Epilepsy and Seizure News
Silent crisis - Gauteng’s 11,000 epilepsy emergencies in 12 months -
“Over the past 12 months, Gauteng recorded 11 344 epilepsy related emergency medical cases, highlighting the continued burden of the condition and the importance of early diagnosis and community ...
CREATe Therapeutics Achieves Complete Seizure Prevention in a Severe Model of Focal Epilepsy -
Breakthrough Preclinical Result in Epilepsy Treatment These findings strengthen our confidence as we progress toward ...
Can Epilepsy Be Cured? A Neurologist Explains What Seizure-Free Really Means -
What does it truly mean to be seizure-free A Neurologist explains the difference between remission and a cure and the latest treatment options for managing the condition ...
After Epilepsy Surgery, When to Stop ASMs Matters -
A multicenter cohort study explores how the timing of ASM withdrawal after epilepsy surgery may influence seizure relapse and long-term outcomes.
Pediatrics in Brevard: Here's what to know about epilepsy, what to do if someone has seizure -
More than 3.4 million people in the United States have epilepsy, so it is a relatively common diagnosis. In fact, it is the fourth-most common neurologic condition in the world. November is National ...
Understanding epilepsy: Seven ways to respond to an epileptic seizure -
At the forefront of epilepsy research and treatment is the University of Alabama at Birmingham Epilepsy Center, a collaborative initiative between the UAB Department of Neurology and UAB Hospital, ...
Maryland doctor explains grand mal epilepsy seizure, shares what to do when someone experiences it -
According to Dr Sood, the best thing to do during an epilepsy seizure is to stay with the person experiencing it and keep them safe without restraint.
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A rare side effect of vagal nerve stimulation: increased seizures and status epilepticus -
CONCLUSION: VNS is generally well tolerated and provides benefits for patients. However, both patients and their families and clinicians should be alert to the rare side effect of triggering seizures.
Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway -
The pathophysiological mechanism of epilepsy has not been fully elucidated. Abnormal synaptic plasticity in the hippocampus may be an important trigger. Decorin (DCN), an extracellular matrix protein, may affect synaptic remodeling by regulating the mTOR signalling pathway. However, its role and molecular mechanism in epilepsy remain unclear. In this study, a chronic epilepsy mouse model induce...
Structural brain imaging biomarkers for predicting seizure recurrence after a first unprovoked seizure -
OBJECTIVES: Predicting seizure recurrence following a first unprovoked seizure (FUS) remains a significant clinical challenge, especially when routine clinical magnetic resonance imaging (MRI) and EEG do not reveal abnormalities diagnostic of epilepsy. Here, we incorporate quantitative structural MRI-derived biomarkers into prediction models for seizure recurrence at 12 months and identify brai...
Seizure-type-specific disruption of hypercapnic cardioventilatory responses in epilepsy models -
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is linked to respiratory and autonomic failure with post-ictal periods of prolonged hypercapnia indicative of impaired central chemoreception. Yet how interictal hypercapnic cardioventilatory responses vary by seizure phenotype is unclear. We aimed to determine whether central chemoreception and autonomic regulation differ across epilepsy p...
Out of the lab, into real life: Evaluating at-home EEG self-monitoring -
Seizure forecasting models require long-term, high-quality data collected in real-life settings using noninvasive or minimally invasive devices, yet, the lack of such systems remains a major barrier to their clinical translation. Here, we aimed to evaluate the signal quality of self-applied at-home EEG monitoring using a wearable system in patients with epilepsy to assess its reliability for fu...
Automated analysis of postictal generalized electroencephalogram suppression for SUDEP risk stratification -
Sudden unexpected death in epilepsy (SUDEP) affects more than 3000 individuals annually, yet objective and scalable biomarkers to assess risk remain limited. Postictal generalized electroencephalogram suppression (PGES) has been proposed as a potential biomarker, but its quantification is often subjective and variable. Here, we developed and validated an automated Cumulative Sum (CuSUM)-based a...
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