Epilepsy News

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs - Cystatin B (CSTB) is an inhibitor of cysteine proteases, particularly cathepsins. Biallelic loss-of-function mutations in the CSTB gene are causative for progressive myoclonic epilepsy type 1 (EPM1), a neurodegenerative disorder characterised by stimulus-sensitive myoclonus and generalised tonic-clonic seizures. Pathomechanisms underlying the disease progression include disturbed proteostasis, ...

Epilepsy in Epidermal Nevus Syndromes: Review - Knowledge in the spectrum of epidermal nevi and epidermal nevus syndrome has been elaborated on and expanded rapidly through the years. In this review, we provide a comprehensive overview of the neurologic manifestations of epidermal nevus syndromes (ENS), with a particular focus on epilepsy, which represents one of the most disabling and frequent systemic complications. Although ENS comprises ...

Potassium channel agonists emerging as treatment options for Focal epilepsy: are we breaking New ground? - INTRODUCTION: Focal epilepsy is a leading cause of neurological disability, with about one-third of patients failing to achieve seizure freedom despite numerous antiseizure medications (ASMs) are available. Most current therapies broadly modulate synaptic transmission, leading to dose-limiting cognitive, psychiatric, and systemic adverse effects. Kv7 (KCNQ) potassium channels, responsible for t...

Enhancing Cross-Patient Seizure Detection with Test-Time Adaptation - Automated seizure detection is essential for effective epilepsy management, yet patient-specific models often generalize poorly across patients due to distribution shifts. Unlike methods focused solely on training-phase generalization, we propose a test-time adaptation strategy that dynamically adjusts model parameters using test samples. Built on ResNet-18, our approach incorporates a learnabl...

Antipsychotic use among paediatric patients living with epilepsy in Uganda - Epilepsy is a common chronic neurological disorder in childhood, often accompanied by behavioural and psychiatric challenges such as aggression, irritability, and hyperactivity. Management of these comorbidities may involve antipsychotic medications, yet data on their use in African settings remain scarce. To examine the prevalence and patterns of antipsychotic prescribing among children and ad...

Knowledge, attitudes, and practices regarding childhood epilepsy among parents of children with epilepsy: a questionnaire-based study - This study examined the knowledge, attitudes, and practices (KAP) among caregivers of children with epilepsy. A cross-sectional survey was conducted from September 2024 to February 2025 in two hospitals in Zibo, China. Structural equation modeling (SEM) was applied to explore the relationships among the KAP components. A total of 385 caregivers participated; most were female (59.5%) and urban r...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.