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Abnormal ECG Findings in Children Undergoing Seizure Evaluation -
CONCLUSIONS: The identification of cardiac abnormalities in children undergoing evaluation for a possible seizure disorder allows not only optimization of seizure management but also guides differential diagnosis, specific cardiological interventions, and avoidance of antiseizure medication that might exacerbate cardiac arrhythmias. It is crucial to pay attention to the ECG channel of the elect...
Longitudinal EEG, Seizure, and Developmental Patterns in Children With CDKL5 Deficiency Disorder in the First 2 Years of Life -
BACKGROUND AND OBJECTIVES: Although there is near-universal early-onset epileptic encephalopathy in cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD), it has been observed clinically that EEGs are initially only mildly abnormal and worsen in the first 2 years of life. This study aimed to identify specific EEG patterns, ictal and interictal, in individuals with CDD during the firs...
Open-label Study of Accelerated Low-Frequency TMS for Treatment-Resistant Depression in People With Epilepsy -
CONCLUSIONS: Accelerated low-frequency right prefrontal TMS appears safe, feasible, and associated with clinically meaningful improvements in depressive symptoms in individuals with epilepsy and TRD. These findings provide initial support for the use of TMS in a population often excluded from neuromodulation trials and highlight the need for controlled studies to determine efficacy and long-ter...
Enablers of Sustainable Pediatric Epilepsy Surgery: A Qualitative Exploration of Global Neurosurgery -
CONCLUSION: Global collaborations create opportunities to increase access to neurosurgical care. Creating interdisciplinary programs across borders requires trust and open communication by all members. Sustainable programs can be further enabled with intentional planning, humility, and bidirectional skill transfer.
A 21-Year Diagnostic Odyssey in TBC1D24-Associated Developmental and Epileptic Encephalopathy With Favorable Response to Corpus Callosotomy: A Case Report -
Developmental and epileptic encephalopathies (DEEs) are one of the most important causes of seizures occurring during the early years of life. Establishing an etiologic diagnosis remains challenging in many affected individuals. Next-generation sequencing (NGS), such as whole-exome sequencing (WES) or targeted gene-panel sequencing, has therefore become a useful tool for identifying these patie...
Trends in Use of Antiseizure Medicines in Women With Epilepsy in Pregnancy During 2018-2023 in an Irish Maternity Hospital: A Cohort Study -
CONCLUSIONS: In this single-centre EHR cohort, trends in use of ASMs in WWE appeared relatively stable, although analyses of less commonly used ASMs were limited by very small numbers. ASMs with safer pregnancy profile were most frequently used in WWE in pregnancy. Additional data are needed to further assess trends and outcomes and to determine the place of newer generation ASMs in WWE in preg...
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