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Neuroprotective Action of Agonists and Modulators of A1 Adenosine Receptors Upon Hyperexcitation: Mechanism of the Antiepileptic Activity and Role of Neuron-Glial Interaction -
Hyperexcitation of neuronal networks is a key mechanism underlying excitotoxic neuronal death in conditions such as epilepsy, ischemic stroke, and traumatic brain injury. Given the inhibitory role of G(i)-coupled receptors, A(1) adenosine receptors (A(1)Rs) represent promising targets for neuroprotective and anticonvulsant therapy. In this study, we investigated the effects of A(1)R agonists (C...
ApoE4 as a Therapeutic Target in Epilepsy: From Pathogenic Mechanisms to Precision Medicine -
BACKGROUND: Epilepsy is a heterogeneous central nervous system disorder characterized by recurrent seizures and is frequently accompanied by cognitive and neuropsychiatric comorbidities. Although apolipoprotein E4 (ApoE4) is well established as a genetic risk factor in Alzheimer's disease, its role as a modifier of epilepsy susceptibility, progression, and therapeutic response remains incomplet...
Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy -
Theta oscillations (4-12 Hz) are a prominent network rhythm within hippocampal and parahippocampal structures. Driven by cholinergic and γ-aminobutyric acidergic inputs originating from the medial septum, physiological theta gates network excitability to control spatial navigation, memory encoding, and sensorimotor integration during specific behavioral states. Theta rhythm also organizes the p...
Diagnostic value of serum NSE, and S-100beta and inflammatory markers levels in epilepsy -
CONCLUSIONS: Sodium valproate can drastically relieve the epileptic symptoms of patients with SE, and there was no great difference in ARs. Hence, it is safe and worthy of popularization and application.
Comparison of selective amygdalohippocampectomy and anterior temporal lobectomy for mesial temporal lobe epilepsy: a systematic review and meta-analysis -
CONCLUSIONS: ATL provides superior seizure control compared to SAH, whereas SAH offers measurable advantages in visual and perioperative morbidity. The nonsignificant trend toward poorer seizure outcomes in SAH highlights the importance of patient selection and anatomical considerations. These findings support individualized surgical decision-making for drug-resistant MTLE, balancing seizure fr...
Machine Learning Using Electroencephalography Predicts Acute Cerebral Injury in the Pediatric ICU -
BACKGROUND AND OBJECTIVES: The objective of this study was to apply and compare machine learning techniques using clinical and electroencephalography (EEG) background features to predict acute cerebral injury in the pediatric intensive care unit (PICU).
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