Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Patients engage with epilepsy monitor in real time, improving seizure detection - A team has built an AI-based interface that enables real-time communication between patients and epilepsy monitoring devices. As part of a small clinical study at the University of Pennsylvania in ...

Seizure action plans: More than management tools for epilepsy - Newswise — Historically, seizure action plans have focused on certain high-risk groups — such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters ...

Seizure or epilepsy? Understanding the critical difference could save lives - A sudden episode of shaking, confusion, or loss of awareness can be frightening - but does it mean epilepsy? Understanding the difference between a seizure and epilepsy is crucial for timely treatment ...

Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? - Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...

Temporal association between adjunctive repetitive transcranial magnetic stimulation and seizure reduction in a pediatric patient with DNM1L-associated EMPF1: a case report - CONCLUSIONS: In this case, adjunctive rTMS applied alongside standard antiepileptic and metabolic "cocktail" therapy was temporally associated with a pronounced reduction in seizure frequency in a patient with DNM1L-associated EMPF1. This temporal association is hypothesis-generating and does not permit attribution of the observed seizure reduction to rTMS; further investigation in larger cohor...

Case Report: Value of MR relaxometry and spectroscopy in multimodal imaging characterization of limbic encephalitis in systemic sclerosis - Central nervous system involvement is uncommon in systemic sclerosis, and inflammatory temporomesial syndromes in this context are rarely reported. We present a 58-year-old man with systemic sclerosis who developed subacute cognitive impairment and dialeptic seizures arising from the right temporal lobe. Video electroencephalography confirmed a right temporal seizure onset zone. Brain magnetic ...

Exploratory epilepsy-derived transcriptomic projection reveals region-sensitive molecular remodeling in Alzheimer's disease - CONCLUSIONS: This study provides a hypothesis-generating cross-disease projection framework for exploring region-sensitive transcriptomic organization in AD. Future cell-type, spatial, and mechanistic evaluation is required.

Case Report: Right frontal periventricular heterotopia underlying secondary network epilepsy with a Lennox-Gastaut phenotype: multimodal SEEG, CCEP, and rs-fMRI evidence - CONCLUSION: In this patient, a focal PVH-related epileptogenic network was associated with secondary bilateral cortical and thalamic recruitment underlying an LGS phenotype. CCEP and rs-fMRI captured complementary aspects of postoperative network change: attenuation of stimulation-evoked propagation and postoperative changes in intrinsic functional connectivity, respectively.

Machine Learning Framework for Integration of Video and EEG Reveals Distinct Seizure Phenotypes in Mouse Models of Epilepsy - Video-electrocorticogram (VEEG) recordings are the gold-standard diagnostic tool for detecting and characterizing seizures in rodent models of seizure and epilepsy. Manual/visual scoring remains the prevailing strategy despite significant limitations. Alternatively, automated and semi-automated analyses have been applied to either EEG or video features alone but integrating these disparate data...

A homozygous GABRA2 variant associated with infantile spasms evolving to Lennox-Gastaut syndrome alters receptor gating - Variants in GABA(A) receptor subunits are increasingly implicated in developmental and epileptic encephalopathies. Although GABRA2 variants have been associated with early-onset epilepsy, the functional consequences of individual variants, particularly those located outside canonical ligand-binding and transmembrane pore-forming regions, remain incompletely understood. We identified a homozygou...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.