positive mutations and piggyback diseases (like epilepsy) and boolean treatment

[lnsiu]

I'll make a new thread for this question since this is highly speculative:

Your comment suggests a further correlation between my lineage and other genetic corruptions. I can trace my lineage back to East Prussia definitively. There are a number of individuals with neurotransmission deficits, and perhaps structural brain abnormalities, particularly on my father's side. Although my father was born in the US, both of his parents were German, and my mother was German.

Spoiler

Koennen Sie Deutsch sprechen? Ich habe in Deutschland drei Jahren gewonnt wenn ich ein kind war. Ich kann noch ein bischen erinnern.

I have done some research regarding the origin of two of my conditions. Being of Germanic descent accounts strongly for one of them. I have long been "drawn" inwardly to other more northernly countries in Europe. I strongly suspect Finnish blood from a few generations ago runs through my veins.

I developed lactose intolerance about two years ago, and went through the process of eliminating cow's milk, but tolerating cheese, and then finally having to eliminate cheese, almost completely, except for very small amounts. I noticed that Finns have a greater propensity for lactose intolerance.

Your comment suggests a further correlation between my lineage and other genetic corruptions. I can trace my lineage back to East Prussia definitively. There are a number of individuals with neurotransmission deficits, and perhaps structural brain abnormalities, particularly on my father's side. Although my father was born in the US, both of his parents were German, and my mother was German. My mother was in tears when the Berlin Wall came down, as she narrowly escaped East Germany before it went up.

Ok,
This seems to be a very difficult topic, but I'll try my best. The idea that there is a mutation that actually is positive - relies on for example studies of relatives with schizophrenia, but also the fact that the only mutations that have the ability to spread worldwide, are strongly positive. i.e. this mutation would be strongly positive for family members not affected by for example; schizophrenia, epilepsy, bipolar etc, but detrimental for those with such serious conditions.

The idea here is that there is a single cause for many conditions and these conditions would piggyback on this positive mutation. Thus being spread worldwide. A very strong positive gene mutation within humans would spread worldwide in a time-laps of about 10.000 years.

This view is much more positive than the notion that this is some sort of degenerative condition within families, and a strong argument for this view (yes, being positive about oneself is a strong argument ).

So, what diseases would be reflected by this single cause?

I believe these conditions have the same cause:
tle,
bipolar,
schizophrenia,
migraine,
gluten intolerance,
psoriasis,
diabetes type 2,
ADHD,
Autism


What seems to be a common(alternative) treatment for all of these conditions?

- Glutenfree diet
- Fishoil
- Excersise



Feel free to add your own thoughts!
(This is highly interdisciplinary and a logical way to check if an alternative method seems promising, if the underlying idea of a single cause is correct)

 

[MichaelJO7]

It is characteristic of one my mutations (MMD2) to manifest itself differently as well as clinically within the same bloodlines. It subsequently stands to reason that one mutation could be responsible for a variety of different ailments, depending upon the countless internal and environmental variables which might promote the manifestation of a mutation. In many such mutations, there is an anticipatory effect. The mutation will likely be clinically observable earlier in the next generation.

I have done some (minimal) reading about Genomes, and how the physiological makeup of a bloodline can change from one generation to the next, due simply to the environmental conditions one generation experiences.

I have a Siberian Husky who is named Max, and he makes circles in the "grass" even when there is no grass, before he lies down. It is a behavior that is passed down.

I do not believe we are bound by our genetics, nor should we allow our genetics determine who we are. I see genetic defects as something to be managed at worst, and overcome, at best. We are more than animals, and can determine many variables which animals can't. Besides, evolution is inconstent with the principle of entropy in physics.

You can't really know where you are going, unless you know where you have been.

 

[lnsiu]

Interesting thoughts on genetics and dualism. DNA and free will. Purpose and meaning and strict physical evolution. I believe you are correct. The sum is larger than each individual part. A broken leg does not make a human.

So, lets say we are looking at the same problem from different angels. A rubics cube of diseases (..and opportunities perhaps?).

If I look at for example turmeric as a plausible alternative treatment for my epilepsy. I would first check how successful turmeric is for known diseases within my relatives. Secondly, i would check how successful turmeric seems to be in treating conditions that I suspect would be close to the condition I myself have or my relatives have.

Does this make sense to you? This has been my current strategy for self treatment. From alternative schizophrenia treatment, I picked excersise and that lowered my seizures from 30 a day to 3.

The big question is: Are there just a handful of popular alternative treatments handed around, or is there a large (boolean) common cause?

 

[MichaelJO7]

My methodology is considerably different. I treat myself based upon what I know to be the problem, and then try to address the problem based upon my own understanding of the problem. I try to understand the foundational science of the problem, how cells work, how chemistry works, how the nervous system works, and then address the problem based upon what I think needs addressing at that point.

I don't think using observance of family is a good away to address a genetic problem because the pool of information is too limited. My reasoning to understand genetics is to have a definitive understanding of what the problem is. It is, for the time being, an ending point, not a beginning point. Genetics addresses propensities which can at some point be useful, simply because understanding the problem can provide relief.

