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Xylitol is generally considered safe used normally It's effect on blood sugar is less extreme than regular sugars, and it's much safer for people with E than aspartame. But if your metabolism is at all sensitive, proceed with caution. When you first start using Xylitol, it can cause diarrhea which can affect absorption of meds. And if you're dieting with it, pay attention to your overall nutrition so you can avoid low blood sugar (which can be seizure trigger for some).