Seek emergency medical attention if the person taking this medicine has nausea, vomiting, stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage. Some of these symptoms may also be early signs of pancreatitis. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
unexplained weakness with vomiting and confusion or fainting;
easy bruising or bleeding, unusual weakness;
fever, skin rash, swollen glands;
fever, chills, body aches, flu symptoms;
urinating less than usual;
blood in your urine;
hallucinations (seeing things that aren't there);
weakness, lack of coordination;
a red, blistering, peeling skin rash;
extreme drowsiness;
unusual bleeding or bruising; or
double vision or back-and-forth movements of the eyes.
Continue using Depakote and talk with your doctor if you have any of these less serious side effects:
drowsiness or weakness;
diarrhea, constipation, upset stomach;
depression, anxiety, or other emotional changes;
changes in your menstrual periods;
enlarged breasts;
tremor (shaking);
hair loss;
weight changes;
a red, blistering, peeling skin rash;
vision changes; or
unusual or unpleasant taste in your mouth.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.