Seizures and ADHD meds

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moonshine

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Hi, I'm miserable for multiple reasons, one of which is the incompatibility between Ritalin and seizures. I'm honestly tired of doctors just shrugging and suggesting that I discuss with another one. Meds are interacting with each other or don't work well enough.

I have simple and sometimes complex partials. I used to have nocturnal tc seizures, but thankfully Lamictal put them under control. I haven't had one in five years. I only get partials if there are triggers. I was used to that, so I learned how to avoid them. Last year I sank into depression and the psychiatrist started suspecting that I also have ADD, so she referred me to a specialist who confirmed it. Better late than never. He gave me Ritalin but warned me that since caffeine is a certain seizure trigger for me, I should watch out for any signs. Well, his guess was right. The med made a huge difference in terms of ADHD symptoms, it was like somebody gave the correct glasses to a short-sighted person. Sadly, I started having clusters of partial seizures in the afternoon. I was impressed by how much the chaos in my brain got reduced, so I thought I'll try for a week and see if my body adjusts. Then I tried every other day - and on those days that I skipped, I had just auras or nothing at all. I'm now waiting to get a prescription for Evanse but I'm quite pessimistic about it. The neurologist said that I shouldn't touch my epilepsy meds because they seem to be working for me, but I'm starting to get doubtful about it. I already take 400 mg per day, so I can't increase it further.

Do you have any experience with such issues? I've read that ADHD and E are often comorbid but meds are usually not causing any issues.
 
Unfortunately there hasn't been a lot of research into the best ways to co-treat epilepsy and ADD. And as with epilepsy in general, there's no single playbook, especially given the different potential triggers (genetic, environmental, trauma, or a combo platter).

I think that your neuro is right -- you don't want to reduce your Lamictal dose, especially because what little research is out there suggests that untreated seizures can make co-occurring ADD worse. The maximum suggested daily dose of Lamictal for epilepsy is 600mg/day, so that's still an option to consider. But it might make sense to ask your neuro if there's an add-on you could take every other day or on an occasional basis, such as ativan.

There are some threads in the CWE archives related to co-occurring ADHD/ADD and epilepsy. Here are a few:
 
Thank you, Nakamova, I already learned plenty from these links, particularly neurofeedback was new to me. I don't know if I can find a provider here, but I'm glad to hear that there are alternatives being researched.
 
Hi moonshine,

I have found I get more info. from my pharmacist than my neuro sometimes. I have read that in some cases Ritalin can trigger seizures
but it's very rare. The Ritalin will also make a person depressed but then that's all part of having epilepsy also along with the seizure meds.
a person takes. Tell your Dr. to do a DNA test on you by doing this they will be able to find the best meds for you that won't interact with
each other and the meds will help you the most unless you are drug resistant like me. You may want to start taking vitamin B12 1000 mcg.
once a day that helps calm the nerves and as you have mentioned cut back on the caffeine. That's one thing my Epileptologist told me
yrs. ago. I wish you the best of luck and May God Bless You!

Sue
 
Thank you, Sue. I sometimes feel like any substance can trigger seizures in me. I can't drink anything with caffeine. Last year I was prescribed Effexor for depression, and I had a horrible cluster of seizures after being seizure-free for several years. Another antidepressant was causing me to feel auras, but I somehow got used to it, I think. I sometimes wonder if Lamictal doesn't match me well. But on the other hand, I've heard about the mental health effects of Keppra, and I don't want to risk sinking any further into depression.

What kind of DNA test is the one you mentioned? I live in Europe, so I don't know if we have such here. I'm meeting my doctor in mid-August, so I can ask her. At least I'll try B12 tablets.

By the way, have you heard of calcium levels affecting the seizure threshold? Mine were slightly elevated last year. I never really bothered finding out what's causing it. What I know is that my body is broken, and epilepsy is just one part of it.
 
Hi moonshine,

My Epileptologist (Dr. specializing in epilepsy) told me to stay away from anti-depressants because they will reverse what the
seizure meds do, that's why I take the vitamin B12 instead. I also found out that drinking diet soda or using anything that had
nutrasweet in it was triggering seizures for me because nutrasweet causes more electrical activity in the brain.

The DNA test is verys simple all your Dr. needs to do is draw a few tubes of blood from you and then get some salvia from
the inside of your mouth. That all needs to be sent to a lab where they will be able to see the amount of enzymes in your liver
and the it will show your body chemistry and by looking at all of that your Dr. will be able to find the best seizure med for you
with the least side effects or it will show if you are drug resistant like me. My Dr. did tell me to much calcium will trigger seizures
for me but zinc will help reduce them so I take 50 mg. of zinc once a day and it's a big help along with the medical marijuana
that has amazed me how that has helped. I buy it on line in a mouth spray and there's no thc in it so I don't get high.
If you want to find out what's causing your seizures ask your Dr. to do a wada test on you and that will tell you what is causing
the seizures. I wish you only the best and May God Bless You!

Sue
 
...where they will be able to see the amount of enzymes in your liver
It sounds like they were conducting a 'liver function test':


Two of the enzymes mentioned in the link above are B6 dependent, namely: alanine transaminase and aspartate aminotransferase.

Also:

All transaminase reactions have the same mechanism and use pyridoxal phosphate
 
It sounds like they were conducting a 'liver function test':


Two of the enzymes mentioned in the link above are B6 dependent, namely: alanine transaminase and aspartate aminotransferase.

Also:



I see, thanks for the details. I actually spoke to a neuro today - for some reason they hadn't booked me with mine ... after waiting for 2 months, but it was pretty frustrating. He started explaining how ADD can cause episodes similar to partial seizures... 🙄 I really didn't buy that. I'll have to wait for 2 more months to speak to my neurologist.
 
I see where you are coming from but my Epileptologist did a DNA test on me to find out the best seizure meds
for me with the least side effects and during this test it will also show the amount of enzymes in a persons liver.
Wishing you only the best and May God Bless You,

Sue
 
Here is a list of known epilepsy causing genes:


Mutations in any one or more of the above genes (click on the above URL) may lead to the root cause\causes of one's epilepsy. A separate DNA (genetic) test will most likely be needed for each gene, to check for mutations.


Then there are different causes which are non genetic.
 
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Here is a list of known epilepsy causing genes:


Mutations in any one or more of the above genes (click on the above URL) may lead to the root cause\causes of one's epilepsy. A separate DNA (genetic) test will most likely be needed for each gene, to check for mutations.


Then there are different causes which are non genetic.
Thanks for sharing these details about genes, that's so interesting!
 
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