My 15 year-old daughter was diagnosed with generalized tonic clonic epilepsy in January. After trying Keppra and Lamictal, which didn't work for her, she has been on 1500 mg of Depakote the last five months and has been seizure free. However, she is always tired. She can sleep over 12 hours a day and is still tired. We reduced her Depakote to 1250mg two weeks ago, but that has had little effect on her tiredness (she is still in the middle of the therapeutic range with the decrease). She has been on Fluoxetine for four years as well. I wonder if the combination of the two medicines is contributing to her tiredness. Anyone have any experience being on both? She also has type 1 diabetes, but managing that is currently the easiest part of her life right now. We had her thyroid tested again last week and those levels are normal. Any ideas?