Epilepsy News

Long-term exposure to polystyrene microplastics exacerbates seizure symptoms via lipid metabolic disruption and ferroptosis: insights from multi-omics analyses - As a consequence of global industrial growth, microplastics (plastic fragments

SnRNA-seq reveals seizure-induced remodelling of excitatory and inhibitory neuron populations - Epilepsy is one of the most common chronic neurological disorders. This study aimed to identify hippocampal neuronal subpopulations with the most prominent transcriptional alterations during the latent period following status epilepticus, thereby elucidating early molecular mechanisms of epileptogenesis in a pilocarpine-induced model. Status epilepticus (SE) was induced in male C57BL/6 N mice v...

Epigenetic histone deacetylase inhibition by sodium butyrate reduces neuroinflammation, improves neurological dysfunction and promotes disease modification of epileptogenesis following traumatic br... - Post-traumatic epilepsy (PTE) is a chronic and debilitating seizure disorder that arises following traumatic brain injury (TBI) and is characterized by persistent neuroinflammation, epigenetic dysregulation, long-term neurological deficits, and recurrent seizures. Despite its clinical significance, there are currently no effective therapies that halt epileptogenesis and improve functional outco...

Interactions between SSR504734, a selective glycine transporter type 1 inhibitor, and antiseizure drugs: pharmacodynamic and pharmacokinetic studies in mice - Studies suggest the potential involvement of glycine in seizures and epilepsy; however, no currently available antiseizure medications directly target glycine transporter 1 (GlyT1) or enhance glycinergic neurotransmission. Here, we examined the effect of SSR504734, a selective GlyT1 inhibitor, on the protective activity of six antiseizure medications, i.e., lamotrigine and topiramate in the max...

Beyond seizures: eye tracking evidence of cognitive dysfunction in epilepsy - A systematic review - CONCLUSIONS: Eye tracking reveals reproducible oculomotor signatures of cognitive network dysfunction in epilepsy. Standardized paradigms and longitudinal designs are essential to determine the mechanistic specificity and predictive value of these measures relative to traditional neuropsychological assessment in epilepsy care.

The efficacy and safety of ketogenic diet therapy among adolescents and adults with drug resistant epilepsy: A systematic review and meta-analysis - Ketogenic diet therapy (KDT), characterised by its high-fat, low-carbohydrate composition, is a valuable approach to reducing seizures in children with drug resistant epilepsies (DRE). Uncertainty remains regarding its benefits in adolescents and adults. This systematic review and metanalysis critically evaluated evidence efficacy, safety and tolerability of KDT in adolescents and adults with D...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.