Epilepsy News

Tongue Wounds Following Convulsive Seizures: Bridging Neurology and Oral Medicine Practice - CONCLUSION: Post-convulsive oral wounds represent clinically significant and potentially severe manifestations of epilepsy that require more than isolated local management. We propose an interdisciplinary clinical algorithm integrating acute surgical care, neurological evaluation, and preventive dental strategies. This approach supports early diagnosis, reduces recurrence, and promotes improved...

The Neurotoxic Mechanisms of Valproic Acid and Their Association With Neurodevelopmental Disorders: A Narrative Review - Valproic acid (VPA), which is an anticonvulsant and mood stabilizer, has been applied in treating several neurological and psychiatric conditions. However, severe neurotoxic side effects may result from its use, especially when taken at certain developmental stages of a child's brain. Consequently, the present narrative review aimed not only to summarize what is presently known about the neurot...

Exosome-based therapy for epilepsy: a systematic review and meta-analysis of preclinical studies - CONCLUSION: Exosome therapy improves seizure phenotypes and protects cognitive function in epilepsy models by suppressing neuroinflammation to promote neuronal survival, providing evidence for further mechanistic and clinical translation studies.

Emerging sensing platforms for epilepsy care and management - The effective management of epilepsy requires analytical tools capable of addressing the lack of specific biomarkers, and current antiepileptic drugs (AEDs) suffer from response variability, a narrow therapeutic index, and unpredictable neurotoxicity. Traditional approaches to quantitative drug monitoring not only fail to deliver precise, real-time results necessary to personalized treatment op...

Atraumatic Bilateral Anterior Shoulder Dislocation With Bilateral Greater Tuberosity Fractures Accompanied by the Diagnosis of Epilepsy: A Case Report - CONCLUSION: Bilateral greater tuberosity fractures associated with atraumatic bilateral anterior shoulder dislocation due to an epileptic seizure are exceedingly rare and may represent the first manifestation of epilepsy. This case demonstrates that seizure-induced muscle contractions can cause severe extremity injuries without external trauma; therefore, every post-seizure patient requires sys...

Brain perfusion imaging in patients with status epilepticus, seizures, and IIC patterns - Over the past decade, Computed Tomography perfusion (CTP) and Magnetic Resonance Perfusion (MRP) imaging have become increasingly valuable tools in the assessment of acute neurological emergencies, including stroke and stroke mimics. These modalities can demonstrate seizure-related alterations in regional cerebral blood flow across the spectrum of epileptic conditions. While ictal states classi...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.