Epilepsy News

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Seizure action plans: More than management tools for epilepsy - Newswise — Historically, seizure action plans have focused on certain high-risk groups — such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters ...

Study: Epilepsy patients benefit from structured 'seizure action plans' - A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These ...

Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring - NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...

First seizure clinic provides visit, pediatric epilepsy diagnosis in less than a week - Please provide your email address to receive an email when new articles are posted on . The model expedites access to specialists after a first seizure. The mean time between the referral and the ...

Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? - Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...

Astrocyte-Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis - Temporal lobe epilepsy (TLE) is characterized by progressive hippocampal remodeling, including reactive astrogliosis and aberrant neuronal positioning. Although lipid disturbances are implicated in epileptogenesis, how astrocyte-associated lipid responses relate to hippocampal remodeling remains poorly understood. Here, human TLE and kainic acid (KA)-treated mouse transcriptomic datasets identi...

Paroxysmal Tonic Upgaze in Pediatric Patients With Down Syndrome: A Case Report - Paroxysmal Tonic Upgaze (PTU) is a paroxysmal movement disorder characterized by episodes of sustained upward deviation of the eyes, which can be misidentified as a seizure. There has been no definite association made between PTU and Down syndrome although Down syndrome has been associated with various other ocular and neurologic conditions. This case report describes three patients with Down s...

The effect of resveratrol on the hippocampus in the pentylenetetrazol (PTZ) - dependent kindling model of epilepsy - CONCLUSION: RSV exerts significant neuroprotective effects in the PTZ kindling model by modulating the SIRT1-mediated stress response and preventing neuronal apoptosis. Notably, this study provides the first in vivo evidence that RSV modulates SERCA2a, CACNA1G, and HCN2 ion channel gene expressions to control intracellular calcium balance and neuronal excitability during epileptogenesis.

Anticonvulsant potential of tolfenamic acid in pentylenetetrazol-induced acute symptomatic seizures in male wistar rats - CONCLUSIONS: The findings demonstrate the significant anticonvulsant and neuroprotective properties of tolfenamic acid in a PTZ-induced seizure model. By delaying seizure onset, reducing severity and duration, and modulating oxidative stress and inflammation, tolfenamic acid shows promise as a potential therapeutic agent for seizure management. Additional clinical trials are necessary to confir...

Contralateral piriform cortex alterations after surgery for temporal lobe epilepsy: A pilot MRI volumetry study - CONCLUSIONS: In this hypothesis-generating pilot cohort, contralateral PCA volume decreased after epilepsy surgery, whereas the PASL-derived signal-intensity measure did not show a corresponding group-level change. These observations do not establish a surgery-induced network mechanism and require confirmation in larger controlled longitudinal cohorts.

Acetazolamide in drug-resistant epilepsy: a systematic review with meta-analysis - CONCLUSION: ACZ retains a measurable but selective antiseizure signal in DRE. However, limitations in decades-old reporting, considerable between-study heterogeneity, limited controlled clinical evidence, and modest sample sizes in phenotype-specific cohorts require researchers to interpret the evidence with caution. Nevertheless, ACZ's observed clinical activity, low cost, and distinct mechani...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.