Epilepsy News

Applicability and feasibility of the updated ILAE seizure classification in secondary referral centers - This prospective multicenter study aimed to evaluate the applicability and feasibility of the updated International League Against Epilepsy (ILAE) seizure classification (basic version) in secondary referral centers, using information from history-taking and basic investigations (routine or sleep electroencephalography, and computed tomography or magnetic resonance imaging when indicated). The ...

Pulvinar responsive neurostimulation for posterior quadrant epilepsy: an illustrative case with connectome projection - Objective To present the rationale for targeting the thalamic pulvinar nucleus with Responsive Neurostimulation (RNS) in refractory epilepsy involving the posterior quadrant, supported by connectome-based analysis and a rare illustrative case of a successful pulvinar implantation. Methods A connectome-based analysis of the pulvinar nucleus was conducted using normative diffusion imaging data fr...

Astrocytic LCN2 drives neuronal dysfunction in epilepsy by suppressing tunnel nanotube-mediated mitochondrial transfer via NLRP3 inflammasome activation - Epileptic seizures disrupt brain homeostasis not only by directly challenging neuronal excitability but also by impairing the intricate astrocyte-neuron cross-talk essential for metabolic support. Herein, we identify a novel pathogenic axis and a compensatory rescue mechanism that are critically interlinked. Following seizures, astrocytes initiate a protective response by forming tunneling nano...

Unique quality of life priorities for people with epilepsy and comorbid functional seizures - OBJECTIVE: Epileptic seizures (ES) and functional seizures (FS) commonly coexist. People with both conditions (ES + FS) report different contributing factors to quality of life (QOL) compared to people with ES only. However, a distinct core outcome set (COS) for measuring QOL among people with ES + FS does not exist.

Boldo leaves reduce seizures, neuroinflammation, and hemichannel activity in a murine model of chronic epilepsy - Epilepsy is a chronic neurological disorder characterized by a propensity for seizures due to an imbalance between excitatory and inhibitory brain activity. This condition also induces neuroinflammation, which contributes to disease progression. Given that hemichannels (HCs) permeabilize the cell membrane of glia playing a critical role in neuroinflammation, we investigated the antiepileptic po...

Pediatric stroke: From emergent evaluation to rehabilitation - Pediatric stroke, though less common than adult stroke, is a significant cause of morbidity and mortality in children, affecting neonates, infants, and adolescents. Strokes in children could be due to ischemic, hemorrhagic, or venous-thrombotic events. Timely recognition and intervention to optimize neurologic outcomes and minimize long-term disability is most critical. Clinical symptoms are de...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.