Epilepsy and Seizure News
Seizure action plans: Management and educational tools in epilepsy care -
Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
Epilepsy: Understanding Seizures, Saving Lives, And Protecting Future Generations -
Epilepsy is not a curse, not a mental illness, not contagious. It is a medical condition deserving compassion. Across societies, countless individuals living with epilepsy continue to endure fear, ...
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time -
Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
Focal treatment-resistant epilepsy symptoms improved with antiseizure medication -
Please provide your email address to receive an email when new articles are posted on . Monthly seizure frequency percentage reduction was 68.73% for the entire study cohort. For those followed up in ...
EPILEPSY AWARENESS: Local neurologist explains condition & seizure first aid -
COLUMBUS, Ga. (WRBL) — Local experts say epilepsy is not a condition to be afraid of. Piedmont Columbus Regional pediatric neurologist Pierre Fequiere treats patients with epilepsy every day and knows ...
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The National Association of Epilepsy Centers Accreditation Criteria Should Include Care for People With Functional/Dissociative Seizures -
No abstract
Health-Related Quality of Life and Family Impact Among Children with Epilepsy: The Role of Seizure Control -
CONCLUSION: Sustained seizure control is associated with better overall HRQoL in children with epilepsy, particularly in social functioning, while other domains and family burden may persist beyond seizure status alone. These findings support integrated management strategies that address both seizure control and psychosocial well-being.
Real-world effectiveness of cenobamate in drug-resistant and ultra-refractory epilepsy: A multicenter study -
OBJECTIVE: To evaluate the real-world effectiveness, safety, and treatment retention of cenobamate (CNB) in patients with drug-resistant epilepsy (DRE), including ultra-refractory epilepsy (URE), high seizure burden, and extensive prior treatment history.
Exome sequencing of pashtun familial epilepsy in Pakistan reveals novel variants in LAMA5, KCNQ2 and GNAO1 -
CONCLUSIONS: This study expands the mutational and phenotypic spectrum of epilepsy-associated genes in a highly consanguineous population and highlights the efficiency of integrating genomic, clinical, and computational approaches for variant interpretation. The findings also suggest a potential recessive contribution of genes traditionally associated with dominant inheritance, warranting furth...
Sulfonadyn Compounds: A Class of Aryl Sulfonamides That Inhibit Dynamin GTPase and Clathrin-Mediated Endocytosis and Are Antiepileptic in Animal Models -
Synthetic modification of dansylcadaverine (1) and our previously identified dynamin I and clathrin-mediated endocytosis inhibitor S1-47 gave rise to new members of the sulfonadyns class of GTP-competitive dynamin inhibitors. Analogues in this class displayed high dynamin I, dynamin II, and clathrin-mediated endocytosis inhibition (inhibition of Tfn-A594 uptake in U2OS cells). Dynamin activity ...
A first in disease trial of the safety, tolerability, and anti-seizure effects of ES-481 in drug-resistant epilepsy -
OBJECTIVES: ES-481 is a novel potent and selective antagonist of TARP-y8-dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES-481 as an add-on anti-seizure medication (ASM) in adults with drug-resistant epilepsy (DRE).
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