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Can the 5-SENSE score guide stereo-electroencephalography in children? First validation in a purely pediatric cohort -
CONCLUSIONS: This is the first validation of the 5-SENSE score in a purely pediatric population. While it shows moderate predictive accuracy, a low score does not exclude the possibility that SEEG might still identify a focal area of seizure onset.
Optimal timing of PD-1 inhibitor immunotherapy administration to stereotactic radiosurgery in malignant gliomas: a propensity score-matched multi-institutional cohort study -
CONCLUSIONS: Pre-SRS PD-1 inhibitor use was associated with more neurological deficits and lower survival, highlighting the need for prospective studies on optimal SRS immunotherapy timing in malignant gliomas.
Real-world outcomes of responsive neurostimulation in patients with Lennox-Gastaut syndrome: A multicenter retrospective study -
OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a severe developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types and high resistance to antiseizure medication (ASM), often necessitating nonpharmacologic therapies, including neuromodulation. Responsive neurostimulation (RNS), a closed-loop brain-responsive neuromodulation device, has emerged as an adjunctive treatmen...
The outcomes of consecutive pregnancies in Australian women with epilepsy -
OBJECTIVE: To investigate the extent to which seizure control and the occurrence of fetal malformation in an initial pregnancy can serve to anticipate the outcome in the next pregnancy.
Clinical and Molecular Spectrum of Proximal 16p11.2 BP4-5 Copy Number Variations: Insights From a Pediatric Cohort -
Copy number variations (CNVs) at the proximal 16p11.2 BP4-BP5 locus are among the most well-characterized genomic regions associated with neurodevelopmental disorders. We aimed to define the clinical and molecular spectrum of these CNVs in a pediatric cohort. A total of 19 patients with pathogenic or likely pathogenic 16p11.2 BP4-BP5 CNVs were identified among 2200 individuals referred for chro...
Apoptosis and Glial Marker Profiles in Hippocampus and Amygdala of Medically Intractable Temporal Lobe Epilepsy -
Medically intractable temporal lobe epilepsy is associated with potential neuronal and glial damage in key brain structures, including the hippocampus and amygdala. This study aimed to examine apoptosis, caspase expression, and glial activation markers in these regions, and to evaluate their associations with clinical variables. Hippocampal and amygdala tissues from 17 patients with medically i...
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