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Atkins-Like Diet Cuts Epileptic Seizures
By Steven Reinberg
HealthDay Reporter
THURSDAY, Jan. 31 (HealthDay News) -- Adults with epilepsy who have failed other treatments may be able to dramatically reduce their number of seizures by following a modified Atkins-like diet, Johns Hopkins researchers report.
The high-protein, low-carbohydrate diet has already been shown to be valuable in controlling seizures in children, and now results from a small study suggest that the diet also works for adults.
"There are a lot of adults with very bad seizures. There are a lot of adults who have failed medicines and are not candidates for other treatments," said lead researcher Dr. Eric H. Kossoff, an assistant professor of neurology and pediatrics at Johns Hopkins School of Medicine.
For the study, Kossoff's team gave the diet to 30 adults who had unsuccessfully tried at least two anti-convulsant drugs and had an average of 10 seizures a week. The eating plan restricts patients to 15 grams of carbohydrates a day. Most of the calories come from fats such as eggs, meats, oils and heavy cream. In addition, patients are free to eat as much protein and no-carb drinks as they want.
"There was good news and bad news," Kossoff said. "The good news was it worked. The bad news it was tough. About 30 percent of the patients stopped the diet. This happened even in patients who had good seizure control who thought the diet was still too tough to do."
After a month on the diet, half the patients reported suffering 50 percent fewer seizures. At three months, about one-third of the patients cut the frequency of seizures by half.
However, by three months, one-third of the patients had dropped out of the study because they found the diet too restrictive, Kossoff said.
MODIFIED ATKINS DIET CAN CUT EPILEPTIC SEIZURES IN ADULTS
Johns Hopkins Medicine
Media Relations and Public Affairs
January 28, 2008
MODIFIED ATKINS DIET CAN CUT EPILEPTIC SEIZURES IN ADULTS
--High-fat, low-carb diet may be an option when other treatments fail
A modified version of a popular high-protein, low-carbohydrate diet can significantly cut the number of seizures in adults with epilepsy, a study led by Johns Hopkins researchers suggests. The Atkins-like diet, which has shown promise for seizure control in children, may offer a new lifeline for patients when drugs and other treatments fail or cause complications.
For almost a century, doctors have prescribed an eating plan called the ketogenic diet to treat children with epilepsy. This diet often consists of a short period of fasting, strictly limits fluids and drastically restricts carbohydrates. It appears to limit or even eliminate seizures, possibly by generating the build-up of ketones, compounds the body produces when it derives calories mostly from fat. Some of the largest studies to scientifically test this diet’s efficacy took place at Johns Hopkins in the mid-1990s, led by pediatric neurologists John Freeman, M.D., and Eileen Vining, M.D.
Why exactly the ketogenic diet works remains unknown, and it is notoriously difficult to follow, relying almost solely on fat and protein for calories. Consequently, doctors typically recommend it only for children, whose parents can strictly monitor their eating habits. The ketogenic diet is almost never prescribed to adults, who generally make their own food choices and often have difficulty complying with the diet’s strict guidelines.
In 2002, Johns Hopkins researchers began testing a modified version of the Atkins diet in children with epilepsy. The modified diet shares the high-fat focus of the ketogenic diet, prompting the body to generate ketones. However, it allows more carbohydrates and protein, doesn’t limit fluids and calories, and has no fasting period. When studies showed that the new diet prevented or curtailed seizures in children, the researchers began testing it for efficacy and ease of use in adults.
Reporting on the results in the February issue of Epilepsia, Eric H. Kossoff, M.D., an assistant professor of neurology and pediatrics at the Johns Hopkins University School of Medicine, said 30 adults with epilepsy, ages 18 to 53 years, who had tried at least two anticonvulsant drugs without success and had an average of 10 seizures per week, were placed on the modified Atkins diet. All patients were seen for free in the Johns Hopkins General Clinical Research Center.
The regimen restricted them to 15 grams of carbohydrates a day. “That’s a few strawberries, some vegetables, or a bit of bread,” says Kossoff. The diet offers most of its calories from fat-eggs, meats, oils and heavy cream-with as much protein and no-carb beverages as patients want.
Each day, patients kept diaries of what they ate and how many seizures they had. The researchers evaluated how each patient was doing at one, three and six months after starting the diet.
Results showed that about half the patients had experienced a 50 percent reduction in the frequency of their seizures by the first clinic visit. About a third of the patients halved the frequency of seizures by three months. Side effects linked with the diet, such as a rise in cholesterol or triglycerides, were mild. A third of the patients dropped out by the third month, unable to comply with the restrictions.
Fourteen patients who stuck with the diet until the six-month mark chose to continue, even after the study ended-a testament to how effective the diet worked to treat their epilepsy, Kossoff notes.
Though the modified Atkins diet won’t be a good fit for all patients, says Kossoff, “it opens up another therapeutic option for adults trying to decide between medication, surgery and electrical stimulation to treat intractable seizures.” A second study to examine the diet’s effects on adults with intractable seizures is under way.
Other researchers who contributed to the study include Hannah Rowley, R.D., and Eileen P.G. Vining, M.D., both of the Johns Hopkins University School of Medicine, and Saurabh R. Sinha, M.D., of Sinai Hospital of Baltimore.
I'm trying to find a diet both to help my Chelestorol & to help with my siezures . Is there any such Diet ?
TeeTee,
Reading your post I get the impression that you don't understand how the modified atkins diet works. Yes you increase your fat intake - and by doing so you decrease the amount of fat stored in your body.
First, since you aren't getting sugar and carbs, your body doesn't have sugar to convert to glucose. So instead it converts the fat to ketones which is why its such a lifesaver to those with uncontrolled epilepsy. Furthermore, since there isn't really any sugar in your diet, when you need more fuel, it burns the stored fat off you body, thereby enabling you to loose more weight, than you would if you were eating snacks such as fruits
you can actually double your calories on this diet (if your eating a typical american diet), and still get all the benefits of it. And if you look at history, there were far fewer instances of heart related problems when the average American was eating a really high fat diet. its just when most people today think of high fat, they aren't thinking of healthy fats like oils and eggs, but unhealthy fats like transfat coupled with sugars like you find in junk food. Greece has one of the lowest rates of heart attacks in the world - they also have one of the highest rates of fat consumption in the world
TeeTees
I agree with you. I don't think any diet is good for you in the long term, if it cuts out food groups.
I, too, lost 23 lbs from Feb to August, by cutting out the junky crap, increased my fruits and veggies and watched portions. Oh yeah, you need to exercise too. Ugh that's harder for me to do.
Honestly by last October ('07) I found, that while I loved them going down:roflmao:, Quarter pounders really made me feel miserable for the rest of the day. I decided I just had to do a better job for myself.
In the process of losing the 23 lbs my cholesterol went down 40pts.:clap: and the triglycerides down 30:woot:
If you watch portions, you'll do great AND you won't feel deprived. I still eat pizza--two pieces instead of 5 or so. I eat fries now and again, but just not as much.
If you watch portions, you'll do great AND you won't feel deprived
Maybe I'll go into details tomorrow. Right now i'm pretty annoyed that i spent all that time gathering sources and quoting studies, etc only to have everything lost because of single mistyped letter - stupid vista
While I've read about ketegenic diets for seizures, I've heard they are quite difficult to stay on. Honestly I don't know how some people manage it.