Epilepsy News

Association of SCN1A and SCN2A Gene Polymorphisms with Antiseizure Medication Responsiveness: A Case-Control Study from Eastern India - CONCLUSIONS: On genetic analysis, the AG genotype of SCN2A rs17183814 was numerically higher among responders than DRE, but the difference was not significant. None of the SCN1A SNPs studied (rs2298771, rs6730344, rs10167228, rs6732655) showed significant associations with treatment response, consistent with previous Indian reports.

EEG findings in Lennox-Gastaut syndrome: Pursuing a moving target - Lennox-Gastaut Syndrome (LGS) is a life-long, drug-resistant developmental epileptic encephalopathy (DEE) that develops in young children between 18 and 24 months of age and up to 18 years of age. The overall incidence is estimated at 0.1 to 0.28 per 100,000 people per year and a lifetime prevalence at age 10 of about 0.26 per 1,000 children. LGS accounts for 1-2 % of all epilepsy cases and 2-5...

Visually Enhanced Mental Simulation (VEMS) in teacher candidates' emergency response to epileptic seizures and attitudes toward epilepsy - CONCLUSIONS: VEMS-based training improved teacher candidates' practical seizure-response skills and attitudes toward epilepsy. Integrating experiential, simulation-based approaches into teacher education may enhance knowledge and foster greater confidence, competence, and preparedness for epilepsy-related emergencies in school settings.

Alexithymia in Adults with Epilepsy: Associations with Affective Symptoms but Not Epilepsy-Related Clinical Variables - OBJECTIVE: Alexithymia, characterized by difficulties in identifying and describing emotions, has been increasingly recognized in neurological disorders. This study aimed to evaluate alexithymia in adult patients with epilepsy (PWE) compared with HCs and to examine its association with affective symptoms and epilepsy-related clinical variables.

Hippocampal volume loss in mesial temporal lobe epilepsy: Magnitude and laterality in a meta-analysis of MRI volumetry studies - CONCLUSIONS: Adult mTLE shows marked ipsilateral hippocampal atrophy with a smaller, consistent contralateral reduction, consistent with partial bilateral structural involvement. Pooled estimates provide clinically interpretable reference values for quantitative MRI in presurgical evaluation, though substantial heterogeneity warrants caution.

Impact of Chronotype-Based scheduling on sleep EEG in first seizure Patients: A pilot study - CONCLUSIONS: Chronotype-based scheduling of S-EEG alone did not significantly improve sleep duration or IED detection under routine clinical conditions. Sleep duration during recordings was short overall, which may have limited the ability to detect circadian effects. These findings suggest that optimization of S-EEG diagnostics may require integrated strategies beyond scheduling alone, includi...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.