Epilepsy and Seizure News
Seizure action plans: Management and educational tools in epilepsy care -
Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
Study: Epilepsy patients benefit from structured 'seizure action plans' -
A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...
Epilepsy: Understanding Seizures, Saving Lives, And Protecting Future Generations -
Epilepsy is not a curse, not a mental illness, not contagious. It is a medical condition deserving compassion. Across societies, countless individuals living with epilepsy continue to endure fear, ...
People with focal epilepsy often have seizures while driving before a diagnosis -
Prior to being diagnosed with epilepsy, 5% of people with a type of epilepsy called focal epilepsy had a seizure while driving, according to a new study published in the June 7, 2023, online issue of ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time -
Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
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Pregabalin-Induced Myoclonus in a Patient Without Kidney Dysfunction -
Pregabalin is FDA-approved for the treatment of neuropathic pain associated with diabetes, postherpetic neuralgia, spinal cord injury, and as an adjunctive treatment for partial seizures and thus is a commonly prescribed agent in the primary care, neurological, and pain management settings. Adverse effects of pregabalin include dizziness, somnolence, diplopia, blurry vision, and respiratory dep...
Second-Generation of Deuterium-Substituted Glutamate Uptake Enhancers Exhibit Superior Drug-Like Properties in Preclinical Evaluation -
Strategic deuterium-hydrogen exchange applied to the first-in-class positive allosteric modulators (PAMs) of the glutamate transporter EAAT2/GLT-1, ( R )-AS-1 and ( R )-AS-7, yielded novel analogues with improved drug-like properties. Specifically, incorporation of deuterium into the pyrrolidine-2,5-dione ring significantly prolonged the elimination half-life and increased both plasma and brain...
Agree to Disagree: Reliability of Seizure Frequency Assessments -
No abstract
Association between Interictal Spike Rate and Seizure Frequency in a Large Epilepsy Cohort -
BACKGROUND AND OBJECTIVES: Tracking and predicting seizure frequency in patients with epilepsy is important for prognostication and therapy management. Interictal spikes have been proposed as a biomarker of seizure burden, but their association with seizure frequency has not been well quantified across epilepsy subtypes. Our objective was to measure the association between spike rate and seizur...
Anti-GAD antibody-associated epilepsy in pregnancy -
Anti-GAD antibody-associated epilepsy (AAE) is a rare neurological condition arising as a consequence of autoantibodies against the intracellular antigen glutamic acid decarboxylase (GAD) 65. It most commonly manifests in women of childbearing age, with persistent seizures, often refractory to therapy. Here described is a woman in her first pregnancy, with anti-GAD AAE, managed in pregnancy wit...
Persistent Delirium in the Elderly: A Case Report and Review of Multifactorial Contributors and Management Challenges -
CONCLUSION: This case underscores the potential for exceptionally prolonged delirium in medically complex older adults, diagnostic complexity in differentiating persistent delirium from ictal-related psychosis and other conditions, and individualized pharmacotherapy considerations. Early multidisciplinary intervention, capacity assessments, and caregiver support are critical.
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