Epilepsy News

Prevalence and predictive factors of epilepsy in multiple sclerosis: A cross-sectional study from Saudi Arabia - CONCLUSION: This study confirms increased epilepsy prevalence among MS patients in Saudi Arabia. Older age is a key risk factor, emphasizing the importance of early screening and management strategies.

Efficacy and quality of life outcomes in deep brain stimulation for epilepsy: A meta-analysis and systematic review - CONCLUSION: DBS reduces seizure burden and yields early improvements in QOL among patients with DRE, with pooled QOLIE-31 estimates suggesting clinically meaningful gains in the early postoperative period. However, later timepoint estimates were more variable and should be interpreted cautiously, as they do not represent longitudinal trajectories within the same patients. These findings support...

Lateralized neural and oculomotor alterations in temporal lobe epilepsy: A combined eye-tracking and event-related potential study - CONCLUSIONS: These findings demonstrate that LTLE and RTLE are associated with dissociable oculomotor-ERP patterns. This study establishes that eye-tracking and ERP techniques can objectively reveal latent cognitive deficits in TLE, offering a valuable complement to standard neuropsychological tests.

Intracranial biomarkers for anterior thalamic deep brain stimulation in epilepsy: a long-term observational study - Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is an established treatment for patients with drug-refractory epilepsy (DRE), yet long-term therapeutic outcomes are highly variable and challenging to predict. This variability is compounded by the delayed and gradual effects of DBS, the difficulty of consistent seizure monitoring, and the absence of physiological bioma...

Efficacy and Safety of Zonisamide Addition in Children With Developmental Epileptic Encephalopathy/Epileptic Encephalopathy: A Real-World Study - CONCLUSION: Adjunctive zonisamide provides sustained efficacy and favorable tolerability in children with DEE/EE, including young children < 6 years and highly drug-resistant cases. Gender and prior treatment history predict long-term efficacy, supporting its reliable risk-benefit profile for refractory epilepsy.

AFG2A-related encephalopathy, expanding the neurodevelopmental and epileptic spectrum - OBJECTIVES: To expand the clinical features, epilepsy phenotype, and genotype in individuals with AFG2A-related encephalopathy (AFG2A-RE), previously known SPATA5-related encephalopathy, and to explore potential associations between genotype and epilepsy manifestations.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.