Epilepsy News

PAK1 Is Involved in Epileptogenesis by Regulating the Synaptic Plasticity of Hippocampal Neurons Through LIMK - PAK1, a key regulator of cytoskeletal remodeling, is associated with synaptic plasticity, but its role in epilepsy remains unclear. This study investigated whether PAK1 contributes to epileptogenesis by modulating hippocampal synaptic plasticity via the LIMK signalling pathway. A chronic epilepsy model was induced in mice via the use of pentylenetetrazol (PTZ). LV-PAK1-shRNA was stereotacticall...

Neighbourhood topology unveils pathological hubs in the brain networks of epilepsy-surgery patients - Pathological hubs in the brain networks of epilepsy patients are hypothesized to drive seizure generation and propagation. In epilepsy-surgery patients, these hubs have traditionally been associated with the resection area (RA): the region removed during the surgery with the goal of stopping the seizures, and which is typically used as a proxy for the epileptogenic zone. However, recent studies...

Reproducibility of temporally evolving seizure patterns and network connectivity in focal epilepsy - Clinical semiology, waveform patterns, frequency band characteristics, neuronal spiking activity, and connectivity network dynamics exhibit notable reproducibility across seizures in the same patient. However, whether these reproducible features distinctly delineate the epileptogenic zone (EZ), propagation zone (PZ), and non-involved zone (NIZ) and the underlying temporal dynamics remain unclea...

A deep hybrid CSAE-GRU framework with two-stage balancing for automatic epileptic seizure detection using EEG-derived features - INTRODUCTION: Epilepsy is a neurological disorder characterized by abnormal neuronal discharges in the brain, posing a persistent challenge in clinical diagnosis. This study presents a high-performance epileptic seizure detection framework that integrates advanced feature extraction and classification techniques using EEG signals.

Case Report: Electroacupuncture combined with transcutaneous auricular vagus nerve stimulation for treating antiseizure medication-resistant juvenile myoclonic epilepsy - CONCLUSION: This case suggests that combined electroacupuncture and taVNS may be a promising non-pharmacological adjunct in the treatment of ASM-resistant JME, contributing to improved seizure control and multidimensional QOL outcomes.

Advances in understanding the role of inflammatory factors and immune cells in the pathology of epilepsy, mediated by neuroimmune interactions within the gut-brain axis - Epilepsy is a prevalent chronic neurological disorder, affecting approximately 70 million individuals globally, with its pathogenesis primarily attributed to recurrent seizures caused by abnormal neuronal discharges in the brain. Recent research has increasingly recognized the critical role of neuroinflammation in the central nervous system in the onset and progression of epilepsy. Furthermore,...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.