Epilepsy and Seizure News
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Automated seizure detection using wearable devices: updated systematic review and meta-analysis of tonic-clonic and focal seizure detection -
INTRODUCTION: Wearable devices have emerged as promising tools for continuous seizure monitoring in patients with epilepsy. This study aimed to update the evidence on the diagnostic performance of non-invasive wearable sensors for seizure detection, extending the previous systematic review by Naganur et al., which included studies published up to November 10, 2021.
Peri-ictal magnetic resonance imaging findings in pediatric seizures: a scoping review on pearls and pitfalls from a heterogeneous population -
CONCLUSIONS: Peri-ictal MRI abnormalities in children are most frequently described in PFS and SE, where recurring patterns of acute edema and later structural changes have been reported. However, existing evidence is heterogeneous and weighted toward early-life and acute symptomatic populations, limiting generalizability. Associations between early imaging changes and longer-term outcomes rema...
High-frequency, high-intensity electrical stimulation selectively activates human fast-spiking interneurons -
Electrical brain stimulation has been used to treat epilepsy with therapeutic success, but without complete understanding of its cellular mechanisms of seizure suppression. Using acute human brain slices obtained from pharmaco-resistant epilepsy patients, we delivered high-frequency, high-intensity extracellular electrical stimulation while recording from neocortical layer 2/3 pyramidal neurons...
Expanding clinical variability in FBXW7-related neurodevelopmental disorder: a multicenter case series -
CONCLUSIONS: This case series expands the phenotypic spectrum associated with FBXW7-related neurodevelopmental disorder and highlights variable expressivity and incomplete penetrance, including clinically relevant variants presenting with mild or atypical phenotypes. These findings support considering FBXW7 across a broad range of neurodevelopmental presentations and inform genetic counseling.
A continuous network physiology analysis of brain-heart interactions in epileptic seizures -
The investigation of brain-heart interplay (BHI) has gained significant momentum in recent years, and has emerged as a pivotal area of neurophysiological research. The applications of BHI span cognitive neuroscience, sleep research, and neurological disorders, where the analysis of cortical and autonomic dynamics can provide a mechanistic overview of functional regulation. Epilepsy is known to ...
Transcranial focal current stimulation in super-refractory status epilepticus in a pregnant patient -
Super-refractory status epilepticus (SRSE) during pregnancy is a rare, life-threatening condition with limited therapeutic options. Transcranial focal current stimulation (TFS) has shown benefit in refractory epilepsy, but its use in SRSE during pregnancy has not been reported. We describe a woman in her 20s at 12 weeks' gestation with longstanding focal drug-resistant epilepsy who developed SR...
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