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Cognitive impairment patterns and associated clinical and imaging characteristics in young patients with Sturge-Weber syndrome -
CONCLUSIONS: Early, extensive left hemispheric abnormalities can be associated with preserved verbal but impaired non-verbal functions consistent with right-hemispheric reorganization and crowding. However, more than one-third of both left and right-hemispheric patients may develop a global cognitive impairment. This severe cognitive outcome is associated with extensive hemispheric calcificatio...
Neurocognitive Outcomes of In Utero Exposure to Antiseizure Medication: An Australian Cohort Study -
BACKGROUND AND OBJECTIVES: Continuation of antiseizure medication (ASM) during pregnancy is essential for seizure control in most women with epilepsy, yet few studies have characterized the neurocognitive phenotypes associated with prenatal ASM exposure, with limited data on newer agents. The aim of this study was to determine whether in utero exposure to specific types of ASM monotherapies is ...
Cognitive and behavioral clinical outcome assessments in children with developmental and epileptic encephalopathies: Issues and instruments -
Children with developmental and epileptic encephalopathies (DEEs) face cognitive and behavioral challenges that may have a greater impact than seizures on their quality of life (QoL). The need to assess these nonseizure outcomes for evaluating treatments is increasingly recognized. Advances in genomic technologies have transformed the diagnostic landscape of rare genetic epilepsies, including D...
Use of artificial intelligence in magnetic resonance imaging across the epileptic patient's journey: A meta-analysis of four clinical applications -
OBJECTIVE: The application of artificial intelligence/machine learning (AI/ML) to magnetic resonance imaging (MRI) promises to enhance and support clinical decision-making in epilepsy. However, there currently lacks an appropriate assessment of clinical utility and study rigor of current AI/ML-driven models that are targeted toward supporting decision-making within the clinical workup in epilepsy.
Hypersensitivity reaction risk when restarting cenobamate after discontinuation: Insights from a prolonged hospitalized cohort -
OBJECTIVE: To evaluate the risk of hypersensitivity reactions, including dermatological rashes, when cenobamate (CNB) is restarted at maintenance doses after temporary discontinuation.
Interictal epileptiform discharges in calcified neurocysticercosis-associated epilepsy: An exploratory study -
The objective of the study was to assess the frequency of interictal epileptiform discharges (IEDs) in calcified neurocysticercosis (NCC) and its relationship with calcification burden. Forty-nine patients with calcified NCC (low-burden, 1-2 calcifications, n = 24; high-burden, ≥15 calcifications, n = 25) and seizure history underwent prolonged (8-h) electroencephalography (EEG), interpreted by...
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