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The dual role of BDNF in epilepsy: insights from calpain-mediated TrkB-FL cleavage -
Despite the efficacy of current antiseizure medications in managing seizures, approximately one-third of patients develop refractory epilepsy, highlighting an urgent need to uncover the molecular mechanisms driving epileptogenesis. This process emerges from a complex interplay of molecular alterations, involving changes in neuronal signaling pathways. Among these, brain-derived neurotrophic fac...
Clinical feature-guided targeted genetic testing in early-onset developmental and epileptic encephalopathy: a real-world diagnostic approach in a resource-limited setting -
OBJECTIVE: In low- and middle-income countries (LMICs), access to trio-based whole-exome or whole-genome sequencing is limited, which may delay genetic diagnosis in developmental and epileptic encephalopathies (DEE). We used clinical features to guide targeted genetic testing and reviewed the results through multidisciplinary discussion in a Vietnamese pediatric cohort with early-onset DEE and ...
Understanding the perceived impact of a peer-led epilepsy self-management intervention in Uganda: a qualitative study -
CONCLUSIONS: Peer-led self-management support may enhance engagement, coping, and self-efficacy among people with epilepsy in resource-limited settings. Addressing stigma and strengthening social and healthcare support may be critical for improving outcomes in low-middle income countries.
High-dose cerium dioxide nanorods induce behavioral and electroencephalographic abnormalities through 5-HT1B receptor signaling disruption with an evaluation of anpirtoline's therapeutic potential -
Cerium dioxide nanorods (CeO(2) NRs) have drawn extensive research attention in the past few years for their exceptional generation of reactive oxygen species (ROS) and intrinsic catalytic properties. The two ends of the biological effect show a dose-dependent difference: protection of cells at low doses and damage to cells at high doses. Although the above processes are well documented in othe...
Early-life prolonged hyperthermic seizures alter disease trajectory in the Scn1a(+/-)(tm1Kea) mouse model of Dravet syndrome -
Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy caused most often by de novo loss-of-function mutations in SCN1A, the gene encoding the alpha subunit of the voltage-gated sodium channel (Na(v)1.1). Animal models such as the Scn1a(+/-)^(tm1Kea) mouse display relevant DS phenotypes including sensitivity to hyperthermia-induced seizures and later-life spontaneous ...
Temporal evolution of EEG hallmarks in childhood Lennox-Gastaut syndrome -
CONCLUSION: EEG hallmarks of LGS emerged progressively during childhood, with slow spike-and-wave preceding GPFA during sleep. Following early clinical manifestations, a prolonged developmental phase may precede full electroclinical expression of LGS, with implications for early diagnosis and longitudinal EEG surveillance.
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