Epilepsy News

Role of the miR-340-5p/IRF1/USP18 Axis in Neuroinflammation Associated with Epilepsy - Epilepsy is a prevalent neurological disorder, in which maladaptive neuroinflammation critically contributes to epileptogenesis. In this study, we identified a previously unrecognized signaling axis that regulates inflammatory responses and inflammatory cell death in experimental epilepsy. Integrated bioinformatic analyses of the GSE73878 and GSE18740 datasets, together with transcription facto...

Rapid administration of undiluted IV push valproic acid - OBJECTIVE: Delays associated with traditional intravenous (IV) infusion of valproic acid (VPA) may lead to delays in emergent seizure treatment and headache management. Undiluted IV push (IVP) administration of VPA may be safe and well tolerated; however, evidence evaluating safety across dosing ranges is limited. This study evaluated the safety and tolerability of IVP administration of undilut...

Analysis of Risk Factors Affecting Epilepsy Seizure Frequency with Statistical Models - CONCLUSION: While our study found that stress, sleep deprivation, fasting/prolonged hunger, and excessive physical activity may increase seizure frequency, it was also determined that some additional, unidentified environmental or genetic factors affect seizure frequency. The limited sample size, heterogeneity of the patient population, and reliance on patients' subjective assessments constitut...

Clozapine-Associated Generalized Seizure at Therapeutic Dose Without Prior Epilepsy: A Case Report - CONCLUSION: Clozapine may precipitate seizures at therapeutic doses in patients with latent epileptiform susceptibility. When therapeutic drug monitoring is unavailable, careful clinical assessment, EEG evaluation, and exclusion of alternative causes are essential. Dose reduction with anticonvulsant therapy may permit safe continuation of clozapine.

Ethnopharmacological relevance of Chinese medicinal materials and natural products in epilepsy: a critical multi-target review integrating neurons, glia and inflammatory signaling - Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures, substantial comorbidity, and persistent pharmacoresistance in approximately one-third of affected patients. Chinese medicinal materials, including botanical drugs, selected animal-derived medicinal materials, extracts, and defined natural metabolites, have long been used as adjunctive approaches for seiz...

Nucleus-specific thalamic involvement in seizure networks differentiates neuromodulation outcomes - Closed-loop neuromodulation via responsive neurostimulation (RNS) of the thalamus has emerged as a promising therapy for drug-resistant epilepsy (DRE), particularly in patients with broad or multifocal onset. However, response to thalamic RNS is inconsistent, and there is a crucial need to identify factors that distinguish responders from non-responders. Given the heterogeneous composition of t...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.