Epilepsy News

Follow-up and outcome of patients with primary BH4 deficiencies - BH4 deficiencies may occur with or without hyperphenylalaninemia (HPA). If identified early through neonatal screening for PKU, the clinical follow-up aims to prevent the onset of typical disease symptoms. In contrast, for the conditions not associated with HPA, diagnosis usually occurs once symptoms manifest, and follow-up focuses on monitoring the treatment's effectiveness in restoring normal...

Neuroinflammatory PET in Epilepsy: Prospects for Epileptogenic Zone Localization and Presurgical Planning - Neuroinflammatory PET offers a direct in vivo means of quantifying neuroinflammatory processes through molecular targets expressed by activated glia, including the 18 kDa translocator protein (TSPO), monoamine oxidase B, and the P2X7 receptor. This review synthesizes current evidence for neuroinflammatory PET in epileptogenic zone (EZ) localization across these and emerging targets. TSPO PET de...

Cannabidiol Attenuates Seizure Progression and Recognition Memory Deficit Induced by Hippocampal HCN(1) Knockdown in the Kindling Model of Epilepsy in Male Rats - Epilepsy is a neurological disorder characterized by excessive neuronal firing, frequently originating in the hippocampus. Hyperpolarization-activated cyclic nucleotide-gated channel-1 (HCN(1)) regulates neuronal excitability and resting membrane potential, yet its role in seizure progression remains unclear. Cannabidiol (CBD), an effective anticonvulsant, may exert part of its effects through ...

Long-Term Outcome of Patients With Posterior Predominant Gliosis Secondary to Perinatal Insult: An Ambispective Cohort Study - CONCLUSIONS: These results depict the long-term effects of posterior gliosis on epilepsy, neurodevelopment, and also highlights its socioeconomic impact. Neonatal hypoglycemia being the most common cause, this study thus also emphasizes the need for its primary prevention and multidisciplinary care of those affected.

Vagus nerve stimulation for refractory status epilepticus: A systematic review - CONCLUSION: VNS implantation may be considered a treatment option for patients with acute-to-subacute SRSE who do not respond to medical treatment. However, functional disability remains substantial, and the likelihood of long-term seizure freedom is uncertain. Given the potential for publication bias and the exploratory nature of the subgroup analyses, the findings of this review should be int...

Memory performance, hippocampal volumes and memory fMRI in frontal versus temporal lobe epilepsy - CONCLUSION: These findings reveal similarities but also underline task- and material-specific differences in memory performance and functional integrity between TLE and FLE.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.