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It depends on your individual metabolism, and other external factors (like alcohol, which can increase absorption). In general though, the half-life of Dilantin is 22 hours, with a range of 7 to 42 hours. That means for some people, it takes only 7 hours for a given dose to process through the system, and for others it's as long as 42 hours. So it's tough to predict in your particular case. Overnight, when people tend to be less active, the Dilantin might process more slowly through the system than during the daytime. When I was on Dilantin, if I thought I missed a dose my instructions were to wait until the next scheduled dosing and take my regular dose then. And to be careful in the intervening time -- i.e. make sure I'm eating in a well-balanced way, stay away from excessive caffeine or alcohol, don't overdo, avoid stress. But I'm very responsive to medication, and not particularly sensitive to small variations in dosage. If you have any doubt or worry at all, you should call your neurologist for instructions about how to proceed.