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Effectiveness of adjunctive low-dose clobazam in adults with focal drug-resistant epilepsy and incomplete response to cenobamate: A real-world study -
OBJECTIVE: Cenobamate (CNB) is a highly effective antiseizure medication (ASM) for focal drug-resistant epilepsy (DRE); nevertheless, even with CNB treatment and optimized therapy, a substantial proportion of patients continued to experience seizures. Preliminary observations suggest that clobazam (CLB), a 1,5-benzodiazepine, may enhance CNB efficacy. We aimed to evaluate the real-world effecti...
The role of China's acute seizure action plan in the management of out-of-hospital seizures in children with epilepsy: a pilot study -
INTRODUCTION: This study aimed to explore the function and applicability of localized China acute seizure action plan (CASAP) in the management of out-of-hospital seizures in children with epilepsy, and to provide a theoretical basis and practical framework for further optimisation and promotion of this action plan.
Elucidating the putative role of cannabigerol: a hypothesis-generating review of neuroinflammatory and neuroprotective mechanisms with implications for drug-resistant epilepsy -
Drug-resistant epilepsy (DRE) affects approximately 30% of individuals with epilepsy and remains a major clinical challenge despite the availability of multiple antiseizure medications (ASMs). Beyond recurrent seizures, accumulating evidence implicates chronic neuroinflammation, blood-brain barrier (BBB) dysfunction, excitotoxic injury, and progressive neurodegeneration as processes associated ...
Headache comorbidity in epilepsy and functional/dissociative seizures: an exploratory cross-sectional study in a tertiary epilepsy center -
INTRODUCTION: Headache disorders are common in patients with epilepsy and functional/dissociative seizures (FDS) and may influence quality of life and clinical outcomes. Migraine has been proposed as a reciprocal risk factor for epileptic and functional seizures. We aimed to determine the prevalence of headache disorders and associated clinical factors in a cohort of patients undergoing video-E...
Uncovering the Key Influencers of Healthy Lifestyle Behaviors in Patients With Epilepsy: A Cross-Sectional Study -
CONCLUSION: Adults with epilepsy demonstrated only moderate engagement in health-promoting behaviors, with physical activity emerging as the most vulnerable domain. Targeted, nurse-led interventions that include structured lifestyle education, individualized physical activity planning, diet adherence monitoring, and medication adherence counseling may help overcome condition-specific barriers a...
Clinical phenotype and genetic analysis of a child with Autosomal dominant intellectual developmental disorder type 5 caused by SYNGAP1 gene variant: A case report and literature review -
CONCLUSION: This study has identified a SYNGAP1 c.725G>A variant in the Chinese population and confirmed it as a potential cause of MRD5, which expanded the mutational spectrum of this disorder.
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