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Investigation of the Antiepileptic and Anti-inflammatory Effects of Empagliflozin on Penicillin-induced Epileptiform Activity in Rats -
CONCLUSION: Empagliflozin demonstrated anticonvulsant and anti-inflammatory effects by delaying seizure onset, reducing SWF, and modulating pro-inflammatory cytokine levels. These findings suggest that empagliflozin may have therapeutic potential in epilepsy through SGLT-2 inhibition.
Clinical Impact of Adjusted Valproic Acid Level in Patients with Hypoalbuminemia: A Single-Center Cohort Study -
Valproic acid (VPA) is highly protein-bound, thereby impacting its free fraction and clearance in hypoalbuminemia. There is limited data on VPA use in such patients. Thus, this study evaluates the impact of adjusted VPA concentration (aVPAc) in predicting effectiveness and adverse effects compared to total VPA (tVPA) levels in hypoalbuminemic patients. A retrospective cohort study involved adul...
Human Mediodorsal Thalamus in Seizure Propagation -
CONCLUSIONS: The thalamic MD subregion was often involved after the other thalamic sites, but the MD sites, along with the massa intermedia connecting the two thalami, were significantly involved when seizures spread to contralateral hemisphere. Our findings suggest that a single thalamic lead capturing both MD subregions may yield important clinical information about laterality, origin, and ge...
Identification of Additional Cases of Severe Neonatal GABA-Transaminase Deficiency -
GABA-transaminase (GABA-T) deficiency is a rare disorder of GABA metabolism characterized by neonatal encephalopathy, epilepsy, hypotonia and intellectual disability. It is caused by biallelic pathogenic variants in the ABAT gene. We report a case of a newborn female born to a G10P5 mother, with abnormal fetal movements and polyhydramnios in utero. At birth, she presented with hypotonia, hypers...
Neuroinflammation in GAD65 Antibody-Associated Epilepsy Measured Using [(18)F]DPA-714 PET/MRI -
The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy is a challenge. We used the translocator protein radioligand [^(18)F]DPA-714 and PET to evaluate brain microglial activation. [^(18)F]DPA-714 PET brain images of 11 patients with GAD65 antibody-associated epilepsy and seven controls were analyzed. Patients with acute symp...
Epilepsy phenotypes of Renu syndrome: Novel insights from a European multicentre retrospective cohort study -
CONCLUSIONS: The phenotype of the seizure disorders observed in this cohort was dominated by focal impaired consciousness seizures with observable manifestations and a relatively favourable course of epilepsy.
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