Get emergency medical help if you have any of these signs of an allergic reaction: hives; fever; swollen glands; painful sores in or around your eyes or mouth; difficulty breathing; swelling of your face, lips, tongue, or throat. This medication may cause severe or life-threatening skin rash, especially in children and in people who are allergic to other seizure medications. Serious skin rash may also be more likely to occur if you are taking lamotrigine together with valproic acid (Depakene) or divalproex (Depakote). Seek emergency medical attention if you have a fever, sore throat, swollen glands, and headache with a severe blistering, peeling, and red skin rash.
If you have to stop taking lamotrigine because of a serious skin rash, you may not be able to take it again in the future.
Call your doctor at once if you have any new or worsening symptoms such as: mood or
behavior changes, depression,
anxiety, or if you feel agitated, hostile,
restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:
- the first sign of any skin rash;
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
- chest pain;
- pale skin, easy bruising or bleeding;
- fever, chills, body aches, flu symptoms; or
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- dizziness or drowsiness;
- blurred vision;
- nausea, vomiting, diarrhea, upset stomach;
- headache;
- lack of coordination;
- weight loss;
- sleep problems (insomnia), unusual dreams; or
- runny or stuffy nose.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.