Welcome to the Coping With Epilepsy forums - a peer support community for folks dealing (directly or indirectly) with seizure disorders. You can visit the forum page to see the list of forum nodes (categories/rooms) for topics.
Please have a look around and if you like what you see, please consider registering an account and joining the discussions. When you register an account and log in, you may enjoy additional benefits including no ads, access to members only (ie. private) forum nodes and more. Registering an account is free - you have nothing to lose!
PNPO
https://www.sciencedirect.com/topics/medicine-and-dentistry/pnpoLearn more about PNPO
https://metabolicas.sjdhospitalbarcelona.org/sites/default/files/pnpo_deficiency_eng.pdfPNPO Deficiency
Epilepsy as a Pyridoxine-Dependent Condition: Quantitative Urinary Biomarkers of Epilepsy. Family Disorders of Pyridoxine Metabolism
The above two quotes were taken from the following URL:Meanwhile, disturbances in the metabolism of glutamate, GABA, tryptophan (TRP), serotonin, taurine, dopamine, and norepinephrine, which are synthesized and/or metabolized by PLPdependent enzymes [20–32], have been repeatedly found in epileptic patients. The increased levels of excitatory amino acids—glutamate, aspartate, and glycine [21–27] along with the reduced levels of inhibitory amino acids and amines—GABA, serotonin, and taurine [28–32] were detected in the plasma, cerebrospinal fluid (CSF), and epileptogenic foci of patients with different forms of epilepsy. Moreover, a moderate increase in the activity of glutamic acid dehydrogenase, the glutamate-synthesizing enzyme, which is specifically inhibited by PLP, has been found in epileptic foci [33].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142116/Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy
https://folk.uib.no/mfapu/Pages/BV/BVSite/pdf_files/literature/ueland_2015_arn_35_33.pdfDirect and Functional Biomarkers of Vitamin B6 Status