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Genotype-phenotype correlations and clinical spectrum of ALG13-related developmental epileptic encephalopathy -
CONCLUSIONS: This pooled analysis delineates the phenotypic spectrum of ALG13-related epilepsy and emphasizes the prominence of the N107S hotspot variant. Earlier seizure onset is associated with more severe neurodevelopmental outcomes. These findings refine the genotype-phenotype spectrum of ALG13-related disease and support early genetic testing and standardized long-term follow-up.
Semiological features of epilepsy seizures and paroxysmal non-epileptic events in children: A systematic review and meta-analysis -
No abstract
Psychological stress during wartime and its association with seizure-related emergency department utilization -
OBJECTIVE: Psychological stress is commonly reported as a seizure precipitant in epilepsy, yet evidence from major crises remains limited and inconsistent. We examined whether the October 2023 Israel-Hamas conflict affected acute seizure-related healthcare utilization among adults with epilepsy.
"Un chapeau" can fit many different heads - A clinical vignette for CASPR2 autoimmune encephalitis -
No abstract
WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse -
Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably. Despite advances in antiseizure medications, approximately 30% of patients remain treatment-resistant, hi...
Peripheral inflammatory markers and metabolic profiles in temporal lobe epilepsy and functional dissociative seizures -
CONCLUSION: After controlling for age, sex, and BMI, metabolic markers-particularly leptin and adiponectin-remained independently associated with diagnostic group, whereas inflammatory cytokines did not demonstrate robust independent differences. These findings suggest that metabolic dysregulation may represent a more prominent differentiating factor than systemic inflammation among patients wi...
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