Well, SJ, 'tis flu season and your daughter probably has it. If she is not holding any food down or liquid down, her meds are also not likely to be absorbed into her system either. That one alone can cause a seizure. Check her temp, give her lots of non-decaffeinated drink with electrolytes (a good sports drink will do) and a lot of rest. I'm not sure if Topimax would negatively interact with any ibuprofen, aspirin, antacids, etc. I keep a written record of drugs that work well for me. Maybe a flu shot next October will help? Any stuff for a cold can potentially cause a seizure, especially if it has menthol. I'm all for hot chicken soup. It's decaffeinnated, pumps liquids into a system especially with a fever, feels great if anybody has chills from that fever and I understand it has some healthy stuff in it.
My son had the flu, and he also had a flu shot last year. He's a really healthy, young fit 20 year old, but he was pretty sick with a fever last week. He was definitely resting and recovering. He's back to normal, now. I had one scary thought. The MRSA flu is very strong. If your daughter does not have that, I'd highly recommend that she gets a MRSA shot asap when she recovers.
And, just purely out of curiosity, did your daughter see a school nurse? Hopefully no drugs that conflicted with her Topimax were administered. I'd ask your daughter if she got any school meds.