Ubiome results

SandyC

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Here are my daughter's Ubiome results. For her, certain foods trigger seizures. She has been on the Keto/MAD for the past 3 years. It has helped with the seizures, but I am really wanting to balance her gut flora, and I don't feel like this can be done while on such a low carb diet. The probiotic results section show that she has NO probiotic strains, but the overall bacterial load show much diveristy. Not exactly sure how to interpret this. Is there anything that stands out to anybody?


Bacteria at the
phylum rank
Firmicutes: 54.17%
Bacteroidetes: 39.88%
Proteobacteria: 4.00%
Actinobacteria: 1.74%
Verrucomicrobia: 0.16%
Lentisphaerae: 0.03%
Fibrobacteres: 0.02%
Cyanobacteria: < 0.01%


Bacteria at the
Class rank
Clostridia: 48.96%
Bacteroidia: 39.88%
Deltaproteobacteria: 3.54%
Erysipelotrichia: 2.05%
Bacilli: 1.81%
Actinobacteria: 1.74%
Negativicutes: 1.34%
Betaproteobacteria: 0.29%
Verrucomicrobiae: 0.16%
Gammaproteobacteria: 0.09%
Alphaproteobacteria: 0.09%
Lentisphaeria: 0.03%
Fibrobacteria: 0.02%


Bacteria at the
order rank
Clostridiales: 48.89%
Bacteroidales: 39.88%
Desulfovibrionales: 3.54%
Erysipelotrichales: 2.05%
Lactobacillales: 1.81%
Coriobacteriales: 1.69%
Selenomonadales: 1.34%
Burkholderiales: 0.28%
Verrucomicrobiales: 0.16%
Enterobacteriales: 0.09%
Rhodospirillales: 0.09%
Actinomycetales: 0.05%
Thermoanaerobacterales: 0.04%
Fibrobacterales: 0.02%
Rhodocyclales: < 0.01%
Bacillales: < 0.01%
Oscillatoriales: < 0.01%



Bacteria at the
family rank
Lachnospiraceae: 26.28%
Bacteroidaceae: 25.57%
Ruminococcaceae: 9.78%
Porphyromonadaceae: 9.21%
Clostridiaceae: 6.66%
Rikenellaceae: 5.07%
Desulfovibrionaceae: 3.54%
Erysipelotrichaceae: 1.95%
Lactobacillaceae: 1.75%
Coriobacteriaceae: 1.69%
Acidaminococcaceae: 1.26%
Peptostreptococcaceae: 1.16%
Oscillospiraceae: 0.81%
Clostridiales Family XIII. Incertae Sedis: 0.35%
Sutterellaceae: 0.17%
Verrucomicrobiaceae: 0.16%
Oxalobacteraceae: 0.11%
Enterobacteriaceae: 0.09%
Rhodospirillaceae: 0.09%
Veillonellaceae: 0.08%
Caldicoprobacteraceae: 0.08%
Peptococcaceae: 0.05%
Thermoanaerobacteraceae: 0.04%
Victivallaceae: 0.03%
Mycobacteriaceae: 0.03%
Actinomycetaceae: 0.02%
Fibrobacteraceae: 0.02%
Streptococcaceae: 0.01%
Catabacteriaceae: < 0.01%
Prevotellaceae: < 0.01%
Eubacteriaceae: < 0.01%
Micrococcaceae: < 0.01%


