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Association between graded short-term lymphocyte count decline and epilepsy risk in HIV-positive patients: a retrospective cohort study -
To evaluate whether varying degrees of lymphocyte count decline in HIV-positive adults are associated with increased short-term incidence of epilepsy or convulsions. A retrospective cohort study was conducted using the TriNetX global research network. HIV-positive patients with a lymphocyte count ≥ 1.2 × 10³/µL were categorized based on subsequent decline within 3 months: mild (1.01-1.19), mode...
Response to anti-seizure medications in children carrying novel or previously reported HCN1 gene variants -
OBJECTIVE: Variants in the HCN1 gene cause a syndrome of childhood epilepsy and developmental disability with a broad phenotypic range. Many affected children manifest with early infantile epileptic encephalopathy (EIEE) and highly drug-resistant epilepsy. There are anecdotal reports that seizures in this syndrome are exacerbated by some anti-seizure medications (ASMs), including lamotrigine an...
Intranasal Biodegradable Nanomedicine for Epilepsy Management: Targeting the Brain Beyond the Blood-Brain Barrier -
Epilepsy is a common chronic neurological disorder characterized by recurrent, unprovoked seizures arising from abnormal neuronal hyperexcitability and hypersynchronous electrical activity within the brain. Despite advances in antiseizure medications, effective epilepsy management remains challenging because of pharmacoresistance, limited blood-brain barrier (BBB) permeability, inadequate intra...
Seizure As the Sentinel Event: An Atypical Presentation of Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis in a Young Adult Male -
This case report details an atypical presentation of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis in a 21-year-old male, characterized by a "seizure-first" phenotype. The patient's initial generalized tonic-clonic seizure led to a misdiagnosis of epilepsy, and subsequent psychiatric symptoms were incorrectly attributed to the side effects of antiepileptic medication or a new, undiagno...
Therapeutic Use of Medical Cannabis Beyond Pain Management in Physical Medicine and Rehabilitation -
Medical cannabis has emerged as a rapidly evolving therapeutic modality with expanding clinical interest beyond its traditional role in pain management. Particularly relevant to Physical Medicine and Rehabilitation (PM&R), where the focus extends beyond symptom control to functional restoration and optimal quality of life, key non-pain indications described in the literature include management ...
Elevated serum plasminogen activator inhibitor-1 is associated with seizure burden, drug resistance, and neuroinflammatory markers in pediatric epilepsy -
CONCLUSION: PAI-1 is significantly elevated in pediatric epilepsy and is associated with seizure burden, neuroinflammatory activation, BBB disruption, drug resistance, and poorer quality of life. In this clinical setting, PAI-1 may be more useful as a risk-stratification biomarker for identifying children with higher disease burden and possible treatment resistance, rather than as a standalone ...
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