High oxalate in the urine and plasma was first
found in people who were susceptible to
kidney stones. Many kidney stones are
composed of calcium oxalate. Stones can
range in size from the diameter of a grain of
rice to the width of a golf ball. It is estimated
that 10% of males may have kidney stones
some time in their life. Because many kidney
stones contain calcium, some people with
kidney stones think they should avoid calcium
supplements.
However, the opposite is true. When calcium
is taken with foods that are high in oxalates,
oxalic acid in the intestine combines with
calcium to form insoluble calcium oxalate
crystals that are eliminated in the stool. This
form of oxalate cannot be absorbed into the
body. When calcium is low in the diet, oxalic
acid is soluble in the liquid portion of the
contents of the intestine (called chyme) and is
readily absorbed from the intestine into the
bloodstream. If oxalic acid is very high in the
blood being filtered by the kidney, it may
combine with calcium to form crystals that
may block urine flow and cause severe pain.
It would be interesting to see if increased
elimination of heavy metals occurs after
oxalate elimination by antifungal therapy and
low oxalate diet. In addition, oxalates from the
diet or from yeast/fungus in the
gastrointestinal tract bind calcium,
magnesium, and zinc, perhaps leading to
deficiencies even when dietary sources should
be adequate.
such crystals may also form in the
bones, joints, blood vessels, lungs, and even
the brain
Laboratory tests recommended by a respected lab for oxalates:
Oxalic acid (oxalates) -Tests for all forms of oxalic
acid and its salts or conjugate bases, oxalates
Arabinose - Important Candida indicator which
strongly correlates with oxalates
Glycolic acid (glycolate) - Indicator of genetic
disease of oxalate metabolism called Hyperoxaluria
type I due to a deficiency in the enzyme activity of
alanine glyoxylate amino transferase (AGT).
Glyceric acid (glycerate) - Indicator of genetic
disease of oxalate metabolism called Hyperoxaluria
type II due to a deficiency in an enzyme (GRHPR)
that has two biochemical activities: glyoxylate
reductase (GR) and hydroxypyruvic reductase
(HPR).
Ascorbic acid (ascorbate, vitamin C)-Indicates
nutritional intake of vitamin C and/or excessive
destruction. Vitamin C can be excessively
converted to oxalates when free copper is very
high.
Pyridoxic acid - Indicator of vitamin B-6 intake.
The enzyme activity alanine glyoxylate amino
transferase (AGT) requires vitamin B-6 to eliminate
glyoxylic acid or glyoxylate, a major source of
excess oxalates.
Furandicarboxylic acid, hydroxy-methylfuroic
acid - Markers for fungi such as Aspergillus
infection, one of the proven sources of oxalates
Bacteria markers - A high amount of bacterial
markers may indicate low values of beneficial
bacteria such as Lactobacilli species that have the
ability to destroy oxalates.
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