Epilepsy News

Nonlinear neurodynamics of N2 sleep EEG predict outcomes of anterior nucleus of the thalamus deep brain stimulation in epilepsy: A pilot study - OBJECTIVE: Anterior nucleus of the thalamus deep brain stimulation (ANT-DBS) is an effective therapeutic option for drug-resistant epilepsy (DRE); however, substantial inter-individual variability in treatment response limits its clinical optimization. This study aimed to develop an objective and explainable preoperative prediction model for ANT-DBS outcomes using nonlinear dynamical features d...

Views of caregivers, clinicians, and epilepsy advocacy group representatives on survey instruments used to assess behavior, communication, and quality of life in individuals with Lennox-Gastaut syn... - CONCLUSION: Participants identified strengths and limitations of existing instruments and highlighted several unmet measurement needs. These insights underscore the need for relevant, inclusive tools that are aligned with the lived experiences of individuals with LGS and their families.

Single-neuron responses to neurostimulation: Insights for epilepsy - Invasive neurostimulation has been used in humans to treat and diagnose epilepsy for decades. Despite such ubiquitous probing and recording from the human brain, the efficacy of surgical outcomes has remained stable. One potential reason for the gradual improvement in outcome efficacy is the continued reliance on passive recordings of meso-scale field potentials for diagnosis. Yet, recordings f...

Epilepsy outcomes following single and repeat epilepsy surgeries in tuberous sclerosis complex - OBJECTIVE: Epilepsy surgery in tuberous sclerosis complex (TSC) is underutilized but associated with improved seizure control and better neurocognitive outcomes. Here we focus on utilization of repeated surgeries to improve seizure control.

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy - CONCLUSION: Epileptic seizures in patients with KBG syndrome are usually generalized and have an onset between infancy and mid-teens. Common epileptological features in KBG syndrome comprise the good response to antiseizure medication and, in most cases, the remitting nature of epilepsy. Drug-resistant epilepsy can be observed in up to one-third of cases.

Thalamocortical connectivity and nucleus-specific thalamic dysfunction in temporal lobe epilepsy: an integrative review - Temporal lobe epilepsy (TLE) is increasingly recognized as a distributed network disorder extending beyond mesial temporal structures. Among the brain regions implicated in epileptic network organization, the thalamus has emerged as a key hub due to its extensive structural and functional connections with cortical, limbic, and subcortical systems.This integrative review aimed to synthesize curr...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.