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Aurora-Associated Geomagnetic Activity and Health: A Review With Focus on Neurological Implications -
Geomagnetic activity (GMA), particularly during auroras, has emerged as an intriguing area of research due to its potential health impact. Prior studies indicate that fluctuations in geomagnetic fields can affect diverse physiological and psychological outcomes. The aim of this article is to comprehensively review the impact of GMA on neurological health with an emphasis on implications for pat...
TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice -
CONCLUSIONS: Our findings establish the Akt/mTOR axis as a critical pathway mediating the protective actions of TPPU against epilepsy and its comorbidities in murine models. This work not only advances our understanding of epilepsy pathophysiology but also identifies novel targets for the development of comprehensive therapeutic strategies.
Neuroprotective activity of the α7-nAChR positive allosteric modulator PNU-120596 on short term outcomes after traumatic brain injury -
Traumatic brain injury (TBI) often leads to long-lasting neurological, cognitive, and behavioral impairments. Despite its high global burden, no disease-modifying therapies currently exist to mitigate secondary injury processes that contribute to chronic neurological deficits. Activation of α7 nicotinic acetylcholine receptors (α7-nAChRs), which are expressed on neurons, glia, and immune cells,...
A neural mass modelling framework for evaluating EEG source localisation of seizure activity -
This study addresses the challenge of objectively evaluating electroencephalography and magnetoencephalography (EEG/MEG) source localisation algorithms in the absence of an experimentally verifiable ground truth, specifically for the characterisation of ictal dynamics. 
Approach. A simulation framework is presented for generating biologically plausible ictal dynamics and their corresponding...
Functional and effective connectivity methods from SEEG for characterizing epileptogenic networks in refractory epilepsy: a comprehensive review and future directions -
Brain Connectivity Analysis based on Stereoelectroencephalography (SEEG) has been increasingly explored as a tool for studying Epileptogenic Networks and supporting therapies for Refractory Epilepsy. In this Review, we summarize recent methodologies and findings on SEEG-based Functional and Effective Connectivity, which aim to define the dependence and influence between spatially distributed ne...
Established and emerging neuromodulation for drug-resistant epilepsy -
Drug-resistant epilepsy concerns approximately 30% of epilepsy patients. Surgical interventions might not be an option, especially in case of generalized or multifocal seizures or if there is a high risk of neurological defects caused by the resection. Currently widely approved neuromodulation approaches consist of invasive methods: vagus nerve stimulation (VNS), deep brain stimulation (DBS) an...
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