Gut-Brain Epilepsy Project - Important Info

Keith

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#gutbrainepilepsyproject
New UCLA study:
"The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet"
Published: May 24, 2018
•Changes in the gut microbiota are required for the anti-seizure effects of the KD
•Specific KD-associated bacteria mediate and confer the anti-seizure effects of the KD
•KD microbiota regulate amino acid γ-glutamylation and hippocampal GABA/glutamate
Paper here:
https://www.cell.com/cell/fulltext/S0092-8674(18)30520-8

Article about the new paper:
https://www.livescience.com/62659-keto-diet-epilepsy-gut-bacteria.html
 

Keith

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Bernard

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From the Bloom Science page:
... Based on the bacterial strains identified by Hsiao’s team, the company plans to develop a product that would be classified as a medical food, which would take a less stringent path for regulatory approval and lead to a designation that it is generally regarded as safe (GRAS). Colasin said Bloom also plans to pursue conventional regulatory approval as a Live Biotherapeutic Product for its proprietary strains of bacteria, leveraging the orphan drug pathway with the FDA.
Sounds like yogurt.
 

Keith

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Bernard, agreed, but with particular strains of microbiota along with a prebiotic to help feed them. The protocol should be personalized to include many dietary and other factors.

The new paper is revealing microbial mechanism behind KD in seizure disorder.
"A. muciniphila is capable of metabolizing components from the KD and CD diet to support P. merdae growth, and that this cooperative interaction reduces GGT activity. In turn, reductions in GGT activity in P. merdae promote A. muciniphila growth . . . KD alters the gut microbiota, promoting select microbial interactions that reduce bacterial gamma-glutamylation activity, decrease peripheral GG-amino acids, elevate bulk hippocampal GABA/glutamate ratios, and protect against seizures."
 

Jake

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If seizures are controlled would this be of any benefit to anyone?
 

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If seizures are controlled would this be of any benefit to anyone?
I would think that if your seizures are controlled (100%) and your quality of life is good (ie. medication side effects are tolerable), you wouldn't want to change anything.

But if you don't have 100% control or side effects are intolerable, it might be worth investigating.
 

Keith

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June 2018:
Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet
"Compared with baseline, fecal microbial profiles showed lower alpha diversity after KD therapy and revealed significantly decreased abundance of Firmicutes and increased levels of Bacteroidetes. We also observed that Clostridiales, Ruminococcaceae, Rikenellaceae, Lachnospiraceae, and Alistipes were enriched in the non-responsive group."
https://www.sciencedirect.com/science/article/pii/S0920121118301578?via=ihub

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The last two citations both reference the same strains. Is that because they both tested patients on the Ketogenic diet and it's a diet specific result, or does it hold some correlation with epilepsy patients who are not on the ketogenic diet? Either way, I find the research fascinating.
 

Keith

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Another new take on KD related to flora shift (2019):
"Relative abundance of bifidobacteria as well as E. rectale and Dialister is significantly diminished during the intervention. An increase in relative abundance of E. coli is observed on KD."

"As relative abundance of health-promoting, fiber-consuming bacteria becomes less abundant during KD, we raise concern about the effects of the diet on the gut microbiota and overall health."
The ketogenic diet influences taxonomic and functional
composition of the gut microbiota in children with severe
epilepsy

https://www.nature.com/articles/s41...-0Ywc-nEp_6atIsmuMFkkY8NzCvtNwa6-IVchCqgzW5NQ
 
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