[Research] Vitamin B6/magnesium therapy for autism, PDD, and ADHD

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Glutamate in Pyridoxine-Dependent Epilepsy

Background. Pyridoxine-dependent epilepsy is a rare autosomal recessive disorder. Untreated patients suffer from a progressive encephalopathy with mental retardation, intractable epilepsy, and progressive neurological signs and symptoms. Lifelong supplementation with vitamin B6 is the treatment of choice. However, despite early treatment, many patients develop mental retardation.

Objectives. To assess the role of glutamate as an excitatory neurotransmitter and neurotoxin in pyridoxine-dependent epilepsy.

Methods. We examined...

http://pediatrics.aappublications.org/content/94/3/318.short

Andrew
 
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