Epilepsy News

Aggression in epilepsy and sleep: from historical accounts to brain networks and human behaviour - For a long time, epilepsy has been associated with violent behaviour, acquiring a highly stigmatising reputation, shaped mainly by 19th-century medical theories that postulated a direct connection between epilepsy and the criminal personality. Such stigma exerts a negative effect on the quality of life of people with epilepsy and remains a significant concern in forensic settings. This narrativ...

Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy - OBJECTIVE: In patients with drug-resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real-time biomarkers. Here, we identified acute and chronic suppression of slow gamma local field potential (LFP) oscillati...

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real-world clinical-practice study - OBJECTIVE: Developmental and epileptic encephalopathies (DEEs) are characterized by drug-resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.

Sudden Arrhythmic Death Presenting with Convulsive Syncope In A Young Man With Severe Coronary Atherosclerosis And Hyperthyroidism: A Case Report - CONCLUSION: The most likely explanation for the patient's clinical presentation is a fatal arrhythmia arising from the synergistic effects of severe CAD, left ventricular hypertrophy, and hyperthyroidism, ultimately leading to cardiogenic syncope and sudden cardiac death. This case highlights that arrhythmias secondary to CAD can mimic epilepsy-like seizures and, therefore, need to be carefully...

Position Statement on Noninvasive Seizure Detection/Alerting Devices: A Joint Statement of the American Epilepsy Society, the Epilepsy Foundation, and the Danny Did Foundation - No abstract

Therapeutic drug monitoring of antiepileptic drugs in the West Bank, Palestine: a 25-year retrospective cohort study from a multi-branch laboratory network - CONCLUSIONS: Frequent out-of-range AED levels, particularly for phenytoin and valproic acid, reflect complex pharmacokinetic and systemic challenges in the West Bank. The overall sub-therapeutic rate (40.4%) highlights the urgent need for enhanced TDM programs, improved patient adherence strategies, and strengthened pharmaceutical care infrastructure in this conflict-affected region.

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.