RobinN
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Serum biotin levels were below normal in 74% of 264 epileptic patinets on long-term anticonvulsant therapy. Low biotin levels appear to result from an acceleration of biotin catabolism by phenytoin, carbamazepine, and phenobarbital. In addition, carbamazepine and primidone may inhibit intestinal absorption of biotin. Interestingly, dermatitis and ataxia, side effects of many anticonvulsants, are also observed in patients with an inborn error biotin-dependent enzymes.
There is no evidence that biotin supplementation interferes with the effect of anticonvulsants. To the contrary, correction of biotin deficiency might reduce seizure frequency, as suggested by the fact that biotin-responsive seizures have occurred in some patients with inborn errors of biotin metabolism.
http://findarticles.com/p/articles/mi_m0FDN/is_1_12/ai_n19170695/