Epilepsy and Seizure News
Seizure action plans: Management and educational tools in epilepsy care -
Historically, seizure action plans have focused on certain high-risk groups—such as people with drug-resistant epilepsy and people with a history of status epilepticus or seizure clusters. Neurology ...
New genetic switch could improve gene therapy for drug-resistant epilepsy -
Epilepsy affects more than 50 million people worldwide, making it one of the most common neurological disorders. Although medication helps many patients achieve seizure control, approximately ...
Modifiable Factors Responsible for Most Epilepsy Relapses -
In patients with newly diagnosed epilepsy, nearly 70% of seizure relapses are linked to potentially modifiable factors, including poor adherence and inadequate ASM dosing, rather than drug resistance.
Seizure Burden in Resistant Epilepsy May Ease With the Tincture of Time -
Nearly 70% of patients with focal treatment-resistant epilepsy (FTRE) experience fewer seizures over time, new results of a multicenter study showed. However, the improvements occurred independent of ...
Enrolment concludes in Biohaven’s RISE3 trial for epilepsy -
Biohaven has concluded enrolment in the pivotal RISE3 Phase II/III trial assessing the selective Kv7.2/7.3 channel activator, opakalim (BHV-7000), for refractory focal epilepsy. T ...
Teacher Who Was Filmed Having a Seizure During Class Shares How She Navigates Epilepsy as an Educator (Exclusive) -
Yareli Jessica Gijon experienced her first seizure at age 12 and was later diagnosed with epilepsy after years of uncertainty She has learned to manage her condition while teaching by recognizing ...
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Exploring the Role of Early Add-On Cenobamate in Uncontrolled Focal Epilepsy: A Critical Appraisal of the Evidence -
CONCLUSIONS: Cenobamate may offer substantial benefit in adults with uncontrolled focal epilepsy, with a favorable efficacy-tolerability balance, high retention, and possible advantages when introduced earlier (after two ASMs). Its interaction profile underscores the importance of careful management of concomitant ASMs. Because the comparative signals derive largely from non-randomized data, pr...
Resveratrol Ameliorates PTZ-Induced Seizure Activity and Diaphragm Muscle Dysfunction by Regulating Calcium Handling and Apoptotic Pathways in Rats -
This study aimed to investigate the chronic effects of epilepsy, a common health problem, on the diaphragm muscle and the therapeutic potential of resveratrol against these effects. Thirty-two adult male Wistar rats were divided into four groups (n = 8): Sham, resveratrol (Res, 5 mg/kg/day), pentylenetetrazol (PTZ), and PTZ + Res. Seizure activity and frequency in the epileptic groups were moni...
Magnetic resonance-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy (MINE): a single-centre, prospective, randomised, open-label, blinded-endpoint controlled trial protoc... -
INTRODUCTION: Drug-resistant mesial temporal lobe epilepsy (mTLE) is a common and disabling focal epilepsy syndrome for which surgery offers the best chance of seizure freedom. Traditional open surgery (eg, anterior temporal lobectomy or selective amygdalohippocampectomy) is effective but may be associated with perioperative morbidity and neurocognitive sequelae. Magnetic resonance-guided laser...
A Nomogram for Early Prediction of Post-Traumatic Epilepsy in Children With Traumatic Brain Injury: Development and Internal Validation -
CONCLUSIONS: We present a practical admission-based nomogram for early risk stratification of PTE after pediatric TBI. The model may help prioritize neurological surveillance and follow-up in children at increased risk. External validation is required before routine clinical implementation.
At-home EEG-based sleep monitoring in people living with Lennox-Gastaut syndrome: The HEADFIRST study -
OBJECTIVES: Sleep dysfunction is a common but poorly characterized symptom in people living with Lennox-Gastaut syndrome (LGS). Sleep impairments exacerbate seizures while ictal activity causes sleep disturbance, leading to a cycle of sleep-epilepsy worsening. The HEADFIRST study was conducted to assess whether caregivers could self-operate a dry-electrode EEG headband (Waveband) to collect in-...
Prevalence of neurocysticercosis among individuals with seizure presentations in South East Asia: A systematic review and meta- analysis -
CONCLUSION: Approximately one in five individuals with seizure presentations in the SEA region has NCC, a prevalence comparable to that reported in other endemic regions such as Sub-Saharan Africa. Further studies with broader regional coverage are needed to better define the burden and guide control strategies.
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