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The Five Sign: A hand posture suggesting insulo-opercular involvement in focal seizures -
OBJECTIVE: The Five Sign is a previously underrecognized ictal hand posture characterized by full extension and spreading of the fingers. We aimed to determine its localizing value and underlying network basis in patients with drug-resistant focal epilepsy.
Uncovering Individual Language Vulnerability in Epilepsy Through Functional Connectivity Laterality -
CONCLUSION: Our findings suggest an individual vulnerability of language networks to seizure burden, although this uncorrected, exploratory finding requires replication in larger, independent samples. Incorporating functional connectivity measures into presurgical clinical fMRI analysis may enhance our ability to predict and protect language function in patients with TLE by prioritizing further...
A Phase I study of the pharmacokinetics (PK), bioavailability, dose proportionality, safety, and tolerability of topiramate injection compared to Oral topiramate in healthy adult participants -
This Phase I study evaluated the safety, tolerability, and pharmacokinetics of a 30-min topiramate injection (intravenous [IV] TPM) infusion compared with oral topiramate (oral TPM) in healthy adult participants. In this randomized, open-label, dose escalation, crossover study with 37 healthy participants received single doses of 50, 100, or 200 mg of an oral TPM tablet and an IV TPM formulatio...
Subclinical seizure burden and cognitive impairment: The value of ambulatory EEG monitoring in underserved populations -
OBJECTIVES: Ambulatory electroencephalography (aEEG) allows prolonged outpatient monitoring and improves seizure detection compared with routine EEG, particularly for subclinical seizures. aEEG is especially valuable in underserved populations, where socioeconomic barriers and comorbidities contribute to delayed diagnosis and poor seizure control. The objective of the study is to evaluate seizu...
Developmental pathways to autism in tuberous sclerosis complex: Evidence from a longitudinal cohort -
The association between autism spectrum disorder (hereafter referred to as autism) and tuberous sclerosis complex (TSC) is well established, yet the developmental pathways linking genetic mutation, cortical pathology, and epilepsy with autism remain unclear. The Tuberous Sclerosis 2000 Study recruited children newly diagnosed with TSC (N = 125). Data on mutation status, cortical tuber burden (m...
Diagnostic delay in infants with very early-onset rare and ultra-rare genetic epilepsies -
AIM: To evaluate time to diagnosis in infants with very early-onset genetic epilepsies, identify contributing factors to diagnostic delay, and assess the impact of a definite diagnosis on clinical management.
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