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A recent NY Times article suggests that some multivitamins, particularly B6 and B12 may slightly affect sleep, depending on when they are taken:
Here's the link:
http://www.nytimes.com/2010/12/14/health/14really.html?ref=health
After controlling for age, sex and other variables, the scientists found a slightly higher rate of poor or interrupted sleep in people taking multivitamins. But because they found only an association, they could not rule out the possibility that people with poorer sleep are simply more likely to seek out multivitamins.
If there is an effect, the problem is separating the effects of individual vitamins. There is some evidence that B vitamins may play a role. Some studies have shown that ingesting vitamin B6 before bed can lead to very vivid dreaming, which can wake people up. B6 helps the body convert tryptophan to serotonin, a hormone that affects sleep. Other studies have shown that vitamin B12 can affect melatonin levels, promoting wakefulness.
For those who suspect their multivitamins may be curtailing sleep, the best solution may simply be to take the pills in the morning, or at least several hours before bed.
Here's the link:
http://www.nytimes.com/2010/12/14/health/14really.html?ref=health