Bacteria at the
genus rank
Bacteroides: 25.53%
Blautia: 14.96%
Faecalibacterium: 7.01%
Sarcina: 5.68%
Alistipes: 5.01%
Barnesiella: 4.86%
Roseburia: 3.79%
Bilophila: 2.73%
Parabacteroides: 2.24%
Odoribacter: 1.73%
Pseudobutyrivibrio: 1.71%
Eggerthella: 1.38%
Lachnospira: 1.37%
Phascolarctobacterium: 1.26%
Intestinimonas: 1.22%
Moryella: 1.09%
Oscillospira: 1.05%
Fusicatenibacter: 1.01%
Erysipelatoclostridium: 0.89%
Flavonifractor: 0.88%
Desulfovibrio: 0.76%
Turicibacter: 0.64%
Eisenbergiella: 0.62%
Anaerotruncus: 0.56%
Intestinibacter: 0.48%
Subdoligranulum: 0.33%
Butyricimonas: 0.32%
Lactonifactor: 0.27%
Terrisporobacter: 0.24%
Gordonibacter: 0.19%
Clostridium: 0.18%
Dielma: 0.18%
Sutterella: 0.17%
Akkermansia: 0.16%
Oscillibacter: 0.15%
Holdemania: 0.13%
Herbaspirillum: 0.11%
Pseudoflavonifractor: 0.09%
Megasphaera: 0.08%
Peptoclostridium: 0.08%
Kluyvera: 0.08%
Dorea: 0.05%
Anaerostipes: 0.05%
Peptococcus: 0.05%
Asaccharospora: 0.04%
Gelria: 0.04%
Thalassospira: 0.03%
Collinsella: 0.03%
Marvinbryantia: 0.03%
Victivallis: 0.03%
Coprobacter: 0.02%
Actinomyces: 0.02%
Caldicoprobacter: 0.02%
Candidatus Soleaferrea: 0.02%
Fibrobacter: 0.02%
Anaerosporobacter: 0.01%
Streptococcus: 0.01%
Butyricicoccus: 0.01%
Anaerofilum: < 0.01%
Catabacter: < 0.01%
Klebsiella: < 0.01%
Romboutsia: < 0.01%
Shuttleworthia: < 0.01%
Coprobacillus: < 0.01%
Robinsoniella: < 0.01%
Senegalimassilia: < 0.01%
Epulopiscium: < 0.01%
Anaerofustis: < 0.01%
Hydrogenoanaerobacterium: < 0.01%
Kocuria: < 0.01%
 

Nakamova

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Hey SandyC --

Have you seen a nutritionist or gastroenterologist with these results? A specialist would most likely have access to this kind of data for comparison purposes and would be able to evaluate any red flags.
 
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Site to help with uBiome results and normalizing microbiome

You may wish to look at: cfsremission(dot)com/2017/10/08/update-and-recap/
The site has many posts dealing with correcting different bacteria genus.

For example, Sarcina is about 3x normal, there is a post on what is known to decrease it, cfsremission(dot)com/2017/10/12/decreasing-sarcina-genus/
 

Keith

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Great job posting, you are a CWE pioneer, the first to participate here in the Gut-Brain Epilepsy Project!

You've posted the exact charts we needed, excellent work. It's also good to see the actual charts provided which include a pie chart. Here's an example of how they look. This one was from a 2.5 year old autistic child where they decided to use FMT (fecal microbiota transplant) which balanced the Proteobacteria overgrowth to a large extent and autistic symptoms improved.


But I don't think there's a way to post photos here other than with links to photos, so what you've provided is just as good.

Having no probiotic strains, meaning no growth of Lactobacillus and Bifidobacteria is indeed the major issue. This is a separate chart provided by uBiome. When people see no growth in these strains they tend to doubt the results are accurate because the test can't really tell what's happening in the small intestine. But this is still crucial information because most people do show growth of these protective microbiota. They protect the small intestine from pathogenic overgrowth. And they also produce the full range of B-vitamins and amino acids. Have you tried probiotics and prebiotics? Begin slowly in very small doses as these things can cause seizure. I'd suggest probiotics weighted heavily toward Bifidobacteria as some strains of Lactobacillus may be inflammatory.

These results may be too high in Bacteroides which are raised by a ketogenic or low carb diet. Also reduced is Akkermansia which tends the gut lining. Proteobacteria may be somewhat high, but not so far off.

Rikenellaceae: 5.07% is something to research.
 
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Keith

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Sandy, I've noticed in your profile that your daughter is an adult. Does she have gastrointestinal symptoms?

You may be very interested in seeing this new research paper:
May 2017:
"Here, to the best of our knowledge, we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of epilepsy."
Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442093/
 
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