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My most recent Lamictal Rx had the generic substituted because the doctor forgot to specify "no substitutions". I thought I'd go ahead and try it, since the generic would save me $420/year. I've felt a little funny on it -- no seizures, but one moment of brain fog that may be a warning. If it happens again, I'll go back to the brand despite the cost.
The same thing happened to me this past spring with Keppra. The thing is, they look so similar, it is hard to distinguish between generic and brand name unless one reads the labels. Anyway, I did feel different, more brain fog, and had several CP seizures, one where I was burned again. I finally realized it was the generic medicine and told my epileptologist about it. She wrote a new prescription and personally called my pharmacy telling them NO generic. For me, paying that extra $$ is worth my life. It is a matter of life and death, as many accidents I have suffered from seizures.