Epilepsy News

The Pallidothalamic Tract in Functional Neurosurgery: A Systematic Review - CONCLUSIONS: PTT-targeted interventions yield meaningful motor improvements in Parkinson disease and dystonia, with preliminary evidence supporting additive dual-target benefits. Seizure-reducing effects in refractory epilepsy have been reported. Evidence remains limited by small uncontrolled studies, heterogeneous outcomes, and inconsistent adverse-event reporting. Prospective trials will eluc...

prickle-mediated epilepsy in flies is a brain-derived neurodevelopmental defect - Damaging DNA variants in PRICKLE genes cause epilepsy from flies to humans. While classic work, primarily in flies, has demonstrated that PRICKLE proteins work with other planar cell polarity proteins to polarize epithelial sheets, the function of PRICKLE proteins in the nervous system is still unclear and may play distinct roles in the nervous system of different organisms. We thus sought to c...

Levetiracetam versus valproate for new-onset or previously treated but inadequately controlled epilepsy in children: a systematic review and meta-analysis of randomized controlled trials - CONCLUSIONS: No significant difference in seizure freedom was detected between levetiracetam and valproate, although the low-certainty finding was sensitive to one trial. Time-related outcomes favored valproate but were exploratory and limited by inadequate handling of censoring. Levetiracetam was associated with fewer overall adverse events and less weight gain, while behavioral and hepatic sa...

The effect of seizure-free period on seizure recurrence following antiseizure medication withdrawal: a systematic review and meta-analysis - BACKGROUND: The seizure-free period before withdrawal is an important factor that influences the risk of epilepsy relapse. Our study aimed to evaluate the effect of the seizure-free period on the relapse risk after antiseizure medication(ASM) withdrawal in epilepsy populations and identify the optimal timing of ASM withdrawal.

Clinical, molecular-genetic, and therapeutic characteristics of patients with Dravet syndrome: Initial results from a hospital-based registry - CONCLUSIONS: This hospital registry provides the first systematic description of the clinical, molecular-genetic, and therapeutic characteristics of patients with DS In Russia. The diagnostic delay observed underscores ongoing challenges and the need for greater vigilance among pediatricians and neurologists.

Prospective, Population-Based Evaluation of Costs and Outcomes of Status Epilepticus According to the New Definition - CONCLUSIONS: This study provides population-based data on costs and outcomes of SE in Germany, serving as a basis for future cost-effectiveness analyses. Compared with earlier studies, lower direct costs and shorter LOS were observed. Identification of high-risk constellations may support clinical decision-making and optimize monitoring, treatment escalation, and allocation of intensive care re...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.