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First Report of a Child With a DeSanto-Shinawi Syndrome and a Polymorphous Low-Grade Neuroepithelial Tumor of the Young -
Loss-of-function variants in the WW Domain Containing Adaptor with Coiled-Coil (WAC) gene are associated with DeSanto-Shinawi syndrome (DESSH), a rare autosomal dominant neurodevelopmental disorder usually with onset characterized by global developmental delay appearing in infancy or early youth, intellectual disability, seizures, autism spectrum disorder, attention-deficit/hyperactivity disord...
Valproic Acid-Induced Pancreatitis in a Pediatric Patient With 17q12 Duplication Syndrome -
Drug-induced acute pancreatitis is an uncommon cause of acute pancreatitis. Among the common culprits is valproic acid (VPA) and its derivatives, i.e., Depakote. These medications are commonly prescribed for epilepsy, bipolar disorder, and migraines. Although VPA-induced pancreatitis is rare, it has a variable disease course and may progress to severe disease, which can become fatal. Our case r...
Longitudinal Australian trends in the initiation of valproate medication among women of reproductive age and concurrent use of prescription contraceptives -
CONCLUSIONS: A decline in valproate prescribing has occurred in Australia. At the time treatment commenced, the great majority of women dispensed valproate were not covered by any form of PBS prescription contraceptive, which is of concern.
Assessment of Driving Restrictions Following Craniotomy: A Survey of Canadian Neurosurgeons -
CONCLUSION: This study emphasizes the lack of standardized practices regarding return to driving recommendations for patients undergoing craniotomy without prior seizures. Development of national return to driving guidelines would assist Canadian clinicians in making informed decisions regarding the optimal timeframe for the safe return to driving.
Probiotics and seizure susceptibility in preclinical epilepsy models: mechanistic insights from a systematic review and meta-analysis -
The gut microbiota can affect neuronal excitability, inflammation, and oxidative balance via the gut-brain axis, shaping seizure susceptibility. To translate these findings into clinical approaches, a synthesis of preclinical microbiome-based evidence is needed. This systematic review and meta-analysis examined the putative anticonvulsant, anti-inflammatory, antioxidant, and neuroprotective eff...
Investigating the role of cortical microglia in a mouse model of viral infection-induced seizures -
Microglia, resident immune sentinels in the brain, are crucial in responding to tissue damage, infection, damage signals like purines (ATP/ ADP), and clearing cellular debris. It is currently unknown how microglial reactivity progresses and contributes to seizure development following Theiler's Murine Encephalomyelitis Virus (TMEV) infection. Previously, it has been demonstrated that purinergic...
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