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Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation -
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) can reduce seizures in patients with drug-resistant epilepsy. However, seizure freedom is rare, and there is no early response biomarker to predict long-term seizure suppression. To evaluate a candidate short-term biomarker of therapeutic response to DBS, we studied 18-min trials of ANT stimulation in patients with drug-...
Acute Intrapartum Seizure in a Pregnant Woman with Epilepsy Receiving Divalproex: Maternal-Fetal Consequences and Emergency Obstetric Management-A Case Report -
CONCLUSION: Careful multidisciplinary management of epilepsy during pregnancy is essential. Breakthrough seizures during labor may lead to acute fetal compromise and require emergency delivery. Close antenatal, intrapartum, and postpartum monitoring is crucial to optimize maternal and neonatal outcomes.
Cardiac repolarization abnormalities and SUDEP risk in epilepsy -
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, yet its mechanisms remain complex and multifactorial. Cardiac repolarization abnormalities are proposed biomarkers, but evidence is scarce, especially in low- and middle-income countries where epilepsy is highly prevalent.
Sudden unexpected death in epilepsy: An Italian expert consensus statement on risk, mechanisms, prevention, and therapeutic strategies -
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature mortality in people with epilepsy, particularly in those with tonic-clonic seizures (TCSs), developmental and epileptic encephalopathies (DEEs), and drug-resistant epilepsy. Although awareness of SUDEP has increased, major uncertainties remain regarding individualized risk stratification, mechanistic interpre...
Predictors of Seizure Occurrence After Mild Cognitive Impairment and Alzheimer's Disease in Older Adults in the Veterans Affairs Healthcare System: A Retrospective Cohort Study -
CONCLUSION: Our study showed that seizure risk is elevated in MCI and AD, with specific comorbidities associated with risk of seizure occurrence and cognitive decline, suggesting potentially actionable targets for risk stratification and clinical monitoring.
Response to: "Early benzodiazepine treatment and electrographic seizures after febrile status epilepticus" -
We appreciate Inui et al.'s comments regarding the divergent prognostic outcomes of patients with electrographic seizures (ESz) between our studies. The poorer prognosis in their cohort compared to ours likely stems from three key differences. First, baseline disease severity significantly differed. Our cohort predominantly consisted of milder cases, such as febrile seizures, with only 17.2% re...
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