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  #21  
Old 05-25-2018, 12:41 PM
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#gutbrainepilepsyproject
New UCLA study:
"The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet"
Published: May 24, 2018
•Changes in the gut microbiota are required for the anti-seizure effects of the KD
•Specific KD-associated bacteria mediate and confer the anti-seizure effects of the KD
•KD microbiota regulate amino acid γ-glutamylation and hippocampal GABA/glutamate
Paper here:
https://www.cell.com/cell/fulltext/S...674(18)30520-8

Article about the new paper:
https://www.livescience.com/62659-ke...-bacteria.html
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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  #22  
Old 05-26-2018, 07:04 AM
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Regarding new paper above:
Quote :
“We have a hundred years of experience with the ketogenic diet, but we didn’t really know why it works,” Colasin said. “The significance of the work published in Cell explains the key role the microbiome plays in this neuroprotective process.”
Bloom Science Plans to Advance Microbial Treatment for Epilepsy
https://www.xconomy.com/san-diego/20...-for-epilepsy/

Anyone here interested in a stool test?!
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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  #23  
Old 05-29-2018, 07:52 AM
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From the Bloom Science page:
Quote :
... Based on the bacterial strains identified by Hsiao’s team, the company plans to develop a product that would be classified as a medical food, which would take a less stringent path for regulatory approval and lead to a designation that it is generally regarded as safe (GRAS). Colasin said Bloom also plans to pursue conventional regulatory approval as a Live Biotherapeutic Product for its proprietary strains of bacteria, leveraging the orphan drug pathway with the FDA.
Sounds like yogurt.
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  #24  
Old 05-29-2018, 11:24 AM
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Bernard, agreed, but with particular strains of microbiota along with a prebiotic to help feed them. The protocol should be personalized to include many dietary and other factors.

The new paper is revealing microbial mechanism behind KD in seizure disorder.
"A. muciniphila is capable of metabolizing components from the KD and CD diet to support P. merdae growth, and that this cooperative interaction reduces GGT activity. In turn, reductions in GGT activity in P. merdae promote A. muciniphila growth . . . KD alters the gut microbiota, promoting select microbial interactions that reduce bacterial gamma-glutamylation activity, decrease peripheral GG-amino acids, elevate bulk hippocampal GABA/glutamate ratios, and protect against seizures."
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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  #25  
Old 08-01-2018, 10:16 PM
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If seizures are controlled would this be of any benefit to anyone?
  #26  
Old 08-03-2018, 01:54 PM
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Originally Posted by Jake View Post:
If seizures are controlled would this be of any benefit to anyone?
I would think that if your seizures are controlled (100%) and your quality of life is good (ie. medication side effects are tolerable), you wouldn't want to change anything.

But if you don't have 100% control or side effects are intolerable, it might be worth investigating.
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  #27  
Old 11-20-2018, 05:51 PM
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New paper:
Altered composition of the gut microbiome in patients with drug-resistant epilepsy
"Patients with four seizures per year or less showed an increase of Bifidobacteria and Lactobacillus."
https://www.sciencedirect.com/scienc...584?via%3Dihub
#gutbrainepilepsyproject
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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  #28  
Old 11-20-2018, 05:56 PM
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Another new paper:
Gut Microbiota, the Ketogenic Diet and Epilepsy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149163/
"Further analysis of species composition before and after treatment showed a significant increase in Bacteroides and a decrease in Firmicutes and Actinobacteria. When comparing responders and non-responders, Clostridiales, Clostridia, Ruminococcaeceae, Lahnospiraceaea, Alistipes and Tikenellacase were significantly increased in non-responders."
#gutbrainepilepsyproject
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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  #29  
Old 11-20-2018, 06:03 PM
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June 2018:
Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet
"Compared with baseline, fecal microbial profiles showed lower alpha diversity after KD therapy and revealed significantly decreased abundance of Firmicutes and increased levels of Bacteroidetes. We also observed that Clostridiales, Ruminococcaceae, Rikenellaceae, Lachnospiraceae, and Alistipes were enriched in the non-responsive group."
https://www.sciencedirect.com/scienc...578?via%3Dihub

#gutbrainepilepsyproject
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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  #30  
Old 11-26-2018, 09:38 AM
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The last two citations both reference the same strains. Is that because they both tested patients on the Ketogenic diet and it's a diet specific result, or does it hold some correlation with epilepsy patients who are not on the ketogenic diet? Either way, I find the research fascinating.
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  #31  
Old 11-26-2018, 10:05 AM
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Bernard, it certainly is fascinating. The way to interpret these things isn't to simply focus on particular strains, but to try to understand what makes for microbial balance. We are doing just that in our discussion group on Facebook, now nearly 3,000 people, posting charts for interpretation. Please join us:
The Gut Club Stool Test Discussion Group
https://www.facebook.com/groups/TheG...scussionGroup/
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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  #32  
Old 04-24-2019, 06:18 PM
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Another new take on KD related to flora shift (2019):
"Relative abundance of bifidobacteria as well as E. rectale and Dialister is significantly diminished during the intervention. An increase in relative abundance of E. coli is observed on KD."

"As relative abundance of health-promoting, fiber-consuming bacteria becomes less abundant during KD, we raise concern about the effects of the diet on the gut microbiota and overall health."
The ketogenic diet influences taxonomic and functional
composition of the gut microbiota in children with severe
epilepsy

https://www.nature.com/articles/s415...6-IVchCqgzW5NQ
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I'm here to explore gut-origin of seizure and gut-brain connection. This includes microbial predisposition (children born imbalanced) and infection where gut and brain dysbiosis lead to metabolic disorder, pH, sugar, amino acid and vitamin imbalances and microbial toxins/aldehydes/lipids as cause of seizure. I believe these are environmental health issues of the highest order. http://www.coping-with-epilepsy.com/...itivity-22787/
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