 Axis - CONCLUSION: B9 reduces PTZ-evoked seizure susceptibility and ameliorates KA-associated cognitive and molecular abnormalities through modulation of the HSPA1A-AP2B1 axis. These findings support B9 as a potential therapeutic strategy for TLE.

Evaluation of Retinal Histological Alterations Following Carbamazepine Administration in Adult Albino Wistar Rats - Background Epilepsy is characterized by recurrent, unprovoked seizures and is a major global chronic neurological public health concern. Objective To evaluate retinal histological alterations, focusing on retinal ganglion cell count and apoptosis, following carbamazepine (CBZ) administration in adult albino Wistar rats. It is an antiepileptic drug mainly used for focal (partial) seizures, where...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.