A hypothalamic hamartoma is a congenital birth defect -- like cleft palate or whatever. It doesn't develop.
But other types of hypothalamic inflammation can develop --
http://www.ncbi.nlm.nih.gov/pubmed/22417140
"Under conditions of brain and hypothalamic inflammation, which may result from overnutrition-induced intracellular stresses or disease-associated systemic inflammatory factors, extracellular and intracellular environments of hypothalamic cells are disrupted, leading to central metabolic dysregulations and various diseases"
So...it seems that overeating is one culprit in hypothalamic disorder, along with inflammation from disease.
Which leads back to treating epilepsy through treating inflammation.
That's an interesting paper and, like so many others, skips over the best part: microbial overgrowth. The term overnutrition is not about overeating as commonly thought, connected with obesity. It's not what we eat, but what we can absorb. Absorption and subsequent biosynthesis relies on microbes. Similarly, in the fairly new science of Nutrigenomics, the word bacteria cannot be found as they ascribe genetic changes to food without mention of microbial fermentation. It's as if we're unwilling to take responsibility for the web of life . . . while we pour raw sewage into coastal waters. Epilepsy, autism, obesity and related cancer, Alzheimer's, heart disease, etc., are environmental issues where environment includes the fetal gastrointestinal tract (crucial to brain development) now considered sterile by modern science, a fallacy for which there is no empirical evidence and should be disproved as soon as possible.
This is illustrated by the fact that diabetes is hardly confined to fat people. There are millions of thin diabetics, including thin children and infants, where health risk is greater than their obese counterparts:
http://www.cnn.com/2012/08/09/health/obesity-paradox-thin-diabetes-time/index.html
http://www.womenshealthmag.com/health/type-2-diabetes
http://articles.timesofindia.indiat...6733_1_diabetic-kids-diabetes-capital-insulin
http://www.thehindu.com/news/states...-common-among-children-too/article3952071.ece
The 39 page, December 2011 paper you found, Karen, is fantastic stuff, of course: Hypothalamic inflammation: a double-edged sword to
nutritional diseases , without mention of microbial toxins, aldehydes and ammonia increasing permeability of the blood brain barrier, leading to inflammation and leptin/insulin resistance via endotoxins. Like so much published science, it's about shortcuts and developing drugs which inhibit the body's natural systems, i.e., enzyme inhibitors which is how all the leading pharmaceutical drugs exert their effect, missing the microbial target, the origin of the problem. This is true whether it be in the non-sterile womb or poor eating habits. Children are now born predisposed to epilepsy and obesity. It's not about diet and exercise as these things are secondary to flora.
Related to inflammation and cancer, the 2011 paper cites this 1997 paper about TNF-alpha (tumor necrosis factor) regulating insulin resistance:
http://www.nature.com/nature/journal/v389/n6651/full/389610a0.html
1985 paper shows TNF relationship to endotoxin:
http://www.ncbi.nlm.nih.gov/pubmed/18566363
TNF blockers treating diabetes, arthritis and psoriasis are big business with lots of health risk. Like the controversial statin drugs, the largest selling drugs in the history of pharmaceuticals, there's also much "research" (industry flack) touting benefits:
http://centennial.rucares.org/index.php?page=Tumor_Necrosis_Factor
http://www.pnas.org/content/102/44/15995.abstract
http://www.globalpost.com/dispatch/...-tfn-blockers-amgen-enbrel-abbott-health-news
http://www.internalmedicinenews.com...proved-for-refractory-ulcerative-colitis.html
http://www.medicinenet.com/script/main/art.asp?articlekey=121930
http://www.empowher.com/rheumatoid-arthritis/content/tnf-blockers-miracle-drugs-or-minefields
http://www.fda.gov/forconsumers/consumerupdates/ucm107878.htm
http://www.medpagetoday.com/ProductAlert/Prescriptions/28396
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm175803.htm
http://www.reuters.com/article/2011/04/14/us-fda-tnf-idUSTRE73D7LB20110414
TNF binds significantly more to gram negative bacteria where overgrowth is known in SIBO:
http://iai.asm.org/content/61/3/830
Here's the drug industry developing shortcuts to obesity problems via hypothalamic inflammation caused by overnutrition:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586330/
And here, a 2012 paper detailing how gut-brain is a two-way street, inflammation "particularly in the hypothalamus" which I believe begins in the gut, everyone's gut, including and especially a mother's gut:
http://www.impactaging.com/papers/v4/n2/full/100431.html
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