Epilepsy News

Frequent cannabis use tied to more severe epilepsy - Adults with hard-to-treat epilepsy who used cannabis most days had more than twice as many convulsive seizures per year and became resistant to antiseizure medications more quickly than nonusers, ...

Frequent cannabis use linked to worse epilepsy - Near-daily cannabis users with drug-resistant epilepsy had over twice as many convulsive seizures as nonusers, researchers report.

Seizure action plans: Management and educational tools in epilepsy care - Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...

Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time - Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...

Epilepsy R&D is breaking out of its old playbook - Genetic medicines and more selective small molecules are finally pushing the field toward new mechanisms — and potentially disease-modifying treatments.

Focal treatment-resistant epilepsy symptoms improved with antiseizure medication - Please provide your email address to receive an email when new articles are posted on . Monthly seizure frequency percentage reduction was 68.73% for the entire study cohort. For those followed up in ...

Every seizure can look and feel very different: NMU holds presentation on epilepsy and seizure training - The presentation hopes to clear up misconceptions regarding epilepsy and seizures as well as how to help those in need.

Using Seizure-Risk Forecasts to ID Best Time for Epilepsy Monitoring - NASHVILLE, Tennessee ― Scheduling video-electroencephalography (vEEG) monitoring on the basis of personalized seizure risk forecasts may improve diagnostic accuracy, emerging research suggests. In a ...

Does Levetiracetam Improve Seizure Outcomes in Pediatric Epilepsy? - Although levetiracetam was associated with improved seizure outcomes compared with placebo in pediatric epilepsy, it did not demonstrate superior efficacy when compared with established active ...

Design, Synthesis, and Pharmacological Evaluation of Sulfur-Containing Pitolisant Analogs as Potent H(3)R Antagonists for Epilepsy Therapy - Although multiple antiseizure drugs (ASDs) are clinically accessible, epilepsy remains a debilitating neurological disorder with a high unmet need for more effective and better-tolerated therapies. Antagonism of the histamine H(3) receptor (H(3)R) represents a promising alternative strategy, exemplified by the clinically approved inverse agonist/antagonist pitolisant (PIT) for narcolepsy. Herei...

Mitochondrial migraine: A multicenter study based on mitochondrial diseases presenting as encephalopathy and/or myopathy - CONCLUSION: In patients with MD presenting as encephalopathy and/or myopathy, the 1-year frequency of migraine was more than five times higher than that in the general population. Epilepsy and elevated resting blood lactate concentration were identified as factors independently associated with migraine. In patients with MELAS, AHF positivity was associated with distinct and severe migraine phen...

Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring - Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability. Here, we investigated whether specific time periods are disproportionately prone to false alarms. We analyzed 2876 NightWatch alarms occurring between 19:00 and 09:00 in 65 children (ages 3-16, 48% female). Temporal distributions differed significantly between tr...

Plain language summary of the mechanisms behind epilepsy in Alzheimer's disease and the use of perampanel - No abstract

Aging, the microbiota-gut-brain axis, and late-life epilepsy: a hypothesis-driven review - Late-life epilepsy is an increasingly important neurological and public health challenge, yet its biological basis remains incompletely understood. The microbiota-gut-brain axis has emerged as a systems-level framework linking peripheral metabolism, barrier integrity, immune signaling, and brain excitability. Growing evidence supports an association between gut dysbiosis and epilepsy, particula...

A homozygous missense variant in NRROS gene is associated with intracranial calcifications, neurodegeneration, and severe infantile epilepsy syndrome - Biallelic loss-of-function variants in NRROS (Negative regulator of reactive oxygen species, previously LRRC33) cause a progressive neurodegenerative disorder characterized by early-onset seizures with brain calcifications. To date, 16 affected individuals from 13 unrelated families have been reported for this condition. We describe two siblings from a consanguineous family with this disorder, ...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.