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A model of new-onset refractory status epilepticus (NORSE) using intrahippocampal kainic acid in adolescent mice -
New-onset refractory status epilepticus (NORSE) is a devastating neurological condition characterized by the sudden onset of prolonged, drug-resistant seizures in previously healthy individuals. A clinically relevant animal model is essential to elucidate its pathophysiology, improve treatment, and reduce morbidity and mortality in NORSE. We developed an adolescent mouse model of NORSE by induc...
Impact of pediatric epilepsy on sleep architecture: A systematic review and meta-analysis -
CONCLUSION: Pediatric epilepsy is significantly associated with multidimensional sleep architecture abnormalities, including increased sleep disturbances, reduced sleep efficiency, and decreased REM sleep proportion. This study highlights the need to integrate sleep assessment and management into comprehensive epilepsy care, providing a data-supported basis for optimizing clinical outcomes.
Cognitive, Behavioral, and Emotional Manifestations in Nodding Syndrome: A Neuropsychological Narrative Review -
CONCLUSIONS: Nodding syndrome represents a complex epileptic encephalopathy characterized not only by seizures but also by significant cognitive, behavioral, and emotional impairment. A clearer neuropsychological characterization may inform clinical assessment and guide future research aimed at improving supportive and rehabilitative interventions.
Building an Ecosystem of Seizure Localization Methods: Neural Fragility as the First Step -
The current treatment for drug-resistant epilepsy is surgical intervention, which relies on accurate identification of the seizure onset zone (SOZ) using intracranial EEG (iEEG) data. iEEG analysis with computational epileptogenic zone identification algorithms (CEZIAs) is a promising step towards better SOZ localization and surgical outcomes. A key step in validation and adoption of CEZIAs is ...
Incidence of new onset neurological disorders due to convulsive status epilepticus in children: A long-term population-based study in Tottori prefecture, Japan -
CONCLUSIONS: In this study, we determined the incidence of new-onset neurological problems due to CSE in children. These results may help to enhance the efficacy of CSE management strategies and improve prognosis.
Toward practical standardization: Development of clinical common data elements for pediatric epilepsy in Korea and exploration of their clinical utility -
CONCLUSION: This study shows that pediatric epilepsy CDEs are feasible in time-limited clinics and enable high-quality data collection, improving care and supporting research and collaboration.
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