Epilepsy News

Surgical management of Rasmussen's encephalitis: A systematic review and meta-analysis of long-term seizure and functional outcomes - CONCLUSION: Complete hemispheric disconnection (whether via hemispherotomy or functional hemispherectomy) is highly effective for controlling seizures in RE, whereas focal resections provide inadequate control. Earlier surgical intervention and shorter disease duration significantly improve long-term seizure freedom. These findings support prompt referral for hemispheric disconnection in patien...

Medical Conditions and Early Development in Toddlers With Down Syndrome - CONCLUSION: Findings highlight the associations between co-occurring medical conditions and developmental heterogeneity among young children with DS. Results underscore the need for further work, including longitudinal research studies, to clarify the role of medical conditions in shaping neurodevelopment in DS.

Management of seizures in patients with brain tumors - PURPOSE OF REVIEW: Discoveries relating to the cancer neuroscience of gliomas have reframed brain tumor-related epilepsy (BTRE) as the product of reciprocal interactions at the neural-tumor interface. This framework provides the rationale for targeted strategies to optimize both seizure control and brain tumor survival outcomes.

Delayed diagnosis of familial glucocorticoid deficiency type 4 in a child with epilepsy: a case report and literature review - CONCLUSIONS: This case expands the mutational spectrum of NNT-related FGD4 and emphasizes the importance of considering adrenal insufficiency in pediatric patients presenting with seizures and hyperpigmentation. Early recognition and diagnosis of adrenal insufficiency enable timely hormone replacement therapy and may reduce the risk of neurological and metabolic complications.

Rare Xq23 Microdeletion Involving the DCX and PAK3 Genes Presenting With Lissencephaly, Agenesis of the Corpus Callosum, and Intractable Epilepsy: A Case Report - X-linked lissencephaly spectrum disorder is a rare neurodevelopmental condition resulting from pathogenic variants that disrupt normal neuronal migration, with doublecortin (DCX) being one of the genes most frequently implicated. Similarly, pathogenic variants of the p21-activated kinase 3 (PAK3) gene are associated with X-linked syndromic intellectual disability, developmental delay, and epile...

Recurrent Generalized Tonic-Clonic Seizures During Emergence from Propofol Target-Controlled Infusion in a Patient Undergoing Gastrointestinal Endoscopy: A Case Report - CONCLUSION: In addition to further strengthening the evidence regarding rare neurological events associated with propofol, this case suggests that propofol administration via TCI based on the Schnider model may not completely eliminate the risk of drug-induced seizures; thus, anesthesiologists should remain vigilant. Furthermore, the sequential administration of midazolam and diazepam may repre...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.