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Immune biomarkers for epilepsy in autism: indications of cytokine alterations in an exploratory cross-sectional pediatric study -
CONCLUSION: These findings raise the possibility that immune system alterations may be associated with EP in children with ASD and could potentially aid diagnosis, although larger studies are needed to confirm these findings.
Functional Neurological Disorder Presenting as Apparent Drug-Resistant Seizures: A Case Report on Emphasizing the Role of Early Diagnosis -
Functional neurological disorder (FND) is a complex and frequently misdiagnosed condition characterized by neurological symptoms such as motor events, sensory deficits, or altered consciousness caused by brain network dysfunction rather than structural abnormalities. Despite its prevalence, FND remains stigmatized and underrecognized, mainly due to its historical association with psychological ...
Trigeminal neuralgia-like pain in a vagus nerve stimulation super-responder with drug-resistant idiopathic generalized epilepsy: A case report -
We report a 38-year-old man with drug-resistant idiopathic generalized epilepsy (IGE) who became seizure-free after being implanted with vagus nerve stimulation (VNS). He developed a trigeminal neuralgia-like pain (TNLP) time-locked with ON stimulations. TNLP did not cease after restoring the initial stimulation parameters. After an unsuccessful trial with carbamazepine, the patient reported a ...
Epilepsy, neuroinflammation and cannabidiol What do we know thus far? -
Epilepsy is a common neurological disorder associated with recurring seizures that in about one-third of individuals are resistant to conventional medications. Neuroinflammation and alterations in the endocannabinoid system are involved in epileptogenesis and represent attractive targets for therapeutic interventions. Randomized placebo-controlled trials have shown that cannabidiol (CBD), one o...
Clinical and genotypic characteristics of 19 children with STXBP1-encephalopathy -
To systematically summarize the clinical phenotypes, treatment responses, prognosis, and genetic characteristics of STXBP1-encephalopathy in Chinese pediatric patients, and to explore the clinical value of genetic testing in this disease. We retrospectively analyzed the clinical data, gene variant information, and treatment outcomes of 19 children with STXBP1-encephalopathy admitted to the Depa...
Hemiconvulsion-Hemiplegia-Epilepsy Syndrome Associated With SARS-CoV-2 Infection and a Heterozygous IRF3 Variant in a 10-Month-Old Girl: A Case Report -
Hemiconvulsion-Hemiplegia-Epilepsy (HHE) syndrome is a rare pediatric epilepsy syndrome characterized by prolonged focal febrile seizures, postictal hemiparesis, and progressive unilateral brain injury, often followed by chronic epilepsy. We report a previously healthy 10-month-old girl who presented with a prolonged left-sided focal fever-associated seizure. She tested positive for SARS-CoV-2 ...
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