Epilepsy News

The negative chronotropic control of the insula: An SEEG-based investigation - The insula is implicated in heart rate modulation within brain-cardiac interactions, yet direct electrophysiological evidence remains limited. This study investigates dynamic insula-cardiac coupling during ictal heart rate fluctuations to elucidate the insula's role in chronotropic regulation. Patients with drug-resistant epilepsy exhibiting both insular stereoelectroencephalography coverage an...

Phenomenological insights into disclosure and concealment decision-making among people with epilepsy experiencing generalized tonic-clonic seizures - CONCLUSIONS: This study offers a new perspective on illness disclosure decision-making among PWE with GTCS, highlighting its existential significance beyond information management. The findings indicate that disclosure or concealment is an ongoing, context-dependent process of relational classification through which participants seek to construct safe and protective social spaces. These decisio...

Responsive Neurostimulation for Treatment of SCN1A-Associated Developmental and Epileptic Encephalopathies - CONCLUSIONS: These descriptive findings suggest that RNS, particularly thalamic targeting, may be a palliative consideration for select SCN1A-spectrum patients while underscoring variable benefit and the importance of multidimensional outcome assessments.

Apelin-13 suppresses seizure-associated high-frequency oscillations and attenuates neuroinflammatory damage in a Pentylenetetrazole-induced rat acute epilepsy model - The Apelin-13/APJ system exerts anti-excitatory, antioxidant, and anti-inflammatory effects in the central nervous system, however, its influence on seizure-associated pathological high-frequency oscillations (HFOs) and concurrent neuroinflammatory tissue injury has not been investigated in vivo. This study evaluated the effects of intracerebroventricular Apelin-13 pretreatment on seizure sever...

Epigenetic and post-transcriptional control of epileptogenesis by NEAT1: From molecular pathways to biomarker potential - Epilepsy, a chronic neurological condition that is defined by episodes of spontaneous recurrent seizures initiated by abnormal excessive neuronal synchronisation and cortical hyperexcitability. Despite the progress in diagnostic procedures and in the creation of antiepileptic drugs, about one-third of the patients persist in experiencing drug-recalcitrant epilepsy, thus enhancing the necessity ...

Effective treatment for lithium pilocarpine-induced status epilepticus: clonazepam and lacosamide combination - This study aimed to investigate the potential of clonazepam (CLZ), one of the benzodiazepines used in the first-line treatment of status epilepticus, in combination with anti-seizure medications such as levetiracetam (LEV), lacosamide (LCM), valproic acid (VPA), and fosphenytoin (fPHT), which are used in second-line treatment, in polytherapy. Fifty-six male Sprague-Dawley rats were randomly ass...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.