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Epilepsy as a Pyridoxine-Dependent Condition: Quantitative Urinary Biomarkers of Epilepsy. Family Disorders of Pyridoxine Metabolism
The above two quotes were taken from the following URL:Meanwhile, disturbances in the metabolism of glutamate, GABA, tryptophan (TRP), serotonin, taurine, dopamine, and norepinephrine, which are synthesized and/or metabolized by PLPdependent enzymes [20–32], have been repeatedly found in epileptic patients. The increased levels of excitatory amino acids—glutamate, aspartate, and glycine [21–27] along with the reduced levels of inhibitory amino acids and amines—GABA, serotonin, and taurine [28–32] were detected in the plasma, cerebrospinal fluid (CSF), and epileptogenic foci of patients with different forms of epilepsy. Moreover, a moderate increase in the activity of glutamic acid dehydrogenase, the glutamate-synthesizing enzyme, which is specifically inhibited by PLP, has been found in epileptic foci .
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142116/Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy
https://folk.uib.no/mfapu/Pages/BV/BVSite/pdf_files/literature/ueland_2015_arn_35_33.pdfDirect and Functional Biomarkers of Vitamin B6 Status