Epilepsy News

Three-Phase Seizure Segmentation in Stereotactic EEG Using Envelope-Based Multivariate Changepoint Analysis - CONCLUSION: The proposed framework achieves temporal precision comparable to reported inter-rater reliability (Cohen's κ = 0.35 -0.69) and provides an interpretable, data-driven approach for comprehensive seizure phase characterization, with potential utility in clinical decision-making.

Sodium valproate and gabapentin reduce the seizure-like behavior induced by pentylenetetrazol and mechanical stress in Drosophila melanogaster: sex influence on behavioral responses - Epilepsy is a multifactorial neurological condition characterized by abnormal, recurrent neuronal discharges. The search for new anticonvulsant treatments requires experimental models that replicate the pharmacological responses of drugs commonly used for this condition. This study aimed to evaluate the effect of pentylenetetrazol (PTZ), a pro-convulsant agent, combined with thermal or mechanic...

A systematic review of human status epilepticus in organophosphate poisoning: A real-world Stage 1 Plus model? - OBJECTIVE: To describe clinical phenotypes of organophosphate (OP)-related status epilepticus (SE) and to determine whether they could represent a real-world model of Stage 1 Plus SE, a stage possibly requiring early polytherapy from the start.

Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis: A shared phenotype across brain-expressed sodium channelopathies - OBJECTIVE: Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain-of-function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A-, SCN3A-, and SCN8A-related developmental and epileptic encephalopathy. Here, we investigated whether N...

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology - OBJECTIVE: Despite advancements in "autoimmune epilepsy," more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across global regions.

Cenobamate use for drug-resistant epilepsy in children: A real-world single-center study - CONCLUSIONS: The findings of this single-center real-world study are in line with prior controlled studies and real-world experience in adult patients, as well as with the limited published experience in children. The efficacy and lack of serious side effects found in this study supports the use of cenobamate as a treatment for epilepsy also in children and infants.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.