Epilepsy News

Epilepsy outcomes following single and repeat epilepsy surgeries in tuberous sclerosis complex - OBJECTIVE: Epilepsy surgery in tuberous sclerosis complex (TSC) is underutilized but associated with improved seizure control and better neurocognitive outcomes. Here we focus on utilization of repeated surgeries to improve seizure control.

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy - CONCLUSION: Epileptic seizures in patients with KBG syndrome are usually generalized and have an onset between infancy and mid-teens. Common epileptological features in KBG syndrome comprise the good response to antiseizure medication and, in most cases, the remitting nature of epilepsy. Drug-resistant epilepsy can be observed in up to one-third of cases.

Thalamocortical connectivity and nucleus-specific thalamic dysfunction in temporal lobe epilepsy: an integrative review - Temporal lobe epilepsy (TLE) is increasingly recognized as a distributed network disorder extending beyond mesial temporal structures. Among the brain regions implicated in epileptic network organization, the thalamus has emerged as a key hub due to its extensive structural and functional connections with cortical, limbic, and subcortical systems.This integrative review aimed to synthesize curr...

Hypomelanosis of Ito with Local Overgrowth due to a Somatic Complex MTOR Gene Variant Consistent with Smith-Kingsmore Syndrome in One of Monozygotic Twins Detectable Only by RNA Sequencing: A Case ... - CONCLUSIONS: This case highlights several important clinical insights. The presence of discordant clinical features in monozygotic twins may be indicative of mosaicism. Cutaneous findings, such as Blaschko lines, may be subtle and easily overlooked. The concept of mosaicism should be considered in the context of localized brain dysplasias. RNAseq has been identified as a valuable diagnostic too...

Assessing a reduced-channel algorithm for end-to-end seizure detection on multiday EEG using inter-rater agreement with epileptologists - Automated electrographic seizure detection software often rely on the high channel counts of traditional electroencephalography (EEG) recording systems. However, these systems are notoriously cumbersome, limiting both the duration of and access to EEG monitoring. Recent medical-grade wearable devices approach these issues by using small, discreet sensors and reduced channels for ease of use dur...

Long-term seizure outcomes in patients with drug-resistant mesial temporal lobe epilepsy due to hippocampal sclerosis - CONCLUSION: 62% of the patients were classified as Engel I. Although previous studies have suggested that certain factors may influence prognosis, our findings did not yield any statistically significant results in this regard. It is crucial that patients undergo surgical evaluation without delay to achieve seizure control and improve cognitive function.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.