Can side effects get worse

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Is it possible for side effects to get worse or new ones start to show up over the years while you're taking it?
Yup, the same way people can get develop (or get rid of) allergies or migraines later in life.
Our metabolisms change over time, and that can affect how well meds are absorbed. If that leads to higher levels in your blood that might produce worse side effects.
Other factors can be hormonal shifts, addtional meds we might be taking, greater sensitivity to fatigue, dehydration, etc.
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