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Post-stroke seizure and epilepsy after intravenous alteplase: A retrospective cohort with SeLECT score profiling -
CONCLUSIONS: In this retrospective cohort, alteplase exposure was not significantly associated with PSE after adjustment for baseline seizure risk. Although the point estimate suggested a possible increase in PSE risk, the small number of outcome events limits definitive conclusions. Larger prospective studies are needed to better clarify the relationship between thrombolysis and PSE.
Intracranial EEG findings and outcomes in MRI-negative epilepsy with temporal lobe semiology and scalp EEG features -
We sought to correlate seizure and cognitive outcomes with seizure onset zones (SOZs) determined from intracranial EEG (iEEG) in patients with MRI-negative drug-resistant focal epilepsy with scalp EEG and semiological features of temporal lobe epilepsy (TLE). We identified 66 patient cases with these imaging, EEG, and semiological characteristics evaluated at the Medical College of Wisconsin fr...
Proceedings from ERN EpiCARE "BEYOND SEIZURES" meeting, Aalesund, Norway, May the 27th. Advancing holistic care for rare and complex epilepsies in adults -
No abstract
Practice variability in vagus nerve stimulation settings for drug-resistant epilepsy and a pilot quality improvement initiative to optimize stimulation parameters -
CONCLUSIONS: Substantial practice variability in VNS parameter settings with suboptimal utilization of therapy existed, which improved following introduction of the pilot intervention. Standardized protocols can ensure timely delivery of therapeutic parameters. These strategies have been underutilized in earlier studies, likely overestimating the time to response from VNS therapy.
Ozone Treatment Attenuates Neuroinflammation and Alters miRNA Expression in a Rat Model of Post-Traumatic Epilepsy -
The aim of this study was to investigate the effects of intraperitoneal ozone therapy in a post-traumatic epilepsy (PTE) model. An in vivo PTE model was established in male Sprague-Dawley rats, which were randomised to control (n = 8), PTE (n = 10), and PTE + Ozone (n = 10) groups. 0.7 mg/kg ozone was administered intraperitoneally for 3 consecutive days. Seizure activity was video recorded for...
Loss of cyclin-dependent kinase-like 5 results in susceptibility to audiogenic seizures in mice -
CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early-onset, treatment-resistant epilepsy. Mice lacking CDKL5 display several clinically relevant phenotypes, but spontaneous seizures are not consistently reported, and it is unknown if CDD model mice are susceptible to sensory stimulus-triggered seizures, a well-documented clinical feature of CDD. H...
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