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Type 3 Sturge-Weber Syndrome Presenting With Concurrent Epilepsy and Migraine -
Sturge-Weber syndrome is a rare congenital disorder with vascular malformations affecting the brain, skin, and eyes. Type 3 Sturge-Weber syndrome, the rarest form, presents with isolated leptomeningeal angiomas, often causing diagnostic delays. This report highlights an unusual presentation where both recurrent focal seizures and migraine-like headaches were prominent, long-standing features. A...
Clinical outcomes following stereotactic MRI-guided laser ablation in children with tuberous sclerosis complex and intractable epilepsy -
OBJECTIVE: In children with tuberous sclerosis complex (TSC) and drug-resistant epilepsy (DRE), magnetic resonance imaging-guided stereotactic laser ablation (SLA) therapy offers less-invasive treatment compared to craniotomy and resection. Our study seeks to further expand on the long-term outcomes in patients with TSC-related DRE who have undergone SLA.
Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder -
Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti-seizure treatments, nearly 30%-40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and long-lasting solutions. By addressing the underlyin...
Clinical and genetics spectrum of 392 Chinese patients with genetic epilepsy with febrile seizures plus -
CONCLUSION: The phenotypic spectrum of GEFS+ was broad and FS and FS+ constituted the main phenotypes. Multiple types of seizures and intellectual disability/developmental delay (ID/DD) were more likely to occur in children with low fever sensitivity. Sodium voltage-gated channel genes, especially SCN1A, and GABA receptor-related genes were frequent in the genotypic spectrum of GEFS+. GABA rece...
Seizure occurrence in FCD type II is predicted by lesion position and linked to cytoarchitectural alterations -
Focal cortical dysplasia (FCD) is a common malformation of cortical development and a major cause of early-onset, drug-resistant epilepsy. FCD type II is defined by abnormal lamination, altered cellular composition, and pathological cells, notably dysmorphic neurons (DNs) and balloon cells. DNs are thought to drive epileptogenicity through both cell-autonomous and non-cell-autonomous mechanisms...
Status Epilepticus Related to Maintenance Electroconvulsive Therapy: A Case Report and Brief Review of the Literature -
Prolonged seizures (PS), tardive seizures (TS), and status epilepticus (SE) are rare but severe complications related to electroconvulsive therapy (ECT). Factors increasing the risk for these conditions and measures making ECT safe after PS, TS, and SE are insufficiently studied. Therefore, we report and discuss the case of a 43-year-old woman with recurrent major depressive disorder and a hist...
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