As others have said, talk to your local FD. They'll give you the best answer. I was a firefighter/EMT before I started having seizures. Usually a lockbox is possible.
The precautions you take depend on you and your wife's personalities, the frequency and warning of the seizures, and other health problems (or lack thereof). I have fairly frequent generalized tonic-clonic seizures (what some people still call "grand mal"), and sometimes localized atonic seizures, and daily partial seizures. I live alone for most of the week (wife commutes between two cities) in a fifth-floor apartment and/or in hotel rooms when I'm traveling. Also, I sail (with a partner).
My apartment is pretty much like anyone else's apartment. I cook, shower, sit out on the balcony, or whatever I want to do. If I go status epilepticus while no one else is here, or fall in the shower and cover the drain, I could die. I know about these risks, and just accept them because I also know I could get hit crossing the street, or in any number of other inane activities.
I have had some injuries from falls at the wrong place and time, but my attitude is that epilepsy controls several aspects of my life, and I don't want it to affect the food I cook or the furniture I buy - if that makes sense. I just know the risks and accept them in exchange for a life less preoccupied with my seizures, which do a good enough job reminding me that they're there without me putting reminders throughout my apartment.
Now, that's just me. But I am otherwise somewhat of a risk taker - I would say a calculated risk taker. Also, I have a seizure alert dog which makes me MUCH more willing to do things that I might normally be hesitant to do. I would be lying if I said that I didn't check in with my dog every time I step into the shower, and I've put off showering when she wasn't acting quite right. Also, she'll let me know if I need to avoid stairs, sit down, not get up, etc. So, it's pretty easy for me to go on business-as-usual. If I didn't have that, if I am to be honest, I would be much more cautious.
I can say this, the risk of seizure is ALWAYS on my mind. I am always aware of what I am likely to fall on or drop should a seizure start. Having that constantly hanging over my head gets pretty old pretty fast. I am lucky that my wife pretty much lets me be. She doesn't nag me when I'm going to do something risky. She knows that I know the risks, and she lets me live my life.
I'm certainly not suggesting you are being overprotective, but you definitely should check in with how she's feeling about this, if you don't already. Everyone has limits to how much they want to let this slip into their lives. She is undoubtedly becoming quite aware of how these seizures will place limits on daily activities. Just make sure that your not making her feel worse about this by trying to protect her from herself. I would find out what she's concerned about, and mitigate those concerns and nothing else.
I worked in an office where, after a seizure in which I hit my head and got a little gash, they installed child corner guards all over the place. I found this humiliating - the idea that I, as an adult, was not capable of assessing and accepting the risk of hitting my head on a desk. I had them removed. In retrospect, I know that the decision to install the guards was out of concern for me, but that was not the message I received at the time.Just make sure you don't send that same message to your wife.