Epilepsy and Seizure News
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Fenofibrate as adjuvant therapy in persons with active epilepsy: A double-blind, randomized, placebo-controlled trial -
This study aimed to assess efficacy and safety of fenofibrate as adjuvant therapy on seizure control and epileptogenic biomarkers in persons with active epilepsy(a-PWE). This single-center randomized, double-blind, placebo-controlled, parallel-group trial was conducted over 6 months. a-PWE (n = 80, 40 in each group) who have ≥ 2 seizures in preceding 3 months despite receiving ≥ 2 antiseizure m...
Benefits and adverse effects of ketogenic diet treatment in pediatric patients with inborn errors of metabolism -
CONCLUSIONS: The KD is an effective and generally well-tolerated therapeutic option in pediatric IEMs, with benefits extending beyond seizure control. Adverse effects are typically manageable, although GI intolerance may limit long-term use. Ketogenic diet should be considered not only for refractory epilepsy but also for selected metabolic indications.
Peroxynitrite-Activated Valproic Acid Precursor for Monitoring Oxidative Stress and Reducing Epileptic Seizures in an Epilepsy Model -
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, which poses a significant threat to human health. Increasing evidence indicates that the pathological mechanism of epilepsy is closely related to the presence of peroxynitrite (ONOO^(-)). To address this issue, we have developed a dual-molecule release precursor, DVN, with different functional components, which con...
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS -
OBJECTIVE: Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross-network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Spontaneous Splenic Rupture in a Patient With Combined Congenital Factor XIII and Factor VII Deficiencies: A Case Report -
Spontaneous (atraumatic) splenic rupture (SSR) is an uncommon and potentially fatal emergency, most frequently linked to infection, cancer, or hematologic disorders. Although clotting factor XIII (FXIII) and factor VII (FVII) deficiencies are uncommon bleeding disorders on their own, their coexistence and association with spontaneous splenic rupture have not been reported before. A 26-year-old ...
Mental health of children with epilepsy in Ukraine during the war -
OBJECTIVE: The ongoing conflict in Ukraine has created a severe humanitarian crisis, disproportionately affecting vulnerable populations such as children with chronic conditions. We set out to determine information about mental health in children with epilepsy in Ukraine affected by the conflict.
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