Epilepsy News

Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus - CONCLUSIONS AND RELEVANCE: Results of this cross-sectional study suggest that acute neuroaxonal injury, as reflected by elevated NfL levels, was substantially greater in cNORSE than in the cohorts with eSE and in controls without status epilepticus. The rapid early rise in NfL highlights a narrow therapeutic window, emphasizing the need for prompt, effective, and potentially neuroprotective int...

Enlarging the phenotypical spectrum of DYNC1H1-related epilepsy - No abstract

Ictal semiology in fronto-opercular epilepsy: A systematic review - A systematic review of the ictal semiology of fronto-opercular seizures in focal epilepsy was carried out to assess possible anatomical-clinical correlations and help guide interpretation of ictal semiology during pre-surgical evaluation. PubMed and Embase databases were searched using the following keywords: "fronto-opercular OR frontal opercular OR Frontal operculum OR superior perisylvian OR...

Insights from multimodal simultaneous SEEG-EEG and SEEG-MEG recordings: A case of combined generalized and focal epilepsy - Despite formal recognition of "combined generalized and focal epilepsy" in the 2017 International League Against Epilepsy classification, its implications for therapeutic decision-making remain ambiguous. We report a case demonstrating how focal cortical pathology can interact with distributed epileptic networks using multimodal electrophysiology. A patient with long-standing presumed generaliz...

Parishin B Attenuates PTZ-Induced Seizures in Zebrafish and Is Associated with Neurotransmitter Balance and ACLY-Related Metabolic Pathways - Background: Epilepsy is a chronic neurological disorder characterized by recurrent seizures, complex neurochemical, and metabolic disturbances. Parishin B, a major bioactive component of Gastrodia elata, has shown neuroprotective potential, but its systemic mechanisms remain unclear. Methods: A pentylenetetrazol (PTZ)-induced seizure model in zebrafish larvae was developed and used to evaluate ...

Lacosamide Safety During Pregnancy and Breastfeeding: A Single-Centre Experience and Comprehensive Narrative Review - (1) Background: The management of epilepsy during pregnancy requires balancing effective seizure control against potential teratogenic effects of antiseizure medications (ASMs). Data on the safety of lacosamide (LCM), a third-generation ASM, during pregnancy and breastfeeding are limited. (2) Methods: To evaluate the safety and efficacy of LCM during pregnancy and breastfeeding, we report a sin...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.