Neurofeedback News
Medical News Today
PubMed
First-trimester trace-element profiles in pregnant women with epilepsy: An exploratory prospective association between selenium and subsequent seizure recurrence -
CONCLUSION: Pregnant women with epilepsy showed a distinct first-trimester trace-element profile. Lower first-trimester selenium was prospectively associated with subsequent seizure recurrence; however, this exploratory finding requires external validation before any predictive or clinical interpretation.
AAV-mediated Modulation of Dorsal Raphe Serotonergic Neurons Recapitulates Fenfluramine Efficacy in a Rat Model of Dravet Syndrome -
Dravet Syndrome (DS) is a catastrophic developmental and epileptic encephalopathy (DEE) primarily caused by SCN1A haploinsufficiency. It is characterized by refractory hyperthermia-induced seizures, neurodevelopmental delay, and an elevated risk of sudden unexpected death in epilepsy (SUDEP) compared to other childhood epilepsies. While the small molecule fenfluramine (FFA) provides profound cl...
TNF signaling at the brain-heart interface: neurovascular injury and cardiovascular vulnerability in epilepsy -
Epilepsy is increasingly viewed as a systemic disorder in which recurrent seizures intersect with vascular, autonomic, respiratory, and cardiac processes to influence cardiovascular vulnerability. Seizure-related neuroinflammation involves multiple interacting mediator pathways, including HMGB1/TLR4-RAGE signaling, inflammasome/IL-1β activation, IL-6/IL-6R-gp130 signaling, albumin/TGF-β signali...
Clock neurons modulate seizure timing through a diurnal switch -
People with epilepsy experience daily oscillations in seizure risk. Using a video-tracking model to automate detection, we explored mechanisms underlying spontaneous seizures in Drosophila and find that flies, like people, exhibit daily oscillations in seizure risk. These rhythms are absent in flies lacking a molecular circadian clock and are independent of sleep. Thermogenetic screening and ce...
Zona incerta somatostatin(+) neurons modulate seizure progression through hypothalamic circuits -
GABAergic neurons critically regulate epileptic seizures, yet circuit mechanisms mediated by subtype-specific GABAergic neurons in the zona incerta (ZI) remain unclear. Here we reveal the essential role of ZI somatostatin^(+) GABAergic neurons in seizure modulation in the mouse hippocampal kindling model. In vivo Ca^(2+) fiber photometry and optogenetics show that ZI GABAergic neurons are gradu...
Clinical outcomes and risk factors in pediatric epilepsy associated with focal cortical dysplasia: a retrospective cohort study of 628 imaging-confirmed cases -
CONCLUSION: Children with FCD show marked clinical heterogeneity, and their prognosis is closely associated with neurodevelopmental deficits, lesion extent, and electrophysiological characteristics. Early identification of these high-risk factors, together with cluster-based stratified management, may be of substantial importance for improving patient outcomes.
Science Daily