Here's the current protocol. I'm most impressed these days with French green clay 3x/day and hyaluronic acid at bedtime. I'm also discovering how C. diff bacteria may be a large part of the problem along with yeast due to low commensal (good) bacteria. I would post a download link, but the system here won't allow it.
CHISPA PROTOCOL:
HOLISTIC APPROACH TO GUT REPAIR AND BALANCING GUT FLORA
This protocol is a work-in-progress inspired by our dog, Chispa, who suffers from
IBD/IBS in her jejunum (second section of small intestine) confirmed through
endoscopy, May 2011. It applies to gut repair in general. Her malady manifests in seizure
clusters, a gut-brain connection where adhesions (scars) of lacteal ducts of the lymphatic
system in Peyer’s Patches are intimately associated with nerve fibers and bundles.
Damage has been caused by yeast overgrowth leading to an ulcerative condition. Possible
cause is over-vaccination/medication and/or protozoal infection via a local, sewage-
contaminated lake (Lake Mangonia, West Palm Beach drinking water supply) or eating
feral cat/raccoon/opossum droppings. Toxins such as ammonia and aldehydes (alcohol)
produced by yeast lower seizure threshold. Epilepsy is by definition idiopathic (unknown
cause) yet may often be attributed to overlooked gut damage. Standard treatment focuses
on symptoms only, treating the problem from the neck up with a cocktail of barbiturates
and neuro-drugs rather than healing intestines. Chispa was seen by seven (7)
veterinarians and a neurologist, all without protocol to diagnose cause. Gastrointestinal
symptoms around seizure activity are obvious. Canine and human epilepsy websites
currently do not focus on gut issues as cause of seizure, a gross omission. People with
ulcerative colitis, for example, are discovering this connection to misdiagnosed epilepsy.
Imbalanced/damaged gut flora may be caused by protozoans who eat commensal (good)
bacteria allowing yeast overgrowth and viruses to thrive. Our goal is to regrow bacteria
so they will control (eat) yeast. Killing yeast directly is another goal, but they grow back
quickly, so this alone is not a long-term fix. Moreover, bacteria are the most important
mammalian symbiant, responsible for immunity including crucial antioxidant enzymes to
reduce inflammation. The small intestine is the center of all health connected to both liver
and pancreas. The small intestinal lining may be the most important quarter-inch in the
body where nutrient absorption takes place, so deficiency occurs rapidly; malabsorption
syndrome. Crucial minerals required to activate enzymes such as zinc, selenium and
molybdenum are deficient in gut dysbiosis. Silica, sulfur and hyaluronic acid are
deficient, needed for repair. These things must be added in the right form/dose as some
may be counterproductive, causing irritation. Softer foods and elimination of grains and
reduction of sugar are important. Science is finally associating gut diseases such as
epidemic Celiac, IBD, IBS, ulcerative colitis and Crohn’s with all major physical
(diabetes, cancer, heart disease) and mental illness (see poster below) along with common
symptoms: asthma, acid reflux, high/low cholesterol, obesity and arthritis.
CHISPA PROTOCOL
PRIMARY THERAPY
1) Fluconazole antifungal, the only prescription drug we are testing at relatively
small dose, long-term therapy. Ten (10) months at 70 mg daily with morning
meal. Chispa weighs about 38 lbs.; this drug is processed in the liver; antioxidants
for liver function are part of the protocol.
2) Selenium in organic form (Se-Methyl-Selenocysteine), 100 mcg daily with
morning meal. This form of selenium is safer and better absorbed than common l-
selenomethionine. Selenium activates the most important antioxidant SOD
enzymes to reduce inflammation, also required for thyroid hormone conversion.
3) Zinc-carnosine (PepZin GI) for gut repair, one capsule twice daily with meal.
Zinc activates enzymes and is required for immunity including vitamin D
absorption. The protocol may also include zinc picolinate (easiest on gut, best
absorbed form of zinc) to balance copper where copper toxicity and deficiency are
the same. Copper is required to kill yeast and is biounavailable without zinc.
Carnosine also provides healthy brain function, known to calm cases of cluster
seizure kindling effect in the amygdala regions of the brain.
4) Biotin, 5,000 mcg daily with morning meal; normally produced by bacteria which
are deficient; crucial to metabolism of fats which may trigger IBS (spastic colon)
symptoms. Bacteria eat biotin, so it stimulates their growth.
5) MSM, 1 gram daily with morning meal, provides bioavailable sulfur for gut repair.
Over time, MSM helps create a slippery gut lining such that parasites and yeast
cannot adhere and are flushed out.
6) Liquid molybdenum, 4 drops (100 mcg) twice daily with meals, activates
enzymes required to metabolize toxins produced by yeast such as aldehydes
(alcohol), sulfites and ammonia, normally deficient in food. It’s especially good
for itchy skin and raising seizure threshold.
