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Teaching NeuroImage: Child With Structural Epilepsy and Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion -
No abstract
Prediction of Long-Term Postsurgical Seizure Recurrence From MRI Brain Hub Disruption in Patients With Temporal Lobe Epilepsy -
BACKGROUND AND OBJECTIVES: Patients with temporal lobe epilepsy (TLE) can achieve seizure freedom in the early period after surgery, yet up to half experience seizure recurrence in the following years (i.e., long-term). TLE is associated with disruption of highly connected brain regions (hubs), which may reduce the likelihood of long-term surgical success. We tested whether disruption of physio...
Implantation of Deep Brain Stimulator Through Polyetheretherketone (PEEK) Cranioplasty -
CONCLUSIONS: This case series highlights how PEEK cranioplasties can be drilled through for therapeutic procedures, such as DBS electrode implantation, without compromising their structure. These cases illustrate the versatility, safety, and adaptability of PEEK implants for additional necessary interventions.
Subtle Hippocampal Subfield Volumetric Alterations in Clinically Diagnosed MRI-Negative Temporal Lobe Epilepsy -
CONCLUSION: These results imply that selective CA4-DG atrophy is a defining characteristic of the MRI-negative TLE phenotype, thereby corroborating the "dentate gate" failure hypothesis. Quantitative volumetry provides a crucial diagnostic tool in settings with limited resources, where advanced techniques like 3-T MRI or invasive monitoring are not accessible. This objective structural marker, ...
Microglial pathological synaptic pruning in epilepsy: pathophysiology and therapeutic potential -
Epilepsy affects around 70 million people worldwide, and roughly one-third of them respond poorly to standard antiepileptic drugs. Current treatments are directed almost entirely at neurons, leaving the contribution of non-neuronal cells largely unaddressed. Microglia, the resident immune cells of the central nervous system, both support neuronal survival and shape neural circuits by pruning sy...
Decades of Epilepsy Surgery Follow-up: What's Known and What's Not? -
No abstract
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