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Cervical Sympathetic Blockade for Psychogenic Nonepileptic Seizures Associated With Post-traumatic Stress Disorder: A Case Report and Neurobiological Framework -
Psychogenic nonepileptic seizures (PNES), also termed functional seizures, are episodes that resemble epileptic seizures but occur without the abnormal ictal electrical activity characteristic of epilepsy. PNES is frequently associated with trauma exposure, post-traumatic stress disorder (PTSD), and abnormalities in autonomic regulation. Emerging evidence suggests that altered interactions amon...
Neurosurgical Outcomes of Epilepsy Surgery Between 2017 and 2025: A Retrospective ESSQ-19 Study From a Tertiary Care Center -
Introduction Epilepsy is a common neurological disorder. Despite being on anti-epileptic drug therapy, a subset of patients continue to experience seizures. In such patients with drug-resistant epilepsy, surgery remains a viable treatment option. Patient-reported satisfaction provides an important perspective on post-epilepsy surgery outcomes. This study aimed to descriptively assess postoperat...
Association of depression and epilepsy in rural northern Rwanda: a prospective longitudinal study with a patient-centered approach -
CONCLUSIONS: Kinyarwanda PHQ-9 and HDRS versions were successfully deployed for screening and diagnosing depression symptoms in PwE in rural settings. Treatment of epilepsy and co-morbid depression improved clinical outcomes. Implementation of depression screening in routine health practice in Rwanda is warranted.
Prevalence and potential risk factors associated with idiopathic epilepsy in Golden Retrievers -
CONCLUSIONS AND CLINICAL IMPORTANCE: Golden retrievers have an increased risk of IE, often presenting with cluster seizures. The association between IE and gastrointestinal disease might lead to new therapeutic strategies, but further investigations are needed.
Efficacy of Levetiracetam Combined with Sodium Valproate (Oral) in the Treatment of Senile Epilepsy and Its Effects on Cognitive Function, Inflammatory Factors and Neurotransmitters -
CONCLUSION: Levetiracetam combined with sodium valproate demonstrated superior comprehensive efficacy in the treatment of senile epilepsy. This regimen effectively improved seizure control, cognitive function, inflammatory status, and neurotransmitter balance, supporting its value as a reliable therapeutic option for elderly patients with epilepsy under routine clinical conditions and standardi...
The Gut Microbiota-Epilepsy Axis: Bibliometric Trends, Mechanistic Insights, and Microbiota-Targeted Next-Generation Therapeutic Opportunities -
Epilepsy is a complex neurological disorder with diverse underlying causes. Growing evidence suggests that gut dysbiosis may promote epileptogenesis by disrupting short-chain fatty acids, tryptophan-kynurenine metabolism, immune signaling, and neuronal excitability. In this review, we combine findings from human and animal studies to explain how gut dysbiosis may influence seizures through the ...
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