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High-dose cerium dioxide nanorods induce behavioral and electroencephalographic abnormalities through 5-HT1B receptor signaling disruption with an evaluation of anpirtoline's therapeutic potential -
Cerium dioxide nanorods (CeO(2) NRs) have drawn extensive research attention in the past few years for their exceptional generation of reactive oxygen species (ROS) and intrinsic catalytic properties. The two ends of the biological effect show a dose-dependent difference: protection of cells at low doses and damage to cells at high doses. Although the above processes are well documented in othe...
Early-life prolonged hyperthermic seizures alter disease trajectory in the Scn1a(+/-)(tm1Kea) mouse model of Dravet syndrome -
Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy caused most often by de novo loss-of-function mutations in SCN1A, the gene encoding the alpha subunit of the voltage-gated sodium channel (Na(v)1.1). Animal models such as the Scn1a(+/-)^(tm1Kea) mouse display relevant DS phenotypes including sensitivity to hyperthermia-induced seizures and later-life spontaneous ...
Temporal evolution of EEG hallmarks in childhood Lennox-Gastaut syndrome -
CONCLUSION: EEG hallmarks of LGS emerged progressively during childhood, with slow spike-and-wave preceding GPFA during sleep. Following early clinical manifestations, a prolonged developmental phase may precede full electroclinical expression of LGS, with implications for early diagnosis and longitudinal EEG surveillance.
Dravet Syndrome Updates: Evolving Insights and Emerging Therapeutics -
PURPOSE OF REVIEW: This narrative review aims to evaluate current literature on Dravet syndrome, integrating significant new findings into the existing knowledge of pathophysiology and disease course, and highlighting emerging treatments.
Copy number variants across the developmental epilepsy-developmental and epileptic encephalopathy spectrum: an Indonesian case series -
Developmental epilepsy (DE) and developmental and epileptic encephalopathy (DEE) comprise neurodevelopmental disorders in which epilepsy occurs alongside developmental impairment of varying contributions from the underlying etiology and epileptic activity. Advances in genetic testing, including whole-exome sequencing (WES), whole-genome sequencing (WGS), and chromosomal microarray analysis (CMA...
Transition of spike to seizure networks in the rat somatosensory and motor cortex requires mitogen-activated protein kinase signaling -
OBJECTIVE: During epileptogenesis, epileptic spikes emerge before seizures, yet the network mechanisms linking spike activity to seizure generation remain unclear. Previously, we showed that mitogen-activated protein kinase kinase (MAP2K) inhibition reduces spiking in tetanus toxin (TeNT)-injected rats. Here, we advanced the TeNT rat model to transition from spike to seizure networks to better ...
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