Epilepsy News
Recent news about epilepsy, seizures and treatments.
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Cardiac Autonomic Modulation in Seizure Disorders With and Without Interictal Epileptiform Discharges: A Retrospective Heart Rate Variability Analysis Using Archived Digital EEG Recordings -
Background Cardiac autonomic dysfunction is increasingly recognized in epilepsy and has been implicated in cardiovascular complications and sudden unexpected death in epilepsy (SUDEP). Heart rate variability (HRV) provides a non-invasive measure of cardiac autonomic modulation; however, the influence of interictal epileptiform discharges (IEDs) on resting HRV remains uncertain. This study compa...
Ertapenem-Associated Neurotoxicity in a Patient With Chronic Kidney Disease and Hypothyroidism: A Case Report - Carbapenems are broad-spectrum antibiotics used to treat infections caused by multidrug-resistant organisms and are associated with neurotoxicity, especially in high-risk groups. Although ertapenem generally has a lower risk of seizures, factors such as advanced age, pre-existing neurological conditions, renal impairment, and hypoalbuminemia can raise the likelihood of adverse effects. We repor...
Dyke-Davidoff-Masson Syndrome Underlying Hemiplegic Cerebral Palsy in an Adolescent: A Case Report - Dyke-Davidoff-Masson syndrome (DDMS) is a rare clinicoradiological syndrome involving unilateral cerebral hemiatrophy with compensatory calvarial changes. It typically presents with seizures, contralateral hemiparesis or hemiplegia, and developmental delay. The clinical manifestations may overlap with those of hemiplegic cerebral palsy, potentially delaying recognition of the underlying structu...
Age-stratified interictal epileptiform discharges in SCN1A-related epilepsy: Association with early sodium channel-blocking antiseizure medication exposure - CONCLUSION: Prolonged early exposure to SCBs was associated with the presence of IEDs in the 6-13-year age band in individuals with SCN1A-related epilepsy. These exploratory findings should be considered hypothesis-generating and require confirmation in prospective multicenter cohorts.
Design and optimization of nafimidone-inspired hybrid scaffolds targeting NaV1.2 for antiepileptic therapy with reduced cardiac liability - Epilepsy remains a major neurological disorder in need of safer and more effective antiepileptic agents. In this study, nineteen nafimidone-guided derivatives were designed, synthesized, and biologically evaluated to identify new anticonvulsant leads with improved efficacy, brain accessibility, and safety. Initial in vivo screening in the MES model identified compounds 11b and 12a among the mos...
Pediatric refractory status epilepticus: Predictors of in-hospital outcomes from a Chinese tertiary center - Refractory status epilepticus (RSE) is a life-threatening neurological emergency in children. However, real-world evidence on pediatric RSE remains limited. This study characterized treatment patterns, in-hospital outcomes, and predictors of clinical outcomes within a resource-constrained regional referral network. We performed a single-center retrospective cohort study of pediatric patients ad...
Ertapenem-Associated Neurotoxicity in a Patient With Chronic Kidney Disease and Hypothyroidism: A Case Report - Carbapenems are broad-spectrum antibiotics used to treat infections caused by multidrug-resistant organisms and are associated with neurotoxicity, especially in high-risk groups. Although ertapenem generally has a lower risk of seizures, factors such as advanced age, pre-existing neurological conditions, renal impairment, and hypoalbuminemia can raise the likelihood of adverse effects. We repor...
Dyke-Davidoff-Masson Syndrome Underlying Hemiplegic Cerebral Palsy in an Adolescent: A Case Report - Dyke-Davidoff-Masson syndrome (DDMS) is a rare clinicoradiological syndrome involving unilateral cerebral hemiatrophy with compensatory calvarial changes. It typically presents with seizures, contralateral hemiparesis or hemiplegia, and developmental delay. The clinical manifestations may overlap with those of hemiplegic cerebral palsy, potentially delaying recognition of the underlying structu...
Age-stratified interictal epileptiform discharges in SCN1A-related epilepsy: Association with early sodium channel-blocking antiseizure medication exposure - CONCLUSION: Prolonged early exposure to SCBs was associated with the presence of IEDs in the 6-13-year age band in individuals with SCN1A-related epilepsy. These exploratory findings should be considered hypothesis-generating and require confirmation in prospective multicenter cohorts.
Design and optimization of nafimidone-inspired hybrid scaffolds targeting NaV1.2 for antiepileptic therapy with reduced cardiac liability - Epilepsy remains a major neurological disorder in need of safer and more effective antiepileptic agents. In this study, nineteen nafimidone-guided derivatives were designed, synthesized, and biologically evaluated to identify new anticonvulsant leads with improved efficacy, brain accessibility, and safety. Initial in vivo screening in the MES model identified compounds 11b and 12a among the mos...
Pediatric refractory status epilepticus: Predictors of in-hospital outcomes from a Chinese tertiary center - Refractory status epilepticus (RSE) is a life-threatening neurological emergency in children. However, real-world evidence on pediatric RSE remains limited. This study characterized treatment patterns, in-hospital outcomes, and predictors of clinical outcomes within a resource-constrained regional referral network. We performed a single-center retrospective cohort study of pediatric patients ad...
Science Daily
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.