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Individual differences in susceptibility to color induced visual discomfort -
Color and certain color combinations are known to affect visual discomfort and cortical excitation. They also increase the likelihood of seizure activity in patients with photosensitive epilepsy. What remains unclear is the extent of the individual differences in susceptibility in experiencing color induces visual discomfort in the non-clinical population. In the current study, we examine ratin...
Myoclonin1 haploinsufficiency in motile ciliated cells partially recapitulates epileptic features of Efhc1-deficient mice in adult age -
Mutations in the EFHC1 (EF-hand domain containing 1) gene, which encodes myoclonin1, a homolog of the Chlamydomonas axonemal protein Rib72, have been identified in patients with epilepsies including juvenile myoclonic epilepsy (JME). Myoclonin1 is expressed in choroid plexus epithelial cells during fetal development and in motile cilia of ependymal cells lining brain ventricles as well as in tr...
Entraining chimeras: The effect of driving with regular, irregular, and real-world phases -
Chimera states in coupled oscillator networks are paradigmatic examples of partial synchronization in nonlinear systems, with direct relevance to real-world network dynamics, such as neuronal dynamics. Since real-world networks are not isolated, but embedded in larger interacting systems, chimeras have also been studied under the influence of other networks and external signals. In particular, ...
Clinical case of a pregnant woman with arteriovenous malformation, hemorrhagic venous infarcts and epileptic seizures: a case report -
CONCLUSION: This clinical case presents interest due to the combination of medical conditions, which resulted in cerebrovascular incidents with different localizations and characteristics during pregnancy, complicated with epileptic seizures.
Perirhinal cortex gains control of hippocampal seizures via broad downstream circuits in male mouse models -
The perirhinal cortex (PRh) has extensive interconnections with limbic structures, including the fasciola cinerea (FC), a recently identified node and therapeutic target in temporal lobe epilepsy. However, the neural circuit basis between PRh and FC in seizure progression remains unclear. Here we show that the PRh provides the principal excitatory input to the FC and plays an important role in ...
Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation -
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, with its onset and progression closely linked to neuroinflammation, where abnormal activation and migration of microglia serve as a key pathological process. This study focuses on the regulatory role of gastrodin, the principal active component of the traditional Chinese medicine Gastrodia elata, and its target P2R...
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