EEG Functional Connectivity Methods for Seizure-related Disorders -
EEG functional connectivity analysis is increasingly used to study neurological disorders. However, the lack of standardization in connectivity estimation limits its clinical translation. This work addresses the need for more guidance in connectivity pipeline design by evaluating numerous techniques in two seizure-related disorders to identify optimal approaches. Retrospective EEG data were ana...
Exploring DHODH inhibition with silibinin as a promising approach to treat drug resistance in epilepsy -
Mitochondrial dysfunction and excessive production of reactive oxygen species (ROS) are key contributors to the pathogenesis of drug resistant epilepsy (DRE). Recent findings suggest DHODH, a mitochondrial enzyme may influence neuronal excitability by affecting intrinsic firing set points. Dysregulated DHODH activity may elevate set points, contributing to persistent hyperexcitability in epilep...
Brain signal irregularity may provide clues to understanding epileptic process -
Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
Breakthrough tech enables seizure localization in minutes -
New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
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