Epilepsy News

From insult to hyperexcitability: pharmacological targeting of MyD88 and JAK/STAT3 pathways in epilepsy - Neuroinflammation is hypothesized to be a fundamental driver of epileptogenesis, potentially contributing to the transformation of the healthy brain into a state prone to spontaneous recurrent seizures. This manuscript explores the pivotal roles of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) in modulating neuronal excitability and structural plasticity. We del...

Severity-dependent proteomic alterations in the rat hippocampus following pilocarpine-induced status epilepticus - Status epilepticus (SE) is a prolonged seizure state that can induce lasting hippocampal damage and promote the development of spontaneous seizures and cognitive deficits. The severity and duration of SE affect long-term outcomes; however, many studies rely on behavioral assessments such as the Racine scale, which may miss subclinical or non-convulsive seizures and leave the molecular effects o...

Hippocampal AIM2 inflammasome regulate seizure and cognitive impairment in mice with temporal lobe epilepsy - Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures. Approximately 30% of patients are resistant to current antiepileptic drugs, highlighting the need for further investigation into the underlying mechanisms of epilepsy. Studies have shown significant neuroinflammatory responses in specific brain regions of human epilepsy foci and in animal models. AIM2 (...

Hemispherotomy for atypical teratoid rhabdoid tumor-associated drug-resistant epilepsy: illustrative case - BACKGROUND: Drug-resistant epilepsy (DRE) following treatment for atypical teratoid rhabdoid tumor (ATRT) is rare. The authors report a case in which hemispherotomy was performed to palliate new-onset DRE after ATRT therapy.

Anatomical localization and resection of a refractory epileptic focus in the right supplementary motor area/presupplementary motor area using augmented reality: illustrative case - BACKGROUND: Medically refractory seizures occur in up to 30% of patients with epilepsy. Treatments may include neuromodulation, ablative procedures, and stereotactic surgery. Cutting-edge technology, such as neuroimaging, anatomical mapping, electroencephalography, and augmented reality (AR), assist in localization and safer treatment planning.

Cortical and etiological determinants of stimulation-induced seizures in children undergoing stereo-EEG - OBJECTIVE: Electrical stimulation during stereo-electroencephalography (SEEG) is used for functional mapping and seizure induction in epilepsy surgery candidates. However, its effects in pediatric populations remain underexplored. The aim of this study is to characterize stimulation-induced seizures (SISs) in children undergoing SEEG and evaluate associations with stimulation parameters, cortic...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.