I do use turmeric, and ginger, cloves, cinnamon, cayenne pepper, jalapeno pepper, and Vitamin A and C rich foods, potassium rich foods, calcium supplements, all to address a particular problem. Calcium supplementation helps to change the pH of the gut. Mine is far too acidic. Cayenne pepper, and jalapeno pepper dilate blood vessels, and contain capsaicin, a blood thinner. Cinnamon and cloves act as antioxidants and antihistamines and improve respiration. Vitamin E helps maintain cell membrane stability in the brain, as well as the body. Potassium is necessary for muscle relaxation for me because I am constantly burning potassium. Green tea reduces inflammaton in my lungs. Garlic is a great antioxidant; is has helped prevent countless colds and other infections since I started taking it over decade ago. Ginger is good for upset stomachs, as are fennel and anise. I eat fish regularly for its oil. I do not use turmeric much, and can't say precisely what it does because I have not experienced its benefits. I also eat a high fiber diet, and use probiotics.

I am presently reading a molecular biology book, and am narrowing down why I have diabetic type seizures. That could again be a genetic component of MMD2. I may have other mutations.

Many genetic mutations do not present themselves until later in life.

Life is far too complex for there to be one common cause. It certainly makes life much more difficult, but more interesting as well.

 

[AlohaBird]

I agree with Michael that there is not one common cause for all maladies but I also agree with Insiu that there often can be a treatment that helps more than one ailment.

This may be because, while there is not a common cause, there may be a common mediator or mechanism involved. I think this is inflammation.

Inflammation can be caused by gluten or other food sensitivity, chemicals in foods or our environment, imbalance of gut flora etc.
Anything that gets the body's defense mechanisms in a tizzy will cause inflammation.

But then if you have chronic systemic inflammation going on, it can manifest in multiple ways. Some people get psoriasis, some people get IBS, some people get seizures, some people get migraines, some get other neurological and mental health issues.

And a lot of times there is a lot of overlap. I have seizures and migraines. Lots of autistic and ADHD kids also have digestive issues. Michael has MMD2 and seizures.

The same thing helps my seizures and makes my migraines ancient history. Ketosis.

I highly recommend the website of Dr. Georgia Ede. She is a practicing psychiatrist who got interested in low carb gluten free eating for her own health and also saw how much it helped her patients to better cope with their mental health challenges.

http://www.diagnosisdiet.com

 

[lnsiu]

About being specific vs generalized. A cure for epilepsy would be good. That would be specific. Meanwhile any strategy is fair game and I think both of you know that there is little one to one correlation in genetics. Several genetic alterations might give the same type of epilepsy, but a single alteration might give multiple types of epilepsy(according to research).

In most cases, regardless of what, you will have to deal with probabilities, and I think I have a strong case in this matter.

 

[Andrew]

I thought I'd share this list of known genes which if mutated may result in epilepsy:

http://www.genecards.org/Search/Keyword?queryString=epilepsy#results

 

[lnsiu]

I thought I'd share this list of known genes which if mutated may result in epilepsy:

genecards.org/Search/Keyword?queryString=epilepsy#results

Sure, what do you want to say with that? I think it would be great if you could argument for your view.

"may" is the keyword here. I'll bet there are individuals that do have these changes that do not have epilepsy. I can still put all those changes in a box and call that my theory. One single mutation for all diseases and all gene-changes. You haven't disproven anything.

I said this is highly speculative, and I do believe there are something that is the same.

 

[AlohaBird]

The problem with genetics is that you really can't go take your parents, grandparents and great grandparents DNA strands apart and analyze them.

I have absolutely zero family history of either breast cancer or epilepsy but I got both.

However if you work on creating a body which is not a friendly environment to such mutations, you can prevent any lurking genes you might have from being expressed. Epigenetics is more relevant than genetics.

I believe you do this by keeping blood sugar low and stable, keeping the immune system strong, and keeping inflammation down. All of that comes back to what you eat or don't eat plus lifestyle factors like stress and sleep.

 

[MichaelJO7]

Insui,

I do believe there is ultimately a common cause of all human maladies, but I am not permitted to address that on this forum. Western medicine is very mechanistic, which will never completely solve our physical problems, since we are body, soul, and spirit. Perhaps Sweden is different.

I do agree with AlohaBird, that Epigenetics is more relevant than genetics, particularly in the absence of genetic information.

I have no family history of MMD2 or seizures. I do have considerably family history of neurotransmission deficits, as well as heart disease, and diabetes. Neurotransmission deficits may not become apparent until neurotransmission is overtaxed by traumatic, or repeatedly traumatic experiences and losses.

 

[MichaelJO7]

However if you work on creating a body which is not a friendly environment to such mutations, you can prevent any lurking genes you might have from being expressed. Epigenetics is more relevant than genetics..

I thought this was worth repeating.