Quote from PubMed
Epilepsy and hormones-a critical review. With epilepsy, however, things are often changing and a complicated interplay between hormones, epilepsy and AED may appear. Epilepsy itself possibly brings out diverse effects on different enzyme systems including sex-steriods, the neuro-cardio-endocrine axis and bone health. On the other hand, different AEDs are known to influence neuroendocrine changes that may cause unexpected consequences on health and well being later in life. It is of importance to have in mind and to consider endocrine effects caused by epilepsy itself or by a certain AED when starting antiepileptic therapy, especially when it is expected that long-term treatment will be necessary. Authors: Luef G, Rauchenzauner M. Department of Neurology, Medical University Innsbruck. Feb 20, 2009