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Systems Toxicology Indicates AKT1/PTGS2-Centered Neuroinflammatory-Mitochondrial Crosstalk in Lidocaine Associated Neurotoxicity -
CONCLUSIONS: Lidocaine-associated neurotoxicity may involve an AKT1/PTGS2-centered neuroinflammatory-mitochondrial crosstalk network accompanied by synaptic dysfunction. This study provides a systems-level mechanistic insight into lidocaine neurotoxicity and identifies potential targets for improving the safety of pediatric lidocaine-containing formulations.
Creb1 aggravates glutamate-induced excitotoxicity and KA-induced seizure activity by transcriptionally activating Timp1 -
Epilepsy is a chronic neurological disorder, more common in children and the elderly. Although treatments have advanced, significant challenges remain. This study focuses on its molecular mechanisms to provide new insights and strategies for its treatment. Gene expression omnibus (GEO) database analysis, enrichment analysis, and the establishment of protein-protein interaction (PPI) networks we...
Assessment of fine motor performance and motor speed in pediatric patients with juvenile myoclonic epilepsy -
CONCLUSIONS: Adolescents with JME showed impaired fine motor performance, particularly in patients with uncontrolled seizures and combination ASMs therapy. The 9-HPT may be a useful simple tool for assessing motor dysfunction in JME.
The dual role of BDNF in epilepsy: insights from calpain-mediated TrkB-FL cleavage -
Despite the efficacy of current antiseizure medications in managing seizures, approximately one-third of patients develop refractory epilepsy, highlighting an urgent need to uncover the molecular mechanisms driving epileptogenesis. This process emerges from a complex interplay of molecular alterations, involving changes in neuronal signaling pathways. Among these, brain-derived neurotrophic fac...
Clinical feature-guided targeted genetic testing in early-onset developmental and epileptic encephalopathy: a real-world diagnostic approach in a resource-limited setting -
OBJECTIVE: In low- and middle-income countries (LMICs), access to trio-based whole-exome or whole-genome sequencing is limited, which may delay genetic diagnosis in developmental and epileptic encephalopathies (DEE). We used clinical features to guide targeted genetic testing and reviewed the results through multidisciplinary discussion in a Vietnamese pediatric cohort with early-onset DEE and ...
Understanding the perceived impact of a peer-led epilepsy self-management intervention in Uganda: a qualitative study -
CONCLUSIONS: Peer-led self-management support may enhance engagement, coping, and self-efficacy among people with epilepsy in resource-limited settings. Addressing stigma and strengthening social and healthcare support may be critical for improving outcomes in low-middle income countries.
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