Epilepsy and Seizure News
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Genetic biomarker screening for drug-resistant epilepsy in low- and middle-income countries (LMICs) -
Drug-resistant epilepsy (DRE) presents a major clinical and economic challenge, particularly in lowand middle-income countries (LMICs), where healthcare resources are limited and treatment gaps remain significant. Although epilepsy surgery remains the most effective intervention for eligible DRE patients, outcomes are variable, with success rates ranging from 30% to 70%. Emerging evidence sugge...
Neurological complications of rotavirus infection in pediatric patients: a retrospective cohort study -
CONCLUSIONS: Seizures are the most common neurological complication of rotavirus gastroenteritis. Although typically benign in young children, these events may increase the risk of subsequent epilepsy. Other complications, including hearing loss, should also be considered. Vaccination remains an effective strategy to reduce complication rates.
Reversible high-fat ketogenic formula-induced hypertriglyceridemia in a child with NALCN mutation on a ketogenic diet: a case report -
CONCLUSIONS: KD can be effective in NALCN channelopathies. Nevertheless, personalized dietary modification, favoring MCTs or monounsaturated fats over saturated long-chain triglycerides, and careful monitoring of the lipid profile are essential to ensure metabolic safety and long-term treatment sustainability.
Homocysteine affects the excitability of cultured thalamic neurons to a minor extent -
Homocysteine is a naturally occurring amino acid that serves as an intermediate in the metabolism of methionine. It is involved in several physiological as well as pathological processes. Hyperhomocysteinemia is a condition characterized by elevated plasma homocysteine levels. It is accompanied by multiple neurological pathologies, including epilepsy. Excitability of thalamic neurons plays a su...
Evaluation and Management of Neurologic Complications of Sepsis -
CONCLUSIONS: Neurological complications are frequent, clinically important, and often underrecognized in sepsis. By providing a structured, practical framework, this review supports early recognition, informed evaluation, and individualized management of neurologic complications in sepsis while also emphasizing the long-term impact of brain health.
Consistency of Ictal Epileptogenic Foci in Children With Tuberous Sclerosis Complex and Its Clinical Predictors -
CONCLUSIONS: Ictal epileptogenic foci are consistent in only 25% of the patients with TSC. Interictal epileptogenic foci are often discordant with ictal foci. This instability in the ictal epileptogenic focus might be explained by the presence of larger epileptogenic networks in TSC that undergo evolution over time.
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