Epilepsy News

The History of Child Neurology in Iran: From Ancient Times to the Present - CONCLUSION: Child neurology in Iran has evolved from descriptive neurological knowledge embedded in Persian-Islamic medicine into a hospital-based, research-oriented pediatric subspecialty. Future progress depends on retaining the specialist workforce, strengthening provincial referral pathways, expanding registries and genomic capacity, and improving resilience of clinical and research infrast...

MCH-02, a synthetic macamide analog with in vitro FAAH-inhibitory activity, modulates hippocampal endocannabinoid system and BK channel expression without preventing PTZ-induced progressive seizure... - Epilepsy remains a major neurological disorder, with about 30% of patients showing drug resistance despite the availability of multiple antiseizure medications. The endocannabinoid system (ECS) has emerged as a promising therapeutic target due to its role in regulating neuronal excitability. This study examined the effects of a new macamide-derived fatty acid amide hydrolase (FAAH) inhibitor, N...

Differential circadian time modulates of dentate gyrus and CA1 excitation-inhibition balance and seizure threshold - Circadian rhythms regulate seizure threshold and neuronal excitability in epilepsy. Temporal lobe seizures tend to arise more frequently during the diurnal phase relative to the nocturnal phase, yet dentate gyrus (DG) granule cells display elevated intrinsic excitability and CA1 pyramidal neurons show enhanced synaptic excitability at night. Here, we used male adult ICR mice (8-10 weeks old) as...

Genotype and phenotype analyses of 689 individuals with PCDH19-clustering epilepsy - PCDH19-clustering epilepsy (PCDH19-CE) is an infantile-onset neurodevelopmental disorder characterised by clusters of seizures, typically triggered by fever. PCDH19-CE follows an unusual X-linked inheritance pattern whereby heterozygous females, and males with X-chromosome disomy or pathogenic postzygotic mosaic PCDH19 variants, are affected, while hemizygous males are spared. We aggregate publ...

Outcomes of patients with functional/dissociative seizures after neurobehavioral therapy - CONCLUSIONS: The results of this study suggest that manualized NBT effectively reduces seizure frequency and improves symptom comorbidities and quality of life for patients with FDS. This study supports the value of psychotherapy as a primary or adjunct treatment modality for patients with FDS.

Understanding the lived experience of epilepsy through creative engagement workshops: Insights beyond patient-generated questions - CONCLUSIONS: Patient-generated questions identify information needs, whereas creative engagement methods illuminate the emotional and social experiences in daily life underlying those needs. This richer understanding can guide the development of more authentic and patient-centred care. The development of online versions of the creative workshops is now underway, aiming to extend access to the b...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.