7) French green clay, one teaspoon in the afternoon away from meals adsorbs toxins
and yeast. We mix it with a tablespoon of nutritional yeast. Some sources state it
can cause constipation while others refute this claim.
8) Acacia fiber, 1-2 tablespoons with each meal to avoid constipation and is prebiotic
(bacteria eat it and grow).
9) Nutritional yeast, Lewis Labs Brewer’s Yeast in powder form is packed with
nutrients, prebiotic fiber and protein; used with meals and as snacks in 1-2
tablespoon doses. Is it any wonder yeast cause deficiencies? The product label
reveals extremely high selenium, B vitamins, phosphorus and chromium content.
It’s conspicuously low in manganese which yeast use in self-defense against
natural immunity such as hydrogen peroxide.
10) Hyaluronic acid, 100 mg at bedtime; HA is normally produced by bacteria
which are deficient. It provides protection and intestinal healing, also important in
brain, joints, arteries, eyes, heart and all parts of the body requiring hydration.
Little known is silica as component of HA, so silica in colloidal horsetail form
may be part of the protocol. Silica is often deficient.
11) Coconut kefir, homemade using kefir grains, one tablespoon about an hour after
morning meal mixed with a small amount of fruit and nutritional yeast. A gentler,
natural form of probiotic to avoid reaction of yeast die-off; contains a much wider
variety of bacteria than store-bought probiotics where low bacterial diversity is
implicated in gut disease.
12) Sea salt, sodium deficiency is often overlooked as cause of indigestion,
necessary in chime for work in the small intestine. Sea salt is also mineral rich for
enzyme activation and also a crucial conductor of the body’s electrical currents.
CHISPA PROTOCOL
ADJUNCT THERAPY
1) Blueberries, a few tablespoons fresh or frozen, in the evening away from meal;
natural antioxidant and fiber. Regarding Hippocrates’ quote “Let food be thy
medicine and medicine be thy food,” blueberries may top the list. Parsley and
cilantro are also great foods in small doses to stimulate bile acid.
2) Boron, 3 gm dose or less may be very useful with food as antiprotozoal,
antifungal, vitamin D absorption (which regulates calcium). It’s powerful and
deficient in most soil, so not in food.
3) Moducare, balances cortisol, increases immunity, possibly via increased
circulation, reduces inflammation, lowers cholesterol, increases antioxidant
enzyme activity. Note: if deficient in nutrients required for antioxidant enzymes,
i.e., vitamin D, zinc, calcium, then I believe plant sterols can cause inflammation.
4) Colloidal silver, 1- tablespoon daily dose in ionic or regular form is useful in
initial or emergency therapy to cleanse intestine rapidly, then perhaps a weekly
maintenance. Grapefruit seed extract has similar effect, but may irritate ulcerative
gut lining. Digestive enzymes are also a concern regarding irritation. Nattokinase
and lumbrokinase may be effective in dissolving biofilm, perhaps an irritant.
5) Pomegranate extract, said to be effective co-therapy with fluconazole; powerful
natural antioxidant. Aloe vera gel capsules or juice also useful, especially in
avoiding constipation.
6) Wheatgrass juice powder with 10 drops coptis in emergency to avoid
constipation. We’re now testing kelp powder, a hyaluronidase inhibitor with
iodine required for thyroid support.
7) Zeolite, diatomaceous earth, Adya Clarity are potential adjuncts for fiber,
adsorption of parasites and minerals for enzyme activation.
8) Grape seed extract, antioxidant/antifungal. Astaxanthin is another promising
carotenoid with antioxidative, anticancer, antidiabetic, anti-inflammatory. We’re
also now testing echinacea and bee propolis. Skullcap helps regulate intestinal
nerve function.
9) Carnitine is for liver and brain health, a powerful antioxidant. Carnitine may
resolve shortness of breath due to low oxygen state of acidosis. Taurine, often
combined with carnitine has important gut function.
10) Probiotics, experts state this is a must, but products vary and may be
counterproductive in cases of small intestinal bacterial overgrowth (SIBO).
Probiotics cause die-off reaction (herxheimer), so begin slowly. Bacillus
coagulans, lactobacillus GG and homeostatic soil organisms (HSO) seem
promising, but homemade coconut kefir seems safest, offering broad range of
bacteria.
11) Bone broth, ionic minerals, gelatin and glycine are reasons “soup is good food.”
NOTE ABOUT DIET: Food combing, not mixing foods which lower stomach acid with
foods requiring stomach acid (generally protein vs. carbs) is an important practice for
proper digestion. Keeping stomach acid high cures acid reflux and is responsible for
ionic absorption of minerals and crucial vitamins such as B12.