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In Vivo Longitudinal Mapping of Brain Iron Accumulation After Pilocarpine-Induced Status Epilepticus -
Iron accumulations have been identified in resected tissue from patients with refractory temporal lobe epilepsy. These deposits are linked to ferroptosis, a form of nonapoptotic cell death in which iron catalyzes the formation of reactive oxygen species, leading to lipid peroxidation. Experimentally, this process has recently been associated with seizures based on the increased levels of specif...
The Neurology of Menopause -
PURPOSE OF REVIEW: Menopause is a neuroendocrine process with important implications for neurological health. This review examines the complex, multidirectional relationships between menopause and major central nervous system conditions, including stroke, migraine, epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease.
Epilepsy and Intellectual Disability in a Boy with a 2q13 Microdeletion Affecting the BUB1 Gene -
Background: The chromosomal microdeletion syndrome 2q13 is characterized by craniofacial dysmorphism, developmental delay, intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, cardiac abnormalities, and seizures. Case Presentation: In this study, we present a descriptive genomic observation of a teenage boy presenting with epilepsy, intellectual disabilit...
Perampanel Monotherapy in Epileptic Children: A Systematic Review with Pooled Descriptive Analysis -
This systematic review with a pooled descriptive analysis aimed to improve our understanding of perampanel monotherapy for epilepsy in children today. The databases were created following a PubMed search, adhering to PRISMA guidelines. A total of 12 studies from 74 citations published between 2016 and 2026 met the specified inclusion criteria. The pooled descriptive analysis featured 8 retrospe...
Childhood-Onset Refractory Absence Epilepsy as a Presentation of Glucose Transporter 1 Deficiency Syndrome Type 2: A Case Report With a Diagnostic Challenge -
Glucose transporter 1 (GLUT1) deficiency syndrome is a rare metabolic disorder caused by mutations in the SLC2A1 gene resulting in impaired glucose transport through the blood-brain barrier. The "classic" phenotype in children includes early-onset drug-resistant epilepsy, especially absence epilepsy, cognitive delay, movement disorders, and microcephaly. The ketogenic diet is the only treatment...
Effect of Concomitant Medications on Adverse Event Frequency, Severity, and Time to Resolution in a Cenobamate Open-Label Trial -
CONCLUSIONS: Patients taking fewer concomitant ASMs reported better tolerability as evidenced by fewer and less severe AEs and faster time to resolution. These findings emphasize the importance of optimizing concomitant ASM regimens through dose adjustments, ASM substitution, and treatment simplification to improve tolerability.
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