Epilepsy and Seizure News
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Adjunctive antiepileptic efficacy and safety study of mTOR inhibitors in children with tuberous sclerosis complex -
CONCLUSION: Adjunctive therapy with mTOR inhibitors improves the response rate to antiepileptic treatment in children with TSC, with sirolimus and everolimus demonstrating comparable efficacy. Therapeutic benefits were observed regardless of seizure onset age, and longer treatment duration was associated with greater efficacy. mTOR inhibitors may cause some adverse effects in children, but most...
Deletion of Alg13 disrupts postnatal development and migration of GABAergic cortical interneurons -
CONCLUSION: Alg13 regulates postnatal interneuron development, and its deletion may contribute to epilepsy-related pathophysiology. These results enhance understanding of the molecular mechanisms underlying epilepsy and provide a potential experimental foundation and novel therapeutic targets for the management of Alg13-associated refractory seizures, thereby advancing knowledge of interneuron ...
KCNQ2 Variants in Neonatal Epilepsy: Clinical Characteristics and Neurodevelopmental Outcomes in 30 Patients -
BACKGROUND AND OBJECTIVES: The aim of this study was to characterize clinical features, genetic architecture, treatment responses, and neurodevelopmental outcomes in neonatal epilepsy associated with KCNQ2 variants and to delineate genotype-phenotype correlations.
Ciprofloxacin-induced microbiota dysbiosis triggers seizure susceptibility through the microbiota-gut-brain axis -
CONCLUSION: This study provides evidence linking gut microbiota dysbiosis to seizure susceptibility through neuroinflammatory processes, contributing to the understanding of gut-brain axis involvement in fluoroquinolone-induced seizures.
The Effect of GLP-1 Receptor Agonists on Epilepsy: No Appetite for Seizures -
No abstract
Epilepsy and EEG abnormalities in neurodegenerative dementias: toward a system epilepsy framework -
Epilepsy and epileptiform activity represent underrecognized yet clinically significant features of neurodegenerative dementias, with emerging evidence suggesting they may contribute to disease progression rather than merely representing epiphenomena of neuronal loss. This comprehensive review examines the epidemiology, clinical presentation, electroencephalographic findings, and pathophysiolog...
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