Metabolic Neurology

[BuckeyeFan]

My Neurologist has been working with me on my diminishing cognitive abilities. He has recommended that I see another neurologist about Metabolic Neurology studies.

Does anyone have experience with this fairly new diagnostic field?

 

[Bernard]

I have not heard of this before. Is it at all related to the gut-brain stuff that @Keith has been researching?

 

[Andrew]

Could "Metabolic Neurology studies" be the study of - how - through metabolic (enzymatic) pathways, neurotransmitters/neuromodulators are synthesized (created). Focusing mainly on the processes within the brain?

https://www.sciencedirect.com/topics/neuroscience/neurometabolic-disease

Homo sapiens serotonin and melatonin biosynthesis

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all or all organisms. Its synthetic pathway depends on the species in which it is measured. For example, the tryptophan to melatonin pathway differs in plants and animals. It is speculated that the...

www.mdpi.com

My story: https://www.coping-with-epilepsy.com/threads/40-years-on-vitamin-b6.11674/

**DO NOT ALTER ANY MEDICATION WITHOUT YOUR DOCTOR'S CONSENT**

 

[Andrew]

...Also:

Autism & Epilepsy & General Epilepsy Experiences

Blonde Angel, You might be interested in "The Autoimmune Epidemic" written by Donna Nakasawa. She has had severe health challenges to overcome. She specifically addresses toxins in our environment, like toxic dump sites, and the clusters of disorders, like Lupus, that appear in proximity to...

www.coping-with-epilepsy.com

And:

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review

The B-vitamins comprise a group of eight water soluble vitamins that perform essential, closely inter-related roles in cellular functioning, acting as co-enzymes in a vast array of catabolic and anabolic enzymatic reactions. Their collective effects are ...

www.ncbi.nlm.nih.gov

The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families - BMC Bioinformatics

Background - Enzymes that depend on vitamin B6 (and in particular on its metabolically active form, pyridoxal 5'-phosphate, PLP) are of great relevance to biology and medicine, as they catalyze a wide variety of biochemical reactions mainly involving amino acid substrates. Although PLP-dependent...

bmcbioinformatics.biomedcentral.com

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota–gut–brain ...

www.ncbi.nlm.nih.gov

Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors

The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. ...

www.ncbi.nlm.nih.gov

 

[BuckeyeFan]

I have not heard of this before. Is it at all related to the gut-brain stuff that @Keith has been researching?

From what I understand it is more about how the brain metabolizes sugar (possibly other things). By seeing where the metabolism is not occuring, they can help diagnose Alheismers vs Dementia vs other issues. The pioneer in this area was from the Cleveland clinic, however has retired. I am looking at going to Columbus to another expert now.

 

[BuckeyeFan]

Could "Metabolic Neurology studies" be the study of - how - through metabolic (enzymatic) pathways, neurotransmitters/neuromodulators are synthesized (created). Focusing mainly on the processes within the brain?

https://www.sciencedirect.com/topics/neuroscience/neurometabolic-disease

Homo sapiens serotonin and melatonin biosynthesis

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all or all organisms. Its synthetic pathway depends on the species in which it is measured. For example, the tryptophan to melatonin pathway differs in plants and animals. It is speculated that the...

www.mdpi.com

My story: https://www.coping-with-epilepsy.com/threads/40-years-on-vitamin-b6.11674/

**DO NOT ALTER ANY MEDICATION WITHOUT YOUR DOCTOR'S CONSENT**

This sounds like it is definitly in that area of processes. I need to learn much more.
Thank You for the info.

 

[Andrew]

The vitamin B6 vitamers include pyridoxine, pyridoxal, and pyridoxamine, as well as their phosphorylated forms such as pyridoxal phosphate, which is a key coenzyme for a surprising variety of enzymes involved in myriad aspects of metabolism.

Vitamin B6: Effects of Deficiency, and Metabolic and Therapeutic Functions

The vitamin B6 vitamersVitamers include pyridoxine, pyridoxal, and pyridoxamine, as well as their phosphorylated forms such as pyridoxal phosphatePyridoxal phosphate, which is a key coenzymeCoenzyme for a surprising variety of enzymes involved in myriad aspects of...

link.springer.com

Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome?

The concept of the gut microbiome is emerging as a metabolic interactome influenced by diet, xenobiotics, genetics, and other environmental factors that affect the host’s absorption of nutrients, metabolism, and immune system. Beyond nutrient digestion and production, the gut microbiome also...

www.frontiersin.org

**DO NOT ALTER ANY MEDICATION WITHOUT YOUR DOCTOR'S CONSENT**