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Semaglutide and Risk of Adult-Onset Seizure: A Target Trial Emulation -
BACKGROUND AND OBJECTIVES: Adult-onset seizure reflects the burden of acquired brain insults, but established disease-modifying preventive strategies are limited. We evaluated whether semaglutide initiation is associated with a lower incidence of adult-onset seizure compared with sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other glucose-lowering drugs (GLDs) in adults with type 2 dia...
Prognostic factors in vagus nerve stimulation for drug-resistant epilepsy. Results from a systematic review and meta-analysis of the literature -
The aim of the present study was to conduct a systematic review and meta-analysis evaluating prognostic factors of response to treatment with VNS implantation in patients with drug-resistant epilepsy. We conducted a systematic review following the PRISMA 2020 guidelines to critically analyze relevant studies. The review question was formulated using the PICO framework: "In patients with drug-re...
Spontaneous orienting of untrained companion dogs naive to human epilepsy toward odor samples from an unfamiliar human in a controlled non-social paradigm: a proof-of-concept -
CONCLUSIONS: Ictal odor may carry salience sufficient to influence initial attention in naïve dogs. However, findings are based on a single donor and require replication with multiple individuals to assess generalizability.
Psychosocial experiences are as important as medical factors in influencing the psychological functioning of children with epilepsy -
Epilepsy can profoundly influence children's psychological functioning, yet the contextual factors shaping this experience remain insufficiently understood. Using data from 104 children with epilepsy, their parents, homeroom teachers, and 1829 classmates, this study examined factors affecting children's psychological functioning. A range of diagnostic, psychological, and social variables were a...
Network reprogramming after resection of occipital meningioangiomatosis: Evidence from multimodal localization and longitudinal fMRI -
CONCLUSION: Multimodal findings localized the seizure onset to the right posterior region with widespread propagation. Postoperative rs-fMRI showed network changes consistent with partial normalization, paralleling sustained seizure freedom-though causality cannot be inferred from a single case.
"Homicide and Zonisamide": a review of the literature and illustrative case report on second and third generation antiseizure medications and psychiatric effects -
CONCLUSION: Homicidal ideation should be contextualized within a spectrum of ASM-associated psychiatric adverse effects (PAEs). Zonisamide may have contributed to symptom emergence in a susceptible individual within a multifactorial neuropsychiatric context. To our knowledge, this is the first case report explicitly documenting homicidal ideation as an adverse event of zonisamide.
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