Epilepsy and Seizure News
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PubMed
Seizures, Sleep, and the Midnight Sun -
The well-known bidirectional link between seizures and sleep may be most conspicuous in environments where the chief zeitgeber - sunlight - undergoes extreme but consistent changes over the course of a year. Routine circannual encounters with the midnight sun and midday darkness strategically position Earth's polar regions as natural laboratories to study this effect. We reviewed 2337 studies t...
Mortality, suicidality and deliberate self-harm in functional seizures: systematic review, age-based, sex-based and region-based meta-analyses -
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Using valproate in epilepsy -
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3,4-Dimethoxyacetophenone ameliorates epileptogenesis by suppressing BDNF, c-fos, and JAK-2/ STAT-3 expression in a pentylenetetrazole-induced kindling model of epilepsy -
Epilepsy is a neurological condition that affects approximately 50 million individuals worldwide. Current treatments mainly alleviate symptoms and have substantial adverse effects, with about 1/3 of patients not responding to existing medications. This underscores the urgent need for new drugs that can overcome these challenges. According to recent studies, the Janus kinase/ signal transducer a...
A prospective, open-label randomized controlled trial: efficacy of prednisolone with vitamin B12 versus prednisolone in children with infantile epileptic spasms syndrome -
CONCLUSION: Prednisolone demonstrated moderate efficacy in controlling spasms in children with IESS. However, the addition of vitamin B12 did not significantly improve seizure control, relapse rates, or developmental outcomes compared with prednisolone alone. Larger multicentre studies evaluating baseline vitamin B12 status are warranted to clarify the role of targeted supplementation in the ma...
Clinical meaning of significant intraindividual asymmetries in material-specific memory performance within the unimpaired range in 432 people with epilepsy -
Material-specific memory deficits can provide lateralizing information regarding epileptogenic foci or structural lesions. Intraindividual performance asymmetries may occur despite overall unimpaired performance. This study investigates the clinical relevance of such asymmetries in people with epilepsy (PWE). We retrospectively analyzed data from 432 PWE who demonstrated unimpaired verbal and f...
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